Article
Chemistry, Applied
Chaoqun You, Like Ning, Hongshuai Wu, Chaobo Huang, Fei Wang
Summary: This study developed a novel biocompatible and pH-responsive nanohydrogel from cellulose nanocrystals and biological molecules, which showed enhanced cell adhesion and reactive oxygen species production, leading to efficient tumor cell killing with high ROS yield and strong cytotoxicity while minimizing side effects. This highlights the great potential of biocompatible natural polysaccharide-based materials for biomedical applications and offers a new strategy for reducing toxicity and side effects in traditional chemotherapy.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Multidisciplinary
Shancheng Yu, Huan Zhang, Shiya Zhang, Mingli Zhong, Haiming Fan
Summary: Ferrite nanoparticles have promising applications in cancer therapy by utilizing their magnetic and catalytic properties to generate highly toxic free radicals for tumor cell killing. The enzymatic activity of ferrite can be enhanced by external energy sources and combined with other nanomaterials to increase the production of reactive oxygen species, leading to more effective cancer treatment.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Kaixin Liao, Boyi Niu, Haibing Dong, Luxuan He, Yixian Zhou, Ying Sun, Dan Yang, Chuanbin Wu, Xin Pan, Guilan Quan
Summary: This study developed a versatile nanomedicine that could effectively treat melanoma by increasing ROS accumulation. The nanomedicine achieved ROS accumulation through mechanisms such as photothermal reaction, glutathione consumption, and mitochondrial dysfunction, leading to oxidative stress and apoptosis of tumor cells. The experimental results demonstrated superior antitumor efficacy and good biosafety of the nanomedicine.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Baojin Ma, Yuta Nishina, Alberto Bianco
Summary: The study designed a multifunctional nanoplatform using reduced graphene oxide and manganese dioxide nanoparticles for efficient photothermal and chemodynamic combined therapies in cancer treatment. The nanoplatform enhanced cancer therapy efficiency by depleting GSH and generating ROS.
Article
Materials Science, Multidisciplinary
C. Lin, Yixia Liang, Mingyan Guo, Phei Er Saw, Xiaoding Xu
Summary: Polyprodrugs, which connect drug molecules to a polymer backbone via stimuli-responsive linkages, have shown promising potential in protecting drugs, increasing drug loading, and releasing drugs in response to specific triggers. This article presents the recent developments in reduction, pH, hypoxia, reactive oxygen species (ROS), enzymes, and light-responsive polyprodrugs. The multi-stimulus triggered multi-functionality of polyprodrugs is discussed, along with strategies to enhance targeting, penetration, and uptake. The existing clinical applications and prospects of polyprodrugs are also proposed.
MATERIALS TODAY ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Dennis Diaz, Xavier Vidal, Anwar Sunna, Andrew Care
Summary: Encapsulins, a class of self-assembling protein nanocompartments, have been re-engineered to serve as nanoreactors for the production of reactive oxygen species (ROS) through light-responsive activation. This light-controlled encapsulin nanoreactor shows potential in triggering photosensitized oxidation reactions in tumor cells, highlighting its utility in photodynamic therapy in biomedicine and biotechnology.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Arjaree Jobdeedamrong, Man Theerasilp, Nutthanit Thumrongsiri, Paweena Dana, Nattika Saengkrit, Daniel Crespy
Summary: In this study, GSH-responsive and self-immolative polyprodrug nanoparticles were prepared for cancer treatment. These nanoparticles showed high drug loading and efficient redox-responsive release, displaying high cytotoxicity against cancer cells and low cytotoxicity against cancer cells treated with GSH scavenger or normal cells.
Article
Chemistry, Analytical
Ying Sun, Qimeng Wu, Quanyou Fu, Hailin Cong, Youqing Shen, Bing Yu, Hao Hu
Summary: Combination chemotherapy is a common strategy to enhance treatment effectiveness and avoid multidrug resistance. Integrating synergistic drugs into a nanocarrier can improve drug stability, targeting, and loading, ensuring that the drugs work together at the intended destination.
Article
Chemistry, Multidisciplinary
Kyung Kwan Lee, Jong-Won Kim, Chang-Soo Lee, Sang Cheon Lee
Summary: Copper(II) arsenite-encapsulated ferritin nanoparticles (CuAS-FNs) were developed as oxidative stress-amplifying anticancer agents. The CuAS-FNs showed pH-dependent release behavior and released arsenite and Cu2+ ions in cancer cells. The released arsenite ions increased the intracellular concentration of hydrogen peroxide (H2O2), while the Cu2+ ions elevated the level of hydroxyl radicals (& BULL;OH) via Fenton-like reaction. The CuAS-FNs effectively suppressed MCF-7 tumors without systemic toxicity, making them a promising nanosystem for cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Sijin Xiang, Zhongxiong Fan, Zichen Ye, Tianbao Zhu, Dao Shi, Shefang Ye, Zhenqing Hou, Xiaolan Chen
Summary: This study developed a PPA nanoamplifier by conjugating ART with PEG-functionalized Pd@Pt nanoplates, which showed specific intratumoral esterase-responsive ART release and enhanced ROS-mediated tumor therapy. The PPA nanoamplifier combined the in situ decomposition of ART's endoperoxide bridges by Fe2+ to superoxide anions and peroxidase-like enzymatic catalysis of endogenous H2O2 by PP to hydroxyl radicals, achieving amplified ROS signals and high-efficiency non-Fenton CDT. Additionally, PPA displayed GSH destruction potential and photoacoustic property for imaging-guided CDT.
Article
Nanoscience & Nanotechnology
Shu Shen, Xuexue Liu, Pingping Jiang, Shifang Bei, Lin Wu, Song Shen
Summary: In this study, reversibly assembled and disassembled micelles were designed for ferroptosis and sonodynamic therapy of cancer. The micelles released reactive oxygen species in the tumor, generating a synergistic antitumor effect.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Junge Zhao, Liping Liu, Liyuan Gu, Zeyu Li, Yilong Li, Zhiguang Wu, Bei Sun, Xijin Wang, Tiedong Sun
Summary: This article reports a glucose oxidase (GOx) and Fe3+-loaded metal organic framework system (GOx@MOF@Fe3+), which achieved combined starvation therapy and chemodynamic therapy through electrolysis. The system released Fe3+ and GOx under electrolysis, improving the effectiveness of chemodynamic therapy. Meanwhile, GOx consumed glucose and oxygen to block nutrients.
MATERIALS TODAY ADVANCES
(2023)
Article
Biochemistry & Molecular Biology
Eva Miglbauer, Oliya S. Abdullaeva, Maciej Gryszel, Eric Daniel Glowacki
Summary: This article presents a concept of an electrochemical device that produces controlled amounts of ROS via a Fenton-like process. The device consists of a cathode and anode, where the cathode reduces dissolved oxygen to hydrogen peroxide, and the anode electrochemically corrodes to yield chromium ions. The interaction between peroxide and chromium forms a highly oxidizing mixture of hydroxyl radicals and hexavalent Cr ions. The device shows promising results in vitro with a cancer cell line, demonstrating its potential for on-demand delivery of ROS.
Article
Chemistry, Multidisciplinary
Hongzhang Deng, Zuo Yang, Xiaoyu Pang, Caiyan Zhao, Jie Tian, Zhongliang Wang, Xiaoyuan Chen
Summary: This study prepared a series of nanoparticles with tunable acid dissociation constant, successfully enhancing the efficacy of CDT in cancer treatment by converting H2O2 into highly toxic hydroxyl radical to kill tumor cells and avoiding clearance by cytoplasmic antioxidants.
Article
Chemistry, Multidisciplinary
Wenhao Wang, Fangqin Fu, Zhengwei Huang, Wenhua Wang, Minglong Chen, Xiao Yue, Jintao Fu, Xiaoqian Feng, Ying Huang, Chuanbin Wu, Xin Pan
Summary: By inhaling the nanoreactor, the drug core enclosed by a biomimetic protein shell can significantly increase drug accumulation in the lungs and enhance the effectiveness of ferroptosis therapy.
Review
Pharmacology & Pharmacy
Sabina Quader, Kazunori Kataoka, Horacio Cabral
Summary: CNS tumors are highly lethal and treatment-resistant, mainly due to the difficulty of delivering drugs to the brain tumor site. Supramolecular nanomedicines show promise in addressing this challenge and improving brain tumor targeting.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Yu Han, Panyue Wen, Junjie Li, Kazunori Kataoka
Summary: Cisplatin is a successful chemotherapy drug, but its resistance and toxicity limit its clinical application. Targeted nanomedicine offers hope for maximizing efficacy and minimizing toxicity. This article reviews the recent progress and challenges in managing cisplatin resistance and toxicity and highlights future directions for development.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Anjaneyulu Dirisala, Satoshi Uchida, Junjie Li, Joachim F. R. Van Guyse, Kotaro Hayashi, Sai V. C. Vummaleti, Sarandeep Kaur, Yuki Mochida, Shigeto Fukushima, Kazunori Kataoka
Summary: This study integrates the protective effect against nucleases and the endosomal escape capability into a single polyplex by fine-tuning the catiomer chemical structure and incorporating the endosomal escape modality for efficient mRNA delivery. The methylene spacer length on the catiomer side chain significantly affects the nuclease stability of the polyplex, and introducing a charge-conversion polymer can improve endosomal escape efficiency by approximately 80-fold in cultured cells. The system synergizes PLO's protective effect against nucleases and CCP's endosomal escape capability, leading to enhanced protein expression efficiency from mRNA delivery.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Jean Felix Mukerabigwi, Rui Tang, Yufei Cao, Fathelrahman Mohammed, Qinghao Zhou, Min Zhou, Zhishen Ge
Summary: Multi-drug resistance (MDR) is a major obstacle in cancer therapy, and overcoming MDR is highly desired. The development of a polyprodrug that can target both cancer cells and mitochondria has shown great potential in reversing MDR. The polyprodrug, named TF@CNM + DOX, was designed using folic acid (FA) and tetraphenylphosphonium (TPP) targeting moieties to sequentially deliver CNM and DOX to cancer cells and mitochondria, respectively. This dual-targeting approach enhances intracellular oxidative stress and enables ROS-responsive drug release, effectively inhibiting the growth of DOX-resistant tumors.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qinghao Zhou, Debabrata Dutta, Yufei Cao, Zhishen Ge
Summary: In this study, polymeric metal-organic framework nanoparticles were used as carriers for the combination of photodynamic therapy and enhanced STING activation, resulting in improved immunotherapeutic efficacy. The nanoparticles showed excellent stability and could release the STING agonist and induce cell apoptosis under light irradiation. The combination of photodynamic-immunotherapy reversed the immunosuppressive tumor microenvironment and enhanced endogenous STING activation, effectively suppressing the growth of primary and distant tumors.
Article
Polymer Science
Kexiang Chen, Chenhui Cui, Zhen Li, Zhe Song, Qiang Zhang, Youshen Wu, Zhishen Ge, Yilong Cheng, Yanfeng Zhang
Summary: Multicomponent polymerization (MCP) is a widely used method to synthesize multifunctional polymers, offering high efficiency, mild reaction conditions, and high yield. In this study, a novel covalent adaptable network (CAN) with dynamic thioaminal covalent bonds was developed through a simple one-pot thiol-aldehyde-amine MCP. The obtained thioaminal CANs showed a tensile strength of up to 45 MPa and exhibited reprocessability, recyclability, and reconfigurable shape memory behaviors. The thiol-aldehyde-amine MCP presents a simple and efficient strategy for preparing versatile thioaminal CANs.
Article
Polymer Science
Yasuhiro Nakagawa, Kotaro Ushidome, Keita Masuda, Kazunori Igarashi, Yu Matsumoto, Tatsuya Yamasoba, Yasutaka Anraku, Madoka Takai, Horacio Cabral
Summary: Multi-arm star-shaped block copolymers consisting of poly(furfuryl glycidol) (PFG) and poly(ethylene glycol) (PEG) were developed for drug delivery. The block copolymers showed controlled sizes and effectively loaded and released model drugs. When injected intravenously, they exhibited prolonged blood circulation, indicating their potential as long-circulating nanocarriers.
Article
Polymer Science
Takayoshi Watanabe, Hayato Laurence Mizuno, Jumpei Norimatsu, Takumi Obara, Horacio Cabral, Kouhei Tsumoto, Makoto Nakakido, Daisuke Kawauchi, Yasutaka Anraku
Summary: This article discusses the use of ligand-installed nanocarriers for enhancing drug delivery in medulloblastoma. The conjugation of anti-CD276 antibodies to the surface of polyion complex micelles improved the cellular uptake efficiency into CD276-expressing medulloblastoma cells. This study demonstrates the potential of anti-CD276 antibody-installed nanocarriers for promoting drug delivery in medulloblastoma.
Article
Polymer Science
Akinori Goto, Yasutaka Anraku, Shigeto Fukushima, Akihiro Kishimura
Summary: Introduces a novel method for preparing enzyme-loaded polyelectrolyte complex vesicles with semi-permeable membranes, which can improve the loading efficiency and enzymatic activity. CD-loaded PICsomes showed prolonged blood circulation and enhanced permeability and retention effect in tumor accumulation. The combination of CD@PICsomes and 5-FC demonstrated superior antitumor activity with reduced adverse effects.
Editorial Material
Chemistry, Multidisciplinary
Warren C. W. Chan, Natalie Artzi, Chunying Chen, Xiaodong Chen, Dean Ho, Tony Hu, Kazunori Kataoka, Luis M. Liz-Marzan, Rahmi Oklu, Wolfgang J. Parak
Review
Pharmacology & Pharmacy
Panyue Wen, Wendong Ke, Anjaneyulu Dirisala, Kazuko Toh, Masaru Tanaka, Junjie Li
Summary: The stealth effect is crucial for enhancing the capabilities of nanomaterials in drug delivery applications. Through analyzing the efficiency and factors involved, we propose an integrated perspective on engineering stealth nanomaterials. The analysis reveals a common pharmacokinetics behavior, known as the pseudo-stealth effect, which leads to a rapid drop in blood concentration despite a relatively long b-phase. We suggest that a holistic approach, considering surface structure and geometry, is essential for improving the stealth effect.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Anum Kayani, Arsalan Raza, Jiale Si, Debabrata Dutta, Qinghao Zhou, Zhishen Ge
Summary: Polymersomes have been extensively studied as nanocarriers for drug delivery for two decades. Although they have many advantages, including high stability and simultaneous encapsulation of hydrophilic and hydrophobic drugs, they often face issues with non-targeted delivery and poor membrane permeability. Recent advancements in surface functionalization and membrane permeability control have addressed these challenges and improved the efficiency of drug delivery using polymersomes. This review provides a detailed overview of the role of polymersome membranes and future developments in promoting them as in vivo drug delivery nanocarriers.
Article
Polymer Science
Zhen Li, Yanxiu Wen, Zhe Song, Chuang Zhang, Chenhui Cui, Dongxu An, Zhishen Ge, Yilong Cheng, Qiang Zhang, Yanfeng Zhang
Summary: The researchers have developed a dynamic cross-linked polyethylene material (PE-MA-Epo) with high dielectric constant and polarization capability, which can fully recover its performance after electrical tree healing. This material demonstrates performance comparable to biaxially oriented polypropylene films and shows great potential for applications in next-generation electrical equipment.
Article
Pharmacology & Pharmacy
Hsi-Kai Tsou, Cheng-Hsin Wu, Long Yi Chan, Kazunori Kataoka, Nanae Itokazu, Minoru Tsuzuki, Hsuan Hu, Guan-Yu Zhuo, Keiji Itaka, Chin-Yu Lin
Summary: Large-area craniofacial defects pose a challenge for orthopaedists. In order to develop a safe and effective tissue engineering strategy, cytokines and chemokines can be utilized to attract endogenous stem cells for bone regeneration. The combination of BMP2 and TGF-beta3 mRNA nanomedicine promotes bone formation and provides an alternative cell-free tissue engineering method for craniofacial defect healing.
Article
Chemistry, Multidisciplinary
Yufei Cao, Jiale Si, Moujiang Zheng, Qinghao Zhou, Zhishen Ge
Summary: Radiotherapy is widely used in the treatment of various cancers and has the advantages of precise controllability and deep tissue penetration. However, it is limited by side effects and tumor hypoxia. The combination of radiotherapy and other modalities can improve therapeutic efficacy and reduce toxicity.
CHEMICAL COMMUNICATIONS
(2023)