Review
Biochemistry & Molecular Biology
Jana Stofilova, Monika Kvakova, Anna Kamlarova, Emilia Hijova, Izabela Bertkova, Zuzana Gul'asova
Summary: There is a need for new therapies for ulcerative colitis, as many patients are unresponsive to available treatments. Strategies targeting dysbiosis of gut microbiota have been tested, but the effectiveness of conventional probiotics varies. New candidates for next-generation probiotics could provide more targeted treatment options.
Article
Microbiology
Cristiano Pagnini, Maria Carla Di Paolo, Riccardo Urgesi, Lorella Pallotta, Gianfranco Fanello, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: This study aimed to investigate the clinical efficacy and safety of LGG administration in UC patients with mild-moderate disease activity. The results showed that monotherapy with LGG is safe and effective for inducing remission in UC patients.
Article
Microbiology
Lingyun Xu, Yingchao Li, Yingli He
Summary: Anxiety and depression still exist in UC patients even in the remission period. This study found that the composition of intestinal microbiota differs between UC patients with anxiety and depression and those without, with a decrease in probiotics and an increase in pathogens in the former group. These findings may provide new insights into the recurrence of UC caused by impaired psychological function and offer potential treatment strategies for UC patients with psychological issues.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Qianqian Liu, Wenwen Jian, Lu Wang, Shenglin Yang, Yutian Niu, ShuaiJing Xie, Kim Hayer, Kun Chen, Yi Zhang, Yanan Guo, Zeng Tu
Summary: In this study, Lactobacillus acidophilus C4 with high acid and bile salt resistance was evaluated for its beneficial effect on DSS-induced colitis in mice. The results showed that oral administration of L. acidophilus C4 alleviated colitis symptoms and minimized colon tissue damage. Further investigation revealed that L. acidophilus C4 repaired the mucosal barrier and maintained the intestinal microecological balance, suggesting its potential for colitis therapy.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianjue Hu, Leilei Yu, Qixiao Zhai, Jianxin Zhao, Fengwei Tian
Summary: This study evaluated the probiotic characteristics of four yeast strains and their ability to alleviate DSS-induced colitis. The results showed that S. cerevisiae QHNLD8L1 effectively protected mice from colitis, with increased body weight, colon length, histological injury relief, decreased gut inflammation markers, and intestinal barrier restoration. Additionally, S. cerevisiae QHNLD8L1 reduced the abundance of pathogenic bacteria and increased the abundance of beneficial bacteria, as well as enhanced carbon metabolism and fatty acid biosynthesis function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Marissa Renardy, Alexander J. Prokopienko, Joseph R. Maxwell, Deborah A. Flusberg, Sahak Makaryan, Jangir Selimkhanov, Majid Vakilynejad, Kalyanasundaram Subramanian, Lucia Wille
Summary: In this study, a novel cellular kinetic-pharmacodynamic quantitative systems pharmacology model of live biotherapeutic products (LBPs) was developed to describe their kinetics and behavior in therapy. The model can simulate the impact of treatment dose, frequency, and duration as well as vancomycin pretreatment on butyrate production. This model can inform decision making for future microbiome therapies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Toxicology
Rong-Rong Miao, Sheng Zhan, Xue-Tao Hu, Wen-Min Yuan, Li-Juan Wu, Shu-Xiang Cui, Xian-Jun Qu
Summary: The study found that M10 has a better effect in treating ulcerative colitis by modifying the gut microbiota than Myricetin, increasing probiotics and inhibiting pathogenic microorganisms.
TOXICOLOGY LETTERS
(2021)
Article
Nutrition & Dietetics
Anna Pietrzak, Marcin Banasiuk, Mariusz Szczepanik, Agnieszka Borys-Iwanicka, Tomasz Pytrus, Jaroslaw Walkowiak, Aleksandra Banaszkiewicz
Summary: This study evaluated the effectiveness of oral sodium butyrate as an add-on to standard therapy in children and adolescents with newly diagnosed IBD. The results showed that a 12-week supplementation with sodium butyrate did not show efficacy in these patients.
Article
Immunology
Stefania De Santis, Aurelia Scarano, Marina Liso, Francesco Maria Calabrese, Giulio Verna, Elisabetta Cavalcanti, Annamaria Sila, Antonio Lippolis, Maria De Angelis, Angelo Santino, Marcello Chieppa
Summary: The health status of mother microbiota has a significant impact on the neonatal gut microbiota. Using a murine model of UC predisposition, this study evaluated the effects of maternal diet during pregnancy and lactation on offspring microbiota, indicating that a diet enriched with bioactive polyphenols from tomato can reduce dysbiosis in genetically predisposed offspring.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yinhua Ni, Yi Zhang, Liujie Zheng, Nianke Rong, Yuru Yang, Ping Gong, Yi Yang, Xuerong Siwu, Chenyang Zhang, Linxi Zhu, Zhengwei Fu
Summary: The effects of probiotic strains BL986 and LC122 on intestinal barrier function and gut microbiota in IBD zebrafish were investigated. The results showed that both probiotics improved intestinal mucosal barrier function and altered the composition and function of the microbiota in different IBD models. The impact of probiotics on IBD was influenced by the subtypes of IBD and the age of the zebrafish.
Article
Biochemistry & Molecular Biology
Zi-han Wang, Guang-yao Zhang, Cong Sun, Shu-xin Ning, Da-yong Zhou, Liang Song
Summary: This study investigated the therapeutic effects and mechanisms of WPI-stachyose conjugates as prebiotic-functional components in a mouse model of dextran sodium sulfate (DSS)-induced ulcerative colitis (UC). The treatment with WPI-stachyose conjugates showed significant improvements in reducing pro-inflammatory cytokines and restoring gut microbiota composition, as well as alleviating symptoms associated with UC. The findings highlight the potential therapeutic application of WPI-stachyose conjugates in addressing DSS-induced UC and provide insights into innovative therapeutic strategies.
Article
Multidisciplinary Sciences
Rafael Correa, Igor de Oliveira Santos, Heloisa Antoniella Braz-de-Melo, Livia Pimentel de Sant'Ana, Raquel das Neves Almeida, Gabriel Pasquarelli-do-Nascimento, Paulo Sousa Prado, Gary P. Kobinger, Corinne F. Maurice, Kelly Grace Magalhaes
Summary: ZIKV infection can significantly alter the gut microbiota composition in adult immunocompetent mice, leading to changes in the proportions of bacterial populations.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Guangcong Ruan, Minjia Chen, Lu Chen, Fenghua Xu, Zhifeng Xiao, Ailin Yi, Yuting Tian, Yi Ping, Linling Lv, Yi Cheng, Yanling Wei
Summary: The pathogenesis of ulcerative colitis is unclear but is believed to be related to an imbalance in gut microbiota. This study found that Roseburia intestinalis may play a role in relieving colitis by upregulating Toll-like receptor 5 transcription.
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and investigated its effect and alleviation mechanism on colitis in mice. Results showed that MFGM-GA-astaxanthin effectively improved bioaccessibility of astaxanthin, reduced oxidative stress, alleviated colitis symptoms, repaired intestinal barrier function, and restored abnormalities of gut flora. This study provides a promising therapeutic approach for colon diseases using astaxanthin nanoparticles.
Article
Gastroenterology & Hepatology
Andreas Blesl, Philipp Wurm, Silvio Waschina, Hans Peter Groechenig, Gottfried Novacek, Christian Primas, Walter Reinisch, Maximilian Kutschera, Constanze Illiasch, Barbara Hennlich, Pius Steiner, Robert Koch, Wolfgang Tillinger, Thomas Haas, Gerhard Reicht, Andreas Mayer, Othmar Ludwiczek, Wolfgang Miehsler, Karin Steidl, Lukas Binder, Simon Reider, Christina Watschinger, Stefan Fuerst, Patrizia Kump, Alexander Moschen, Konrad Aden, Gregor Gorkiewicz, Christoph Hoegenauer, Austrian IBD Study Grp ATISG
Summary: This study examined the association between fecal microbial composition and response to systemic corticosteroids in patients with active ulcerative colitis. It found that baseline microbial diversity and composition could not predict response to corticosteroids, but responders had significant changes in microbial diversity and composition after 4 weeks of treatment.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Jun Inoue, Masahiro Kishikawa, Hitoshi Tsuda, Yasuaki Nakajima, Takahiro Asakage, Johji Inazawa
Summary: The study identified the metabolically essential gene PDHX for cell growth in ESCC, showing that its expression is required for maintaining PDH activity and ATP production, and knockdown inhibited CSCs proliferation and tumor growth. PDHX and CD44 genes were upregulated in ESCC tumors, functioning cooperatively in cancer stemness. The PDH inhibitor CPI-613 was effective in inhibiting CSCs proliferation in vitro and ESCC xenograft tumor growth in vivo.
Article
Geography, Physical
Naoki Hayashi, Yudzuru Inoue, Tatsuichiro Kawano, Jun Inoue
Summary: Volcanic eruptions can significantly impact adjacent ecosystems, with vegetation changes related to eruptions still poorly understood. This study in southern Kyushu District, Japan, found distinct vegetational differences before and after the eruption, depending on the amount of pyroclastic flow reaching the area. In areas with thicker pyroclastic flow, evergreen forests were replaced by grasslands dominating the landscape for at least 900 years, while areas less affected by pyroclastic flows saw forests developing within a few centuries of the eruption.
Article
Geography, Physical
Jun Inoue, Chikako Okuyama, Ryoma Hayashi, Yoshio Inouchi
Summary: The study found that frequent fires occurred near the shores of Lake Biwa during the postglacial period based on charcoal records, suggesting anthropogenic causes. The comparison between charcoal records and cultural changes indicates that the fires were influenced by lifestyle and culture rather than population size in the district.
JOURNAL OF QUATERNARY SCIENCE
(2021)
Article
Cell & Tissue Engineering
Yuji Kuramochi, Tomonari Awaya, Mami Matsuo-Takasaki, Miho Takami, Yuri An, Jingyue Li, Yasuko Hemmi, Tamami Wakabayashi, Yutaka Arai, Jun Inoue, Michiya Noguchi, Yukio Nakamura, Isao Asaka, Kazunori Akimoto, Megumu K. Saito, Yohei Hayashi
Summary: ALD is an X-linked genetic disorder characterized by demyelination and adrenal insufficiency. hiPSC lines derived from ALD patients provide valuable tools for studying disease models and developing new therapies.
STEM CELL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kengo Sasaki, Tomoyuki Mori, Namiko Hoshi, Daisuke Sasaki, Jun Inoue, Reiko Shinkura, Akihiko Kondo
Summary: The study revealed the suppressive effect of W27 IgA on bacteria related to the genus Escherichia in the human colonic microbiota in an in vitro model, as well as the delay of growth of Escherichia coli isolated from human fecal samples at relatively low concentrations of W27 IgA.
SCIENTIFIC REPORTS
(2021)
Article
Agronomy
David S. Howlett, J. Ryan Stewart, Jun Inoue, Masanori Saito, DoKyoung Lee, Hong Wang, Toshihiko Yamada, Aya Nishiwaki, Fabian G. Fernandez, Yo Toma
Summary: Miscanthus-dominated semi-natural grasslands in Japan store significant amounts of soil carbon and have long-term effects on soil carbon accumulation. However, the accumulation rate can be influenced by the catena position and vegetation amount.
Article
Environmental Sciences
Jun Inoue, Natsuko Takenaka, Takamoto Okudaira, Michinobu Kuwae
Summary: This study examined the spheroidal carbonaceous particles (SCPs) in sediment records from Beppu Bay in southern Japan and found that the SCP deposition variation is consistent with trends in industrial activity and atmospheric pollution. These findings suggest that SCPs could serve as potential markers for the Anthropocene characterized by industrialization.
ANTHROPOCENE REVIEW
(2023)
Article
Plant Sciences
Naoki Hayashi, Jun Inoue
Summary: This study used phytolith records in paleosols to reconstruct the vegetation transition from the terminal Pleistocene to the early Holocene in the southernmost parts of mainland Japan, with a focus on herbaceous plants. The study found that Andropogoneae species and other grassland plants gradually replaced the existing forest vegetation during the transition from the terminal Pleistocene to the early Holocene, and evergreen broad-leaved forests had developed at least by 7,300 cal BP.
REVIEW OF PALAEOBOTANY AND PALYNOLOGY
(2022)
Article
Environmental Sciences
Jun Inoue, Kanta Sunada
Summary: Orbital-insolation variation can directly influence long-term wildfire activity through changes in evaporation rate of fuel or forest litter. In a study conducted in central Japan, it was found that spring insolation plays a crucial role in determining long-term wildfire activity. Simulation results showed that the duration of high fire risk is 10-60% longer under maximum spring insolation period compared to the minimum period.
MODELING EARTH SYSTEMS AND ENVIRONMENT
(2023)
Article
Environmental Sciences
Michinobu Kuwae, Bruce P. Finney, Zhiyuan Shi, Aya Sakaguchi, Narumi Tsugeki, Takayuki Omori, Tetsuro Agusa, Yoshiaki Suzuki, Yusuke Yokoyama, Hirofumi Hinata, Yoshio Hatada, Jun Inoue, Kazumi Matsuoka, Misaki Shimada, Hikaru Takahara, Shin Takahashi, Daisuke Ueno, Atsuko Amano, Jun Tsutsumi, Masanobu Yamamoto, Keiji Takemura, Keitaro Yamada, Ken Ikehara, Tsuyoshi Haraguchi, Stephen Tims, Michaela Froehlich, Leslie Keith Fifield, Takahiro Aze, Kimikazu Sasa, Tsutomu Takahashi, Masumi Matsumura, Yukinori Tani, Peter R. Leavitt, Hideyuki Doi, Tomohisa Irino, Kazuyoshi Moriya, Akira Hayashida, Kotaro Hirose, Hidekazu Suzuki, Yoshiki Saito
Summary: By integrating datasets of 99 proxies, we assessed the potential of the Beppu Bay sediments as a candidate for the Global Boundaries Stratotype Section and Point (GSSP) of the Anthropocene. The cumulative number of anthropogenic fingerprints revealed unprecedented increases above the base of the 1953 flood layer. This site exhibits a range of evidence, including changes in carbon and nitrogen cycling, pollution of heavy metals, deposition of novel materials, occurrence of hypoxia and eutrophication, microplankton community changes, abnormal spring air temperatures, and lithological changes, indicating that the base of the 1953 layer is the best candidate for GSSP level.
ANTHROPOCENE REVIEW
(2022)
Correction
Gastroenterology & Hepatology
Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Lingling Kong, Ryutaro Yoshida, Norihiro Okamoto, Masato Kinoshita, Haruka Miyazaki, Yuna Ku, Eri Tokunaga, Yuki Ito, Daisuke Watanabe, Makoto Ooi, Masakazu Shinohara, Kengo Sasaki, Yoh Zen, Takenori Kotani, Takashi Matozaki, Zibin Tian, Yoshikatsu Kanai, Yuzo Kodama
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Environmental Sciences
Zeshu Yu, Marty Kwok-Shing Wong, Jun Inoue, Sk Istiaque Ahmed, Tomihiko Higuchi, Susumu Hyodo, Sachihiko Itoh, Kosei Komatsu, Hiroaki Saito, Shin-ichi Ito
Summary: Using environmental DNA monitoring, we were able to reveal the spatial distribution patterns of small pelagic fishes in the Kuroshio Current system and hypothesize that predator-prey relationships influence their distribution in these fish communities.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Environmental Sciences
Richard S. Vachula, Ann Sullivan Ojeda, Emma D. Henderson, Jun Inoue
Summary: Spheroidal carbonaceous particles (SCPs) are potential markers for the onset of the Anthropocene, but their atmospheric dispersal modeling is limited. We developed the DiSCPersal model, which is corroborated by empirical data from Osaka, Japan. The model reveals the primary controls of dispersal distance and explains the differences in dispersal distances reported in the literature, highlighting the need to incorporate localized dispersal patterns when interpreting SCP preservation.
Article
Geosciences, Multidisciplinary
Sandy P. Harrison, Roberto Villegas-Diaz, Esmeralda Cruz-Silva, Daniel Gallagher, David Kesner, Paul Lincoln, Yicheng Shen, Luke Sweeney, Daniele Colombaroli, Adam Ali, Cheima Barhoumi, Yves Bergeron, Tatiana Blyakharchuk, Premysl Bobek, Richard Bradshaw, Jennifer L. Clear, Sambor Czerwinski, Anne-Laure Daniau, John Dodson, Kevin J. Edwards, Mary E. Edwards, Angelica Feurdean, David Foster, Konrad Gajewski, Mariusz Galka, Michelle Garneau, Thomas Giesecke, Graciela Gil Romera, Martin P. Girardin, Dana Hoefer, Kangyou Huang, Jun Inoue, Eva Jamrichova, Nauris Jasiunas, Wenying Jiang, Gonzalo Jimenez-Moreno, Monika Karpinska-Kolaczek, Piotr Kolaczek, Niina Kuosmanen, Mariusz Lamentowicz, Martin Lavoie, Fang Li, Jianyong Li, Olga Lisitsyna, Jose Antonio Lopez-Saez, Reyes Luelmo-Lautenschlaeger, Gabriel Magnan, Eniko Katalin Magyari, Alekss Maksims, Katarzyna Marcisz, Elena Marinova, Jenn Marlon, Scott Mensing, Joanna Miroslaw-Grabowska, Wyatt Oswald, Sebastian Perez-Diaz, Ramon Perez-Obiol, Sanna Piilo, Anneli Poska, Xiaoguang Qin, Cecile C. Remy, Pierre J. H. Richard, Sakari Salonen, Naoko Sasaki, Hieke Schneider, William Shotyk, Migle Stancikaite, Dace Steinberga, Normunds Stivrins, Hikaru Takahara, Zhihai Tan, Liva Trasune, Charles E. Umbanhowar, Minna Valiranta, Juri Vassiljev, Xiayun Xiao, Qinghai Xu, Xin Xu, Edyta Zawisza, Yan Zhao, Zheng Zhou, Jordan Paillard
Summary: This article presents an expanded charcoal records database with new age models based on recalibration of radiocarbon ages. The database provides a wider geographical coverage and more extensive metadata for studying fire regimes.
EARTH SYSTEM SCIENCE DATA
(2022)
Correction
Biochemistry & Molecular Biology
Chuya Shinzato, Konstantin Khalturin, Jun Inoue, Yuna Zayasu, Miyuki Kanda, Mayumi Kawamitsu, Yuki Yoshioka, Hiroshi Yamashita, Go Suzuki, Noriyuki Satoh
MOLECULAR BIOLOGY AND EVOLUTION
(2021)