Review
Biology
Leonidas N. Diamantopoulos, Markos Kalligeros, Thorvardur R. Halfdanarson, Nikolaos Diamantis, Christos Toumpanakis
Summary: There are various systemic combination regimens being investigated for advanced well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs). This review provides an overview of the clinical trials and prospective studies on combination treatments. Results show a wide range of efficacy in reported combinations, and only a few phase 3 trials have shown practice-changing results. Peptide receptor radionuclide therapy (PRRT)-based combinations and anti-vascular endothelial growth factor (VEGF) agent combinations with standard chemotherapy have shown promising results, while immune-checkpoint inhibitor-based combinations have limited applicability.
Article
Endocrinology & Metabolism
Leonidas Nikolaos Diamantopoulos, Faidon-Marios Laskaratos, Markos Kalligeros, Ruchir Shah, Shaunak Navalkissoor, Gopinath Gnanasegaran, Jamie Banks, Jack Smith, Benjamin Jacobs, Michail Galanopoulos, Dalvinder Mandair, Martyn Caplin, Christos Toumpanakis
Summary: In this study, above-label doses of somatostatin analogs showed promising antiproliferative effects in patients with inoperable/metastatic gastroenteropancreatic neuroendocrine tumors. Symptomatic improvement and disease control were observed in some patients after 3-weekly administration, with certain factors associated with inferior or better progression-free survival. Higher doses of SSAs may be beneficial as a bridge to other treatments, particularly for patients with specific tumor characteristics.
NEUROENDOCRINOLOGY
(2021)
Review
Oncology
Teresa Alonso-Gordoa, Ray Manneh, Enrique Grande, Javier Molina-Cerrillo
Summary: Neuroendocrine tumors (NET) are a complex and heterogeneous group of malignancies, with over one-third of patients diagnosed at an advanced stage. Somatostatin analogs (SSA) are the cornerstone in treating advanced well-differentiated NET, but many patients eventually develop resistance to this treatment. Increasing the SSA dose may help control symptoms and tumor growth in some cases, but there are still unanswered questions about the optimal dose, frequency, and patient selection for high-dose SSA use.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Oncology
A. Custodio, P. Jimenez-Fonseca, A. Carmona-Bayonas, M. J. Gomez, M. I. Del Olmo-Garcia, I. Lorenzo, J. A. Diaz, N. Canal, G. De la Cruz, C. Villabona
Summary: This study shows that patients with uncontrolled carcinoid syndrome had more frequent emergency department visits, higher likelihood of hospital admission, longer hospital stays, and significantly higher hospitalization and emergency department costs compared to patients with controlled carcinoid syndrome. Better control of carcinoid syndrome may result in lower medical costs.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carel W. le Roux, Niels Hartvig, Christiane Lundegaard Haase, Rikke Baastrup Nordsborg, Anne Helene Olsen, Altynai Satylganova
Summary: The joint effect of obesity and cardiovascular risk status on healthcare resource utilization was examined in a UK database study, showing that higher BMI categories and established CVD patients had greater healthcare resource utilization. Timely management of obesity and CVD-risk factors is important in preventing increasing healthcare resource utilization.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Claudia Gulea, Rosita Zakeri, Jennifer K. Quint
Summary: Through latent class analysis, this study identified five clusters of comorbidities in HF patients and found that patients in the metabolic-vascular group had the worst prognosis, while the anemic group had intermediate risk. There were also variations in healthcare use among different comorbidity groups.
Article
Information Science & Library Science
Sezgin Ayabakan, Indranil R. Bardhan, Zhiqiang (Eric) Zheng
Summary: Technological advancements and the COVID-19 pandemic have accelerated process virtualization, particularly in healthcare where telehealth has greatly transformed care delivery. However, telehealth can increase healthcare spending if it leads to new types of resource utilization. By analyzing visit-level patient data, this study finds that telehealth visits reduce future outpatient visits by 13.6% on average, resulting in a cost reduction of $239 within 30 days after the visit. The benefits of telehealth are more pronounced for diseases with high virtualization potential, such as mental health, skin, metabolic, and musculoskeletal diseases. The findings highlight the importance of promoting telehealth use in a value-based healthcare system, particularly for diseases with high virtualization potential.
INFORMATION SYSTEMS RESEARCH
(2023)
Review
Medicine, Research & Experimental
David Cella, Jennifer Evans, Marion Feuilly, Sebastian Neggers, Dirk Van Genechten, Jackie Herman, Mohid S. Khan
Summary: Based on a systematic literature review, LAN was favored over OCT in the treatment of acromegaly and NETs, with technical problems and pain during injections being the most influential factors in treatment experience.
ADVANCES IN THERAPY
(2021)
Article
Economics
Rena C. Moon, Harold Brown, Ning Rosenthal
Summary: This study aimed to describe the healthcare resource utilization of patients with COVID-19 and found that COVID-19 is associated with high level of healthcare resource utilization and in-hospital mortality. More than one-third of inpatients required post hospital healthcare services.
Article
Medicine, General & Internal
Vered H. Eisenberg, Dean H. Decter, Gabriel Chodick, Varda Shalev, Clara Weil
Summary: The goal of this study was to evaluate the burden of endometriosis in the community by comparing healthcare resource utilization, total direct medical costs, infertility, and comorbidity rates of women with and without a diagnosis of endometriosis. The study found that endometriosis was significantly associated with infertility, comorbidities, higher utilization of healthcare services, pain medications, and antidepressants, as well as higher direct medical costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Wyatt P. Bensken, Philip M. Alberti, Kurt C. Stange, Martha Sajatovic, Siran M. Koroukian
Summary: This study examines the differences in disease prevalence, utilization, and costs between patients with health-related social needs and those without such needs, using ICD-10 Z-codes. The results show that patients with health-related social needs have higher disease prevalence, more negative health events, and greater total annual costs.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Ygal Plakht, Harel Gilutz, Jonathan Eli Arbelle, Dan Greenberg, Arthur Shiyovich
Summary: Healthcare resource utilization (HRU) is highest in the last year-of-life and accounts for a significant portion of healthcare expenditure. We examined changes in HRU and costs during the last year-of-life among survivors of acute myocardial infarction (AMI) and assessed whether these changes can predict imminent mortality. Our retrospective analysis included AMI patients who survived at least one year. Mortality and HRU data were collected over a 10-year follow-up period. We found that HRU parameters and total costs were strong predictors of mortality during the following year. In addition, the utilization of hospital services was directly associated with mortality, while the association with ambulatory services utilization was reversed. The discriminative ability of a multivariable model including HRU parameters to predict mortality in the subsequent year was 0.88.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Carrie Lenneman, David Harrison, S. Lindsey Davis, Lavanya Kondapalli
Summary: Cardiac surgery with tricuspid valve and potentially pulmonic valve replacement is currently the most effective treatment strategy for carcinoid heart disease. A multidisciplinary team is required for the management, and aggressive management before and after surgery is critical. Percutaneous valve repair may be a potential option in the future.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Mustafa Gokhan Gozel, Can Huseyin Hekimoglu, Emine Yildirim Gozel, Esen Batir, Mary-Louise Mclaws, Emine Alp Mese
Summary: The introduction of a national infection control program in Turkey significantly reduced the prevalence of 3 major device-associated healthcare associated infections from 2008 to 2017. Rates for DA-HAIs declined significantly in hospitals of different bed capacities and geographic locations, with all regions showing improvement by 2017.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Anesthesiology
Wolf H. Stapelfeldt, Ashish K. Khanna, Andrew D. Shaw, Apeksha Shenoy, Seungyoung Hwang, Mitali Stevens, Nathan J. Smischney
Summary: Perioperative hypotension is associated with increased postoperative healthcare resource utilization, leading to longer length of stay, higher odds of discharge to a care facility, and higher readmission rates within 30 days. Additionally, patients with perioperative hypotension tend to have more emergency department visits and longer readmission length of stay within 6 months post-discharge.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Surgery
Jennifer Verbesey, Alvin G. Thomas, Matt Ronin, Jennifer Beaumont, Amy Waterman, Dorry L. Segev, Stuart M. Flechner, Matthew Cooper
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
Intan Purnajo, Jennifer L. Beaumont, Martin Polinsky, Evo Alemao, Matthew J. Everly
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
Matthew Cooper, David B. Leeser, Stuart M. Flechner, Jennifer L. Beaumont, Amy D. Waterman, Patrick W. Shannon, Matthew Ronin, Garet Hil, Jeffrey L. Veale
Summary: The National Kidney Registry's Advanced Donation Program allows living donors to donate in advance and receive a voucher for a future transplant. A Monte Carlo simulation study suggests that NKR should be able to meet the increasing demand for voucher redemptions over the next 50 years.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Amy D. Waterman, John D. Peipert, Yujie Cui, Jennifer L. Beaumont, Andrea Paiva, Amanda F. Lipsey, Crystal S. Anderson, Mark L. Robbins
Summary: Individualized education plans can enhance patients' readiness and knowledge about living and deceased donor kidney transplants, and promote their proactive pursuit of transplantation. The study indicates that a focused and coordinated educational effort can improve transplant-seeking behaviors and waitlisting rates among patients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Oncology
David C. Metz, Eric Liu, Vijay N. Joish, Lynn Huynh, Todor Totev, Mei Sheng Duh, Kiernan Seth, Susan Giacalone, Pablo Lapuerta, Michael A. Morse
CANCER MANAGEMENT AND RESEARCH
(2020)
Article
Oncology
Mrinal M. Gounder, Priscilla Merriam, Ravin Ratan, Shreyaskumar R. Patel, Rashmi Chugh, Victor M. Villalobos, Mark Thornton, Brian A. Van Tine, Amr H. Abdelhamid, Jennifer Whalen, Jay Yang, Anand Rajarethinam, Mei Sheng Duh, Priyanka J. Bobbili, Lynn Huynh, Todor Totev, Angela K. Lax, Shefali Agarwal, George D. Demetri
Summary: For patients with advanced epithelioid sarcoma (ES) who have received two or more lines of systemic therapy, the overall response rate is less than 15%, the disease control rate is 20%, the median duration of response is 4.5 months, and the median progression-free survival is 6.0 months. Serious adverse events include febrile neutropenia, pain, and anemia.
Article
Rheumatology
Jennifer L. Beaumont, Elizabeth S. Davis, Jeffrey R. Curtis, David Cella, Huifeng Yun
Summary: The study estimated meaningful change thresholds for fatigue and pain interference in rheumatoid arthritis patients, finding the MCT range to be 1-2 points and showing low correlations between change scores and retrospective ratings.
JOURNAL OF RHEUMATOLOGY
(2021)
Letter
Hematology
Larysa Sanchez, Xavier Leleu, Jennifer L. Beaumont, Hailin Yu, Stacie Hudgens, Maryana Simonova, Holger W. Auner, Hang Quach, Sosana Delimpasi, Ivan Spicka, Ludek Pour, Iryna Kriachok, Meletios A. Dimopoulos, Ganna Usenko, Roman Hajek, Reuben Benjamin, Dinesh Kumar Sinha, Christopher Venner, Thomas Illmer, Mamta Krishnan Garg, Don Ambrose Stevens, Sundar Jagannath, Moshe Levy, Larry D. Anderson, Nizar Jacques Bahlis, Thierry Facon, Michele Cavo, Yi Chai, Xiwen Ma, Shijie Tang, Hoyee Leong, Jatin Shah, Sharon Shacham, Michael Kauffman, Paul Richardson, Sebastian Grosicki
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Oncology
Lynne Wagner, Janet A. Tooze, Daniel L. Hall, Beverly J. Levine, Jennifer Beaumont, Jenna Duffecy, David Victorson, William Gradishar, Joseph Leach, Thomas Saphner, Keren Sturtz, Mary Lou Smith, Frank Penedo, David C. Mohr, David Cella
Summary: A targeted eHealth intervention, FoRtitude, was evaluated to reduce fear of recurrence among breast cancer survivors, showing statistically significant reductions in fear of recurrence postintervention. Cognitive behavior therapy and attention control conditions had comparable effects, while telecoaching improved adherence and retention during the intervention. Future research is needed to explore optimal integration of cognitive behavior therapy and health management content, as well as the impact of eHealth delivery features on reducing fear of recurrence, especially in the COVID-19 era.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Clinical Neurology
Maurice T. Driessen, Joshua M. Cohen, Oscar Patterson-Lomba, Stephen F. Thompson, Michael Seminerio, Karen Carr, Todor Totev, Rochelle Sun, Erica Yim, Fan Mu, Rajeev Ayyagari
Summary: This retrospective study using real-world data demonstrated the long-term effectiveness of fremanezumab treatment for migraine patients, with continuous improvements in clinical outcomes regardless of dosing regimen or number of prior treatment failures.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Maurice T. Driessen, Joshua M. Cohen, Stephen F. Thompson, Oscar Patterson-Lomba, Michael J. Seminerio, Karen Carr, Todor Totev, Rochelle Sun, Erica Yim, Fan Mu, Rajeev Ayyagari
Summary: This study assessed the effectiveness of fremanezumab for different types of migraines in a real-world clinical setting. The results showed that fremanezumab is effective for the treatment of migraines regardless of the type or other contributing factors.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Infectious Diseases
Kyle D. Hueth, Philippe Thompson-Leduc, Todor I. Totev, Katherine Milbers, Tristan T. Timbrook, Noam Kirson, Rodrigo Hasbun
Summary: The use of the multiplex ME panel contributes to reduced hospital stay, shorter acyclovir therapy duration, and potentially reduced antibiotic therapy.
Article
Rheumatology
George J. Greene, Jennifer L. Beaumont, Emily J. Bacalao, Azra Muftic, Karen Kaiser, Amy R. Eisenstein, Arthur M. Mandelin, David Cella, Eric M. Ruderman
Summary: This study evaluated the effect of a patient-centered "treat-to-target" (T2T) rheumatoid arthritis (RA) disease management approach on patient outcomes and satisfaction with care. The study found that integrating the PROMIS assessment system into RA treatment can improve disease activity and increase patient satisfaction.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Clinical Neurology
Maryia Zhdanava, H. Lynn Starr, Todor Totev, Patrick Lefebvre, Aditi Shah, Kristy Sheng, Dominic Pilon
Summary: This study examined the impact of the COVID-19 pandemic on long-acting antipsychotic prescribing for schizophrenia in the US, as well as patient outcomes and healthcare provider perspectives on COVID-19 vaccination. The findings suggest that overall, prescribing patterns and medication adherence remained relatively stable, but efforts are needed to address vaccine hesitancy among patients.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Maryia Zhdanava, H. Lynn Starr, Patrick Lefebvre, Todor Totev, Aditi Shah, Kristy Sheng, Dominic Pilon
Summary: The purpose of this study was to identify the factors that enable the routine use of long-acting injectable antipsychotics (LAIs) and understand the changes in LAI prescribing patterns during the COVID-19 pandemic. The results showed that LAIs were commonly recommended for patients with poor adherence, and patient/caregiver involvement in treatment decisions was a key factor affecting the prescription of LAIs.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)