期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 361, 期 10, 页码 2354-2359出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900066
关键词
C-H difluoroacetylation; Quinoxalin-2(1H)-ones; Copper-Catalyzed; Ethyl bromodifluoroacetate
资金
- National Natural Science Foundation of China [21776056]
- Natural Science Foundation of Hebei Province (CN) [B2018202253, B2016202393, B2015202284]
- Program for the Top Young Innovative Talents of Hebei Province (CN) [BJ2017010]
A copper-catalyzed direct C-H difluoroacetylation of quinoxalinones at the C-3 position with ethyl bromodifluoroacetate has been developed. In this reaction, diverse difluoroacetylated quinoxalin-2(1H)-ones with a wide range of functional groups could be obtained in moderate to good yields, using cheap, commercially available reagents. This protocol would offer a meaningfully synthetic method for pharmacologically interesting difluoroacetylated quinoxalin-2(1H)-one derivatives.
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