期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 10, 页码 10356-10363出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b18721
关键词
cationic surfactant cetyltrimethylammonium bromide; micelle swelling approach; evaporation induced aggregating assembly
资金
- NSF of China [21673048, 21701153, 21875044]
- Key Basic Research Program of Science and Technology Commission of Shanghai Municipality [17JC1400100]
- Qatar University under GCC Co-Fund Program [GCC-2017-001]
- Youth Top-notch Talent Support Program of China
Magnetic mesoporous silica microspheres with core-shell structure and large pores are highly desired in macromolecules delivery and biocatalysis, biospeparation, and adsorption. In this work, a controllable solvent evaporation induced solution-phase interface co-assembly approach was developed to synthesize core-shell structural magnetic mesoporous silica microspheres with ultralarge mesopore size (denoted as LP-MMS). The synthesis was achieved by employing large-molecular-weight amphiphilic block copolymers poly(ethylene oxide)-block-poly(methyl methacrylate) (PEO-b-PMMA) and small surfactant cetyltrimethylammonium bromide as co-templates, which can co-assemble with silica source in tetrahydrofuran/water solutions. The obtained LP-MMS microspheres possess uniform rasberry-like morphology with a diameter of 600 nm, large primary spherical mesopores (ca. 36 nm), large specific surface area (348 m(2)/g), high specific pore volume (0.59 cm(3)/g), and fast magnetic responsivity with high magnetization (15.9 emu/g). The mesopore morphology can be transformed from spherical to cylindrical through introducing a shearing force during the interfacial co-assembly in the synthesis system. The designed LP-MMS microspheres turn out to be good carriers for enzyme (trypsin) immobilization with a high loading capacity of 80 mu g/mg and demonstrate excellent biocatalysis efficiency up to 99.1% for protein digestion within 30 min and good recycling stability with negligible decay in digestion efficiency after reuse for five times.
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