期刊
AGING-US
卷 11, 期 3, 页码 1065-1068出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101822
关键词
cancer cell of origin; cancer stem cells (CSCs); senescence; metabolism; anti-oxidant response; tamoxifen resistance
资金
- Lunella Biotech, Inc
Here, we discuss the expected hallmark(s) of the cancer cell of origin and how this may be related to a new tumor cell phenotype, namely energetic cancer stem cells (e-CSCs). e-CSCs show many features that would be characteristic of the cancer cell of origin, including the over-expression of p21-WAF (CDKN1A), a key marker of senescence. It is tempting to speculate that the cancer cell of origin and e-CSCs are closely related entities. e-CSCs possess a hybrid phenotype, sharing key hallmarks of senescence, stemness and cancer. e-CSCs are hyper-proliferative and have elevated mitochondrial metabolism, with an NRF2-mediated anti-oxidant response signature, including glutaredoxin (GLRX) and ALDH3A1 over-expression, possibly related to their escape from senescence. Finally, in e-CSCs, BCAS1 (Breast carcinoma-amplified sequence-1) protein expression was up-regulated by >100-fold. BCAS1 is a candidate oncogene associated with stemness and aggressive oncogenic behavior, such as Tamoxifen resistance.
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