miR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification

Evidences for a New Role of miR-214 in Chondrogenesis

(2018) Vânia Palma Roberto et al.   Scientific Reports

Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study

(2017) Tarun Chakravarty et al.   LANCET

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Altered MicroRNA Expression Is Responsible for the Pro‐Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves

(2017) Rui Song et al.   Journal of the American Heart Association

Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3

(2017) Jack M. Heath et al.   Cardiovascular Engineering and Technology

Role of scleraxis in mechanical stretch-mediated regulation of cardiac myofibroblast phenotype

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The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype

(2016) Rushita A. Bagchi et al.   BMC BIOLOGY

MiR-214 Attenuates Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1

(2016) Lei Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

PERK-eIF2α-ATF4 pathway mediated by endoplasmic reticulum stress response is involved in osteodifferentiation of human periodontal ligament cells under cyclic mechanical force

(2016) Shuang-Yan Yang et al.   CELLULAR SIGNALLING

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

(2016) Defang Li et al.   Nature Communications

Integrated microRNA and messenger RNA analysis in aortic stenosis

(2016) Sean Coffey et al.   Scientific Reports

Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis

(2016) Swetha Rathan et al.   Scientific Reports

The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells

(2015) Vishal Patel et al.   FASEB JOURNAL

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

(2015) Souvik Dey et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection

(2015) Li-Xin Jia et al.   JOURNAL OF PATHOLOGY

miRWalk2.0: a comprehensive atlas of microRNA-target interactions

(2015) Harsh Dweep et al.   NATURE METHODS

Identification of MicroRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression

(2014) Dong-liang Chen et al.   HEPATOLOGY

Bcl-xLProtein Protects from C/EBP Homologous Protein (CHOP)-dependent Apoptosis during Plasma Cell Differentiation

(2014) Brian T. Gaudette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Twist-related protein 1 negatively regulated osteoblastic transdifferentiation of human aortic valve interstitial cells by directly inhibiting runt-related transcription factor 2

(2014) Xi-Wu Zhang et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

TIMP-1 via TWIST1 Induces EMT Phenotypes in Human Breast Epithelial Cells

(2014) R. C. D'Angelo et al.   MOLECULAR CANCER RESEARCH

Potential drug targets for calcific aortic valve disease

(2014) Joshua D. Hutcheson et al.   Nature Reviews Cardiology

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activating Transcription Factor 4 Promotes Esophageal Squamous Cell Carcinoma Invasion and Metastasis in Mice and Is Associated with Poor Prognosis in Human Patients

(2014) Hongwu Zhu et al.   PLoS One

Evolution of themiR199-214cluster and vertebrate skeletal development

(2014) Thomas Desvignes et al.   RNA Biology

Aortic Valve: Mechanical Environment and Mechanobiology

(2013) Sivakkumar Arjunon et al.   ANNALS OF BIOMEDICAL ENGINEERING

Endoplasmic Reticulum Stress Participates in Aortic Valve Calcification in Hypercholesterolemic Animals

(2013) Zhejun Cai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA-214 suppresses osteogenic differentiation of C2C12 myoblast cells by targeting Osterix

(2013) Kaikai Shi et al.   BONE

Hemodynamic and Cellular Response Feedback in Calcific Aortic Valve Disease

(2013) Sarah T. Gould et al.   CIRCULATION RESEARCH

Inflammation and Mechanical Stretch Promote Aortic Stiffening in Hypertension Through Activation of p38 Mitogen-Activated Protein Kinase

(2013) Jing Wu et al.   CIRCULATION RESEARCH

ATF4 Promotes β-Catenin Expression and Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells

(2013) Shibing Yu et al.   International Journal of Biological Sciences

Aortic Stenosis in the Elderly

(2013) Ruben L.J. Osnabrugge et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Bleeding Complications After Surgical Aortic Valve Replacement Compared With Transcatheter Aortic Valve Replacement

(2013) Philippe Généreux et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

miR-214 targets ATF4 to inhibit bone formation

(2012) Xiaogang Wang et al.   NATURE MEDICINE

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

(2012) Eva van Rooij et al.   NATURE REVIEWS DRUG DISCOVERY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells

(2011) Casey J. Holliday et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease

(2011) Jan-Hung Chen et al.   CIRCULATION RESEARCH

Disturbed flow: p53 SUMOylation in the turnover of endothelial cells: Figure 1.

(2011) Wakako Takabe et al.   JOURNAL OF CELL BIOLOGY

Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

(2011) Craig R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner

(2010) Kartik Balachandran et al.   AMERICAN JOURNAL OF PATHOLOGY

Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress Response

(2010) Souvik Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: Implication of FGFR2 signaling

(2010) Hichem Miraoui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease

(2009) Kartik Balachandran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dynamic deformation characteristics of porcine aortic valve leaflet under normal and hypertensive conditions

(2009) Choon Hwai Yap et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis

(2009) Tetsuya Ueda et al.   LANCET ONCOLOGY

MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN

(2008) H. Yang et al.   CANCER RESEARCH

Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice

(2008) Tokumitsu Watanabe et al.   DEVELOPMENTAL DYNAMICS

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Twist-1 regulates the miR-199a/214 cluster during development

(2008) Y.-B. Lee et al.   NUCLEIC ACIDS RESEARCH