Article
Chemistry, Analytical
Sinuo Feng, Yu Xue, Jianshe Huang, Xiurong Yang
Summary: In this study, an electrochemical biosensor was successfully developed for the sensitive and specific determination of miR-21. The biosensor utilized COFs and DTN as the biosensing interface and employed a CHA strategy. The biosensor showed a low detection limit of 0.33 fM and a wide linear response ranging from 1 fM to 10 nM miR-21.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ruike Liu, Baoshan He, Huali Jin, Zhiguang Suo
Summary: A fluorescent aptasensor was developed for the detection of lead ion. The sensor exhibited high selectivity and sensitivity, making it suitable for the identification of lead ions in real samples.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Chitra Padmakumari Kurup, Syazana Abdullah Lim, Minhaz Uddin Ahmed
Summary: This paper provides a comprehensive review of electrochemiluminescent (ECL) nanomaterial-based aptasensors, including their challenges and applications. The incorporation of nanomaterials for signal amplification is highlighted, and various nanomaterials such as gold nanoparticles, metal nanoparticles, metal oxides, carbon nanomaterials, metal organic frameworks, and quantum dots are discussed. The review also presents relevant concepts and explanations for the design of ECL aptasensors and discusses the underlying problems and possibilities for future research and development in this field.
BIOELECTROCHEMISTRY
(2022)
Article
Chemistry, Analytical
Zhoubing Zhang, Xiaorun Jia, Xueqin Xu
Summary: A ratiometric electrochemical aptasensor based on gold nanoparticles (AuNPs) functionalization and hybridization chain reaction (HCR) has been designed for the detection of streptomycin. The aptasensor utilizes the binding of streptomycin aptamer and capture probe to detach ferrocene from the sensing interface, followed by the capture of methylene blue electrochemical probe through HCR. The use of ratiometric method improves the accuracy and sensitivity, enabling the detection of streptomycin in milk and honey samples.
Article
Chemistry, Analytical
Jing Zhang, Zi Yang, Bingzhi Chai, Lu Gao, Jie Zhao, Xiaojian Xu
Summary: An ultrasensitive electrochemical aptasensor for microcystin-LR detection was developed using core-satellite gold nanopaticle/silver nanocluster nanoassemblies as electrochemical labels. The aptasensor showed a low detection limit and a wide linear range, with excellent selectivity, reproducibility, and stability.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Lixia Su, Yonghuan Su, Bingqian Liu
Summary: A new strategy for immobilization-free detection of E. coli was developed using a composite as capture probes and signal amplification labels, achieving target detection through a specific sandwich format. This method showed linear detection of E. coli concentration with a low limit of detection.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Multidisciplinary
Yuchao Chen, Wenhao Dai, Dongdong Wang, Haifeng Dong
Summary: A nanomachine consisting of cancer cell membrane vesicle-encapsulated gold nanoparticles with programmable DNA was developed, enabling homing-targeting ability and fast dynamic response for microRNA amplification analysis in living cancer cells. The DNA nanomachine holds great potential for early-stage cancer diagnosis.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Xianjing Zhang, Jun Guo, Bo Song, Feng Zhang
Summary: The polymerase chain reaction (PCR) is widely used in medical diagnosis and forensic identification. In this study, we discovered that metal ions can improve the specificity and yield of PCR amplification. We identified a spatiotemporal regulation mechanism of metal ions in PCR and proposed a new strategy for designing regulation kits for PCR-based biomedical applications.
Article
Chemistry, Analytical
Yan Lv, Shuo Qi, Imran Mahmood Khan, Xiaoze Dong, Mingwei Qin, Lin Yue, Yin Zhang, Zhouping Wang
Summary: An efficient analytical method is needed to detect the misuse of tetracycline (TC) in animal husbandry and aquaculture, which poses a great threat to food and environmental safety. In this study, a cascade amplification SERS aptasensor was constructed for sensitive determination of TC using aptamer, enzyme-free DNA circuits, and SERS technology. Under optimal conditions, the developed aptasensor demonstrated a distinct linear response to TC with a low limit of detection of 15.91 pg mL-1. The proposed sensing strategy showed excellent specificity, storage stability, and practicality, providing a promising idea for the development of specific and sensitive signal amplification analysis platforms in the field of food safety.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Yu Gu, Xuejiao Yang, Shanwen Hu, Chunxian Guo, Bo Chen, Cunxia Fan, Chang Ming Li
Summary: A novel glucometer-based microfluidic platform was developed for sensitively detecting cancer biomarker HER2. The assay uses rolling cycle amplification technology with a miniaturized personal glucose meter, on a small-sized microfluidic chip with high sensitivity and wide dynamic range, showing great potential for clinical diagnosis at home or in urban areas.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Nanoscience & Nanotechnology
Huimin Zhou, Yao Jiang, Wenjing Zhao, Shusheng Zhang
Summary: In this study, a light-activated nanodevice based on DNA nanotechnology was constructed for high precision detection of low-abundance miRNA. The nanodevice enabled on-demand imaging of miRNA in living cells with high spatial and temporal control.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Spectroscopy
Nuo Duan, Changxin Li, Mingqian Song, Zhouping Wang, Changqing Zhu, Shijia Wu
Summary: An aptamer-based optical assay was developed for analyzing Pb2+, a hazardous heavy metal in the food chain harmful to human health, with higher sensitivity and successful detection results.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Multidisciplinary
Lei He, Rongrong Huang, Pengfeng Xiao, Yuan Liu, Lian Jin, Hongna Liu, Song Li, Yan Deng, Zhu Chen, Zhiyang Li, Nongyue He
Summary: Aptamers have high specificity and affinity toward various targets, making them widely used in analytical techniques. In order to improve biosensor sensitivity, different amplification strategies are being explored, such as using nanomaterials or enzyme mimics.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biophysics
Yahui Wang, Wei Song, Haiyan Zhao, Xin Ma, Shuying Yang, Xiujuan Qiao, Qinglin Sheng, Tianli Yue
Summary: In this study, an aptasensor for detecting Ochratoxin A was successfully constructed using gold nanoparticles decorated molybdenum oxide nanocomposites, hybridization chain reaction, and a restriction endonuclease-aided walker DNA machine. The sensor demonstrated excellent analytical performance and high sensitivity, with a detection limit as low as 3.3 fg mL-1, showing great potential for practical applications in various sample types.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Applied
Haoran Liu, Longyingzi Xie, Yiwen Wang, Yanlin Liu, Ruijie Fu, Yongliang Cui, Qiyang Zhao, Chengqiu Wang, Bining Jiao, Yue He
Summary: A portable immunosensor based on ALP-labeled and secondary antibody-modified AuNPs is proposed for sensitive detection of CBD. The enzymatic reactions and signal amplification strategy involving AuNPs enable a low detection limit of 0.37 ng/mL. Good-consistency results are obtained when using this portable method to analyze citrus fruit, canned citrus, and cabbage, demonstrating its potential for CBD monitoring in resource-poor settings.
Article
Materials Science, Multidisciplinary
Xiang Gao, Weihua Li, Houyi Ma
MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION
(2020)
Article
Green & Sustainable Science & Technology
Xiang Gao, Ru Yan, Yujie Lv, Hongfang Ma, Houyi Ma
JOURNAL OF CLEANER PRODUCTION
(2020)
Article
Chemistry, Analytical
Pengfei Cao, Nan Wang, Hongxiu Dai, Houyi Ma, Meng Lin
Summary: A flexible electrode based on MoO3-MoS2/PPy nanomaterials was synthesized for non-enzymatic detection of hydrogen peroxide, exhibiting high electrochemical sensing performance and a detection limit of 0.18 mM. The flexible electrode has customizable shape and adjustability advantages, making it a potential platform for constructing clinically diagnosed in vivo portable instruments and real-time environmental monitoring.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Lijun Zhang, Nan Wang, Pengfei Cao, Meng Lin, Ling Xu, Houyi Ma
MICROCHEMICAL JOURNAL
(2020)
Article
Chemistry, Inorganic & Nuclear
Nan Wang, Pengfei Cao, Shengjun Sun, Houyi Ma, Meng Lin
Summary: Research interest in hollow multimetallic noble nanoalloys with high surface area/volume ratio, abundant active sites, and effective catalytic activity has grown. A simple and mild strategy was proposed to synthesize platinum- and palladium-decorated hollow gold-based nanoalloys by the galvanic replacement reaction at room temperature. Characterizations of hollow nanoalloys were conducted, showing excellent electrocatalytic activities for hydrogen evolution reactions. The approach not only expands the application range of the galvanic replacement reaction but also provides new ideas for the preparation of multialloys and high-entropy alloys at room temperature.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
You Wu, Ru Yan, Yangyang Duan, Juan Qiu, Ting Chen, Houyi Ma
Summary: By utilizing an eco-friendly tannic acid conversion film technology, TA and TA/Zn films were successfully fabricated in this study, demonstrating excellent corrosion protection and enhanced adhesion between the substrate and coating.
SURFACES AND INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Yangyang Duan, You Wu, Ru Yan, Meng Lin, Shengjun Sun, Houyi Ma
Summary: In this study, a self-strengthening coating was successfully constructed using silver nanoparticles, chitosan, and sodium alginate, which exhibited enhanced corrosion resistance and antibacterial properties. The coating continuously strengthened in corrosive medium, showing high protection efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Nan Wang, Pengfei Cao, Houyi Ma, Meng Lin
Summary: The study systematically investigated the influence of mercury on the morphology and formation mechanism of gold amalgams in the presence of different reducing agents. The stability of the reducing agents in the colloidal system and their combining capacity to gold nanoparticles can affect the alloying process of mercury and gold. The binding ability of the reducing agent to gold plays a dominant role in the nanoamalgam formation process compared to the blocking effect of CTAB molecules.
Article
Chemistry, Applied
Yangyang Duan, You Wu, Ru Yan, Meng Lin, Shengjun Sun, Houyi Ma
Summary: The polyelectrolytes coating with self-healing and self-strengthening dual-function shows remarkable properties in early-stage immersion and excellent performance in later-stage immersion for corrosion protection on titanium sheets in fluorine-containing artificial saliva.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Chemistry, Physical
You Wu, Yangyang Duan, Juan Qiu, Xiang Gao, Houyi Ma
Summary: By incorporating BTA-CaCO3@TA microspheres into waterborne epoxy resin coatings, an eco-friendly and long-term pH-responsive intelligent anti-corrosion coating was developed, showing excellent long-term corrosion protection performance.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Applied
Xiang Gao, Yujie Lv, Hongfang Ma, Houyi Ma
Summary: In this study, a smart coating with rust conversion and self-healing characteristics was prepared. The coating exhibited improved anti-corrosion performance and service life through enhanced adhesion at the interface and the formation of chelate products. It is expected to find wide applications in the field of traditional coatings.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Electrochemistry
Ruiying Peng, Chuang Sun, Boyu Yuan, Houyi Ma, Chao Lai, Qinghong Wang, Liang Li, Chao Wang
Summary: In this study, the digital holographic surface imaging (DHSI) method was used in combination with electrochemical tests to observe the nonuniform concentration changes on the copper substrate surface caused by the initial nucleation and growth of zinc in a symmetrical battery system. The results showed that the later dendritic growth of zinc was closely related to the nucleation and earlier deposition process. This method offers a promising avenue for understanding the interfacial electrochemistry in all aqueous metal-ion batteries.
ELECTROCHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Congcong Xu, Pengfei Cao, Nan Wang, Houyi Ma, Meng Lin
Summary: The gold-ruthenium/zinc oxide nanorod composite showed a nearly 30% increase in electrochemical catalytic efficiency under the irradiation of an external light source, offering a new design approach for photoresponsive electrocatalysts.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Pengfei Cao, Nan Wang, Duo Chen, Shengjun Sun, Houyi Ma, Meng Lin
Summary: A series of gold nanoparticles were synthesized by stepwise growth method using citrate as a reducing agent and stabilizer. The optical and electrochemical properties of the nanoparticles were found to be closely related to the particle size, with an increase in particle size leading to an increase in the full width at half maximum in the UV-visible absorption spectrum and a positive shift in the electrochemical oxidation potential.
Article
Chemistry, Multidisciplinary
Nan Wang, Wei Zhao, Miaolei Zhang, Pengfei Cao, Shengjun Sun, Houyi Ma, Meng Lin
Summary: Bismuth was introduced as an intermediate in the production of Au-X bimetallic nanoalloys through the galvanic replacement reaction. The resulting Au-X nanoalloys exhibited good activity for electrocatalytic reactions in alkaline media, providing an option for the formation of multimetal nanoalloys with similar electrochemical potentials and compositions.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)