期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 22, 页码 7299-7303出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201901748
关键词
acylboron compounds; amino acids; boron; copper; oxidation
资金
- Institute for Chemical Reaction Design and Discovery (WPI-ICReDD)
- KAKENHI (JSPS) [17H06370]
- JSPS (KAKENHI) [16J01384]
- [JP18H03907]
- Grants-in-Aid for Scientific Research [16J01384] Funding Source: KAKEN
Potassium acyltrifluoroborates (KATs) were prepared through copper(I)-catalyzed borylation of aldehydes and subsequent oxidation. This synthetic route is characterized by the wide range of aldehydes accessible, favorable step economy, mild reaction conditions, and tolerance of various functional groups, and it enables the facile generation of a range of KATs, for example, bearing halide, sulfide, acetal, or ester moieties. Moreover, this method was applied to the three-step synthesis of various alpha -amino acid analogues that bear a KAT moiety on the C-terminus by using naturally occurring amino acids as the starting material.
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