Article
Medicine, Research & Experimental
Zhengzheng Xiao, Jing Liang, Qing Deng, Chaojun Song, Xiaoli Yang, Zebin Liu, Zheng Shao, Kun Zhang, Xiaobin Wang, Zhengwei Li
Summary: Pimozide in combination with bromocriptine can significantly inhibit cell growth and proliferation, increase apoptosis and cell cycle arrest in bromocriptine-resistant prolactinoma cells, by targeting STAT5/Bcl-xL and STAT5/cyclin D1 signaling pathways. Furthermore, pimozide also has inhibitory effects on spheroid formation of pituitary adenoma stem-like cells and the expression of cancer stem cell markers, CD133 and nestin, suggesting its potential as a therapeutic agent for prolactinomas.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Lin Cai, Jian Chen, Jianglong Lu, Qun Li, Xianbin Chen, Linlin Zhang, Jinsen Wu, Weiming Zheng, Chengde Wang, Zhipeng Su
Summary: This study identified a small subset of sphere-forming cells with tumor stem-like cell properties in rat prolactinoma MMQ cells, which resist dopamine agonist treatment. These cells showed higher cell viability and lower PRL and D2R expression compared to MMQ cells, indicating potential mechanisms underlying tumor recurrence based on TSLCs.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Neurosciences
Chao Tang, Junhao Zhu, Feng Yuan, Jin Yang, Xiangming Cai, Chiyuan Ma
Summary: The study found that Curcumin can enhance the growth-inhibitory effect of BRC on prolactinoma cell lines by activating the ERK/EGR1 signaling pathway and inhibiting the AKT/GSK-3 beta signaling pathway, making the cells more sensitive to BRC.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Motoyuki Igata, Yoshitaka Yagi, Satoko Hanatani, Masaji Sakaguchi, Norio Ishii, Kayo Yoshinaga, Junji Kawashima, Hiroyuki Motoshima, Eiichi Araki
Summary: This study investigated the use of dopamine receptor agonist bromocriptine in treating type 2 diabetes in a female patient with a history of prolactinoma. The results showed that bromocriptine significantly improved the patient's glycemic control levels.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Anahid Hamidianjahromi, Nicholas A. Tritos
Summary: Dopamine agonists (DAs), commonly used for hyperprolactinemia and prolactinomas, may lead to impulse control disorders (ICDs) such as gambling addiction, compulsive shopping, and hypersexuality. Diagnosing ICDs in patients receiving DAs requires suspicion and screening questionnaires. Patients with ICDs should discontinue or reduce DA therapy and receive psychiatric consultation and cognitive behavioral therapy.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Medicine, General & Internal
Hira Irfan, Waqas Shafiq, Ahmed Imran Siddiqi, Sara Ashfaq, Sadaf Attaullah, Asim Munir Alvi, Sardar Ali Khan, Muhammad Abu Bakar, Umal Azmat
Summary: This study reviewed the clinical presentation, treatment modalities, and therapeutic outcomes of patients with prolactinomas in the South Asia region. The results showed that menstrual irregularity/amenorrhea and visual disturbance were the most common symptoms. Dopamine agonists effectively reduced the size of prolactinomas and normalized prolactin levels. Cabergoline was more effective than bromocriptine in the treatment of prolactinomas.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Endocrinology & Metabolism
Yunzhi Zou, Depei Li, Jiayu Gu, Siyu Chen, Xia Wen, Jiajun Dong, Xiaobing Jiang
Summary: The study revealed a very low recurrence rate of prolactinomas after withdrawal of DAs, with a recurrence proportion of 2%. More prospective studies with larger sample sizes and longer follow-up periods are encouraged to confirm this finding.
BMC ENDOCRINE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Matheo Augusto Morandi Stumpf, Felipe Moura Maia Pinheiro, Gilberto Ochman Silva, Valter Angelo Sperling Cescato, Nina Rosa Castro Musolino, Malebranche Berardo Carneiro Cunha-Neto, Andrea Glezer
Summary: Dopamine agonists (DA) are the preferred treatment for prolactinoma and hyperprolactinemia. However, intolerance to DA can occur in 3 to 12% of cases, leading to treatment discontinuation. This review discusses the definition, pathogenesis, frequency, and management of DA intolerance, as well as introduces a case report on the use of intravaginal cabergoline.
Article
Cell Biology
Xiaopeng Chen, Bin Cheng, Dafei Dai, Yuhai Wu, Zhiwen Feng, Chaogang Tong, Xiangming Wang, Jun Zhao
Summary: High expression of HPSE promotes HCC metastasis by mediating the necroptosis of MVECs and activating the HPSE/SDC-1/TNF-α axis and p38 MAPK pathway.
CELL DEATH DISCOVERY
(2021)
Article
Immunology
Aleksei Parshenkov, Thierry Hennet
Summary: Altered surface glycosylation is a major characteristic of tumor cells and can be recognized by lectins, which can distinguish tumor cells from healthy cells based on the expression of glycosylation-dependent markers. Lectins induce cell death through various pathways, and their broad cytotoxic response makes them potential candidates for therapies targeting tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Christoph Grohmann, Charlene M. Magtoto, Joel R. Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A. Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S. Simpson, Hao Dong, Bridget Dorizzi, Annette Jacobsen, Emma Morrish, Natasha Silke, James M. Murphy, Joan K. Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Guillaume Lessene, John Silke, Rebecca Feltham
Summary: In this study, the authors extended the tTPD platform by developing NanoTACs that degrade NanoLuc tagged substrates. They benchmarked each tTPD system using an interchangeable tag reporter system.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Intidhar Ben Salem, Manel Boussabbeh, Julie Pires Da Silva, Nour Elhouda Saidi, Salwa Abid-Essefi, Christophe Lemaire
Summary: In this study, we investigated the mechanism of Dichlorvos-induced toxicity in cardiac cells. Cell death by necroptosis was induced after 24-hour exposure to Dichlorvos, while autophagy was enhanced following 6-hour exposure. Autophagy acts as a protective mechanism against the toxicity induced by this pesticide. The inhibition of deacetylase sirtuin 1 (SIRT1) increased necroptosis, while its activation decreased cell death.
Article
Pharmacology & Pharmacy
Suchitra Mohanty, Poonam Yadav, Harini Lakshminarayanan, Priyanshu Sharma, Aravindhan Vivekanandhan, Devarajan Karunagaran
Summary: The study found that RETRA selectively induces necroptosis in cervical cancer cells without cytotoxic effects on normal cells. The induction of cell death by RETRA is associated with mitochondrial hyperpolarization and increased ROS production, emphasizing its importance in the treatment of cervical cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Josephine Nemegeer, Kelly Lemeire, Peter Vandenabeele, Jonathan Maelfait
Summary: An optimized staining procedure for detecting serine (S) phosphorylated RIPK3 (S227) and MLKL (S358) in human HT-29 cells infected with herpes simplex virus 1 (HSV-1) was described, including a tyramide signal amplification (TSA) step to improve sensitivity. This method allows visualization of critical signaling events during ZBP1-induced necroptosis.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Endocrinology & Metabolism
Jackson Sapuleni, Magdalena Szymanska, Rina Meidan
Summary: By activating SIRT1, key ovulatory and angiogenic genes are upregulated in human granulosa-lutein cells, but this also leads to the advancement of cell death pathways. These effects appear to be regulated by cAMP.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Neurosciences
Jiong Yue, Wei Li, Chao Liang, Bing Chen, Xin Chen, Lukang Wang, Zhenle Zang, Sixun Yu, Shiyong Liu, Song Li, Hui Yang
EXPERIMENTAL NEUROLOGY
(2016)
Article
Cell Biology
Xin Zheng, Song Li, Zhenle Zang, Jintao Hu, Jiayin An, Xiangdong Pei, Feng Zhu, Weihua Zhang, Hui Yang
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Oncology
Jiayin An, Xiangdong Pei, Zhenle Zang, Zheng Zhou, Jintao Hu, Xin Zheng, Yin Zhang, Jiaojiang He, Lian Duan, Rufei Shen, Weihua Zhang, Feng Zhu, Song Li, Hui Yang
Article
Multidisciplinary Sciences
Jiayin An, Yin Zhang, Jiaojiang He, Zhenle Zang, Zheng Zhou, Xiangdong Pei, Xin Zheng, Weihua Zhang, Hui Yang, Song Li
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
J. Hu, J. Yan, X. Zheng, Y. Zhang, Q. Ran, X. Tang, T. Shu, R. Shen, L. Duan, D. Zhang, Q. Guo, W. Zhang, H. Yang, S. Li
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2019)
Article
Oncology
Xiao Ding, Kexia Fan, Jintao Hu, Zhenle Zang, Shunli Zhang, Yin Zhang, Zhichao Lin, Xiangdong Pei, Xin Zheng, Feng Zhu, Hui Yang, Song Li
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Biochemical Research Methods
Qingxia Yang, Jiajun Hong, Yi Li, Weiwei Xue, Song Li, Hui Yang, Feng Zhu
BRIEFINGS IN BIOINFORMATICS
(2020)
Article
Endocrinology & Metabolism
H. Yin, X. Zheng, X. Tang, Z. Zang, B. Li, S. He, R. Shen, H. Yang, S. Li
Summary: This study evaluated the transcriptional changes in growth hormone-secreting pituitary adenomas (GH-PAs) and identified differentially expressed genes associated with invasive GH-PAs. Functional enrichment analysis revealed suppressed pathways related to epithelial cell differentiation and development, while other pathways showed an active trend in invasive GH-PAs. The study also identified specific genes and chromosomal regions linked to the invasiveness of GH-PAs, providing new insights for understanding the underlying mechanisms of these tumors.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Immunology
Xin Zheng, Song Li, Hui Yang
Summary: TLR3 is an important member of the TLR family that can recognize double-stranded RNA and play a role in immune responses, and it has also been detected in some tumors. TLR3 may play protumor or antitumor roles in different tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pathology
Yuyang Peng, Hui Yang, Song Li
Summary: Glycometabolic plasticity, characterized by the ability of cancer cells to modulate glycometabolism in response to different stimuli, plays a key role in cancer progression, metastasis, and treatment resistance. Understanding the molecular mechanisms of glycometabolic plasticity in cancer is crucial for cancer research and treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Kexia Fan, Xiao Ding, Zhenle Zang, Yin Zhang, Xiaoshuang Tang, Xiangdong Pei, Qingbo Chen, Huachun Yin, Xin Zheng, Yong Chen, Song Li, Hui Yang
Summary: This study investigates the role of dynamin-related protein 1 (Drp1) in pituitary adenomas (PA) and finds that Drp1 inhibits PA cell proliferation by damaging mitochondria, inhibiting oxidative phosphorylation (OXPHOS), and reducing ATP production. In addition, overexpression of Drp1 induces apoptosis and autophagy in PA cells, and represses PA growth in vivo. Therefore, targeting mitochondrial metabolic homeostasis may be a promising antineoplastic strategy for PA therapy.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Yin Zhang, Lei Zhang, Kexia Fan, Yajun Gou, Zhenle Zang, Xiao Ding, Hui Yang, Song Li
Summary: The invasiveness and high proliferation rate of growth hormone-secreting pituitary adenomas (GHPAs) are associated with abnormal mitochondrial dynamics. In this study, it was found that invasive GHPA samples had decreased numbers, volumes, and membrane areas of mitochondria compared to noninvasive samples. Downregulation of Drp1 protein may contribute to this abnormal mitochondrial dynamics, leading to enhanced invasion and proliferation of tumor cells. Mitochondrial hypofission might activate the STAT3 pathway to regulate tumor cell functions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
HuaChun Yin, JingXin Tao, Yuyang Peng, Ying Xiong, Bo Li, Song Li, Hui Yang
Summary: The study proposed a new machine learning approach, MSPJ, for identifying DEGs in small gene expression datasets, showing the best performance in most small datasets and potentially advancing research on molecular mechanisms underlying complex diseases or phenotypes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Oncology
Xiao Ding, Weihua Zhang, Song Li, Hui Yang
AMERICAN JOURNAL OF CANCER RESEARCH
(2019)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)