☆ 4.4 Article

Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV

AIDS (2019)

期刊

AIDS

卷 33, 期 2, 页码 229-236

出版社

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1097/QAD.0000000000002060

关键词

arterial inflammation; high-sensitivity cardiac troponin T; HIV; lipoprotein-associated phospholipase A2; oxidized low-density lipoprotein; subcutaneous adipose tissue; visceral adipose tissue

类别

Immunology Infectious Diseases Virology

资金

Gilead Sciences
Roche Diagnostics
Association of Nursing in AIDS Care and New England AIDS Education and Training Center
KOWA
Theratechnologies
Bristol Myers Squibb, Inc
Harvard Clinical and Translational Science Center, from the National Center for Research Resources [K23 HL092792, K23 HL136262, M01 RR01066, UL1 RR025758, UL1 TR001102]
Nutrition Obesity Research Center at Harvard [P30 DK040561]

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

摘要

Objective: Persons living with HIV (PLWH) well treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD risk. Designs/methods: One hundred and fifty-five HIV-infected and 70 non-HIV infected individuals were well phenotyped for body composition. Adipose depots were assessed via single-slice abdominal computed tomography (CT). Circulating markers of arterial disease and generalized inflammation [lipoprotein-associated phospholipase A2 (LpPLA2), oxidized low-density lipoprotein (oxLDL), high-sensitivity cardiac troponin T (hs-cTnT), high-sensitivity C-reactive protein (hsCRP)] were evaluated. Results: Despite similar BMI and visceral adipose tissue (VAT), HIV-infected individuals had significantly lower subcutaneous adipose tissue [SAT, 199 (126-288) vs. 239 (148-358) cm(2), P = 0.04] than non-HIV infected individuals. Among HIV-infected individuals, reduced SAT inversely correlated with LpPLA2 (rho = -0.19, P = 0.02) and hs-cTnT (rho = -0.24, P = 0.004), whereas increased VAT significantly and positively related to LpPLA2 (rho = 0.25, P = 0.003), oxLDL (rho = 0.28, P = 0.0005), hs-cTnT (rho = 0.28, P = 0.0007) and hsCRP (rho = 0.32, P = < 0.0001). Similar analyses among the non-HIV infected individuals revealed significant relationships between SAT and LpPLA2 (rho = -0.24, P = 0.05), as well as VAT and LpPLA2 (rho = 0.37, P = 0.002), oxLDL (rho = 0.24, P = 0.05) and hsCRP (rho = 0.29, P = .02). In modelling performed among the HIV group, simultaneously controlling for VAT, SAT, age and relevant HIV-related parameters, reduced SAT was an independent predictor of LpPLA2 (P = 0.04) and hs-cTnT (P = 0.005) and increased VAT was an independent predictor of LpPLA2 (P = 0.001), oxLDL (P = 0.02), hs-cTnT (P = 0.04) and hsCRP (P = 0.04). Conclusion: Fat redistribution phenotypes, characterized by SAT loss and/or VAT accumulation, may be linked to arterial injury and inflammation in HIV.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

主要评分

4.4

评分不足

次要评分

新颖性

重要性

科学严谨性

评价这篇论文

Proteomic Signatures of Human Visceral and Subcutaneous Adipocytes

Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku

Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)