Article
Biochemistry & Molecular Biology
Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman, David J. Gallacher
Summary: Loperamide has a large safety margin at therapeutic doses, but can cause cardiac toxicity and proarrhythmia at overdose exposures, leading to conduction slowing and alterations in repolarization time. Inhibition of the I-Na channel and hERG-mediated I-Kr are the likely basis for loperamide's cardiac electrophysiological toxicity.
Review
Cardiac & Cardiovascular Systems
Bruna Cremonezi Lammoglia, Gabriela Hasselmann, Marcelo Pires-Oliveira, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Fernando Sabia Tallo, Murched Omar Taha, Rildo Yamaguti Lima, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues
Summary: Loperamide is a synthetic opioid commonly used to treat diarrhea. However, it can pose cardiac risks, such as arrhythmias and QT interval prolongation. Research suggests that the side effects of loperamide may be significant.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Medicine, General & Internal
Emmanuel Isang, Laylan Shali, Charles B. Morris, Jeremy Mahlow
Summary: Loperamide, an over-the-counter antidiarrheal, can work on the mu opioid receptor and may lead to cardiotoxicity when taken in high doses, causing serious cardiac arrhythmias. It is important for healthcare providers to recognize and be familiar with loperamide overdose in order to prevent potential multiorgan failure and increased mortality.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Obstetrics & Gynecology
Svitlana Arbuzova, Margaryta Nikolenko, David Wright, Howard Cuckle
Summary: This study investigates additional clinical risk factors for preeclampsia. Questionnaires and telephone interviews were conducted to record a range of pregnancy related factors, personal history of health conditions and family history. The study finds that the occurrence of cholelithiasis is significantly higher in preeclampsia cases, and the risk is increased if the mother is also affected.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Medicine, General & Internal
Margarida Coelho, Diogo Abreu, Laura Silva, Miguel Pereira, Fernando Mautempo
Summary: The recycling of used batteries can lead to occupational and environmental exposure to lead, which raises public health concerns. This case study describes a 26-year-old woman who experienced symptoms such as palpitations, headaches, fatigue, and insomnia after starting work in a battery recycling company. Blood tests revealed anemia and high lead concentrations, but after leaving the company, her symptoms gradually decreased and the lead levels in her blood decreased as well.
ACTA MEDICA PORTUGUESA
(2023)
Review
Medicine, General & Internal
Vivek Modi, Matthew Krinock, Ravi Desai, Steven Stevens, Sudip Nanda
Summary: Reports of cardiac arrhythmias due to loperamide toxicity are increasing in the literature. Analysis suggests that loperamide's ability to block ion channels may be the cause. However, there are currently no established guidelines for managing these life-threatening symptoms.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Oncology
Katelyn M. Atkins, Danielle S. Bitterman, Tafadzwa L. Chaunzwa, David E. Kozono, Elizabeth H. Baldini, Hugo J. W. L. Aerts, Balaji K. Tamarappoo, Udo Hoffmann, Anju Nohria, Raymond H. Mak
Summary: This study found that MHD is insufficient to predict LAD V15Gy with confidence, and there is discordance between MHD and LAD V15Gy. For patients with locally advanced NSCLC, isolated low LAD V15Gy can significantly reduce the risk of MACE.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Multidisciplinary Sciences
Qian Wang, Xiaohui Duan, Mingrui Dong, Shaojie Sun, Pan Zhang, Fang Liu, Li Wang, Renbin Wang
Summary: The study analyzed the clinical and pathological characteristics of sural biopsy in nitrous oxide (N2O)-induced peripheral neuropathy. The main manifestations of peripheral nerve damage caused by N2O abuse are weakness in the lower limbs and distal sensory disorders. The nerve conduction study results showed a mixed axonal and demyelinating neuropathy as the most common type of neuropathy. Sural biopsy revealed chronic axonal degeneration as the main pathological change.
Article
Computer Science, Information Systems
Mohammad Reza Nosouhi, Keshav Sood, Neeraj Kumar, Tricia Wevill, Chandra Thapa
Summary: This article presents a machine learning-based approach for early detection of bushfires by detecting anomalies in spatiotemporal measurements of environmental parameters. The proposed method trains a model to learn the normal behavior of environmental data and uses a classification model to verify detected anomalies. The effectiveness of the approach is confirmed through experiments.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Review
Hematology
Cristina Gutierrez, Tomas G. Neilan, Natalie S. Grover
Summary: CAR-T cell therapy has revolutionized the care for patients with hematologic malignancies, but it can cause cardiovascular and pulmonary complications. However, these complications should not deter patients with good functional status from receiving this life-saving therapy.
Review
Oncology
Calogera Claudia Spagnolo, Giuseppe Giuffrida, Salvatore Cannavo, Tindara Franchina, Nicola Silvestris, Rosaria Maddalena Ruggeri, Mariacarmela Santarpia
Summary: Immune checkpoint inhibitors have revolutionized the treatment of solid tumors, but their use is associated with unique toxicities related to the enhancement of the immune response. This review provides a comprehensive overview of endocrine and metabolic adverse events of immune checkpoint inhibitors and summarizes the latest studies and recommendations on their clinical approach and management.
Review
Pharmacology & Pharmacy
Xiaoli Tang, Zengwu Wang, Shengshou Hu, Bingying Zhou
Summary: Drug-induced cardiotoxicity not only affects drug development but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Mitochondrial impairment, a common form of cardiotoxicity, has not received enough attention in preclinical cardiac safety tests. This review discusses the characteristics of mitochondria in cardiomyocytes, drug-induced mitochondrial toxicities, and the integration of mitochondrial toxicity and proarrhythmic risk assessments in cardiac safety evaluation.
Article
Computer Science, Artificial Intelligence
Francisco Valente, Jorge Henriques, Simao Paredes, Teresa Rocha, Paulo de Carvalho, Joao Morais
Summary: The study aimed to develop a new risk assessment methodology that combines the best characteristics of traditional risk score models and machine learning approaches to provide personalized models, high interpretability, and reliability estimation. The proposed approach showed comparable performance to standard models but with better interpretability and personalization, outperforming existing risk models and machine learning models.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2021)
Article
Oncology
Juanzi Zeng, Heming Wu, Donghua Liu, Liang Li, Jiaquan Li, Qiuming Wang, Min Ye, Qingyan Huang, Zhikang Yu, Jinfeng Zhang
Summary: This study found that the GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity in breast cancer patients induced by anthracycline-/paclitaxel-based chemotherapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Antonello E. Rigamonti, Michele Dei Cas, Diana Caroli, Adele Bondesan, Silvano G. Cella, Rita Paroni, Alessandro Sartorio
Summary: Ceramide risk score (CERT1) has been reported as a potential marker for cardiovascular disease (CVD) risk prediction. This study aimed to evaluate CERT1 in obese subjects with and without metabolic syndrome (MetS) and compared them to a normal-weight group. Obesity was associated with higher CERT1 values, and the predictors of CERT1 included waist circumference, insulin resistance, and inflammation. However, the clinical diagnosis of MetS may not accurately assess CVD risk in the obese population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Nutrition & Dietetics
Gilberto Fabian Hurtado-Torres, Rosa Laura Sandoval-Munro
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2015)
Letter
Nutrition & Dietetics
Gilberto Fabian Hurtado-Torres, Rosa Laura Sandoval-Munro
Editorial Material
Nutrition & Dietetics
Gilberto F. Hurtado-Torres
Letter
Nutrition & Dietetics
Gilberto Fabian Hurtado-Torres, Rosa L. Sandoval-Munro, Anamaria Bravo-Ramirez
CLINICAL NUTRITION
(2012)
Article
Nutrition & Dietetics
Victoria Lima-Rogel, Silvia Romano-Moreno, Esperanza de Jesus Lopez-Lopez, Francisco de Jesus Escalante-Padron, Gilberto Fabian Hurtado-Torres
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2016)
Letter
Nutrition & Dietetics
Gilberto Fabian Hurtado-Torres, Juan Pablo Castanedo-Cazares
NUTRITION IN CLINICAL PRACTICE
(2013)
Letter
Nutrition & Dietetics
Gilberto Fabian Hurtado-Torres
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Letter
Nutrition & Dietetics
Gilberto Fabian Hurtado-Torres
NUTRITION IN CLINICAL PRACTICE
(2021)
Letter
Nutrition & Dietetics
Gilberto Fabian Hurtado-Torres
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Review
Rheumatology
Gilberto Fabian Hurtado-Torres, Lourdes Larisa Gonzalez-Baranda, Carlos Abud-Mendoza
REUMATOLOGIA CLINICA
(2015)
Letter
Nutrition & Dietetics
Gilberto Fabian Hurtado-Torres, Rosa-Laura Sandoval-Munro
NUTRICION HOSPITALARIA
(2014)
Letter
Medicine, General & Internal
Gilberto F. Hurtado-Torres, Rosa L. Sandoval-Munro
NEW ENGLAND JOURNAL OF MEDICINE
(2012)
Letter
Nutrition & Dietetics
A. Bravo Ramirez, G. F. Hurtado Torres, M. Martinez Martinez, C. Abud Mendoza
NUTRICION HOSPITALARIA
(2012)
Article
Nutrition & Dietetics
A. Ma Bravo Ramirez, A. Chevaile Ramos, G. F. Hurtado Torres
NUTRICION HOSPITALARIA
(2010)
