期刊
AGEING RESEARCH REVIEWS
卷 50, 期 -, 页码 72-80出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2019.01.005
关键词
Dementia; Lewy bodies; Alzheimer's disease; Mortality
资金
- Health Education England
- National Institute for Health Research HEE/NIHR ICA Programme Clinical Lectureship [ICA-CL-2017-03-001]
- EPSRC [EP/N027280/1] Funding Source: UKRI
- MRC [MC_PC_17214] Funding Source: UKRI
Objective: To synthesize the evidence across longitudinal studies comparing survival in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Methods: We conducted a systematic review and meta-analysis of studies comparing survival in clinically diagnosed DLB to AD. Longitudinal cohort studies were identified through a systematic search of major electronic databases from inception to May 2018. A random effects meta-analysis was performed to calculate survival time and relative risk of death. Results: Overall, 11 studies were identified including 22,952 patients with dementia: 2029 with DLB (mean diagnosis age 76.3; 47% female) compared with 20,923 with AD (mean diagnosis age 77.2; 65.1% female). Average survival time in DLB from diagnosis was 4.11 years (SD +/- 4.10) and in AD 5.66 (SD +/- 5.32) years, equating to a 1.60 (95% CI: -2.44 to -0.77) years shorter survival in DLB (p < 0.01). Relative risk of death was increased by 1.35 (95%CI: 1.17-1.55) in DLB compared to AD (p < 0.01). Differences in survival were not explained by follow-up time, age at diagnosis, gender, or cognitive score. Conclusions: There is consistent evidence for higher and earlier mortality in DLB compared to AD. This is important for all stakeholders and underlines the importance of expanding research into DLB.
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