期刊
APPLIED CLAY SCIENCE
卷 168, 期 -, 页码 31-35出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.clay.2018.10.013
关键词
Half maximum inhibitory concentration; SOD activity; CAMKII alpha protein expression; Bare; Phase pure CaAl LDH; Anticancer activity; Apoptosis
资金
- CSIR-CGCRI
- Department of Science and Technology (DST Nanomission, India) [GAP 0258]
- Department of Science and Technology, India, INSPIRE [IF 140912]
In continuation of our previous work, which proposed a new direction of application of the bare, phase pure CaAl LDH as an active anticancer agent, the efficacy of the system was assessed by determination of half maximal inhibitory concentration (IC50) of the same on human colon cancer (HCT 116) cell line and human breast cancer (MCF 7) cell line. This was in turn established by tracing the involvement of Ca2+ ion with the CAMKII alpha protein- a key player in the Ca2+/Calmodulin pathway which remains overexpressed in human colon cancer cell. CAMKII alpha regulates the reactive oxygen species (ROS) production by decreasing the activity of superoxide dismutase (SOD) enzyme and hence SOD activity was also evaluated in our study. The results exhibit significant involvement of the bare, phase pure CaAl LDH at cellular level to down regulate CAMKII alpha and SOD gene and its active involvement in apoptosis could also be traced.
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