Article
Biochemistry & Molecular Biology
Dan Xia, Yuan Liu, Wuxiu Cao, Junwei Gao, Donghui Wang, Mengxia Lin, Chunyong Liang, Ning Li, Ruodan Xu
Summary: Coaxial electrospinning nanofibrous patches combining anti-bacterial and anti-inflammation agents have the potential to accelerate wound healing, which is achieved through co-loading and sequential release of drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Neha Raina, Rakesh Pahwa, Jasmine Kour Khosla, Prem N. Gupta, Madhu Gupta
Summary: PCL, as a versatile and promising biomaterial of synthetic origin, has been extensively employed in wound healing applications and is considered as a polymeric material of choice in various biomedical applications. Due to its impressive biological properties and mechanical strength, PCL plays an important role in wound treatment. Additionally, PCL is widely used for scaffold fabrication and combined with other polymers for wound healing purposes.
Article
Nanoscience & Nanotechnology
Lanxiang Liu, Xiang Li, Gang Dong, Hong Zhang, Yun-Feng Tao, Rui He, Juan Xu, Jinju Ma, Baoshan Tang, Bei Zhou
Summary: In this study, a bioactive shellac-based wound dressing was designed and developed, which exhibited high adhesion energy and reversible binding. A novel compound was added to enhance antibacterial and blood coagulation properties. The dressing showed rapid hemostasis, wound sealing, and promoted wound healing. Molecular dynamics simulations demonstrated the beneficial effects of the shellac molecule on wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Lanxiang Liu, Xiang Li, Gang Dong, Hong Zhang, Yun-Feng Tao, Rui He, Juan Xu, Jinju Ma, Baoshan Tang, Bei Zhou
Summary: Developing safe and effective wound dressings is a constant goal in biomaterials research. In this study, we have designed and developed a novel shellac-based dressing that exhibits high adhesion energy, pH sensitivity, and promotes wound healing. A new compound has also been synthesized to improve the antibacterial and blood coagulation properties of the dressing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xiangchun Meng, Xiao Xiao, Sera Jeon, Dabin Kim, Byung-Joon Park, Young-Jun Kim, Najaf Rubab, SeongMin Kim, Sang-Woo Kim
Summary: A bioadhesive triboelectric nanogenerator (BA-TENG) is designed for instant wound sealing and accelerated wound healing. It is fabricated with biocompatible materials and integrates a flexible TENG as the top layer and bioadhesive as the bottom layer. The BA-TENG can produce stable electricity supply and strong sealing capability, and when driven by ultrasound, it can significantly accelerate wound healing. The E-field generated by BA-TENG promotes cell migration and proliferation.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Mohamed S. El-Okaily, Amany A. Mostafa, Judyta Dulnik, Piotr Denis, Pawel Sajkiewicz, Azza A. Mahmoud, Reham Dawood, Amr Maged
Summary: Nanofiber membranes made of polycaprolactone and bioactive glass nanoparticles were prepared using electrospinning. The incorporation of bioactive glass increased the crystallinity of polycaprolactone, and nanofibers containing 5% bioactive glass showed the best mechanical properties. Atorvastatin-loaded nanofibers with a 10% coating polymer exhibited gradual drug release and promoted wound closure in human skin fibroblast cells.
Review
Polymer Science
Jiahao Yang, Shige Wang
Summary: This review discusses the design criteria and functionalities of hydrogel bio-adhesives for wound healing and comprehensively explores recent advances in polysaccharide-based multifunctional hydrogel bio-adhesives. Polysaccharides such as chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, and others are discussed. The current challenges and future research directions of polysaccharide-based hydrogel bio-adhesives for wound healing are proposed.
Article
Materials Science, Multidisciplinary
Mehrez E. El-Naggar, Ola A. Abu Ali, Dalia Saleh, M. A. Abu-Saied, M. K. Ahmed, E. Abdel-Fattah, S. F. Mansour, El-Refaie Kenawy
Summary: The Tl-HAP@PCL nanofibers, fabricated by encapsulating hydroxyapatite modified with different contributions of thallium ions within polycaprolactone scaffolds, showed variations in roughness, contact angle, and mechanical properties, demonstrating promising wound dressing capability and cell viability.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Biotechnology & Applied Microbiology
Xingtai Huang, Qirui Wang, Runyi Mao, Zeying Wang, Steve G. F. Shen, Juan Mou, Jiewen Dai
Summary: In this study, a versatile organic-inorganic composite scaffold was constructed by embedding two-dimensional vermiculite nanosheets in polycaprolactone electrospun fibers. This scaffold can enhance angiogenesis through activation of the HIF-1 alpha signaling pathway and promote diabetic wound healing.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Yasaman Saghafi, Hadi Baharifar, Najmeh Najmoddin, Azadeh Asefnejad, Hassan Maleki, Sayed Mahmoud Sajjadi-Jazi, Alireza Bonkdar, Forough Shams, Kamyar Khoshnevisan
Summary: This study developed gel-based polycaprolactone/chitosan (PCL/CS) nanofibrous dressings containing bromelain (BRO) and silver nanoparticle (Ag NPs) through electrospinning. The resulting nanofibers exhibited uniform morphology without beads, with an average diameter of 176 +/- 63 nm. Adding BRO and Ag NPs improved the tensile strength of the nanofibers and enhanced their antibacterial activity against E. coli and S. aureus bacteria. In vivo experiments demonstrated that the wound healing process was significantly accelerated with the dressings containing BRO and Ag NPs. Therefore, gel-based PCL/CS nanofibrous dressings loaded with BRO and Ag NPs have promising potential for skin wound healing.
Article
Biochemistry & Molecular Biology
Liuzhu Zhou, Ling Cai, Hongjie Ruan, Li Zhang, Jun Wang, Huijun Jiang, Yuan Wu, Shanwu Feng, Jin Chen
Summary: Burn injuries pose significant burdens on public health, requiring efficacious antibacterial wound-healing dressings. The PCL-COS-Qe/Ru nanofiber membranes demonstrated superior antioxidant and antibacterial activities, showing great potential as ideal options for treating burn injuries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Touseef Nawaz, Muhammad Iqbal, Barkat Ali Khan, Naveed Ahmed, Asif Nawaz, Akhtar Rasul, Waleed Y. Rizg, Abdulmajeed M. Jali, Rayan A. Ahmed, Awaji Y. Safhi
Summary: This study investigated a pharmaceutical acriflavine-loaded polycaprolactone nanoemulsion for burn wound healing. The optimized nanoemulsion was found to be stable with desirable physicochemical properties. In vivo experiments showed that the nanoemulsion formulation had high wound healing potential.
Review
Chemistry, Multidisciplinary
Hailong Fan, Jian Ping Gong
Summary: Underwater adhesives are in high demand due to their specific challenges in development and performance on wet or submerged surfaces. Current strategies include different types of underwater adhesives and their development and performance based on various mechanisms and strategies. Possible research directions and prospects for underwater adhesives are also discussed.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Huaikai Shi, Kevin H-Y Tsai, Duncan Ma, Xiaosuo Wang, Reena Desai, Roxanne J. Parungao, Nicholas J. Hunt, Yuen Yee Cheng, Hao Zhang, Ye Xu, Ulla Simanainen, Qian Tan, Mark S. Cooper, David J. Handelsman, Peter K. Maitz, Yiwei Wang
Summary: This study developed a PCL scaffold that can release androgen and anti-androgen drugs, and investigated their impact on burn wound healing. The dual release of DHT and F from the scaffold showed accelerated wound healing without adverse effects on androgen-dependent organs.
Article
Chemistry, Applied
Hanieh Shokrani, Amirhossein Shokrani, Farzad Seidi, Muhammad Tajammal Munir, Navid Rabiee, Yousef Fatahi, Justyna Kucinska-Lipka, Mohammad Reza Saeb
Summary: Tissue adhesives are widely used for wound treatment, prevention of wound leaks, severe bleeding, and drug delivery. Future research needs to focus on understanding biomaterials, tissue surface properties, fabrication procedures, and the development of new adhesive technologies.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Wei Zhang, Tianjiao Ji, Sophie Lyon, Manisha Mehta, Yueqin Zheng, Xiaoran Deng, Andong Liu, Alona Shagan, Boaz Mizrahi, Daniel S. Kohane
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Multidisciplinary Sciences
Wei Zhang, Tianjiao Ji, Yang Li, Yueqin Zheng, Manisha Mehta, Chao Zhao, Andong Liu, Daniel S. Kohane
NATURE COMMUNICATIONS
(2020)
Article
Polymer Science
Wei Zhang, Yan Cao, Ziwei Lai, Shichen Yu, Tingbin Yang, Xilan Liu, Qing-Yun Guo, Yuchu Liu, Wei Chen, Mingjun Huang, Jing Wang, Stephen Z. D. Cheng
Editorial Material
Chemistry, Multidisciplinary
Wei Zhang
ACS CENTRAL SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Zipei Zhang, Xiyu Li, Wei Zhang, Daniel S. Kohane
Summary: This review highlights recent advances in drug delivery systems for treating ear disorders by accessing the ear through the tympanic membrane (TM). The methods discussed include non-invasive (on the surface of the TM) and invasive (in the middle ear, ideally on the round window [RW]). Major hurdles to otic drug delivery are identified, along with representative examples of drug delivery systems used to deliver drugs across the TM to the middle and inner ear (crossing the RW as well).
ADVANCED FUNCTIONAL MATERIALS
(2021)
Editorial Material
Chemistry, Multidisciplinary
Wei Zhang, Daniel S. Kohane
Article
Chemistry, Multidisciplinary
Qing-Yun Guo, Xiao-Yun Yan, Wei Zhang, Xing-Han Li, Yongsheng Xu, Shuqi Dai, Yuchu Liu, Bo-Xing Zhang, Xueyan Feng, Jiafu Yin, Di Han, Jiahao Huang, Zebin Su, Tong Liu, Mingjun Huang, Chih-Hao Hsu, Stephen Z. D. Cheng
Summary: Hexagonal mesoporous silica was prepared from single-source giant surfactants constructed using DPOSS and PS, yielding high porosity and a uniform pore size distribution. Varying PS tail lengths can adjust pore size, enhancing both efficiency and stability of nanocatalysts.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Engineering, Biomedical
Tianjiao Ji, Yang Li, Xiaoran Deng, Alina Y. Rwei, Abraham Offen, Sherwood Hall, Wei Zhang, Chao Zhao, Manisha Mehta, Daniel S. Kohane
Summary: A self-assembling delivery system was developed for site-1 sodium channel blockers to prolong nerve blockade and reduce systemic toxicity. The system mimicked specific interactions of the blockers with sodium channel peptides, utilizing modified peptides with hydrophobic domains for nanofiber assembly. The strategy could potentially be applied to designing drug delivery systems for receptor-mediated drugs.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Dali Wang, Yang Li, Xiaoran Deng, Matthew Torre, Zipei Zhang, Xiyu Li, Wei Zhang, Kathleen Cullion, Daniel S. Kohane, Christopher B. Weldon
Summary: The authors present a simple and effective aptamer-based depot system for controlled release of small molecule therapeutics. The system forms aptamer/drug complexes that sustain the release of drugs, leading to improved in vivo delivery of channel blockers. This approach greatly prolongs local anesthesia and reduces systemic toxicity, demonstrating the potential usefulness of aptamers as specific drug delivery systems.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ellen H. Rumley, David Preninger, Alona Shagan Shomron, Philipp Rothemund, Florian Hartmann, Melanie Baumgartner, Nicholas Kellaris, Andreas Stojanovic, Zachary Yoder, Benjamin Karrer, Christoph Keplinger, Martin Kaltenbrunner
Summary: Combating environmental pollution requires a focus on sustainability, particularly from advancing technologies like soft robotics. We introduce compatible materials for fully biodegradable soft actuators, which exhibit high performance and can withstand high electric fields. We also build a robotic gripper based on these biodegradable soft actuators, promoting the use of biodegradable materials in soft robotics.
Article
Chemistry, Multidisciplinary
Tao Wen, Bo Ni, Yuchu Liu, Wei Zhang, Zi-Hao Guo, Yi-Chien Lee, Rong-Ming Ho, Stephen Z. D. Cheng
Summary: Utilizing the controlled self-assembling of a giant surfactant, a bottom-up method for constructing line gratings with sub-10 nm resolution has been developed. The process involves solvent vapor annealing to self-assemble the giant surfactant into lamellae structures, followed by thermal annealing to promote long-range ordering. This simple and economic approach results in highly oriented and defect-free sub-10 nm line patterns on a large scale.
Article
Chemistry, Multidisciplinary
Wei Zhang, Brendan Harty, Yueqin Zheng, Zipei Zhang, Xiyu Li, Dali Wang, Daniel S. Kohane
Summary: The study investigated the permeation of macromolecules across the tympanic membrane in chinchillas using polyethylene glycols (PEGs) solutions, finding that as the molecular weight of the polymers increased, the flux across the membrane decreased. Additionally, the release of PEG from a poloxamer 407 hydrogel further decreased flux, with a direct relationship between the apparent diffusion coefficient and molecular weight of the polymers.
Article
Chemistry, Multidisciplinary
Yuchu Liu, Tong Liu, Xiao-yun Yan, Qing-Yun Guo, Jian Wang, Rongchun Zhang, Shuailin Zhang, Zebin Su, Jiahao Huang, Geng-Xin Liu, Wei Zhang, Takuzo Aida, Kan Yue, Mingjun Huang, Stephen Z. D. Cheng
Article
Nanoscience & Nanotechnology
Jing Jiang, Yu Wang, Lun Jin, Chih-Hao Hsu, Shuailin Zhang, Jialin Mao, Wenbin Yin, Tao Li, Bo Ni, Zebin Su, Jiahao Huang, Chrys Wesdemiotis, Kan Yue, Wei Zhang, Stephen Z. D. Cheng
ACS APPLIED NANO MATERIALS
(2020)
