Article
Medicine, General & Internal
Yo-Han Jung, Sang-Won Han, Joong-Hyun Park
Summary: This study aimed to investigate the impact of prior antithrombotic use on blood viscosity in patients with cardioembolic stroke. The results showed that patients who had previously used antiplatelets and anticoagulants had significantly decreased systolic and diastolic blood viscosity. Therefore, prior antithrombotic use may be a useful hemorheological parameter in patients with cardioembolic stroke.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jacopo Francesco Imberti, Davide Antonio Mei, Marco Vitolo, Niccolo Bonini, Marco Proietti, Tatjana Potpara, Gregory Y. H. Lip, Giuseppe Boriani
Summary: Clinical practice in atrial fibrillation patient management is constantly evolving. Various new guidelines have been published in the past few years, and they differ in key elements such as thromboembolic risk assessment, oral anticoagulants prescription, bleeding risk evaluation, and integrated patient management. The importance of an integrated and multidisciplinary approach to patient care is emerging.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Euijae Lee, Jin-Hyung Jung, Kyung-Do Han, Myung-Jin Cha, Seil Oh, Gregory Y. H. Lip
Summary: This study compared the effectiveness and safety of NOACs and warfarin among atrial fibrillation patients with prior GIB using the Korean claims database. The findings showed that NOACs were associated with lower risks of ischemic stroke and major bleeding compared to warfarin in this patient population.
Article
Hematology
Antonella Tufano
Summary: The management of atrial fibrillation (AF) in cancer patients is challenging, and individualized anticoagulation therapy should be tailored. Multidisciplinary collaboration and periodic reassessment are necessary.
THROMBOSIS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Noriko Tsuji, Yoshimitsu Takahashi, Michi Sakai, Shosuke Ohtera, Junji Kaneyama, Kosai Cho, Genta Kato, Shigeru Ohtsuru, Takeo Nakayama
Summary: The use of direct oral anticoagulants (DOACs) has significantly changed the treatment of anticoagulants in patients with non-valvular atrial fibrillation (Af). This study aimed to analyze the changes in anticoagulant prescriptions in Af patients aged >= 65 years, considering the risk of stroke and bleeding. The proportion of anticoagulant prescriptions increased from 41% in 2011 to 56% in 2015, accompanied by an increase in DOAC prescriptions and an increase in prescriptions for high-risk patients. The widespread use of DOACs has greatly impacted the prescription profile of anticoagulant therapy in Af patients.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Luigi Falco, Viviana Tessitore, Giovanni Ciccarelli, Marco Malvezzi, Antonello D'Andrea, Egidio Imbalzano, Paolo Golino, Vincenzo Russo
Summary: Thrombosis-related diseases are a major cause of illness and death, despite advances in pharmacologic therapy. Oxidative stress plays a crucial role in thrombosis pathophysiology. Anticoagulant and antiplatelet drugs used in the management of these diseases have pleiotropic effects, including antioxidant effects. This review aims to summarize the current evidence on the antioxidant effects of oral antithrombotic therapies in patients with atherosclerotic disease and atrial fibrillation.
Article
Clinical Neurology
Peter Bronnum Nielsen, Line Melgaard, Thure Filskov Overvad, Martin Jensen, Torben Bjerregaard Larsen, Gregory Y. H. Lip
Summary: The study found that patients with ICH and AF have a high risk of cerebrovascular ischemic events and a very high risk of all-cause death one year after the incident. Further clinical trials are needed to determine the optimal stroke prevention treatment for ICH survivors with AF.
Article
Cardiac & Cardiovascular Systems
James Freeman, Angela Y. Higgins, Yongfei Wang, Chengan Du, Daniel J. Friedman, Usama A. Daimee, Karl E. Minges, Lucy Pereira, Andrew M. Goldsweig, Matthew J. Price, Vivek Y. Reddy, Douglas Gibson, Shephal K. Doshi, Paul D. Varosy, Frederick A. Masoudi, Jeptha P. Curtis
Summary: This study evaluated the postprocedure care patterns and compared the risk of adverse events for different discharge antithrombotic strategies after left atrial appendage occlusion (LAAO) with the Watchman device. The study found that practitioners rarely followed the recommended postprocedure treatment protocols and that discharge on warfarin or direct oral anticoagulants (DOACs) without aspirin was associated with a lower risk of adverse outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Hematology
Bernadette Corica, Trudie Lobban, Mellanie True Hills, Marco Proietti, Giulio Francesco Romiti
Summary: Female sex is associated with an increased risk of stroke in patients with atrial fibrillation (AF), although there is a trend of lower usage of oral anticoagulants in women with AF.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Lamiae Grimaldi-Bensouda, Jean-Yves Le Heuzey, Jean Ferrieres, Didier Leys, Jean-Marc Davy, Mikel Martinez, Olivia Dialla, Didier Smadja, Norbert Nighoghossian, Jacques Benichou, Clementine Nordon, Emmanuel Touze, Lucien Abenhaim
Summary: Individual direct oral anticoagulants show better efficacy compared to vitamin K antagonists in primary stroke prevention in patients with atrial fibrillation, regardless of the presence of permanent AF.
Article
Hematology
Nour Al-Hussainy, Kristian Hay Kragholm, Soren Lundbye-Christensen, Christian Torp-Pedersen, Manan Pareek, Susette Krohn Therkelsen, Gregory Y. H. Lip, Sam Riahi
Summary: The use of certain direct oral anticoagulants (DOACs) may increase the risk of gastrointestinal bleeding, especially in patients with anemia. This study investigated the differences in the risks of gastrointestinal bleeding and stroke among the four available DOACs in atrial fibrillation patients with moderate or severe anemia. The results showed that apixaban was associated with a significantly lower risk of gastrointestinal bleeding compared to dabigatran and rivaroxaban, while no significant difference in stroke risk was observed among all four DOACs.
THROMBOSIS RESEARCH
(2023)
Article
Hematology
Luise Adam, Martin Feller, Lamprini Syrogiannouli, Cinzia Del-Giovane, Jacques Donze, Christine Baumgartner, Daniel Segna, Carmen Floriani, Laurent Roten, Urs Fischer, Stefanie Aeschbacher, Giorgio Moschovitis, Jurg Schlapfer, Dipen Shah, Peter Amman, Richard Kobza, Matthias Schwenkglenks, Michael Kuehne, Leo H. Bonati, Jurg Beer, Stefan Osswald, David Conen, Drahomir Aujesky, Nicolas Rodondi
Summary: This study successfully developed a bleeding risk prediction model for AF patients on oral anticoagulants, with factors such as age over 75 years, history of cancer, prior major hemorrhage, and arterial hypertension included in the final prediction model. The model showed good calibration and discrimination with a Brier score of 0.23 and a c-statistic of 0.71 at 12 months follow-up.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Urs Fischer, Masatoshi Koga, Daniel Strbian, Mattia Branca, Stefanie Abend, Sven Trelle, Maurizio Paciaroni, Goetz Thomalla, Patrik Michel, Krassen Nedeltchev, Leo H. Bonati, George Ntaios, Thomas Gattringer, Else-Charlotte Sandset, Peter Kelly, Robin Lemmens, P. N. Sylaja, Diana Aguiar de Sousa, Natan M. Bornstein, Zuzana Gdovinova, Takeshi Yoshimoto, Marjaana Tiainen, Helen Thomas, Manju Krishnan, Gek C. Shim, Christoph Gumbinger, Jochen Vehoff, Liqun Zhang, Kosuke Matsuzono, Espen Kristoffersen, Philippe Desfontaines, Peter Vanacker, Angelika Alonso, Yusuke Yakushiji, Caterina Kulyk, Dimitri Hemelsoet, Sven Poli, Ana Paiva Nunes, Nicoletta Caracciolo, Peter Slade, Jelle Demeestere, Alexander Salerno, Markus Kneihsl, Timo Kahles, Daria Giudici, Kanta Tanaka, Silja Raty, Rea Hidalgo, David J. Werring, Martina Goldlin, Marcel Arnold, Cecilia Ferrari, Seraina Beyeler, Christian Fung, Bruno J. Weder, Turgut Tatlisumak, Sabine Fenzl, Beata Rezny-Kasprzak, Arsany Hakim, Georgia Salanti, Claudio Bassetti, Jan Gralla, David J. Seiffge, Thomas Horvath, Jesse Dawson
Summary: This study aimed to compare the effect of early initiation versus later initiation of direct oral anticoagulants (DOACs) on acute ischemic stroke in patients with atrial fibrillation. The results showed that there was no significant difference in the incidence of recurrent ischemic stroke, systemic embolism, major extracranial bleeding, symptomatic intracranial hemorrhage, or vascular death within 30 days between early and later use of DOACs.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Malik Elharram, Michelle Samuel, Ahmed AlTurki, Michael Quon, Hassan Behlouli, Amal Bessissow, Louise Pilote
Summary: This study aimed to investigate the association between oral anticoagulation (OAC) use and thromboembolic events and major bleeding in patients with new postoperative atrial fibrillation (POAF) after noncardiac surgery. The results showed that OAC was not associated with a reduction in long-term thromboembolic events in these patients, but it did increase the risk for major bleeding. Future prospective clinical studies are needed to better understand the efficacy and safety of anticoagulation therapy in the setting of POAF after noncardiac surgery.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Anna Szpotowicz, Iwona Gorczyca, Olga Jelonek, Beata Uzieblo-Zyczkowska, Malgorzata Maciorowska, Maciej Wojcik, Robert Blaszczyk, Agnieszka Kaplon-Cieslicka, Monika Gawalko, Monika Budnik, Tomasz Tokarek, Renata Rajtar-Salwa, Jacek Bil, Michal Wojewodzki, Janusz Bednarski, Elwira Bakula-Ostalska, Anna Tomaszuk-Kazberuk, Anna Szyszkowska, Marcin Welnicki, Artur Mamcarz, Malgorzata Krzciuk, Beata Wozakowska-Kaplon
Summary: Most AF patients at high risk of thromboembolic complications received OACs, but certain medical conditions may result in the lack of OAC therapy in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Heidi S. Ahmed, Na Wang, J. Jeffrey Carr, Jingzhong Ding, James G. Terry, Lisa B. VanWagner, Lifang Hou, Yuankai Huo, Joseph Palmisano, Yinan Zheng, Emelia J. Benjamin, Michelle T. Long
Summary: This study aimed to investigate the association between NAFLD and cardiovascular disease, cancer, and all-cause mortality. The results showed that hepatic steatosis was associated with overall mortality, but the association was weakened when considering time-varying covariates. There was no significant association between hepatic steatosis and cardiovascular disease or cancer. The study highlights the importance of considering concurrent cardiometabolic disease in studying the association between NAFLD and cardiovascular outcomes.
Editorial Material
Hematology
John W. Eikelboom, Jeffrey I. Weitz
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Emelia J. Benjamin, Kim Overvad, Anja Olsen, Christina Catherine Dahm, Henrik Kjaerulf Jensen
Summary: Increasing alcohol intake over a 5-year period is associated with a higher risk of atrial fibrillation (AF), while reducing alcohol intake does not significantly affect AF risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Emelia J. Benjamin, Kevin L. Thomas, Alan S. Go, Patrice Desvigne-Nickens, Christine M. Albert, Alvaro Alonso, Alanna M. Chamberlain, Utibe R. Essien, Inmaculada Hernandez, Mellanie True Hills, Kiarri N. Kershaw, Phillip D. Levy, Jared W. Magnani, Daniel D. Matlock, Emily C. O'Brien, Carlos J. Rodriguez, Andrea M. Russo, Elsayed Z. Soliman, Lawton S. Cooper, Sana M. Al-Khatib
Summary: The contributions of social determinants of health to atrial fibrillation (AF) have received little attention. Social determinants of health affect access to care and management decisions for AF, increasing the likelihood of adverse outcomes among individuals who experience systemic disadvantages. Research is needed to eliminate the substantive inequities in health care delivery and outcomes in AF.
Article
Public, Environmental & Occupational Health
John Erhabor, Ellen Boakye, Ngozi Osuji, Olufunmilayo Obisesan, Albert D. Osei, Hassan Mirbolouk, Andrew C. Stokes, Omar Dzaye, Omar El-Shahawy, Carlos J. Rodriguez, Glenn A. Hirsch, Emelia J. Benjamin, Andrew P. DeFilippis, Rose Marie Robertson, Aruni Bhatnagar, Michael J. Blaha
Summary: This study examines the association between psychosocial stressors and current e-cigarette use among adolescents in the United States. The results show that adolescents who experience psychosocial stressors are more likely to use e-cigarettes, similar to the association between stressors and combustible cigarette use. These findings highlight the importance of targeted school-based interventions to reduce adolescent e-cigarette use.
Review
Cardiac & Cardiovascular Systems
Nick van Es, Raffaele De Caterina, Jeffrey Weitz
Summary: In the past 20 years, there has been a transition from vitamin K antagonists to direct oral anticoagulants (DOACs). DOACs include dabigatran, apixaban, edoxaban, and rivaroxaban. Although DOACs are associated with less serious bleeding, reversal agents may be needed in cases of serious bleeding or urgent surgery/intervention. This paper provides insight into reversing the effects of DOACs, discusses new reversal agents, and outlines a strategic framework for reversing factor XI inhibitors in clinical trials.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Federico Carbone, Luca Liberale, Peter Libby, Fabrizio Montecucco
Summary: Experimental and clinical findings linking vitamin D to cardiovascular risk have prompted consideration of its supplementation for overall health improvement. However, several meta-analyses do not support its clinical effectiveness, and recent research has revealed complex non-classical effects of vitamin D in cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Zhaojie Meng, Shuya Zhang, Wei Li, Yunzhe Wang, Minjie Wang, Xin Liu, Cong-Lin Liu, Sha Liao, Tianxiao Liu, Chongzhe Yang, Jes S. Lindholt, Lars M. Rasmussen, Lasse M. Obel, Jane Stubbe, Axel C. Diederichsen, Yong Sun, Yabing Chen, Paul B. Yu, Peter Libby, Guo-Ping Shi, Junli Guo
Summary: In this study, it was found that blood eosinophil count and eosinophil cationic protein (ECP) concentration are risk factors for cardiovascular diseases. Eosinophils and ECP were shown to contribute to vascular calcification and atherogenesis through the BMPR-1A/1B-Smad-1/5/8-Runx2 signaling pathway.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremiah Wasserlauf, Kelly Vogel, Cailin Whisler, Emelia Benjamin, Robert Helm, Daniel A. Steinhaus, Omair Yousuf, Rod S. Passman
Summary: The aim of this study was to determine the accuracy of the irregular rhythm notification (IRN) feature of the Apple watch in subjects with a previous diagnosis of nonpermanent atrial fibrillation (AF). The results showed that the IRN had a low rate of false positive detections and high specificity in a population with known AF. However, increased sensitivity and wear times would be necessary for disease management.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Esra D. Gumuser, Art Schuermans, So Mi Jemma Cho, Zachary A. Sporn, Md Mesbah Uddin, Kaavya Paruchuri, Tetsushi Nakao, Zhi Yu, Sara Haidermota, Whitney Hornsby, Lachelle D. Weeks, Abhishek Niroula, Siddhartha Jaiswal, Peter Libby, Benjamin L. Ebert, Alexander G. Bick, Pradeep Natarajan, Michael C. Honigberg
Summary: This study examined the prognostic value of clonal hematopoiesis of indeterminate potential (CHIP) in individuals with established atherosclerotic cardiovascular disease (ASCVD). The results showed that any CHIP and large CHIP were associated with adverse outcomes, with TET2 and spliceosome CHIP having the strongest associations.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Clinical Neurology
Alan S. Go, Sana M. Al-Khatib, Patrice Desvigne-Nickens, Nisha Bansal, Cheryl D. Bushnell, Margaret C. Fang, James V. Freeman, Brian F. Gage, Thorsten Hanke, Elaine M. Hylek, Renato D. Lopes, Peter A. Noseworthy, Vivek Y. Reddy, Daniel E. Singer, Kevin L. Thomas, Mellanie True Hills, Mintu P. Turakhia, Susan J. Zieman, Lawton S. Cooper, Emelia J. Benjamin
Summary: Atrial fibrillation (AF) is a strong risk factor for ischemic stroke, which is a major cause of disability and death. With the increasing prevalence of AF and improved survival in cardiovascular disease, the number of people affected by AF will continue to rise. This report summarizes a workshop focused on identifying key research opportunities related to stroke prevention in AF, addressing areas such as improving risk stratification tools, overcoming challenges with oral anticoagulants, and determining the optimal roles of percutaneous left atrial appendage occlusion and surgical closure/excision. The report aims to promote innovative research that leads to personalized and effective stroke prevention strategies in individuals with AF.
Article
Hematology
Samuel K. Lee, Rida A. Malik, Ji Zhou, Wei Wang, Peter L. Gross, Jeffrey I. Weitz, Rithwik Ramachandran, Bernardo L. Trigatti
Summary: This study investigated the effects of PAR4 inhibitory pepducin (RAG8) on coronary artery disease in SR-B1/LDLR double knockout mice fed a high-fat, high-cholesterol diet. The results showed that RAG8 reduced coronary artery atherosclerosis and myocardial fibrosis, as well as platelet and leukocyte accumulation in atherosclerotic coronary arteries.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Adrian D. Elliott, Emelia J. Benjamin, Melissa E. Middeldorp
Summary: Cardiometabolic risk factors, particularly obesity and hypertension, have the highest population-attributable risk for atrial fibrillation (AF). Hypertension, obesity, acute illness, cardiovascular disease, and inflammation are the top five individual risk factors for AF. We propose five key strategies to manage these risk factors for primary prevention of AF.
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Lu-Chen Weng, Shaan Khurshid, Sophia Gunn, Ludovic L. Trinquart, Kathryn Lunetta, Huichun J. Xu, Patrick T. NINDS Stroke Genetics Network, Emelia D. Benjamin, Patrick A. Ellinor, Christopher Anderson, Steven Lubitz
Summary: The polygenic risk score for atrial fibrillation can help distinguish between cardioembolic and noncardioembolic strokes. It improves the discrimination and reclassification of stroke subtypes when combined with clinical risk factors.
Article
Psychiatry
Xuzhi Wang, Chathurangi H. Pathiravasan, Yuankai Zhang, Ludovic Trinquart, Belinda Borrelli, Nicole L. Spartano, Honghuang Lin, Christopher Nowak, Vik Kheterpal, Emelia J. Benjamin, David D. McManus, Joanne M. Murabito, Chunyu Liu
Summary: This study found an association between depressive symptom trajectories and subsequent physical activity collected by mHealth devices. Antecedent depressive symptom trajectories predicted lower levels of physical activity in the future.
JMIR MENTAL HEALTH
(2023)
