Article
Medicine, General & Internal
Tao Zhang, Liang Zhuang, Munawaer Muaibati, Dan Wang, Abuduyilimu Abasi, Qing Tong, Ding Ma, Lei Jin, Xiaoyuan Huang
Summary: This study identified cervical cancer stem cells and revealed the functional changes in cervical stem cells during malignant transformation. The original non-malignant stem cell properties gradually diminished, while the tumor stem cell properties were enhanced. Additionally, stem-like cells in the cervical microenvironment were associated with neoplastic recurrence, and interferon responses were upregulated during lesion progression.
Article
Chemistry, Multidisciplinary
Mariana Sarai Silva-Lopez, Cesar Arturo Ilizaliturri Hernandez, Hugo Ricardo Navarro Contreras, Angel Gabriel Rodriguez Vazquez, Alejandra Ortiz-Dosal, Eleazar Samuel Kolosovas-Machuca
Summary: This study evaluated the ability of Raman spectroscopy technique to discriminate between healthy and premalignant/malignant cervical cells. The results showed increased intensity in Raman spectra of premalignant/malignant cells. The classification efficiency and sensitivity suggest that Raman spectroscopy could be helpful in the screening and diagnosis of premalignant lesions and cervical cancer.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Liliana Torres-Lopez, Miguel Olivas-Aguirre, Kathya Villatoro-Gomez, Oxana Dobrovinskaya
Summary: G-1 can induce cytotoxicity, cell cycle arrest, reduced viability, and apoptosis in acute T-cell lymphoblastic leukemia cell lines. The rise of intracellular Ca2+ and destabilization of microtubules are important factors in the cytotoxic effects of G-1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Richard A. Pepermans, Geetanjali Sharma, Eric R. Prossnitz
Summary: Estrogen plays crucial roles in various cancers, metabolism, and immune regulation. The G protein-coupled estrogen receptor (GPER) has been found to contribute to endocrine therapy resistance in breast cancer and has potential therapeutic value in targeting other diseases such as obesity and diabetes. Ongoing clinical trials are exploring the use of GPER-selective agonists like G-1 in combination with immune checkpoint inhibition for cancer treatment.
Review
Pharmacology & Pharmacy
Shaojie Yang, Zhe Yin, Guoqi Zhu
Summary: This review discusses the role of GPER in aging-related diseases, including vascular and neurological disorders. Activation of GPER has been found to improve cognitive function in the aging brain, with mechanisms different from other estrogen receptors. The review also carefully describes the molecular mechanisms underlying GPER-mediated effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyun Kyung Lim, Hee Jung Kwon, Ga Seul Lee, Jeong Hee Moon, Joohee Jung
Summary: The activation of GPER and the reduction in ROCK1, TAGLN2, and FCHO2 expressions by Chrysin suppress pancreatic cancer progression. This finding provides a new potential strategy for the treatment of pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Zahra Salavatiha, Mohammad Farahmand, Zabihollah Shoja, Somayeh Jalilvand
Summary: This study found varying HPV prevalence among women in Iran with different cervical cytology statuses, and suggests integrating HPV vaccines into the national vaccination programs of Iran for beneficial outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Cell Biology
Nan Han, Sabine Heublein, Udo Jeschke, Christina Kuhn, Anna Hester, Bastian Czogalla, Sven Mahner, Miriam Rottmann, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch
Summary: The study found a positive correlation between GPER and H3K4me3 expression in ovarian cancer patients, with patients overexpressing both having improved overall survival. Activation of GPER led to increased H3K4me3 and p-ERK1/2 levels, as well as decreased cell proliferation and migration, while antagonizing GPER activity had opposite effects. The interaction between GPER and H3K4me3 is of prognostic significance and GPER agonists like G1 have potential as a therapeutic approach for ovarian cancer.
Article
Environmental Sciences
Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, Jose-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Summary: 17 beta-estradiol protects pancreatic beta-cells from apoptosis via estrogen receptors ER alpha, ER beta, and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA) increases basal apoptosis in the same cell type through the same estrogen receptors. The molecular events that trigger these opposite actions have not been identified yet.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Applied
Cristina M. Castillo-Bautista, Luis W. Torres-Tapia, Alfredo Lagunas-Martinez, Carla O. Contreras-Ochoa, Sergio R. Peraza-Sanchez, Rosa Moo-Puc
Summary: Secundiflorol G (SG) is an isoflavan isolated from a Mayan medicinal plant, which has been shown to have cytotoxic effects on cervical cancer cells. Experimental assays indicated that SG induces apoptosis and affects mitochondrial function in HeLa cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Cell Biology
Marilena Kampa, Rosamaria Lappano, Fedora Grande, Bruno Rizzuti, Marcello Maggiolini, Elias Castanas, Yves Jacquot
Summary: This article discusses the interactions of estrogen receptor alpha (ER alpha) with various molecules. The 295-311 region of ER alpha is targeted by post-translational modifications and may play a crucial role in transcription control. In addition to other proteins, this region interacts with G-protein-coupled estrogen receptor (GPER). The corresponding peptide, ER alpha 17p, has shown promising therapeutic potential as a GPER modulator, inducing apoptosis and reducing tumor size in triple-negative breast tumor xenografts in mice.
Article
Oncology
Yi Zhu, Yixin Tang, Zhuolin Jiang, Jie Zhang, Shijun Jia, Yanjie Li, Xinyi Luo, Tomoyasu Kato, Guonan Zhang
Summary: This study assessed the diagnostic efficacy of the vascular index (VI) on superb microvascular imaging (SMI) in distinguishing normal uterine cervical epithelium, high-grade cervical intraepithelial neoplasia (CIN), and cervical cancer. The findings revealed significant differences in microvascular architecture between premalignant and malignant cervical lesions, with VI demonstrating superior diagnostic performance compared to vascular patterns.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alex Hirtz, Yann Bailly, Fabien Rech, Julien Pierson, Helene Dumond, Helene Dubois-Pot-Schneider
Summary: Glioblastoma is a common primary brain tumor with poor treatment outcomes. High expression of GPER1 is associated with better survival, suggesting the protective role of estrogen signaling. The G-1 agonist demonstrates anti-tumor effects on GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ewa Trybus, Teodora Krol, Wojciech Trybus
Summary: The study investigates the mechanisms of action of azelastine hydrochloride in cancer treatment. The results demonstrate that azelastine can induce degradation processes, increase autophagy activity, and activate apoptosis, leading to anti-proliferative, cytotoxic, autophagic, and apoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Wojciech Trybus, Teodora Krol, Ewa Trybus, Anna Stachurska
Summary: Physcion exerts antitumor effects by inducing oxidative stress, autophagy, and apoptosis in HeLa cells, resulting in decreased cell viability, G0/G1 phase cell cycle arrest, and activation of the lysosomal system.
Review
Endocrinology & Metabolism
Adrian Ramirez-de-Arellano, Ana Laura Pereira-Suarez, Cecilia Rico-Fuentes, Edgar Ivan Lopez-Pulido, Julio Cesar Villegas-Pineda, Erick Sierra-Diaz
Summary: This article reviews the role of estrogens in various types of cancer, including prostate cancer. It discusses the expression and regulation of estrogen receptors, their splice variants, ligand binding, and the effect on prostate cancer. The contribution of molecular simulation in predicting estrogenic activities is also assessed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Oncology
Natalia Garcia-Becerra, Adriana Aguilar-Lemarroy, Luis F. Jave-Suarez
Summary: Cervical cancer is a prevalent pathology in females and is the second leading cause of cancer-related deaths in developing countries. The development of cervical cancer is primarily caused by persistent infection with high-risk human papillomavirus. NF-kappa B signaling pathway plays a critical role in the development of cervical cancer.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Immunology
S. Gonzalez-Ochoa, M. C. Tellez-Banuelos, A. S. Mendez-Clemente, A. Bravo-Cuellar, G. Hernandez Flores, L. A. Palafox-Mariscal, J. Haramati, E. J. Pedraza-Brindis, K. Sanchez-Reyes, P. C. Ortiz-Lazareno
Summary: This study found that the use of inhibitors targeting the IL6R/STAT-3 axis and TIGIT can enhance the functional activity of NK cells against castration-resistant prostate cancer cells.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Oscar Jimenez, Tamara Mangiaterra, Sandra Colli, Mercedes Garcia Lombardi, Maria Victoria Preciado, Elena De Matteo, Paola Chabay
Summary: This study evaluated the expression of exhaustion markers in pediatric EBV-associated HL and found a balance between cytotoxic and regulatory markers in EBV+ cases. Additionally, a correlation between PD-1 and LAG-3 expression was observed in EBV-associated cHL, and their co-expression was associated with worse survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jorge Raul Vazquez-Urrutia, Maria Iyali Torres-Bustamante, Cesar Rodrigo Cerda-Cruz, Alejandro Bravo-Cuellar, Pablo Cesar Ortiz-Lazareno
Summary: Prostate cancer is the most common tumor in males and the second leading cause of cancer-related deaths. Current screening methods are not sensitive or specific enough, leading to unnecessary interventions. The current prognostic strategies are invasive and there is a lack of tools for predicting tumor progression and treatment response. miRNAs show promise as biomarkers for screening, surveillance, prognosis and treatment response in prostate cancer.
Article
Medicine, Legal
Jorge Adrian Ramirez de Arellano Sanchez, Jose Miguel Moreno Ortiz, Andres Lopez Quintero, Heidi Pfeiffer, Marielle Vennemann, Hannah Bauer
Summary: Bones are often the only material available for identifying human remains, but proper storage is necessary to maintain DNA integrity. This study evaluated the effects of bone cleaning, buffer composition, storage temperature, and time on DNA recovery. Results showed that temperature and storage time had no significant impact on DNA yield. DNA recovery was higher in bones stored with solid sodium chloride or ethanol-EDTA compared to TENT buffer, and dehydration facilitated bone grinding. Overall, solid sodium chloride was found to be superior for storage transportation of forensic samples.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Immunology
Agustina Moyano, Natalia Ferressini, Elena De Matteo, Maria Victoria Preciado, Paola Chabay
Summary: Our study found that macrophages' PD-L1 expression in pediatric EBV-infected patients might be regulated by EBV's lytic and latent antigens, especially in primary infected patients. Surprisingly, only TGF-beta was related to total PD-L1 upregulation. These findings could be important for the development of EBV-associated tumor therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Natalia Garcia-Becerra, Marco Ulises Aguila-Estrada, Luis Arturo Palafox-Mariscal, Georgina Hernandez-Flores, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suarez
Summary: FOXP3 is a critical transcription factor that plays a key role in the regulation of the lymphoid lineage. It has been found to be highly expressed in cervical cancer cells, and its isoform FOXP3 delta,2 delta,7 promotes proliferation, cell division, and migration in non-tumorigenic keratinocytes. RNAseq analysis revealed that FOXP3 delta,2 delta,7 induces the expression of protooncogenes and modulates essential pathways related to immune response and tumorigenic process.
Article
Medicine, General & Internal
Jessica Alejandra Zapata-Garcia, Alma Rocio Riveros-Magana, Pablo Cesar Ortiz-Lazareno, Georgina Hernandez-Flores, Luis Felipe Jave-Suarez, Adriana Aguilar-Lemarroy
Summary: This study identified genes present in chromosomal gain regions more frequently found in patients with acute lymphoblastic leukemia (ALL) using comparative genomic hybridization (CGH) and RNAseq. Several genes were found to be overexpressed in ALL cell lines and patients, including SALL2 in T-ALL and JUP in B-ALL, which correlated with worse patient prognosis.
Article
Biochemistry & Molecular Biology
Maryam Nasiri-Aghdam, Mariel Garcia-Chagollan, Ana Laura Pereira-Suarez, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suarez
Summary: Infection of epithelial cells with high-risk HPV types and expression of virus oncogenic proteins can lead to genomic imbalance, suppression of tumor inhibitors, and induction of oncogenes. Co-infection with low-risk HPV may decrease the risk of future invasive cancer. By comparing the functional differences between LR-HPV and HR-HPV, we can distinguish cancer-progressing changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Julio Cesar Villegas-Pineda, Adrian Ramirez-de-Arellano, Lesly Jazmin Bueno-Urquiza, Melida del Rosario Lizarazo-Taborda, Ana Laura Pereira-Suarez
Summary: Molecular and cellular components of the tumor microenvironment, including cancer cells and non-cancer cell populations, play essential roles in cancer progression. Cancer-associated fibroblasts (CAFs), as mesenchymal cells, promote carcinogenesis and progression through the secretion of different molecules. Recent findings have increased our understanding of the leading role of CAFs in gynecological cancers, suggesting their potential as therapeutic targets and their possible tumor suppressor effects.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Diana Lorena Cisneros-Garcia, Elena Sandoval-Pinto, Rosa Cremades, Adrian Ramirez-de-Arellano, Mariana Garcia-Gutierrez, Roberto Martinez-de-Pinillos-Valverde, Erick Sierra-Diaz
Summary: Chronic kidney disease (CKD) has become a public health concern, with diabetes and hypertension being the most remarkable risk factors. This study aims to report non-traditional risk factors for end-stage renal disease (ESRD) such as gender, ethnicity, erythematous systemic lupus, pesticide use, and congenital diseases. It is necessary to address these non-traditional risk factors and find multidisciplinary solutions.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Raquel Echavarria, Ernesto German Cardona-Munoz, Pablo Ortiz-Lazareno, Jorge Andrade-Sierra, Luis Francisco Gomez-Hermosillo, Jorge Casillas-Moreno, Tannia Isabel Campos-Bayardo, Daniel Roman-Rojas, Andres Garcia-Sanchez, Alejandra Guillermina Miranda-Diaz
Summary: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). This study explores the roles of oxidative stress, DNA damage, antioxidant enzymes, mitochondrial function, and mitophagy in LN. The study also discusses the importance of Toll-like receptors 7 and 9 in the development of LN, and provides information on conventional treatments and novel alternatives for improving renal function in LN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Agustina Moyano, Natalia Ferressini Gerpe, Maria Eugenia Amarillo, Elena De Matteo, Maria Victoria Preciado, Maria Soledad Caldirola, Paola Chabay
Summary: Macrophages are flexible cells that can be activated as M1 or M2 macrophages depending on the presence of inflammatory cytokines. This study aimed to understand the role of cytokines in macrophage polarization during Epstein-Barr virus (EBV) pediatric infection. The results showed that IL-10 had a negative correlation between different compartments, specifically in patients undergoing viral reactivation. Higher expressions of IL-1 beta, IL-23, and IL-12p40 were observed in children with viral reactivation, while lower expressions of TNF-alpha were demonstrated in patients with broader viral protein expressions. In healthy carrier patients, IL-23 positively correlated with CD163 and IP-10 positively correlated with CD68. These findings suggest that EBV may modulate antigen expression in the presence of TNF-alpha and influence peripheral cytokine expression differently in each stage of infection. Furthermore, peripheral cytokines may play a specific role in macrophage polarization in healthy carriers.