Editorial Material
Psychology, Developmental
Kati Roesmann, Julia Asbrand
Summary: The ability to cope with threats is crucial for young people who are still developing coping mechanisms. Anxious youths exhibited stronger conditioned fear responses and greater electrocortical differences during delayed extinction learning, which were also associated with treatment outcomes. Future research should focus on age- and context-sensitive approaches to establish reliable risk profiles and enable evidence-based, individualized treatment decisions.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Tom C-H Wu, Alan J. Meehan, Jolien Rijlaarsdam, Barbara Maughan, Pasco Fearon, Edward D. Barker
Summary: Difficult temperament in toddlerhood is associated with depressive symptoms and well-being in adulthood, with the relationship potentially mediated by psychopathology in late childhood/early adolescence. The mediated pathways are not moderated by parenting behaviors.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Public, Environmental & Occupational Health
Chloe R. McDonald, Andrea M. Weckman, Julie K. Wright, Andrea L. Conroy, Kevin C. Kain
Summary: The prenatal environment has a significant impact on fetal development and long-term health. Poor maternal health and various diseases during pregnancy can lead to cognitive, metabolic, and cardiovascular disorders in children and adults. Improving access to comprehensive antenatal care globally is necessary to protect the health and safety of women and children.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Psychology, Developmental
Nathan A. Fox, Selin Zeytinoglu, Emilio A. Valadez, George A. Buzzell, Santiago Morales, Heather A. Henderson
Summary: Behavioral inhibition is a temperament that can be identified in early childhood and increases the risk of developing anxiety in late childhood and adolescence. However, not all children with behavioral inhibition go on to develop anxiety disorders, and research has identified within-child and socio-contextual factors that support different developmental pathways. By studying moderators of behavioral inhibition, we can better understand why some children develop anxiety while others remain resilient.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Review
Neurosciences
Patrizia Pezzoli, Sam Parsons, Rogier A. Kievit, Duncan E. Astle, Quentin J. M. Huys, Nikolaus Steinbeis, Essi Viding
Summary: Currently, there is limited understanding of the early neurocognitive mechanisms involved in shaping mental health trajectories from childhood through young adulthood, highlighting the need for more sensitive and reliable individual differences measures. To overcome methodological shortcomings, a novel experimental approach called cognitive microscopy is proposed, which includes adaptive design optimization, temporally sensitive task administration, and multilevel modeling to provide measures of stability, variability, and developmental change in neurocognitive mechanisms within a multivariate framework.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Review
Endocrinology & Metabolism
Hiroaki Itoh, Megumi Ueda, Misako Suzuki, Yukiko Kohmura-Kobayashi
Summary: Metabolic syndrome, associated with obesity, increases the risk of type 2 diabetes, coronary diseases, stroke, and other disabilities. The Developmental Origins of Health and Disease (DOHaD) theory suggests that early developmental environmental imbalance affects health and predisposes individuals to non-communicable diseases, including metabolic syndrome. The 'Thrifty Phenotype' hypothesis proposes that undernourished fetuses develop evolutionary advantageous traits for survival in a hangry environment after birth, but this phenotype increases the risk of metabolic syndrome under an obesogenic diet. Chronic inflammation, referred to as 'Metaflammation', is believed to mediate the connection between obesity and metabolic disorders in metabolic syndrome. However, the contribution of evolutionary maladaptation to the pathophysiology of 'Metaflammation' remains understudied. Investigating 'Metaflammation' from the perspective of selective advantages and mismatches to contemporary lifestyles can provide valuable insights, considering the concept of evolutionarily conserved nutrient sensing and immune signaling systems.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Long T. Nguyen, Carol A. Pollock, Sonia Saad
Summary: The developmental programming hypothesis suggests that adverse environmental insults during critical developmental periods increase the risk of diseases in later life. Kidneys are susceptible to such insults, particularly due to peri-gestational nutrition, which affects kidney development and metabolism. Recent studies have identified oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes as potential novel pathways for therapeutic intervention.
Review
Biochemistry & Molecular Biology
Niraj Kumar Jha, Wei-Chih Chen, Sanjay Kumar, Rajni Dubey, Lung-Wen Tsai, Rohan Kar, Saurabh Kumar Jha, Piyush Kumar Gupta, Ankur Sharma, Rohit Gundamaraju, Kumud Pant, Shalini Mani, Sandeep Kumar Singh, Ricardo B. Maccioni, Tirtharaj Datta, Sachin Kumar Singh, Gaurav Gupta, Parteek Prasher, Kamal Dua, Abhijit Dey, Charu Sharma, Yasir Hayat Mughal, Janne Ruokolainen, Kavindra Kumar Kesari, Shreesh Ojha
Summary: Developmental signalling pathways play a central role in neuronal development and any aberration in these pathways can contribute towards neurological disorders. Extensive research has been conducted in the past decade on these pathways, revealing their potential as therapeutic targets for diseases.
Review
Physiology
Daniel J. Hoffman, Theresa L. Powell, Emily S. Barrett, Daniel B. Hardy
Summary: Nearly 2 billion adults worldwide are overweight, with over half classified as obese, and nearly one-third of global children experience poor growth and development. The global epidemic of obesity and double burden of malnutrition, where overweight coexists with underweight and micronutrient deficiencies, poses a significant challenge to human health. Understanding the developmental origins of health and disease (DOHaD) is crucial in addressing the global issues of obesity and chronic diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Pediatrics
Ariunzaya Amgalan, Nickie Andescavage, Catherine Limperopoulos
Summary: Research shows that neuropsychiatric diseases have developmental origins related to intrauterine exposures, particularly affected by factors such as infection and inflammation. Identifying the timing and mechanisms of injury is crucial in studying fetal brain development, and clinical care should focus on maternal health during pregnancy and monitoring offspring for early recognition and treatment.
Article
Biochemical Research Methods
Manuela Grimaldi, Carmen Marino, Michela Buonocore, Angelo Santoro, Eduardo Sommella, Fabrizio Merciai, Emanuela Salviati, Arianna De Rosa, Tommaso Nuzzo, Francesco Errico, Pietro Campiglia, Alessandro Usiello, Anna Maria D'Ursi
Summary: Originally believed to be present only in bacteria and invertebrates, D-amino acids have also been found in mammalian tissues. Depletion of D-Asp in the brain has been shown to influence amino acid pathways and metabolites related to brain development and function.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Neurosciences
Megan G. McGill, Irina Pokhvisneva, Andrew S. Clappison, Lisa M. McEwen, Roseriet Beijers, Marieke S. Tollenaar, Hung Pham, Michelle Z. L. Kee, Elika Garg, Euclides J. de Mendonca Filho, Neerja Karnani, Patricia P. Silveira, Michael S. Kobor, Carolina de Weerth, Michael J. Meaney, Kieran J. O'Donnell
Summary: Prenatal maternal anxiety predicts child PedBE epigenetic age acceleration, predominantly in males. PedBE age acceleration predicts increased externalizing symptoms in males in the BIBO cohort.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Lin Yang, Zhenmeiyu Li, Guoping Liu, Xiaosu Li, Zhengang Yang
Summary: In this study, the researchers integrated analysis of published human cortical single-cell RNA-Seq datasets with immunohistochemical analyses to show that around gestational week 18, EGFR-expressing human cortical truncated radial glial cells give rise to basal multipotent intermediate progenitors. These progenitors go through several rounds of mitosis and generate different types of glial cells and neurons in the developing human cerebral cortex. The findings provide insights into the lineage progression of cortical radial glial cells.
NEUROSCIENCE BULLETIN
(2022)
Review
Clinical Neurology
Eliza Gordon-Lipkin, Alexander Hoon, Carlos A. Pardo
Summary: This article discusses the relationship between prenatal infections and developmental disabilities, emphasizing the importance of lessons learned from historically significant pathogens in dealing with emerging congenital infections. Prenatal infections are preventable causes of developmental disabilities, and various public health approaches can be used for prevention.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kah Kheng Goh, Chun-Hsin Chen, Hsien-Yuan Lane
Summary: Schizophrenia is characterized by abnormal behavior, and dysregulation of oxytocin may play a role in its expression. Studies have shown potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. Oxytocin has the potential to be a therapeutic agent for schizophrenia and may have implications for future treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)