Review
Pharmacology & Pharmacy
Ziao Zong, Guanghui Tian, Junli Wang, Chuanbin Fan, Fenglian Yang, Feng Guo
Summary: This article provides a comprehensive summary of MOF-based nanocarriers for drug delivery and release, highlighting their designability, biocompatibility, and drug-loading capacity. It also discusses the opportunities and challenges of MOF-based smart delivery vehicles.
Article
Engineering, Biomedical
Wenyu Chen, Huixin He, Pengfei Jiao, Lefei Han, Jianchun Li, Xiu Wang, Xuliang Guo
Summary: A triple-responsive metal-organic framework is designed to release photosensitizers under low oxygen, reactive oxygen species, and low pH conditions, enhancing the efficacy of photodynamic therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yanyi Li, Haobin Huang, Chongwei Ding, Xiaoping Zhou, Hong Li
Summary: In this study, a zero-order drug delivery system using CD-MOF as a carrier for naringin was successfully achieved, showing potential for future applications in pharmaceutical technology.
Article
Chemistry, Multidisciplinary
Xianxian Yao, Danyang Chen, Bin Zhao, Binru Yang, Zhaokui Jin, Mingjian Fan, Geru Tao, Shucun Qin, Wuli Yang, Qianjun He
Summary: The development of stimuli-responsively degradable porous carriers for controlled drug release is important for clinical translation. In this study, a new type of Fe-MOF nanocrystals is engineered as an acid-degradable drug carrier and hydrogen donor. Fe-MOF nanocrystals exhibit acid-responsive degradation for H-2 generation and simultaneous drug release, and can effectively inhibit cancer metastasis and sensitize MDR cancer cells for enhanced chemotherapy. The high anti-MDR/antimetastasis efficacies and biocompatibility make Fe-MOF nanocrystals and Fe-MOF-based nanomedicine highly promising for clinical translation.
Article
Multidisciplinary Sciences
Yuting Lei, Guihua Zhang, Qinglan Zhang, Ling Yu, Hua Li, Haili Yu, Yi He
Summary: The study demonstrates the potential application of zeolitic imidazolate frameworks as high-capacity iodine adsorbents. By using dark-field microscopy, the real-time adsorption process of gaseous I-2 on single ZIF-90 particles is visualized, revealing inter-particle heterogeneity and performance enhancement after the introduction of linker defects.
NATURE COMMUNICATIONS
(2021)
Article
Materials Science, Biomaterials
Isabel Abanades Lazaro, Jose M. Rodrigo-Munoz, Beatriz Sastre, Maria Romero Angel, Carlos Marti-Gastaldo, Victoria del Pozo
Summary: Ti-Ca heterometallic MOF MUV-10 shows good dispersibility in phosphate buffer and low phosphate-induced degradation compared to other MOF systems. It exhibits no cytotoxicity towards immune system cells and no immune response, making it an attractive candidate for biomedical applications and showing its safe use in other fields.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Adam Bieniek, Marek Wisniewski, Joanna Czarnecka, Jedrzej Wierzbicki, Marcin Zietek, Maciej Nowacki, Dariusz Grzanka, Tomasz Kloskowski, Katarzyna Roszek
Summary: Utilizing PPF structures as nanocarriers for hepatoma treatment can enhance the efficacy of SOR drug. By controlling the degradation of the carrier and the release rate of the drug, different effects on hepatoma cells were achieved, effectively reducing tumor size and preventing metastases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Leo Boivin, Pierre D. Harvey
Summary: Metal-organic frameworks (MOFs) are versatile porous materials that can be used to manage viral infections. Various strategies, including sequestration, mineralization, barrier design, controlled drug delivery, photosensitization, and direct contact with cytotoxic MOFs, have been developed to combat viruses such as SARS-CoV-2, HIV-1, and tobacco mosaic virus.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Fatimah A. T. Alsaaed, Hany M. Abd El-Lateef, Mai M. Khalaf, Ibrahim M. A. Mohamed, Mohammed A. Al-Omair, Mohamed Gouda
Summary: A novel drug delivery system based on carboxymethyl cellulose containing copper oxide and zinc oxide was prepared and characterized. The system demonstrated a high activity index against S. aureus and E. coli.
Article
Biochemistry & Molecular Biology
Siamak Javanbakht, Malihe Pooresmaeil, Hassan Namazi, Abolfazl Heydari
Summary: In this study, a novel green synthesis route was described for the growth of metal-organic framework (MOF) from zinc metal and 1,4-benzene dicarboxylic acid in the presence of carboxymethyl cellulose (CMC). The synthesized material showed promising characteristics for prolonged drug release, with high drug loading efficiency and better drug release performance compared to the pristine MOF. Overall, the results confirm the functionality of CMC biopolymer for in situ growth of MOF and its cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Jiale Xia, Yumeng Xue, Bo Lei, Lingling Xu, Mingzi Sun, Na Li, Hongyang Zhao, Min Wang, Meng Luo, Chao Zhang, Bolong Huang, Yaping Du, Chun-Hua Yan
Summary: This study fabricated lanthanide-based porphyrin metal-organic framework nanosheets with promising cancer imaging/chemotherapy capacities, demonstrating ultra-high drug loading and superior tumor tissue penetration, suitable for multimodal tumor imaging and cancer chemotherapy.
NATIONAL SCIENCE REVIEW
(2021)
Article
Chemistry, Physical
Xiajuan Huang, Shijiang Yu, Wenxin Lin, Yan Wang, Qing He, Jinsheng Zheng, Hongliang Zhu, Jianjun Chen
Summary: A Y-based metal-organic framework ZJU-16 with outstanding biocompatibility was synthesized and used as an oral drug carrier, successfully encapsulating an anti-inflammatory drug Ibuprofen sodium. The pH-responsive release behavior of the carrier showed excellent characteristics, allowing drug release in simulated intestinal environments.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biophysics
Abdollah Karami, Ahmed Ahmed, Rana Sabouni, Ghaleb A. Husseini, Miral Al Sharabati, Nour AlSawaftah, Vinod Paul
Summary: This study demonstrated the pH/Ultrasound dual-responsive capability of liposome-coated Fe-BTC for DOX delivery, showing potential as nanocarriers for drug delivery. The successful coating was verified through DLS and TEM techniques, with PBL reducing particle aggregation and improving dispersity in the release medium. TGA results showed the MOF's excellent thermal stability.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Applied
Vahid Zeyni, Soheyla Karimi, Hassan Namazi
Summary: In this study, a zinc-based metal-organic framework/magnetic hydroxyapatite nanocomposite was synthesized and coated with a biocompatible layer of polyethylene glycol as a targeting drug delivery system. The nanocomposites were characterized and utilized as carriers to encapsulate the anticancer drug doxorubicin. Both nanocomposites showed pH-dependent drug release and the Korsmeyer-Peppas model was the best fit to describe the release mechanism. The synthesized systems showed no significant toxicity and exhibited higher toxicity against lung cancer cell lines. Additionally, the nanocomposites demonstrated excellent antioxidant activity. These findings suggest that the prepared drug systems have potential for targeted drug delivery applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Mengru Cai, Boran Ni, Xueling Hu, Kaixin Wang, Dongge Yin, Gongsen Chen, Tingting Fu, Rongyue Zhu, Xiaoxv Dong, Changhai Qu, Xingbin Yin
Summary: This study successfully prepared MOFs-based nanoparticles as a drug delivery platform with fluorescence imaging capability. The nanoparticles showed potential for tumor microenvironment-responsive drug release and exhibited high antitumor activity in vitro experiments.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2022)
Article
Chemistry, Multidisciplinary
Maksym Seredyuk, Kateryna Znovjyak, Francisco Javier Valverde-Munoz, Ivan da Silva, M. Carmen Munoz, Yurii S. Moroz, Jose Antonio Real
Summary: This study reports a new type of neutral Fe-II complex based on a novel asymmetric ligand. The complex forms a one-dimensional supramolecular chain due to its asymmetric shape in the lattice. The different spatial conformations of the 3-methoxy groups in the supramolecular arrangement have different effects on the spin transition process of the compound. It was found that one of the supramolecular arrangements can keep the compound in a high-spin state over a large temperature range.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Marek Wisniewski
Summary: Despite their importance in various processes, the molecular structure of the surface layers of quantum dots in solution remains unknown. Therefore, understanding the interaction mechanism between the surface of Nitrogen enriched Carbonaceous Quantum Dots (N-CQDs) and water is highly desirable. In situ characterization reveals the presence of diffusive and Stern layer over the N-CQDs, confirming the existence of anionic water clusters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Sonia A. Barczak, Blair F. Kennedy, Ivan da Silva, Jan-Willem G. Bos
Summary: In situ neutron powder diffraction was used to monitor the synthesis of TiNiSn alloys from elemental powders, revealing the complex sequence of reactions and the impact of excess Ni. The formation of half-Heusler and full-Heusler phases was found to be influenced by melting events and the presence of molten phases. The study provides important insights into the formation mechanism of TiNiSn and its implications for synthetic design and thermoelectric transport analysis.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Elan D. R. Mistry, Daphne Lubert-Perquel, Irena Nevjestic, Giuseppe Mallia, Pilar Ferrer, Kanak Roy, Georg Held, Tian Tian, Nicholas M. Harrison, Sandrine Heutz, Camille Petit
Summary: A family of boron nitride (BN)-based photocatalysts for solar fuel syntheses have recently emerged. Studies have shown that oxygen doping, leading to boron oxynitride (BNO), can extend light absorption to the visible range. This study demonstrates the importance of paramagnetic isolated OB3 states in inducing red-shifted light absorption and highlights the detrimental effects of diamagnetic O-B-O states on photochemistry in BNO semiconductors. The findings provide fundamental insights into the photophysics of BNO and pave the way for tailoring its optoelectronic and photochemical properties for solar fuel synthesis.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ivan da Silva, Gerardo Gil de Cos, Cristina Gonzalez-Silgo, Javier Lopez-Solano, Andres Mujica, Nivaria R. Ramirez-Rodriguez, Manuel E. Torres
Summary: Solid-state synthesis and phase transitions of RE2(MoO4)3 samples were monitored using X-ray thermodiffraction. The formation of intermediate phases and their coexistence were explained through common structural motifs. Heating-cooling cycles revealed the reversible and reconstructive phase transition. The research highlights the importance of directed and rational synthesis for materials enrichment.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Engineering, Biomedical
Hetmann Anna, Szymczak Bartosz, Czarnecka Joanna, Rusak Tomasz, Wisniewski Marek, Wujak Magdalena, Roszek Katarzyna
Summary: Purinergic signaling has emerged as a crucial target for anti-cancer therapies, and the nanobiocatalytic system of AK-GO has been developed to modify the purinergic signaling components in lung carcinoma cells. The immobilized adenylate kinase effectively controls nucleotide balance and decreases adenosine concentration, leading to reduced proliferation and migration ability of cancer cells. The developed AK-GO nanobiocatalytic system shows good compatibility for biomedical applications.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Engineering, Chemical
Wojciech Ogieglo, Katarzyna Knozowska, Tiara Puspasari, Zain Ali, Joanna Kujawa, Emil Korczeniewski, Artur P. Terzyk, Wojciech Kujawski, Ingo Pinnau
Summary: In this study, we investigated the separation performance of an ethanol-cyclohexane mixture using a thin-film composite membrane made of a heat-treated polyimide. We studied the chemical and structural transformations that occur during the formation of thermally-rearranged and carbon molecular sieve membranes, which significantly impact the properties and separation behavior of the membrane. We achieved excellent separation performance by precise thermal treatment, and highlighted the unique property of pervaporation where the downstream side of the membrane remains dry despite swelling in the upstream region.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Engineering, Biomedical
Gabriela Gasior, Marlena Grodzicka, Tomasz Jedrzejewski, Marek Wisniewski, Aleksandra Radtke
Summary: This publication presents the fabrication of porous iron-based materials using a cost-effective replica method on a polymeric template. The obtained materials with different pore sizes show potential for application in cardiac surgery implants. Corrosion rate and cytotoxic activity of the materials were evaluated. The study found that excessive porosity of the material may cause toxic effects on cell lines due to rapid corrosion.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Xi Chen, Sergei Sapchenko, Wanpeng Lu, Ming Li, Meng He, Yinlin Chen, Mark D. Frogley, Ivan da Silva, Sihai Yang, Martin Schroder
Summary: Metal-organic framework (MOF) materials have gained increasing interest in electronics due to their diverse structures, intrinsic porosity, and designable host-guest interactions. In this study, we investigated the dielectric properties of a series of robust materials, MFM-300(M) (M = Al, Sc, Cr, Fe, Ga, In), upon exposure to different guest molecules. We found that MFM-300(Fe) showed the highest increase in dielectric constant when adsorbing NH3, indicating its potential as a powerful dielectric-based sensor for NH3. Structural analysis and spectroscopy confirmed the electron delocalization induced by host-guest interactions between NH3 and the MOF host, resulting in structural polarization and a high dielectric constant.
INORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Julia Moszczynska, Xinying Liu, Marek Wisniewski
Summary: Liquid hydrogen carriers will have a significant role in energy transportation. The key factors in assessing the applicability of ammonia cracking in large-scale projects are high energy density, easy storage and distribution, simplicity of the process, and low or zero-carbon footprint. Non-thermal plasma solution provides a way to overcome the negative effects of high temperature reactions in the H2 recovery process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Julia Moszczynska, Katarzyna Roszek, Marek Wisniewski
Summary: Non-thermal plasma (NTP) application in medicine is a rapidly developing interdisciplinary field. This review article explains the underlying chemical processes and effects involved in NTP in human (or animal) tissues and bacteria inactivation, as well as the modification of medical surfaces. The review highlights the existing knowledge of NTP-based in vitro and in vivo studies and emphasizes the potential opportunities for developing novel therapeutic methods. A comprehensive understanding of the mechanisms of action of NTP is crucial for further advancements in plasma-based medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Marek Wisniewski, Xinying Liu
Summary: This study investigates CO2 splitting by using a glow discharge reactor packed with carbonaceous materials, and the results indicate that the materials play a dual role as a solid adsorbent and an oxygen scavenger, shifting the overall reaction equilibrium towards CO - the product side.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Ivan da Silva, Gerardo Gil de Cos, Cristina Gonzalez-Silgo, Javier Lopez-Solano, Andres Mujica, Nivaria R. Ramirez-Rodriguez, Manuel E. Torres
Summary: The solid-state synthesis and phase transitions of RE2(MoO4)3 (RE equivalent to Nd, Sm, Eu, and Gd) samples were investigated using X-ray thermodiffraction with synchrotron radiation. The formation and coexistence of intermediate phases were explained by common structural motifs. The reversible and reconstructive alpha [La2(MoO4)3] <-> beta phase transition was observed, clarifying previous controversies.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Ivan da Silva, Gerardo Gil de Cos, Cristina Gonzalez-Silgo, Javier Lopez-Solano, Andres Mujica, Nivaria R. Ramirez-Rodriguez, Manuel E. Torres
Summary: The solid-state synthesis and phase transitions of RE2(MoO4)3 samples (RE equivalent to Nd, Sm, Eu, and Gd) were studied using X-ray thermodiffraction with synchrotron radiation. The formation and coexistence of intermediate phases were explained by common structural motifs and unit cell volumes per atom. The reversible and reconstructive alpha <-> beta phase transition was observed, clarifying controversy in literature. The research highlights the importance of directed and rational synthesis in enriching materials with new or improved properties.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Physical
Slawomir Boncel, Jaroslaw Kaluzny, Jacek Rozanski, Beata Strzemiecka, Tomasz Runka, Lukasz Wojciechowski, Joanna Kujawa, Emil Korczeniewski, Artur P. Terzyk, Paulina Blaszkiewicz, Adam A. Marek, Anna Kolanowska, Rafal G. Jedrysiak, Szymon Ruczka, Grzegorz Dzido, Tomasz Gizewski
Summary: This study demonstrates the successful formation of stable and multifunctional CNT-PAO greases by using two types of multi-wall carbon nanotubes as thickeners and thermo- and electro-active agents. The mechanisms governing fast-thickening behavior and CNT-PAO affinities are analyzed, and the multifunctionality of CNT-PAO greases is revealed.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
