Article
Oncology
M. Maramai, M. T. Achilarre, A. Aloisi, I. Betella, S. Bogliolo, A. Garbi, M. Maruccio, C. Quatrale, G. D. Aletti, A. Mariani, N. Colombo, A. Maggioni, F. Multinu, V. Zanagnolo
Summary: A study on 251 endometrial cancer patients undergoing robotic-assisted surgical staging and SLN biopsy found that cervical re-injection of ICG significantly increased SLN detection rates, reducing the need for side-specific lymphadenectomies.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Ori Tal, Ehud Grinstein, Elinor Goshen, Yakov Oksman, Mordechai Lorberboym, Osnat Elyashiv, Erez Ben Shem, Ofri Peled, Tally Levy
Summary: The combination of ICG and Tc99m-FSC can improve the bilateral sentinel lymph node detection rate in endometrial cancer patients. However, in cases of unilateral mapping failure, relying solely on the anatomic location of the ipsilateral SLN for predicting the location of the complementary node is not reliable due to poor symmetric concordance.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Oncology
Leah A. Marsh, Emeline M. Aviki, Jason D. Wright, Ling Chen, Nadeem Abu-Rustum, Ritu Salani
Summary: This study estimates the annual cost of wasted indocyanine green (ICG) used for sentinel lymph node mapping in patients with endometrial cancer. The findings show that the current manufactured vial size of ICG leads to wasted costs exceeding $2 million for hospitals and $13.3-$17.7 million for patients annually. The study suggests packaging ICG in smaller vials to avoid drug waste and financial impact.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Medicine, General & Internal
Hans Nagar, Nina Wietek, Richard J. Goodall, Will Hughes, Mia Schmidt-Hansen, Jo Morrison
Summary: Pelvic lymphadenectomy provides prognostic information for endometrial cancer patients, but has not shown therapeutic benefits and causes significant morbidity. Sentinel lymph node biopsy (SLNB) has high diagnostic accuracy in detecting pelvic lymph node involvement in early stage endometrial cancer, with different tracers affecting detection rates. Further research is needed to evaluate the value of SLNB in treatment pathways and to conduct high-quality intervention studies.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
Xinyue Zhang, Bingting Bao, Sixue Wang, Mingyu Yi, Li Jiang, Xiaoling Fang
Summary: This study revealed that sentinel lymph node biopsy can accurately predict lymph node metastasis in early stage cervical cancer patients, with a high detection rate and specific sensitivity. Despite heterogeneity in studies, the use of indocyanine green tracer for sentinel lymph node mapping appears to be superior to other methods currently available.
Article
Oncology
Sichen Liang, Zhiqi Wang, Jiayu Chen, Xin Yang, Xudong Liang, Xiuli Sun, Xiaowei Li, Rong Zhou, Yi Li, Jianliu Wang
Summary: The combination of ICG and CNPs showed the highest detection rates of SLNs in endometrial cancer patients, with high sensitivity and negative predictive value. Factors like tumor Grade 3, tumor diameter greater than 2 cm, laparoscopy, and BMI are related to the success or failure of SLN mapping and detection when using CNPs or ICG.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Stefano Cianci, Andrea Rosati, Virginia Vargiu, Vito Andrea Capozzi, Giulio Sozzi, Alessandro Gioe, Salvatore Gueli Alletti, Alfredo Ercoli, Francesco Cosentino, Roberto Berretta, Vito Chiantera, Giovanni Scambia, Francesco Fanfani
Summary: Aging is a risk factor for SLN mapping failure, increasing the risk of mapping failure with each year. Older patients have a higher incidence of independent risk factors such as LVSI, non-endometrioid histotype, and BMI, leading to increased likelihood of unsuccessful mapping.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Julio Jimenez-Lillo, Eduardo Villegas-Tovar, Dulce Momblan-Garcia, Victor Turrado-Rodriguez, Ainitze Ibarzabal-Olano, Borja De Lacy, Alejandro Diaz-Giron-Gidi, Regina Faes-Petersen, Raigam J. Martinez-Portilla, Antonio Lacy
Summary: The study evaluated the detection rate of ICG imaging for sentinel lymph node mapping and lymph node metastases in esophageal cancer, with a detection rate of 89% for SLNM and a sensitivity of 84% for LNMs in the pooled analysis.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Nicolo Bizzarri, Luigi Pedone Anchora, Gabriella Ferrandina, Gian Franco Zannoni, Maria Vittoria Carbone, Camilla Fedele, Elena Teodorico, Valerio Gallotta, Salvatore Gueli Alletti, Vito Chiantera, Anna Fagotti, Giovanni Scambia, Francesco Fanfani
Summary: The study found that the use of ICG in open cervical cancer surgery for SLN detection provides a bilateral detection rate, sensitivity, and negative predictive value comparable to minimally invasive surgery, with potential advantages of ICG compared to other tracers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
William A. Zammarrelli, Anoushka M. Afonso, Vance Broach, Yukio Sonoda, Oliver Zivanovic, Jennifer J. Mueller, Mario M. Leitao, Amelia Chan, Nadeem R. Abu-Rustum
Summary: The study investigated adverse reactions to indocyanine green (ICG) during sentinel lymph node biopsy for endometrial cancer in 1414 patients and found that ICG intracervical administration was generally safe, with no anaphylactic responses. Premedication with corticosteroids may be a reasonable strategy for patients with a history of iodinated contrast allergy.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Petronilla Staubach, Anton Scharl, Atanas Ignatov, Olaf Ortmann, Elisabeth C. Inwald, Thomas Hildebrandt, Michael Gerken, Monika Klinkhammer-Schalke, Sophia Scharl, Thomas Papathemelis
Summary: The study demonstrates that indocyanine green can be as effective as the radioisotope for SLNB in early breast cancer patients, even among those who have undergone NACT. This offers a potential alternative to overcome the limitations associated with radioactive Technetium(99m) colloid, such as limited availability, high costs, and radioactivity exposure.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Miao He, Sichen Liang, Hao Deng, Guo Zhang, Zhiqi Wang, Xin Yang, Yue Wang, Yi Li, Xiuli Sun, Jianliu Wang
Summary: This study compared the feasibility and diagnostic value of sentinel lymph node (SLN) mapping using carbon nanoparticles (CNPs) and indocyanine green (ICG) in endometrial cancer (EC). The results showed that the detection rate, sensitivity, and negative predictive value were similar between the two methods. The study suggested that CNPs could be an alternative to ICG for SLN mapping when near-infrared imaging equipment is lacking.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yanglong Guo, Lu Sun, Xi Chen, Qiang Wen, Zhuyan Shao, Xuedong Tang, XiaoJun Shi, Jinyu Wang, Yingli Zhang, Tao Zhu
Summary: This study aims to compare the effectiveness of sentinel lymph node biopsy and lymphadenectomy for patients with early endometrial cancer and evaluate their impact on patients' quality of life.
Review
Obstetrics & Gynecology
Zibi Marchocki, Maria C. Cusimano, Lauren Clarfield, Soyoun Rachel Kim, Rouhi Fazelzad, Osvaldo Espin-Garcia, Genevieve Bouchard-Fortier, Emma C. Rossi, Katherine I. Stewart, Pamela T. Soliman, Jeffrey A. How, Walter H. Gotlieb, Robert W. Holloway, Manuel M. Ianieri, Silvia Cabrera, Yong Kuei Lim, Sarah E. Ferguson
Summary: Sentinel lymph node biopsy shows good detection rates and diagnostic accuracy in patients with high-grade endometrial cancer, suggesting it can replace complete lymphadenectomies as the standard of care for surgical staging.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Yu Xue, Wei-wei Shan, Qian Wang, Chao Wang, Xue-zhen Luo, Xiao-jun Chen
Summary: SLN mapping with ICG showed high detection rates and acceptable diagnostic efficacy in Chinese women with endometrial cancer, but may lead to higher missed diagnoses in patients with high-intermediate risk.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Pawel Jan Stanirowski, Dariusz Szukiewicz, Agata Majewska, Mateusz Watroba, Michal Pyzlak, Dorota Bomba-Opon, Miroslaw Wielgos
Summary: This study evaluated the placental expression of glucose transporters in term pregnancies complicated by GDM and PGDM. It found a significant increase in GLUT-1 expression in PGDM patients, while no significant differences were observed in other GLUT isoforms. Positive correlations were noted between fetal birthweight and the expression of GLUT-1 in PGDM group and GLUT-12 in the control group.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Oncology
Martina Borcinova, Volker Ragosch, Jiri Jarkovsky, Sylva Bajsova, Radovan Pilka, Ariel Glickman, Sonia Garrido-Mallach, Francesco Raspagliesi, Wiktor Szatkowski, Maja Pakiz, Leon C. Snyman, Roman Kocian, Karl Tamussino, Vladimir Kalist, Martin Michal, Myriam Gracia Segovia, Robert Poka, Barbara Kipp, Grzegorz Szewczyk, Dariusz Wydra, Robert Toth, Alla Vinnytska, Daniela Fischerova, Kathrin Siegler, David Cibula
Summary: This study aimed to investigate the assessment of lower limb lymphoedema (LLL) and suggested that the diagnostic threshold for LLL diagnosis based on limb volume change (LVC) should be increased to >15%. It also highlighted the importance of repeated measurements to distinguish transient oedema from persistent LLL and ensuring a sufficient follow-up duration. Patient-reported swelling correlated poorly with LVC and should only be used as an adjunct to objective LLL assessment.
GYNECOLOGIC ONCOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Dariusz Szukiewicz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Pawel Turczyn, Piotr Wojdasiewicz, Lukasz A. Poniatowski, Daryush Purrahman, Maria Maslinska, Grzegorz Zurek, Katarzyna Romanowska-Prochnicka, Beata Zuk, Brygida Kwiatkowska, Bartlomiej Piechowski-Jozwiak, Dariusz Szukiewicz
Summary: This study evaluates potential reasons for the oversight of omega-3 fatty acid therapy in the treatment and prevention of spinal cord injury. The current research results are inconclusive, but not fully utilizing the potential properties of omega-3 fatty acids due to methodological difficulties might be a potential waste.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Physiology
Mateusz Watroba, Dariusz Szukiewicz
Summary: This article discusses the basic pathomechanisms of Alzheimer's disease and the potential preventive role of sirtuins, particularly SIRT1 and SIRT3, in protecting against Alzheimer's disease-related pathology. Sirtuins can inhibit molecular processes associated with the disease, thus preventing its development. The article also explores the mechanisms by which sirtuins may prevent Alzheimer's disease and presents a rationale for boosting sirtuin activity.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Dariusz Szukiewicz, Piotr Wojdasiewicz, Mateusz Watroba, Grzegorz Szewczyk
Summary: This article discusses the impact of COVID-19 on the female reproductive system and the potential mechanisms related to mast cell activation syndrome (MCAS). However, current clinical data do not confirm a significant increase in the risk of abnormal female reproductive function due to MCAS.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Dariusz Szukiewicz, Seweryn Trojanowski, Anna Kociszewska, Grzegorz Szewczyk
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. It is a complex disorder influenced by genetic, environmental, endocrine, and behavioral factors. The primary clinical manifestations of PCOS are derived from excess androgens, while the secondary manifestations involve multiple metabolic, cardiovascular, and psychological disorders. Diet and lifestyle factors play important roles in the development and course of PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dariusz Szukiewicz
Summary: Insulin has comprehensive anabolic effects on the body, including lipid homeostasis and anti-inflammatory modulation, especially in adipose tissue. Obesity, with its accompanying health problems such as glucose intolerance, insulin resistance, and diabetes, has been increasing worldwide. Despite hyperinsulinemia, impaired tissue sensitivity to insulin paradoxically leads to diseases with an inflammatory component. Visceral fat accumulation in obesity disrupts epigenetic regulatory mechanisms in the immune system, resulting in autoimmunity and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mateusz Watroba, Anna D. Grabowska, Dariusz Szukiewicz
Summary: Diabetes mellitus is a common metabolic disease that can lead to neuropathy in both the peripheral and central nervous systems. Hyperglycemia, oxidative stress, and inflammation are the main factors contributing to the damage of cells in the central nervous system, causing neurodegeneration and dementia. Advanced glycation end products and brain insulin resistance are also involved in the pathogenesis of long-term complications of diabetes mellitus. This review focuses on the effects of dysglycemia on the central nervous system and the mechanisms underlying the loss of blood-brain barrier integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna D. Grabowska, Mateusz Watroba, Joanna Witkowska, Agnieszka Mikulska, Nuno Sepulveda, Dariusz Szukiewicz
Summary: The blood-brain barrier (BBB) plays a crucial role in regulating the flow of substances between the blood and the central nervous system. Disruption of the BBB due to imbalanced blood glucose levels can lead to neuroinflammation and increase the risk of neurodegenerative diseases. Resveratrol (RSV), a natural compound with anti-diabetic, anti-inflammatory, and neuroprotective properties, activates SIRT1, a key regulator of metabolism. This study aimed to assess the response of astrocyte SIRT1 to neuroinflammation and RSV treatment in different glycemic backgrounds. The results showed that abnormal glycemic states had a worse prognosis for RSV therapy effectiveness compared to normoglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dariusz Szukiewicz
Summary: Phytoestrogens (PEs) are estrogen-like compounds derived from plants and fungi, which can disrupt hormonal regulation and potentially lead to developmental and reproductive abnormalities. They bind to various estrogen receptors, including nuclear receptors and a membrane-bound estrogen receptor. This review focuses on the endocrine-disrupting effects of PEs in the context of endometriosis, a hormone-dependent disease with unknown causes that affects women of reproductive age and is associated with pelvic pain, dysmenorrhea, dyspareunia, and infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Justyna Komorowska, Mateusz Watroba, Malgorzata Bednarzak, Anna D. Grabowska, Dariusz Szukiewicz
Summary: Both hypo- and hyperglycemia conditions affect the cytokine profile in the brain compartments, while resveratrol can normalize it. Resveratrol exhibits anti-neuroinflammatory effects, especially in the group with normoglycemia-simulating conditions.
MEDICAL SCIENCE MONITOR
(2023)
Review
Biochemistry & Molecular Biology
Mateusz Watroba, Grzegorz Szewczyk, Dariusz Szukiewicz
Summary: SIRT1 plays a significant role in regulating the inflammatory response, autophagy, and cell response to oxidative stress in the placenta, and may be associated with the development of placental pathology such as pre-eclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Magdalena Chmielinska, Marzena Olesinska, Anna Felis-Giemza, Agnieszka Paradowska-Gorycka, Karolina Palej, Julita Rejmer-Szczesniak, Dariusz Szukiewicz
Summary: Based on the ASAS-EULAR recommendations, patients with axial spondyloarthritis who have failed to respond to at least two courses of NSAID therapy may be considered for modified NSAID treatment. This study aimed to identify risk factors for treatment failure and found that higher zonulin levels, ankylosing spondylitis, X-ray sacroiliitis, magnetic resonance imaging sacroiliitis, long duration of symptoms, high BASDAI score, and high spinal pain intensity were associated with treatment failure. Additionally, positive correlations were observed between haptoglobin concentration with C-reactive protein and erythrocyte sedimentation rate, and between zonulin levels and white blood count.
RHEUMATOLOGY INTERNATIONAL
(2023)