Article
Pharmacology & Pharmacy
Ying-Ming Chu, Ting-Xin Wang, Xiao-Fen Jia, Yao Yang, Zong-Ming Shi, Guang-Hui Cui, Qiu-Yue Huang, Hui Ye, Xue-Zhi Zhang
Summary: In this study, it was discovered that Fuzheng Nizeng Decoction (FZNZ) could induce ferroptosis and endoplasmic reticulum stress in gastric precancerous lesion cells. This process was associated with a decrease in glutathione peroxidase 4 (GPX4) and glutathione levels. ATF3/CHOP/CHAC1 may play a role in mediating this crosstalk, providing a new molecular mechanism for the treatment of gastric precancerous lesions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Huan Wang, Yiming Wang, Jiongyuan Li, Ziyi He, Sarah A. Boswell, Mirra Chung, Fuping You, Sen Han
Summary: By studying the effects of eight different tyrosine kinase inhibitors (TKIs) with varying levels of cardiotoxicity on human cardiomyocytes, potential molecular mechanisms in modulating cardiotoxicity were uncovered, with ER stress-induced inflammation identified as a promising therapeutic target to mitigate certain TKI-induced cardiotoxicity.
Article
Nutrition & Dietetics
Yangguang Bao, Yuedong Shen, Xuejiao Li, Zhaoxun Wu, Lefei Jiao, Jing Li, Qicun Zhou, Min Jin
Summary: This study assessed the effects of salinity and dietary cholesterol levels on the physiological regulation, cholesterol metabolism, fatty acid composition, and stress responses of black seabream. The results showed that feeding black seabream with 1.0% cholesterol diet in low salinity improved osmoregulation, increased cholesterol synthesis, and reduced degradation. It also promoted the biosynthesis of long-chain polyunsaturated fatty acids and attenuated oxidative stress and endoplasmic reticulum stress.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Medicinal
Yan Li, Cuiyu Li, Yuhua Xiong, Bin Fang, Xing Lin, Quanfang Huang
Summary: In this study, we found that didymin can alleviate liver fibrosis mainly by inhibiting endoplasmic reticulum stress, inflammation, and glycerophospholipid metabolism.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Farsad Afshinnia, Thekkelnaycke M. Rajendiran, Chenchen He, Jaeman Byun, Daniel Montemayor, Manjula Darshi, Jana Tumova, Jiwan Kim, Christine P. Limonte, Rachel G. Miller, Tina Costacou, Trevor J. Orchard, Tarunveer S. Ahluwalia, Peter Rossing, Janet K. Snell-Bergeon, Ian H. de Boer, Loki Natarajan, George Michailidis, Kumar Sharma, Subramaniam Pennathur
Summary: Patients with type 1 diabetes (T1D) may experience rapid decline of kidney function due to specific lipidomic predictors, including unsaturated free fatty acids and phosphatidylcholine (PC), which were found to be independently associated with this decline.
Article
Biochemistry & Molecular Biology
Mengdie Luo, Emmanuel Opoku, C. Alicia Traughber, Qimin Hai, Peggy Robinet, Stela Berisha, Jonathan D. Smith
Summary: The study showed that AKR and DBA/2 mouse macrophages exhibit different levels of free cholesterol and CHOP expression after cholesterol loading due to variations in the Soat1 gene. Inhibition of ACAT enzyme revealed that differences in free cholesterol levels were responsible for the differential induction of CHOP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Environmental Sciences
Fu Cheng Yao, Yue Gu, Tian Jiang, Peng Fei Wang, Fei Biao Song, Zhi Zhou, Jun Long Sun, Jian Luo
Summary: Microplastics pollution is prevalent in coastal areas, posing a potential threat to marine organisms. In this study, the impact of polystyrene microplastics (PS-MPs) on Golden Pompano was investigated. The results showed that exposure to high concentrations of PS-MPs led to impaired growth, histopathological changes in the liver, oxidative stress, endoplasmic reticulum stress (ERS), apoptosis, metabolic alterations, and immune disturbance in the fish. These findings highlight the role of ERS in microplastics toxicology and reveal the adverse effects of microplastics on Golden Pompano.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Lei Li, Chun Pong Lee, Xinxin Ding, Yu Qin, Akila Wijerathna-Yapa, Martyna Broda, Marisa S. Otegui, A. Harvey Millar
Summary: Protein cargo of autophagy in plants, specifically ATG11 and ATG5, play a crucial role in the degradation of specific enzymes and proteins in various organelles. Autophagy is also involved in metabolic changes and protein degradation rates under phosphate limitation, and specifically targets proteins involved in chloroplast autophagy and secondary metabolism.
Article
Multidisciplinary Sciences
Alyssa Kriegermeier, Angela Hyon, Brian LeCuyer, Susan Hubchak, Xiaoying Liu, Richard M. Green
Summary: This study evaluated the expression differences of the unfolded protein response (UPR) in pediatric cholestatic liver disease (CLD) and found that decreased expression of the IRE1 alpha /XBP1 pathway is associated with the pathogenesis of CLD. This suggests that the IRE1 alpha /XBP1 pathway may be a potential target for future therapeutics in CLD.
Article
Pharmacology & Pharmacy
Vanessa Blas-Valdivia, Margarita Franco-Colin, Placido Rojas-Franco, Alberto Chao-Vazquez, Edgar Cano-Europa
Summary: The study demonstrated that gallic acid has a neuroprotective effect against hippocampal damage in adult-onset hypothyroid rats by reducing oxidative and endoplasmic reticulum stresses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Hong Chen, Chong Liu, Qian Wang, Mingrui Xiong, Xia Zeng, Dong Yang, Yunhao Xie, Hua Su, Yu Zhang, Yixue Huang, Yuchen Chen, Junqiu Yue, Chengyu Liu, Shun Wang, Kun Huang, Ling Zheng
Summary: The global obesity epidemic has negative effects on human health by causing obesity-related kidney and liver diseases. The researchers found that knockout of the UTX gene inhibits lipid accumulation in the kidney and liver induced by a high-fat diet by increasing circulating serine levels. They also discovered that UTX regulates the degradation of phosphoglycerate dehydrogenase, a key enzyme in serine synthesis, which in turn affects renal and circulating serine levels. Importantly, oral administration of serine improves fatty liver and renal dysfunction induced by a high-fat diet. These findings suggest potential treatment targets for obesity-related metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Jana Messias Sandes, Regina Celia Bressan Queiroz de Figueiredo
Summary: The endoplasmic reticulum (ER) is an important organelle in higher eukaryotic cells responsible for protein folding and assembly. It undergoes strict quality control to ensure proper processing of proteins, with unfolded proteins being targeted for degradation through the ER-associated degradation (ERAD) complex. Additionally, the ER responds to stress through the unfolded protein response (UPR) to restore homeostasis or induce cell death. Protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp. also have similar ER structures and stress response mechanisms, making them attractive targets for chemotherapy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Tianyu Yang, Xiaoyu Ma, Maocheng Jiang, Zhiqiang Cheng, Osmond Datsomor, Guoqi Zhao, Kang Zhan
Summary: Tea tree oil has a alleviating effect on lipid accumulation and inflammation in bovine hepatocytes. The study shows that treatment with tea tree oil can promote fatty acid oxidation, reduce fatty acid synthesis, suppress inflammatory response, and alleviate endoplasmic reticulum stress.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Yilong Zhu, Yiquan Li, Bing Bai, Chao Shang, Jinbo Fang, Jianan Cong, Wenjie Li, Shanzhi Li, Gaojie Song, Zirui Liu, Jin Zhao, Xiao Li, Guangze Zhu, Ningyi Jin
Summary: The study investigated the effects of Apoptin-induced endoplasmic reticulum stress on HepG-2 cells' lipid metabolism, migration, and invasion, and found that it can cause lasting ER stress response, alter lipid metabolism related enzymes expression levels, and reduce migration and invasion abilities of HepG-2 cells. Apoptin can also affect lipid metabolism through ER stress, potentially reducing tumor cells' migration and invasion abilities.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemical Research Methods
Callaway Thatcher, Lone Hoj, David G. Bourne
Summary: Coral reefs globally are facing pressure from climate change, resulting in concerning declines in coral abundance. One mitigation strategy to combat these declines is coral restoration through large-scale coral aquaculture, along with the application of probiotics to provide health benefits.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Ecology
Nils Raedecker, Claudia Pogoreutz, Hagen M. Gegner, Anny Cardenas, Gabriela Perna, Laura Geissler, Florian Roth, Jeremy Bougoure, Paul Guagliardo, Ulrich Struck, Christian Wild, Mathieu Pernice, Jean-Baptiste Raina, Anders Meibom, Christian R. Voolstra
Summary: The study found that under heat stress, nitrogen fixation by coral-associated diazotrophs increased, but the additional fixed nitrogen was not assimilated by the coral tissue or the algal symbionts.
Article
Ecology
Hillary A. Smith, Dylan A. Brown, Chaitanya Arjunwadkar, Stella E. Fulton, Taylor Whitman, Bambang Hermanto, Elissa Mastroianni, Neil Mattocks, Adam K. Smith, Peter L. Harrison, Lisa Bostrom-Einarsson, Ian M. McLeod, David G. Bourne
Summary: Removing macroalgae may be an effective intervention to boost recruitment and facilitate recovery on degraded tropical coral reefs.
RESTORATION ECOLOGY
(2022)
Article
Microbiology
Nine Le Reun, Anna Bramucci, James O'Brien, Martin Ostrowski, Mark V. Brown, Jodie Van de Kamp, Levente Bodrossy, Jean-Baptiste Raina, Penelope Ajani, Justin Seymour
Summary: This study investigates the spatial and temporal dynamics of diatom communities in Australian coastal waters. The results reveal significant biogeographical differences in diatom community composition, with each site having distinct community structures. Temperature and nutrients are identified as the key environmental factors influencing diatom community differences, and specific groups of bacteria also play a role in shaping the spatial dynamics of diatom communities. In addition, the study uncovers some co-occurrences between diatoms and bacteria.
Article
Multidisciplinary Sciences
Jean-Baptiste Raina, Bennett S. Lambert, Donovan H. Parks, Christian Rinke, Nachshon Siboni, Anna Bramucci, Martin Ostrowski, Brandon Signal, Adrian Lutz, Himasha Mendis, Francesco Rubino, Vicente I. Fernandez, Roman Stocker, Philip Hugenholtz, Gene W. Tyson, Justin R. Seymour
Summary: This study demonstrates the chemotactic responses of marine bacteria and archaea towards microscale hotspots of phytoplankton-derived dissolved organic matter (DOM). The specific chemical cues attract different prokaryotic populations, which play important roles in biogeochemical processes and ecological interactions in the marine food web.
Review
Ecology
David J. Hughes, Jean-Baptiste Raina, Daniel A. Nielsen, David J. Suggett, Michael Kuhl
Summary: Sessile invertebrates often have discrete compartments with distinct physicochemical conditions that support specific functions. The coral gastrovascular cavity is a complex compartment with steep and dynamic chemical gradients, distinct microorganisms, and plays a key role in coral biology. Understanding the functions of these compartments will provide valuable insights into sessile invertebrate biology and their adaptation to environmental change.
TRENDS IN ECOLOGY & EVOLUTION
(2022)
Article
Microbiology
Madeleine J. H. van Oppen, Jean-Baptiste Raina
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biodiversity Conservation
Magena R. Marzonie, Line K. Bay, David G. Bourne, Andrew S. Hoey, Samuel Matthews, Josephine J. Nielsen, Hugo B. Harrison
Summary: Scleractinian coral populations are facing increasing exposure to temperatures above their upper limits, leading to declines in coral reef ecosystem health. Variations in thermal tolerance exist among species, individual coral colonies, and populations. This study conducted heat stress experiments to assess heat tolerance across a large environmental gradient. The results showed variations in heat tolerance among species and within reefs, with mild heatwave exposure positively correlated with heat tolerance over the past 35 years, but recent severe heatwaves showing a negative relationship. These findings suggest that marine heatwaves are selecting for tolerant individuals and populations, but recent severe heatwaves may compromise this adaptive potential.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ian M. McLeod, Margaux Y. Hein, Russ Babcock, Line Bay, David G. Bourne, Nathan Cook, Christopher Doropoulos, Mark Gibbs, Peter Harrison, Stewart Lockie, Madeleine J. H. van Oppen, Neil Mattocks, Cathie A. Page, Carly J. Randall, Adam Smith, Hillary A. Smith, David J. Suggett, Bruce Taylor, Karen J. Vella, David Wachenfeld, Lisa Bostrom-Einarsson
Summary: Australia has been implementing innovative intervention and restoration actions to address the decline in coral cover in its reefs. This article outlines the various approaches taken, including in-water programs, research to enhance coral resilience, and investigations into socio-economic perspectives. The progress in coral restoration in Australia demonstrates the increasing urgency to confront the coral reef crisis and the development of new tools for reef management.
Article
Biology
Trent D. D. Haydon, Jennifer L. L. Matthews, Justin R. R. Seymour, Jean-Baptiste Raina, Jamie E. E. Seymour, Kathryn Chartrand, Emma F. F. Camp, David J. J. Suggett
Summary: Anthropogenic stressors lead to declines in reef conditions and coral health. Studying coral populations in extreme habitats can provide insights into their future functionality. By comparing the metabolite profiles of Pocillopora acuta colonies in mangrove and adjacent reef environments, we found that mangrove populations exhibit metabolic plasticity to resist high-temperature exposure. Specific metabolites may serve as biomarkers of heat tolerance, providing novel insight into adaptive coral resilience to elevated temperatures.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Microbiology
Jean-Baptiste Raina, Marco Giardina, Douglas R. R. Brumley, Peta L. L. Clode, Mathieu Pernice, Paul Guagliardo, Jeremy Bougoure, Himasha Mendis, Steven Smriga, Eva C. C. Sonnenschein, Matthias S. S. Ullrich, Roman Stocker, Justin R. R. Seymour
Summary: Behaviors such as chemotaxis play an important role in metabolic exchanges between phytoplankton and bacteria, regulating oceanic productivity and biogeochemistry. This study reveals that chemotaxis increases nutrient uptake and provides a competitive advantage for bacteria in transient interactions with picophytoplankton. These findings highlight the significance of chemotactic interactions in shaping metabolic relationships among abundant microorganisms in the ocean.
NATURE MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Guoxin Cui, Migle K. Konciute, Lorraine Ling, Luke Esau, Jean -Baptiste Raina, Baoda Han, Octavio R. Salazar, Jason S. Presnell, Nils Raedecker, Huawen Zhong, Jessica Menzies, Phillip A. Cleves, Yi Jin Liew, Cory J. Krediet, Val Sawiccy, Maha J. Cziesielski, Paul Guagliardo, Jeremy Bougoure, Mathieu Pernice, Heribert Hirt, Christian R. Voolstra, Virginia M. Weis, John R. Pringle, Manuel Aranda
Summary: Symbiotic cnidarians, such as corals and anemones, have evolved efficient molecular mechanisms for nutrient distribution and recycling in order to thrive in nutrient-poor ocean environments. Using the sea anemone Aiptasia, researchers have discovered that glucose and the presence of algae induce the up-regulation and relocalization of glucose and ammonium transporters, which are critical for symbiont functioning and organism-wide nitrogen assimilation. These findings provide insight into the molecular mechanisms underlying nitrogen conservation and recycling in symbiotic cnidarians.
Article
Biodiversity Conservation
Yingqi Zhang, Shelby E. Gantt, Elise F. Keister, Holland Elder, Graham Kolodziej, Catalina Aguilar, Michael S. Studivan, Dana E. Williams, Dustin W. Kemp, Derek P. Manzello, Ian C. Enochs, Carly D. Kenkel
Summary: Contrary to expectations, the study found that purebred larval offspring of the nearshore mountainous star coral exhibited higher survival rates and lower stress response gene expression profiles under elevated temperature. One potential explanation could be the compromised reproductive output of the nearshore population due to summer bleaching events, resulting in lower storage lipid content in their gametes.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Nerissa L. Fisher, Kimberly H. Halsey, David J. Suggett, Michelle Pombrol, Peter J. Ralph, Adrian Lutz, E. Maggie Sogin, Jean-Baptiste Raina, Jennifer L. Matthews
Summary: This study used transcriptomic and metabolomic approaches to study the mechanisms underlying diatom acclimation and growth under different light intensities. The results showed that diatoms shift their carbon and energy fluxes depending on the growth rate driven by light. Under high light conditions, diatoms upregulate metabolic pathways for fatty acid, glycolic acid, and carbohydrate production to support fast growth. Under low light conditions, diatoms conserve energy through upregulation of carbon retention pathways and regulate metabolites associated with light harvesting, energy storage, and signaling. These findings provide important insights for predicting and manipulating diatom growth and bio-production.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Microbiology
Nine Le Reun, Anna Bramucci, Penelope Ajani, Abeeha Khalil, Jean-Baptiste Raina, Justin R. Seymour
Summary: Reciprocal metabolite exchanges between diatoms and bacteria can enhance the growth of both partners and therefore fundamentally influence aquatic ecosystem productivity. We studied the growth-promoting capabilities of 15 different bacterial isolates from the bacterial community associated with the marine diatom Actinocyclus sp. and found that co-culture with these isolates increased the growth of the diatom host, with different bacteria showing varying effects at different stages of the diatom's life cycle.
FRONTIERS IN MICROBIOLOGY
(2023)