期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 361, 期 8, 页码 1798-1802出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900001
关键词
palladium-catalyzed; alpha-oxocarboxylic acids; decarboxylative annulation; directing group
资金
- Ph. D. Scientific Research Foundation of Guilin University of Technology
- Guangxi Natural Science Fundation [2017GXNSFBA198224, 2018GXNSFAA281203]
- Key Laboratory of Electrochemical and Magneto-chemical Function Materials
An efficient protocol for the preparation of indolo[1,2-a]quinazolines via palladium-catalyzed decarboxylative annulation of indols with alpha-oxocarboxylic acids has been realized by using primary amine as a directing group (DG). This transformation proceeds smoothly with exclusive regioselectivity and represents an one-pot Domino synthesis of indo-lo[1,2-a]quinazolines from alpha-oxocarboxylic acids.
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