期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 14, 页码 4581-4586出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201814320
关键词
cells; drug discovery; polymers; ring opening; self-assembly
资金
- EPSRC [EP/L017393/1, EP/K014668/1, EP/N026322/1]
- EIT Climate KIC (project EnCO2re)
- EU FP7 ERC [278793]
- FCT PhD Programmes [PD/BD/128388/2017]
- POCK
- European Research Council (ERC) [278793] Funding Source: European Research Council (ERC)
- EPSRC [EP/N026322/1, EP/K014668/1, EP/K005030/1, EP/L017393/1] Funding Source: UKRI
- Fundação para a Ciência e a Tecnologia [PD/BD/128388/2017] Funding Source: FCT
The synthesis and aqueous self-assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether-substituted epoxide (hydrophile). They self-assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.
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