期刊
ACS CHEMICAL NEUROSCIENCE
卷 10, 期 5, 页码 2195-2208出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.9b00117
关键词
Cerebral ischemia; mitophagy; inflammasome; neurodegenerative disorder; neuroinflammation
资金
- Department of Science and Technology (DST), Government of India [SB/YS/LS-196/2014]
- International Society for Neurochemistry (ISN)
- Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Government of India
- National Institute of Pharmaceutical Education and Research (NIPER) (Ahmedabad, Gandhinagar, India)
Mitophagy and inflammasomes have a pivotal role in the development of neuropathology. Molecular mechanisms behind mitophagy and inflammasomes are well-understood, but lacunae prevail in understanding the crosstalk between them in various neurological disorders. As mitochondrial dysfunction is the prime event in neurodegeneration, the clearance of impaired mitochondria is one of the main tasks for maintaining cell integrity in the majority of neuropathologies. Along with it, inflammasome activation also plays a major role, which is usually followed by mitochondrial dysfunction. The present review highlights basics of autophagy, mitophagy, and inflammasomes and the molecular mechanisms involved, and more importantly, it tries to elaborate the interplay between mitophagy and inflammasomes in various neurological disorders. This will help in upgrading the reader's understanding in exploring the link between mitophagy and inflammasomes, which has dealt with limitations in past studies.
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