Article
Chemistry, Analytical
Yuqiu Wang, Shuchang Liu, Yongjun Hu, Cuicui Fu, Weiqiang Chen
Summary: Researchers developed a highly sensitive and stable SERS-active substrate by encapsulating Au nanorods in a bilayer silver shell with Raman reporter molecules. The substrate exhibited high reproducibility and stability, and showed significantly improved SERS intensity and detection sensitivity compared to other substrates. It was able to detect the pesticide thiram at a very low concentration, making it a promising tool for ultrasensitive analyte detection.
Article
Polymer Science
Ali Doostmohammadi, Khaled Youssef, Shiva Akhtarian, Ehsan Tabesh, Garrett Kraft, Satinder Kaur Brar, Pouya Rezai
Summary: This article introduces a method for synthesizing MIP shells for molecular imprinting in microorganisms. Experimental results demonstrate that MIP shells have a high affinity for bacteria, and provide a new fabrication method for bioseparation and point-of-care sensing.
Article
Chemistry, Multidisciplinary
Bowen He, Xi Liu, Liwei Chen
Summary: By using advanced transmission electron microscope techniques, two alternative particle attachment growth pathways dominating the growth of Au@Ag core-shell nanocuboids are directly observed. One pathway involves the in situ reduction of AgCl nanoparticles attached to Au nanorods and the subsequent epitaxial growth of the Ag shell. The other pathway involves the adherence of Ag-AgCl Janus nanoparticles to Au nanorods with random orientations, followed by nanoparticle redispersion and the resulting formation of epitaxial Ag shells on the Au nanorods. The particle-mediated growth of Ag shells is accompanied by the redispersion of surface atoms, tending to form a uniform structure, providing a new mechanistic understanding of core-shell nanostructure synthesis.
Article
Chemistry, Analytical
Shaolong Feng, Yaxi Hu, Lei Chen, Xiaonan Lu
Summary: In this study, an ingenious strategy was proposed to hybridize molecularly imprinted polymers (MIPs) with gold nanoparticles for the selective and quantitative detection of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) using surface-enhanced Raman spectroscopy (SERS). The core-shell AuNPs@MIPs nanoparticles were designed to selectively separate and enrich 2,4-D, and an internal standard was embedded for spectral calibration. The results showed accurate differentiation and quantification of 2,4-D in milk at various contamination levels, indicating the potential of this approach for practical agri-food analysis using SERS.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Peihong Tong, Yongjuan Meng, Junyu Liang, Jianping Li
Summary: A highly sensitive MIP-ECL sensor was constructed using ZIF-8-NH2 as the imprinted membrane, showing excellent recognition performance for CCN and a practical application for detecting CCN in human serum with recoveries ranging from 96.0%-103.0%.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Polymer Science
Li Zhang, Hongbo Mo, Chuan Wang, Xiaofeng Li, Shuai Jiang, Weigang Fan, Yagang Zhang
Summary: Novel core-shell magnetic molecularly imprinted polymers (MMIPs) were synthesized for the adsorption of cefixime (CFX). The MMIPs showed high adsorption capacity and selective adsorption ability for CFX, and exhibited excellent reusable performance.
Article
Biophysics
Yan Zhang, Yu-Sheng Feng, Xing-Hui Ren, Xi-Wen He, Wen-You Li, Yu-Kui Zhang
Summary: A nanozyme with bimetallic active sites was synthesized for the detection of vanillin, achieving high sensitivity and satisfactory recovery rates in real samples. This method could potentially be developed into a sensing platform for various applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Physical
E. Shiju, T. Abhijith, Narayana D. Rao, K. Chandrasekharan
Summary: Core-shell structures with tunable multifunctional properties have been studied for their nonlinear optical behavior, showing enhanced optical limiting activity and negative nonlinearity with increasing shell thickness.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Lamia Abu El Maati, Fatemah H. Alkallas, Amira Ben Gouider Trabelsi, Samira Elaissi, Tahani A. Alrebdi, Mahmoud Ahmad
Summary: We report a theoretical simulation of the optical spectra of Au@Ag core/shell nanocubes dimers. The influence of the core/shell size ratio and the dimers separation gap on these spectra have been studied, and the formation of Fano resonance line shape through the investigation of the scattering section variation within the entire wavelengths range has been revealed. The study demonstrates the important duality of the gap separation and core/shell ratio variation in designing Fano resonance interface.
Article
Chemistry, Multidisciplinary
Emily C. Cheshari, Xiaohui Ren, Xin Li
Summary: Carbamate pesticides, such as carbaryl and thiodicarb, are widely used in agriculture due to their lower toxicity and degradable nature compared to organophosphates. This study synthesized and evaluated a core-shell Ag-dual template molecularly imprinted polymer (MIP) composite for detecting carbamate pesticide residues. Computational design was used to study the interactions between the functional monomer and the templates, revealing higher adsorption capacity for carbaryl supported by more hydrogen bonds in the template-monomer complex. The research presents a cost-effective approach utilizing a dual-template imprinted polymer for detection of carbamate pesticide residues.
Article
Biochemistry & Molecular Biology
Luis Calahorra-Rio, Miriam Guadano-Sanchez, Tamara Moya-Cavas, Javier Lucas Urraca
Summary: This paper describes the synthesis of novel molecularly imprinted magnetic nano-beads for the selective extraction (MISPE) of zearalenone mycotoxin in river and tap waters and further analysis by high-performance liquid chromatography (HPLC) with fluorescence detection (FLD). The study successfully synthesized molecularly imprinted polymers and prepared magnetic nanoparticles using a semi-covalent imprinting approach. The optimized solid phase extraction method allowed for the determination of zearalenone in trace levels without significant differences between fortified and found concentrations.
Article
Chemistry, Multidisciplinary
Gauravjyoti D. Kalita, Podma P. Sarmah, Golap Kalita, Pankaj Das
Summary: A facile ligand-assisted approach was used to synthesize bimetallic Au-Pd nanoparticles with a tunable core@shell structure. The Au-Pd materials exhibited superior performance in two important reactions, with the Pd-core-Au-shell structure showing higher activity compared to the Au-core-Pd-shell structure.
NANOSCALE ADVANCES
(2021)
Article
Nanoscience & Nanotechnology
Qiumei Feng, Li Qin, Baoting Dou, Xiguang Han, Po Wang
Summary: This article introduces the use of plasmon-tunable Ag@Au bimetallic core-shell nanostructures to enhance the sensitivity of electrochemiluminescence (ECL) sensors. By altering the size of the Ag core and Au shell, the absorption spectra of the nanostructures closely overlapped with the emission spectra of quantum dots (QDs), resulting in an effective LSPR-enhanced ECL emission. Changing the distance between the QDs and the nanostructures showed that the LSPR-enhanced ECL was distance-dependent. Additionally, the use of a catalytic hairpin assembly-based signal amplification system enabled sensitive analysis of microRNA.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Haiting Ren, Yan Sun, Junjie Wang, Hongxing Qiu, Shenghao Zhang, Yueshou Zhang, Xingxing Yu, Jieyu Hu, Yongjun Hu
Summary: The bimetallic core-shell nanorod SERS substrate nanomaterial (Au NB-DT@Ag NRs) consists of gold nanobipyramids as the inner core and silver-coated nanorods. By modifying with Raman reporter (DT) and varying the amount of silver deposition, the SERS activity of the nanomaterial is improved. The nanomaterial with the best SERS activity can achieve reliable quantitative detection of low concentrations of toxic dyes malachite green and crystal violet.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Applied
Zhiyang Chen, Yue Sun, Jiyong Shi, Wen Zhang, Xinai Zhang, Xiaowei Huang, Xiaobo Zou, Zhihua Li, Ruicheng Wei
Summary: This study introduced an effective and sensitive SERS substrate for rapid detection of thiabendazole in fruit samples. The core-shell gold/silver nanorod (Au@Ag NRs) substrate showed excellent SERS effect, low detection limits, and high recovery rates, indicating its great potential for detecting fruit pesticides residues.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)