Article
Substance Abuse
Jordan P. Davis, David Eddie, John Prindle, Emily R. Dworkin, Nina C. Christie, Shaddy Saba, Graham T. DiGuiseppi, John D. Clapp, John F. Kelly
Summary: The study found that risk factors for relapse to opioid use following treatment for opioid use disorder are mainly related to substance use problems and withdrawal symptoms in women, while in men they are mainly related to age, conduct disorder symptoms, and history of multiple substance use disorders.
Article
Behavioral Sciences
Melissa C. Knouse, Lisa A. Briand
Summary: Females exhibit stronger behavioral responses than males to drugs like cocaine and opioids, possibly driven by ovarian hormones. While there are overlapping neural mechanisms underlying cocaine and opioid abuse, they have divergent effects on synaptic plasticity. This suggests that behavioral sex differences in substance use disorder may be driven by different mechanisms depending on the drug class.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Medicine, General & Internal
Kevin F. Boehnke, Owen Dean, Rebecca L. Haffajee, Avinash Hosanagar
Summary: Enrollment in medical cannabis programs in the United States increased approximately 4.5-fold from 2016 to 2020. Enrollment decreased in recreational states but increased in medical-only states. In 2020, 68.2% of patient-reported qualifying conditions had therapeutic value.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sheila Shanmugan, Jakob Seidlitz, Zaixu Cui, Azeez Adebimpe, Danielle S. Bassett, Maxwell A. Bertolero, Christos Davatzikos, Damien A. Fair, Raquel E. Gur, Ruben C. Gur, Bart Larsen, Hongming Li, Adam Pines, Armin Raznahan, David R. Roalf, Russell T. Shinohara, Jacob Vogel, Daniel H. Wolf, Yong Fan, Aaron Alexander-Bloch, Theodore D. Satterthwaite
Summary: Prior work has shown substantial interindividual variation in the spatial distribution of functional networks across the cerebral cortex, but it remains unknown whether there are sex differences in the topography of individualized networks in youth. In this study, researchers leveraged advanced machine learning to define individualized functional networks in youth and found that there are sex-related spatial patterns in functional topography. These patterns showed high accuracy in classifying participant sex based on functional topography. Additionally, the study revealed that the sex differences in functional topography were correlated with gene expression on the X chromosome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Anesthesiology
Joshua Aviram, Gil M. Lewitus, Yelena Vysotski, Paula Berman, Anna Shapira, Shiri Procaccia, David Meiri
Summary: Studies have shown that women are more susceptible to adverse effects from conventional drugs. This study aimed to investigate the differences of medical cannabis-related adverse effects between women and men in patients with chronic noncancer pain. The results showed that women reported more medical cannabis-related adverse effects, possibly due to both the inherent sex effect and the consumption of specific phytocannabinoid compositions.
Article
Psychology, Clinical
Allen W. Barton, Crystal A. Reinhart, Corey C. Campbell, Doug C. Smith, Dolores Albarracin
Summary: This study aimed to understand the different types of opioid use among high school students entering emerging adulthood. Results demonstrate differences among adolescents engaging in opioid use in late adolescence, with opioid use likely indicative of a broader set of substance use and mental health issues.
ADDICTIVE BEHAVIORS
(2021)
Article
Neurosciences
Herminio M. Guajardo, Rita J. Valentino
Summary: The study demonstrates that decreased MOR function in the female rat locus coeruleus results in diminished effects on cortical activity, potentially explaining sex differences in cognitive consequences.
NEUROSCIENCE LETTERS
(2021)
Review
Psychiatry
Joan Devin, Suzi Lyons, Lisa Murphy, Michael O'Sullivan, Ena Lynn
Summary: This study aimed to provide a comprehensive overview of potential factors for death by suicide in people who use drugs (PWUD). It identified 11 potential factors associated with death by suicide in PWUD, including gender, mental health conditions, periods of heightened vulnerability, age profile, drug use (stimulants, cannabis, or new psychoactive substances), specific medical conditions, lack of dual diagnosis service provision, homelessness, incarceration, intravenous drug use, and race or ethnicity. More primary research on suicide and explicit risk factors is needed.
Article
Public, Environmental & Occupational Health
Sharon Reif, Eric A. Lauer, Rachel Sayko Adams, Debra L. Brucker, Grant A. Ritter, Monika Mitra
Summary: The study found that adults with disabilities were more likely to use prescription opioids compared to those without disabilities, but the likelihood of opioid use disorder did not vary by disability status. Pain relief as the reason for last misuse was associated with an increased risk of prescription opioid use disorder.
PREVENTIVE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Joanna Hockenhull, David M. Wood, Francina Fonseca, Marilena Guareschi, Norbert Scherbaum, Janetta L. Iwanicki, Richard C. Dart, Paul Dargan
Summary: This study investigates the prevalence of non-medical use of codeine in Germany, Italy, Spain and the UK, and suggests that the availability of over-the-counter (OTC) codeine may be associated with higher levels of non-medical use.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Kenji Oki, Kohei Kamemura, Akiyo Tanabe, Mitsuhide Naruse
Summary: The study found that female patients with bilateral primary aldosteronism have worse renal outcomes compared to male patients after receiving mineralocorticoid receptor antagonist treatment. Despite similar systolic blood pressure levels between the sexes, women experienced a greater decline in estimated glomerular filtration rate, especially during the late phase of 6 to 60 months post-treatment initiation.
Review
Endocrinology & Metabolism
Sherry A. McKee, Aimee L. McRae-Clark
Summary: The importance of considering sex and gender in medication trials for substance use disorders is highlighted in this review. While sex and gender differences have not been well-considered in addiction medication development research, there are clinically significant differences in response between women and men, particularly in tobacco cessation. Limited representation of women in clinical research samples calls for improved access to sex-stratified data and incorporation of sex and gender into clinical care guidelines.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Pharmacology & Pharmacy
Arthur Robin Williams, Christine M. Mauro, Tianshu Feng, Josef Waples, Silvia S. Martins, Margaret Haney
Summary: This study investigated the interactions between the use of medical cannabis and prescribed controlled substances. The findings suggest that there were minimal changes in opioid and sedative-hypnotic use among patients using medical cannabis for 6 months.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Substance Abuse
Lauren R. Gorfinkel, Malki Stohl, Eliana Greenstein, Efrat Aharonovich, Mark Olfson, Deborah Hasin
Summary: This study assessed the daily association between Cannabis and opioid use in individual adults with and without pain. The findings suggest that the odds of opioid use are approximately doubled on days when Cannabis is used, and this relationship does not differ between people with different levels of pain, indicating that Cannabis is not being used as a substitute for illegal opioids.
Article
Substance Abuse
Jennifer L. L. Stewart, Kaiping Burrows, Chrysantha B. B. Davis, Ricardo A. A. Wilhelm, Breanna A. A. McNaughton, Rayus Kuplicki, Martin P. P. Paulus, Sahib S. S. Khalsa, Evan J. J. White
Summary: This study aimed to investigate sex differences in the relationship between impulsivity and amphetamine use disorder (AMP). The results showed that both male and female amphetamine users exhibited impulsive behavior in the presence of positive and negative mood states and activated right hemisphere regions during inhibitory processing. However, female amphetamine users had difficulties in planning ahead, while male amphetamine users required additional left hemisphere resources during inhibitory processing.
Article
Gerontology
Sadaf Arefi Milani, Linda B. Cottler, Catherine W. Striley
Summary: As the population ages, the prevalence of dementia is expected to increase. However, low research participation rates among older adults have been hindering progress. This study, which utilized data from HealthStreet, a community engagement program, found that older adults generally have a high willingness to participate in research, but individuals with dementia are less likely to participate in studies that require overnight stays.
AGEING INTERNATIONAL
(2023)
Article
Gerontology
Ayodeji A. Otufowora, Catherine W. Striley, Krishna Vaddiparti, Michael J. Scicchitano, Linda B. Cottler
Summary: This study applied the socioecological model to examine the impact of generational cohorts on study enrollment in health research. The findings suggest that Leading-edge Boomers and individuals with higher trust are more likely to be enrolled in health research compared to their counterparts.
JOURNAL OF INTERGENERATIONAL RELATIONSHIPS
(2023)
Article
Immunology
Phuong T. Tran, Patrick J. Antonelli, Almut G. Winterstein
Summary: This study found that otic quinolones may increase the risk of tendon rupture, particularly Achilles tendon rupture. Clinicians should consider this potential risk and provide appropriate counseling to patients. Further evaluation is needed to understand the risk factors and mechanisms of this rare adverse effect.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Substance Abuse
Alyssa M. Falise, Carolin C. Hoeflich, Sara K. Nutley, Catalina Lopez-Quintero, Catherine W. Striley
Summary: This study used latent class analysis to investigate patterns of polysubstance use among kratom users. Three distinct profiles were identified, providing valuable information for screening interventions and policy-making.
AMERICAN JOURNAL ON ADDICTIONS
(2023)
Letter
Public, Environmental & Occupational Health
Thuy N. Thai, Sonja A. Rasmussen, Nicole E. Smolinski, Sabina Nduaguba, Yanmin Zhu, Brian T. Bateman, Krista F. Huybrechts, Sonia Hernandez-Diaz, Almut G. Winterstein
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Carolin C. Hoeflich, Sara Nutley, Catherine W. Striley, Leslie Miller, Michelle B. Riba, Marcia R. Morris
Summary: The prevalence of depression and/or anxiety symptoms among college students has increased, along with the utilization of pharmacological and/or psychotherapy services. Continued surveillance and identification of students at risk for adverse psychiatric health outcomes is necessary, especially during the COVID-19 pandemic.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Joseph J. Palamar, Nicole D. Fitzgerald, David J. Grundy, Joshua C. Black, Jennifer S. Jewell, Linda B. Cottler
Summary: The use of ketamine has become more widespread in recent years, and there has been an increase in poisonings involving ketamine. Co-use of other drugs, particularly opioids or GHB, appears to be a risk factor for more serious adverse effects.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Brian E. Gawronski, Emily J. Cicali, Caitrin W. McDonough, Linda B. Cottler, Julio D. Duarte
Summary: Pharmacogenetic testing has potential in addressing health disparities, particularly in medically underserved patients. This study aimed to assess the perceptions, knowledge, and attitudes regarding pharmacogenetic testing in this population. The findings revealed a strong interest in testing, as well as concerns and potential barriers that need to be addressed during implementation.
FRONTIERS IN GENETICS
(2023)
Article
Health Policy & Services
Rebecca J. Austin-Datta, Piyush Vilas Chaudhari, Ting-Yuan David Cheng, Geraldine Klarenberg, Catherine Woodstock Striley, Linda B. Cottler
Summary: Electronic nicotine delivery systems (ENDS) usage patterns among community members in Florida, USA were examined. The study found an increase in ENDS use from 2014 to 2021, with factors such as tobacco use, demographic determinants, and certain health history/concerns strongly associated with ENDS use.
JOURNAL OF COMMUNITY HEALTH
(2023)
Article
Medicine, General & Internal
Amir Sarayani, William Troy Donahoo, Christian Hampp, Joshua D. Brown, Almut G. Winterstein
Summary: A retrospective cohort study found that the use of phentermine-topiramate was associated with a lower rate of prenatal exposure compared to topiramate or other antiobesity medications. The study also revealed inadequate contraceptive use and pregnancy testing rates among all groups.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Yasser Albogami, Yanmin Zhu, Xi Wang, Almut G. Winterstein
Summary: This study examines the agreement between Medicaid claims data and Birth Certificate records regarding the presence of neonatal critical conditions. The results show poor agreement between the two sources, except for NICU admission.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sabina O. Nduaguba, Nicole E. Smolinski, Thuy N. Thai, Steven T. Bird, Sonja A. Rasmussen, Almut G. Winterstein
Summary: An algorithm was developed to identify stillbirth episodes using national Medicaid claims data from 1999 to 2014. The algorithm had a moderately high positive predictive value, which was further increased by restricting the analysis to inpatient episodes and using diagnostic codes for singleton stillbirths.
Letter
Obstetrics & Gynecology
Almut G. Winterstein, Sonja A. Rasmussen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Almut G. Winterstein, Vera Ehrenstein, Jeffrey S. Brown, Til Stuermer, Meredith Y. Smith
Summary: The acceptance of real-world evidence (RWE) in decision-making has led to a growth in RWE studies on diabetes and other diseases. However, recent retractions have shown the need for improvements in research conduct, peer review, and editorial processes. To enhance RWE study assessments, the authors propose the use of reporting guidelines, availability of study protocols, inclusion of experts, and detailed data information.
Article
Medicine, Research & Experimental
Jeffrey Duong, Scott McIntosh, Jacqueline Attia, J. Lloyd Michener, Linda B. Cottler, Sergio A. Aguilar-Gaxiola
Summary: This study examines attitudes towards diversity, equity, and inclusion (DEI) among members of the CTSA Program and explores the relationship between their roles and their perceived importance of and commitment to improving DEI. It also investigates barriers and priorities related to health equity research, workforce development, CTSA consortium leadership, and clinical trials participation.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Psychology, Clinical
Jonathan A. Schulz, Sean D. Regnier, Tyler G. Erath, Lindsey C. Mullis, Austin Nugent, Gary S. Atwood, Andrea C. Villanti
Summary: People with disabilities have a higher prevalence of smoking, but there is limited knowledge about cessation interventions tailored for them. This study conducted a systematic review and found two promising interventions using mindfulness-based procedures in adults with mild intellectual disability. However, the interventions did not address the unique needs of people with disabilities.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Chengjia Zhao, Jiankang He, Huihui Xu, Jingjing Zhang, Guohua Zhang, Guoliang Yu
Summary: Sleep is important, but staying up late has become a problem, especially among university students. Previous studies have found a connection between sleep procrastination, sleep biorhythms, and problematic smartphone use (PSU). This two-wave study explored the reciprocal relationship between PSU and sleep procrastination, while also considering the moderating role of sleep biorhythms. The results revealed a reciprocal relationship between PSU and sleep procrastination, with sleep biorhythms moderating this relationship.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Liat Orenstein, Angela Chetrit, Ofra Kalter-Leibovici
Summary: Despite the availability of subsidized smoking cessation services in Israel, social disparities in smoking cessation rates persist. Efforts should focus on reaching subpopulations with low cessation rates and using tailored strategies for successful smoking cessation. Prioritizing smoke-free homes and workplaces is also important.
ADDICTIVE BEHAVIORS
(2024)
Review
Psychology, Clinical
Yijing Zhang, Jun Li, Mengmeng Zhang, Bote Ai, Fenglin Jia
Summary: This meta-analytic review provides the first estimation of the overall bidirectional longitudinal associations between loneliness and problematic Internet use (PIU). The study finds a positive relationship from loneliness to PIU, as well as from PIU to loneliness. Additionally, the study reveals that this relationship is stronger in Eastern countries, with more males, more young adults, and in more recent years.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Aslesha Sumbe, Robert Suchting, Baojiang Chen, Anna V. Wilkinson, Bara Bataineh, Stephanie L. Clendennen, Melissa B. Harrell
Summary: The study examined the metacognitive traits of adolescent and young adult e-cigarette users and the ability of the Metacognitions about Smoking Questionnaire (MSQ) to predict past 30-day e-cigarette use frequency. The results showed a correlation between metacognitive factors and e-cigarette use behavior, with different factors having different predictive abilities for e-cigarette use frequency.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Erynn Christensen, Lucy Albertella, Samuel R. Chamberlain, Maja Brydevall, Chao Suo, Jon E. Grant, Murat Yucel, Rico Sze Chun Lee
Summary: This study evaluated the neurocognitive correlates of problem alcohol use and three non-substance-related addictive behaviors using a large community sample. The results showed differential associations between neurocognition and each addictive behavior, highlighting the need for a more nuanced understanding of non-substance addiction.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Sophie G. Coelho, Matthew T. Keough, Sunghwan Yi, Daniel S. Mcgrath, Hyoun S. Kim
Summary: This study examined the effectiveness of self-regulation strategies in reducing harms associated with in-play sports betting. The results showed that setting monetary limits was effective in reducing financial, interpersonal, and health harms. However, setting time limits was found to increase spending and overall harms. These findings support the applicability of select self-regulation strategies from traditional forms of gambling to in-play betting, and highlight the need for further research on responsible gambling strategies.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Jiayu Li, Yuhong Zhou, Yang Liu, Zhixiang Yu, Xuemei Gao
Summary: This longitudinal study used a person-centered approach to differentiate fear of missing out (FoMO) among subgroups of individuals using latent profile analysis (LPA). The results showed significant differences between profiles in terms of social media engagement, social media self-control failure, and problematic social media use, and high trait-FoMO and high state-FoMO may be important risk factors for social media self-control failure and problematic social media use.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Marc L. Steinberg, Rachel L. Rosen, Ollie Ganz, Olivia A. Wackowski, Michelle Jeong, Cristine D. Delnevo
Summary: Although smoking rates have declined, especially among individuals with mental health concerns, effective messaging that emphasizes the benefits of quitting on mental health is still important. This study shows that focusing on the mental health benefits of quitting smoking can increase motivation to quit among individuals with a history of anxiety and/or depression.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Chrystyna D. Kouros, Lauren M. Papp
Summary: This study aimed to examine the associations between trajectories of prescription drug misuse (PDM) problems and college students' mental health and subjective happiness. The findings indicated that PDM problems were related to depressive symptoms, disinhibition, callousness/aggression, and lower levels of subjective happiness. However, these associations were no longer statistically significant when controlling for alcohol and other drug problems.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Benjamin A. Cristol, Stephanie L. Clendennen, Emily T. Hebert, Melissa B. Harrell
Summary: This study compared symptoms of nicotine dependence among young adults who were exclusive past 30-day (P30D) users of electronic nicotine delivery systems (ENDS) versus exclusive P30D cigarette smokers. The results showed that young adults who used ENDS exhibited higher levels of nicotine dependence symptoms compared to cigarette smokers.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Hyoun S. Kim, Nassim Tabri, David C. Hodgins
Summary: This study examines the co-occurring patterns of problem gambling and addiction severity over a five-year period and predicts the factors influencing these patterns. The results suggest that in a non-clinical sample, problem gambling and other addictive behaviors are likely to decrease simultaneously over time, and mental health disorders significantly influence these co-occurring patterns.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Katherine Walukevich-Dienst, Brian H. Calhoun, Scott Graupensperger, Megan E. Patrick, Christine M. Lee
Summary: This study aims to examine the factors associated with morning cannabis use among young adults. It found that social anxiety motives, cannabis use frequency, and gender were key predictors of morning cannabis use.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Derrick S. Lee, Alayna P. Tackett, Christine Naya, Alyssa F. Harlow, Tyler B. Mason
Summary: This study examined the associations between empirically-generated body mass index (BMI) trajectories and the risk of current use of combustible cigarettes and e-cigarettes among adolescents. The findings showed that overweight and obese adolescents were more likely to use combustible cigarettes and e-cigarettes compared to those with normal weight trajectories. Additionally, adolescents with fluctuating BMI trajectories were associated with higher weight control beliefs. These results highlight the importance of considering weight trajectories and weight control beliefs in understanding tobacco product use among adolescents.
ADDICTIVE BEHAVIORS
(2024)
Article
Psychology, Clinical
Cora von Hammerstein, Joel Billieux
Summary: Chemsex refers to the intentional use of substances in sexualized settings among men who have sex with men. It is a growing public health issue with estimated prevalence rates of 3% to 29% in this population. Chemsex poses risks such as HIV and STI exposure, addiction, cardiovascular problems, and mental health issues. However, there is a research gap in this area, and existing theoretical concepts and therapeutic strategies for addictions and risky sexual behaviors may not be applicable to chemsex due to its unique characteristics and impact on stigmatized minorities.
ADDICTIVE BEHAVIORS
(2024)