Article
Radiology, Nuclear Medicine & Medical Imaging
Min Ling, Jia Zhou, Xiao-Qi Pang, Jia Liang, Ying-fen Qin, Song Huang, Gan-yu Liang, Yan-fang Li, Zi-san Zeng
Summary: This study assessed the white matter microstructural integrity of the visual pathway in diabetes patients and found that nerve fibers were damaged before the onset of retinopathy and further aggravated after onset. These findings suggest that early neurodegeneration is an important event in diabetic retinopathy.
ACADEMIC RADIOLOGY
(2022)
Article
Pediatrics
Li-Min Guo, Meng Zhao, Yue Cai, Na Li, Xiao-quan Xu, Xuan Zhang, Jiu-Lou Zhang, Qi-Lian Xie, Si-si Li, Xiao-Qing Chen, Shu-Dong Cui, Chao Lu
Summary: This study investigated the white matter impairments and neurodevelopmental outcomes of severe intraventricular hemorrhage (IVH) in extremely preterm infants. The results showed that motor and language abilities at age 2 years were associated with mean kurtosis (MK) values of diffusional kurtosis imaging (DKI) at term equivalent age in both posterior limbs of the internal capsule (PLIC) and the corpus callosum. The findings suggest that MK values might provide feasible indicators of neurodevelopmental outcomes in this population.
FRONTIERS IN PEDIATRICS
(2022)
Review
Geriatrics & Gerontology
Li Huang, Qingqing Zhang, Tong Tang, Minguang Yang, Cong Chen, Jing Tao, Shengxiang Liang
Summary: The meta-analysis revealed consistent reductions in fractional anisotropy in 10 white matter regions of patients with T2DM, indicating abnormalities in white matter integrity. This finding contributes to understanding the neuropathological and physiological mechanisms of T2DM and provides evidence for clinical diagnosis and treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neuroimaging
Sarah C. Hellewell, Thomas Welton, Kate Eisenhuth, Michel C. Tchan, Stuart M. Grieve
Summary: Phenylketonuria (PKU) is a genetic disorder causing progressive neurological dysfunction due to phenylalanine metabolism deficiency. This study utilized diffusion kurtosis imaging (DKI) to reveal subclinical changes in white matter structure in PKU patients, providing potential for a sensitive biomarker of cognitive impairment and disease control. The DKI-based metric (K-rad/K-FA ratio) showed clear separation between PKU and control groups in detecting brain abnormalities, highlighting its potential for monitoring disease progression and treatment effectiveness.
NEUROIMAGE-CLINICAL
(2021)
Article
Geriatrics & Gerontology
Zhongxian Yang, Yu Rong, Zhen Cao, Yi Wu, Xinzhu Zhao, Qiuxia Xie, Min Luo, Yubao Liu
Summary: This study explores microstructural and cerebral blood flow abnormalities in individuals with subjective cognitive decline plus using DKI and 3D ASL. Results show significant declines in MK and CBF values in SCD plus participants, suggesting that MK may serve as an early potential neuroimaging biomarker for Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Hossein Sanjari Moghaddam, Esmaeil Mohammadi, Mahsa Dolatshahi, Farnam Mohebi, Agaah Ashrafi, Habibolah Khazaie, Mohammad Hadi Aarabi
Summary: Primary insomnia (PI) is characterized by difficulties in initiating and maintaining sleep along with daytime functioning deficits. DTI studies have shown that patients with PI exhibit white matter disruptions, particularly in frontostriatal, frontothalamic, and corticocortical neural networks, shedding light on the potential etiology and pathology of the disorder. The findings suggest that future research should focus on the neural network alterations in PI patients to better understand the underlying mechanisms of the condition.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Victor A. Del Bene, Jeffrey L. Crawford, Ainara Gomez-Gastiasoro, Tracy D. Vannorsdall, Alison Buchholz, Natalia Ojeda, James C. Harris, Hyder A. Jinnah, David J. Schretlen
Summary: The study found that patients with Lesch-Nyhan disease have decreased white matter integrity compared to healthy adults, with the disease group showing more significant reductions than the variant group. Reductions in white matter integrity were particularly observed in specific regions such as the corpus callosum, corona radiata, and internal capsule. Additionally, the variant group exhibited milder symptoms of dystonia and cognitive deficits.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Weijing Liang, Zexin Fan, Sha Cui, Xueyong Shen, Li Wang
Summary: The study revealed that decreased MK in the frontal and temporal lobes, as well as the genu of the corpus callosum, may be associated with PSD. DKI can be used to explore microstructural changes in the white matter of PSD patients and may serve as an auxiliary diagnostic method for PSD.
NEUROLOGICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Cong Zhou, Jie Li, Man Dong, Liangliang Ping, Hao Lin, Yuxin Wang, Shuting Wang, Shuo Gao, Ge Yu, Yuqi Cheng, Xiufeng Xu
Summary: This meta-analysis examined white matter microstructural alterations in patients with type 2 diabetes mellitus and found reductions in fractional anisotropy in the left inferior network, corpus callosum, and left olfactory cortex. Additionally, a negative correlation was observed between fractional anisotropy in the corpus callosum and BMI in the patient group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hediye Pinar Gunbey, Arzu Ceylan Has, Kerim Aslan, Dilek Saglam, Ugur Avci, Asli Tanrivermis Sayit, Lutfi Incesu
Summary: This study investigated the effects of hypothyroidism on white matter integrity using TBSS, finding significant reductions in FA and AD, and an increase in RD in several WM tracts. The results suggest a demyelination process underlying the clinical aspects of hypothyroidism.
Article
Neurosciences
Nick Teller, Jordan A. Chad, Alexander Wong, Hayden Gunraj, Xiang Ji, Maged Goubran, Asaf Gilboa, Eugenie Roudaia, Allison Sekuler, Nathan Churchill, Tom Schweizer, Fuqiang Gao, Mario Masellis, Benjamin Lam, Chris Heyn, Ivy Cheng, Robert Fowler, Sandra E. Black, Bradley J. MacIntosh, Simon J. Graham, J. Jean Chen
Summary: By comparing simulation and experimental data, it is found that correlated diffusion imaging method performs better in detecting the effect of COVID-19, which reveals less restricted diffusion in the frontal lobe and more restricted diffusion in the cerebellar white matter in patients, consistent with existing studies.
HUMAN BRAIN MAPPING
(2023)
Review
Neurosciences
Kevin K. K. Yu, Gladys L. Y. Cheing, Charlton Cheung, Georg S. Kranz, Alex Kwok-Kuen Cheung
Summary: This meta-analysis revealed more pronounced gray matter atrophy in T2DM compared to T1DM. The reduced gray matter volume in T2DM patients may be attributed to an increased risk of microvascular or macrovascular complications, as well as the disease-specific pathology associated with T2DM.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychiatry
Zhenzhu Chen, Qijing Bo, Lei Zhao, Yimeng Wang, Zhifang Zhang, Yuan Zhou, Chuanyue Wang
Summary: This study investigated the microstructure of white matter (WM) in individuals with attenuated positive symptom syndrome (APSS) using diffusion tensor and T1-weighted imaging. Compared with healthy controls, individuals with APSS showed differences in diffusion index values in certain segments of WM tracts involved in frontal and limbic-cortical connections. Abnormal WM tracts were also associated with impaired general and neurocognitive function.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huihui Wang, Hongwei Wen, Jing Li, Qian Chen, Shanshan Li, Yanling Wang, Zhenchang Wang
Summary: High myopia (HM) patients exhibited microstructural alterations in specific brain regions associated with motor conduction and vision functions, as detected by 3T diffusion kurtosis imaging (DKI). The DKI-derived kurtosis parameters showed negative correlations with disease duration, while the diffusion parameter had positive correlations.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Review
Psychiatry
Zeng Zhang, Liangliang Ping, Ailing Zhai, Cong Zhou
Summary: The meta-analysis found microstructural abnormalities in distributed WM tracts in OCD patients, with heterogeneous results between the VBA and TBSS methods.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Neurosciences
Junping Wang, Peng Zhang, Wei Li, Qin Wen, Feng Liu, Jiayuan Xu, Qiang Xu, Dan Zhu, Zhaoxiang Ye, Chunshui Yu
Summary: Evidence suggests that the OXTR gene influences autism spectrum disorders (ASDs), which are characterized by deficits in prosocial behaviors linked to the personality trait of reward dependence (RD). Higher OXTR-PRSASDS was associated with lower RD and smaller GMV in the right posterior insula and putamen. The GMV in this region positively correlated with RD and mediated the relationship between OXTR-PRSASDS and RD, showing spatial correlation with OXTR gene expression.
Article
Neurosciences
Huaigui Liu, Lixue Xu, Jilian Fu, Qian Su, Nana Liu, Jiayuan Xu, Jie Tang, Wei Li, Fangshi Zhao, Hao Ding, Feng Liu, Wen Qin, Chunshui Yu
Summary: This study identified 14 candidate GC-related genes and linked their spatial correlation with schizophrenia, suggesting a potential association with the development of the disorder.
Article
Neurosciences
Jiahe Guo, Kai Zhang, Jianyu Zhang, Rui Zhao, Yibo Liang, Yu Lin, Shengping Yu, Wen Qin, Xuejun Yang
Summary: Our study aimed to investigate how spatial memory retrieval is represented in the brain. Through the use of both univariate analysis and multivariate pattern analysis, we discovered that spatial memory retrieval involves widespread brain regions, including the hippocampus, frontal and parietal lobes, occipital lobes, and cerebellum. The activation amplitude in the left hippocampus was negatively correlated with task completions, while the classification accuracies based on signal patterns of the right middle temporal gyrus showed a significant positive correlation with retrieval accuracy. This underscores the importance of understanding the separation between navigational and non-navigational states and the utility of multivariate pattern analysis in studying brain functions.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Clinical Neurology
Ling Wang, Hao Ding, Bihong T. Chen, Ke Fan, Qin Tian, Miaomiao Long, Meng Liang, Dapeng Shi, Chunshui Yu, Wen Qin
Summary: LHON patients show occult brain white matter impairment, which may not be correlated with disease duration or retinal nerve fiber layer thickness.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weimin Zheng, Ling Wang, Qian Chen, Xuejing Li, Xin Chen, Wen Qin, Kuncheng Li, Jie Lu, Nan Chen
Summary: The study found that CTSCI patients exhibit altered neural function in the right lingual gyrus and right middle frontal gyrus, as well as changes in functional connectivity between these regions and Vermis_3. These changes are associated with clinical manifestations such as visual analog scale scores, indicating a potential theoretical basis for rehabilitation techniques targeting visual, emotion, and cognition in CTSCI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Neurosciences
Yingchao Song, Qian Su, Qingqing Yang, Rui Zhao, Guotao Yin, Wen Qin, Gian Domenico Iannetti, Chunshui Yu, Meng Liang
Summary: The study using dynamic causal modeling and high-temporal-resolution fMRI revealed a parallel structure for nociceptive and tactile information processing in the 'thalamus-S1-S2' network, with distinct corticothalamic feedback regulations from S1 and S2.
Article
Neurosciences
Xue Zhang, Yingying Xie, Jie Tang, Wen Qin, Feng Liu, Hao Ding, Yuan Ji, Bingbing Yang, Peng Zhang, Wei Li, Zhaoxiang Ye, Chunshui Yu
Summary: The study identified 125 connectivity-related genes, including 20 novel genes, enriched for dendrite extension, signaling pathway, and schizophrenia; 51 genes were associated with connectivity in all brain functional networks, while 51 genes showed network-specific modulatory effects, indicating different biological functions are involved in connectivity modulation of different networks.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Xinjun Suo, Lining Guo, Dianxun Fu, Hao Ding, Yihong Li, Wen Qin
Summary: This study evaluated the quantification accuracy of pyramidal tracts and their branches using four mainstream diffusion models with the HCP dataset. The results showed that the GQI and QBI models outperformed the DTI and DSI models, obtaining more true fibers in the various branches. The group probabilistic maps of the PT branches have been shared publicly, facilitating more precise studies on motor pathway plasticity and damage.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychology, Biological
Jiayuan Xu, Xiaoxuan Liu, Qiaojun Li, Ran Goldblatt, Wen Qin, Feng Liu, Congying Chu, Qiang Luo, Alex Ing, Lining Guo, Nana Liu, Huaigui Liu, Conghong Huang, Jingliang Cheng, Meiyun Wang, Zuojun Geng, Wenzhen Zhu, Bing Zhang, Weihua Liao, Shijun Qiu, Hui Zhang, Xiaojun Xu, Yongqiang Yu, Bo Gao, Tong Han, Guangbin Cui, Feng Chen, Junfang Xian, Jiance Li, Jing Zhang, Xi-Nian Zuo, Dawei Wang, Wen Shen, Yanwei Miao, Fei Yuan, Su Lui, Xiaochu Zhang, Kai Xu, Longjiang Zhang, Zhaoxiang Ye, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Lauren Robinson, Sarah Hohmann, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Jeanne Winterer, Kevin Patrick, Vince Calhoun, Mulin Jun Li, Meng Liang, Peng Gong, Edward D. Barker, Nicholas Clinton, Andre Marquand, Le Yu, Chunshui Yu, Gunter Schumann
Summary: Research shows correlations between urbanization and brain function, neuropsychology, and mental illness symptoms, with the most pronounced effects on the cerebellum and prefrontal cortex. Urbanization impacts brain structure and function, perspective-taking, and depression symptoms, with neural variables acting as mediators.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Neuroimaging
Zirui Wang, Yuan Ji, Yumeng Fu, Feng Liu, Xin Du, Huaigui Liu, Wenshuang Zhu, Kaizhong Xue, Wen Qin, Quan Zhang
Summary: Using transcriptome-neuroimaging spatial association analysis, this study identified 371 genes significantly associated with facial expression recognition-related brain activations. Enrichment analysis revealed the importance of these genes in regulating nervous system development, cell junction organization, and synaptic functions, as well as their higher enrichment in psychiatric diseases with emotion impairments.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Feng Liu, Jiayuan Xu, Lining Guo, Wen Qin, Meng Liang, Gunter Schumann, Chunshui Yu
Summary: Individual differences in human brain structure, function, and behavior can be explained by genetic variations, environmental exposures, and their interactions. While genetic variants associated with brain imaging phenotypes have been identified, the environmental exposures related to these phenotypes are largely unknown. This study proposes that research in environmental neuroscience should focus on understanding the associations between lifetime environmental exposures and brain imaging phenotypes, as well as identifying cumulative environmental effects and their vulnerable age windows.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Jingchun Liu, Caihong Wang, Wen Qin, Hao Ding, Yanmin Peng, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical ischemic stroke can cause long-lasting changes in the cerebral cortex. This study investigated the relationship between cortical structural changes, motor recovery, lesion location, and early impairment of specific subsets of fibers in the corticospinal tract (CST) in patients with subcortical stroke. The findings revealed different patterns of cortical structural changes in patients with partial and complete recovery, which were associated with lesion location and impairment of specific CST fiber subsets.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Jingchun Liu, Caihong Wang, Wen Qin, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical stroke leads to structural changes in multiple areas of the cerebral cortex. The location of the lesion affects the pattern of cortical thickness changes. Motor outcomes and impairment of the corticospinal tract are correlated with cortical thickness in specific gyri. The longitudinal dataset shows gradual changes in cortical thickness and area in regions with structural reorganization.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neuroimaging
Ling Wang, Yi Ji, Hao Ding, Qin Tian, Ke Fan, Dapeng Shi, Chunshui Yu, Wen Qin
Summary: The study used arterial spin labeling (ASL) to investigate abnormal cerebral blood flow (CBF) in patients with Leber's hereditary optic neuropathy (LHON) and its associations with disease duration and neuro-ophthalmological impairment. The results showed differences in brain regions of LHON patients, including the left sensorimotor and bilateral visual areas. LHON patients had lower CBF in the bilateral calcarine compared to healthy controls. Chronic LHON patients also showed lower CBF in the left middle frontal gyrus, sensorimotor cortex, and temporal-partial junction. Disease duration and neuro-ophthalmological impairments were found to affect the metabolism of non-visual areas.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Computer Science, Artificial Intelligence
Jinbo Xu, Matthew McPartlon, Jin Li
Summary: Recent advances in computational protein structure prediction have shown significant improvements by integrating deep learning and co-evolutionary analysis. Using ResNet, predictions of correct protein folds have been successful even without co-evolution information, suggesting potential for learning important protein sequence-structure relationships.
NATURE MACHINE INTELLIGENCE
(2021)
