Article
Chemistry, Multidisciplinary
Han Cong Seow, Jian-Piao Cai, Harry Weijie Pan, Cuiting Luo, Kun Wen, Jianwen Situ, Kun Wang, Hehe Cao, Susan W. S. Leung, Shuofeng Yuan, Jenny K. W. Lam
Summary: Neutralising monoclonal antibody (mAb) is an important weapon against respiratory viral infections, but its effectiveness is hindered by mutant variants. This study developed a dual targeting formulation strategy to deliver a broad-spectrum mAb, WKS13, to both the nasal cavity and lower airways. The aerosol deposition profile of the mixed formulations could be manipulated by adjusting the ratio of two different particle sizes, resulting in effective prophylactic protection against SARS-CoV-2 Delta variant in hamsters. The dual targeting powder formulation of neutralising mAb shows promise for the prophylaxis of respiratory viral infections.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Somayeh Mojtabavi, Maryam Torshabi, Kambiz Gilani, Nasrin Samadi, Mohammad Reza Khoshayand, Mohammad Reza Fazeli, Mohammad Ali Faramarzi
Summary: This study successfully produced an active laccase mouthwash dry powder using spray drying technique and optimized the processing conditions. The laccase mouthwash showed good residual activity and yield, and the native structure of laccase was largely restored upon reconstitution. Furthermore, the laccase mouthwash effectively inhibited the growth of bacteria and exhibited promising tooth whitening effect with lower cytotoxicity compared to chemical mouthwash.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Immunology
Mellissa Gomez, Joseph McCollum, Hui Wang, Shital Bachchhav, Isobel Tetreau, Alana Gerhardt, Chris Press, Ryan M. Kramer, Christopher B. Fox, Reinhard Vehring
Summary: Particle engineering via spray drying was utilized to develop a dry powder format of an adjuvanted tuberculosis vaccine candidate, demonstrating excellent stability and inhalable properties at high temperatures, ensuring the efficacy and effectiveness of the vaccine components.
Article
Pharmacology & Pharmacy
Han Cong Seow, Qiuying Liao, Andy T. Y. Lau, Susan W. S. Leung, Shuofeng Yuan, Jenny K. W. Lam
Summary: This study aimed to develop a dual targeting powder formulation that can simultaneously target the nasal cavity and the lung through a single administration route. Spray freeze drying and spray drying techniques were used to prepare tamibarotene powder formulations, and the powder mixing ratio could be adjusted to modulate the aerosol deposition in the nasal and pulmonary regions. The formulated powder exhibited spherical structures, amorphous characteristics, and improved dissolution profile.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Food Science & Technology
Preethi Jayaprakash, Claire Gaiani, Jean-Maxime Edorh, Frederic Borges, Elodie Beaupeux, Audrey Maudhuit, Stephane Desobry
Summary: This study investigates the benefits and drawbacks of electrostatic spray drying (ESD), a novel technique that uses electrostatic charge and lower temperatures to encapsulate lactic acid bacteria. The study compares the viability of Lacticaseibacillus rhamnosus GG (LGG) using different encapsulation agents and finds that ESD preserves more LGG cells during processing and provides better stability during storage compared to traditional spray drying (SD) and freeze drying (FD).
Review
Food Science & Technology
Yuyan Xu, Mingsheng Dong, Hongmei Xiao, Siew Young Quek, Yukiharu Ogawa, Guangyuan Ma, Chuang Zhang
Summary: Probiotic powders produced by spray drying have advantages of high efficiency, cost-saving, and good powder properties. However, the harsh drying and digestion processes can reduce cell viability, limiting the effectiveness of live cells. Therefore, there is a need to develop targeted delivery systems using spray drying to protect bacteria and maintain their physiological functions. This review highlights recent studies on spray-dried targeted delivery vehicles for probiotics, focusing on strategies to protect bacteria, particle formation mechanism, and the targeted release and colonization of live cells. Further research is needed to improve the functional properties of microcapsules and understand the effects of spray drying on bacterial physiology for industrialization and commercialization.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Rick Heida, Renate Akkerman, Paulo H. Jacob Silva, Anke J. Lakerveld, Daniel Ortiz, Chiara Bigogno, Matteo Gasbarri, Puck B. van Kasteren, Francesco Stellacci, Henderik W. Frijlink, Anke L. W. Huckriede, Wouter L. J. Hinrichs
Summary: Respiratory viruses, including RSV, pose a significant global health burden. Entry inhibitors, such as CD-MUS, have shown promise as antiviral drugs that can prevent infection in the respiratory tract. In this study, CD-MUS was shown to be well tolerated when administered to mice's respiratory tract and retained its activity against RSV after spray drying. This research sets the foundation for future in vivo studies on the efficacy of CD-MUS in animal models of RSV infection.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Hui Wang, Mani Ordoubadi, Patrick Connaughton, Kellisa Lachacz, Nicholas Carrigy, Scott Tavernini, Andrew R. Martin, Warren H. Finlay, David Lechuga-Ballesteros, Reinhard Vehring
Summary: This study developed a new lipid-based particle formulation platform for respiratory drug delivery applications. Rugose lipid particles were successfully produced using a spray drying method, with good manufacturability and promising aerosol performance. The new technique has the potential to produce rugose particles using various other lipids.
PHARMACEUTICAL RESEARCH
(2022)
Article
Food Science & Technology
Shahrzad Nazari Kermanshahi, Anousheh Sharifan, Shima Yousefi
Summary: The study found that using a mixed carrier coating positively influenced the survival of B. coagulans and increased the yield of RJP. Samples with high levels of MD (20%) had lower moisture content and water activity, while solubility was higher. The formulation of 10% MD and 5% PC in the spray drying process demonstrated efficient coating carriers.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2021)
Article
Chemistry, Medicinal
Ashlee D. Brunaugh, Li Ding, Tian Wu, Michael Schneider, Ryan Khalaf, Hugh D. C. Smyth
Summary: Monoclonal antibody-based therapies have the potential to be a valuable treatment modality for acute and chronic lung diseases. Direct delivery to the lungs via inhalation can provide higher drug concentrations at the site of disease with reduced off-target effects. However, there is limited understanding of the impact of particle engineering processes on the stability and performance of dry powder inhaler formulations of monoclonal antibodies.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Engineering, Chemical
Ankit Patil, Pritam Patil, Sagar Pardeshi, Preena Shrimal, Norma Rebello, Popat B. B. Mohite, Aniruddha Chatterjee, Arun Mujumdar, Jitendra Naik
Summary: Drug nanonization and encapsulation efficiency enhancement are crucial for targeted drug delivery. Microfluidic technology is an effective method to achieve these goals by providing intensive mixing and generating uniform nanosized particles. It also enables the development of novel drug delivery systems with controlled size and distribution, reducing batch variation. This comprehensive review discusses the applications of microfluidic systems in synthesizing controlled-sized nanoparticles and recent advancements in micromixers and drug delivery systems. The review also highlights the important role of spray and freeze-drying in nanoparticle production and compares a microreactor-assisted spray and freeze dryer for innovative drug delivery platform development. Additionally, recent patents on microfluidics and drying technologies are critically discussed.
Article
Pharmacology & Pharmacy
Paraskevi Kyriaki Monou, Eleftherios G. Andriotis, Nikolaos Bouropoulos, Emmanuel Panteris, Melpomeni Akrivou, Ioannis S. Vizirianakis, Zeeshan Ahmad, Dimitrios G. Fatouros
Summary: In this study, a multi-component system for pulmonary delivery was developed, including engineered microparticles and investigation of two active pharmaceutical ingredients. All formulations exhibited satisfactory performance and drug release. Physicochemical properties evaluation showed appropriate morphology and aerodynamic performance of the microparticles, with release of the active ingredients monitored in simulated lung fluid.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Engineering, Chemical
Preethi Jayaprakash, Claire Gaiani, Jean-Maxime Edorh, Elodie Beaupeux, Audrey Maudhuit, Stephane Desobry
Summary: In this study, electrostatic spray drying (ESD) was used for the first time to encapsulate beta-galactosidase (beta-gal) and compared with conventional spray drying (SD) and freeze drying (FD) techniques. The results showed that ESD at intermediate temperatures produced microparticles with better characteristics and similar residual enzyme activity to FD in maltodextrin, trehalose, and shellac matrices. Therefore, ESD can be considered as an alternative technique to FD that is efficient, time-saving, and cost-effective.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Biology
Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Cesar Augusto Roque-Borda, Fernando Rogerio Pavan, Andreia Bagliotti Meneguin, Marlus Chorilli, Ana Melero, Antonio Jose Guillot, Caroline Magnani Spagnol, Marcos Antonio Correa
Summary: This study aimed to prepare chitosan biodegradable microparticles containing ascorbic acid and nicotinamide for topical delivery. The microparticles were characterized chemically and their release profile, skin permeation, and retention were evaluated. The results showed that the microparticles successfully delivered the drugs and exhibited antibacterial activity.
Article
Engineering, Chemical
Lorena Pasero, Francesca Susa, Riccardo Chiavarino, Tania Limongi, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano
Summary: Spray freeze-drying is a viable alternative to traditional spray drying for producing therapeutic dry microparticles, particularly suitable for pulmonary drug delivery. This study used ultrasonic spray freeze-drying to generate dry microparticles composed of mannitol or a combination of mannitol and salbutamol sulphate. The particle size, morphology, surface area, porosity, and crystallinity were influenced by solid concentration and feed flow rate. The aerodynamic properties for drug deposition were found to depend on solid concentration and feed flow rate.
Article
Pharmacology & Pharmacy
Behnaz Daneshmand, Homa Faghihi, Maryam Amini Pouya, Shabnam Aghababaie, Majid Darabi, Alireza Vatanara
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Yasaman Mirfakhraei, Homa Faghihi, Amir Hossein Mohammad Zade, Majid Darabi, Alireza Vatanara
Article
Medicine, Research & Experimental
Fakhrossadat Emami, Asmita Banstola, Alireza Vatanara, Sooyeon Lee, Jong Oh Kim, Jee-Heon Jeong, Simmyung Yook
MOLECULAR PHARMACEUTICS
(2019)
Article
Chemistry, Medicinal
Shahriar Milani, Homa Faghihi, Abdolhosein Roulholamini Najafabadi, Mohsen Amini, Hamed Montazeri, Alireza Vatanara
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2020)
Article
Pharmacology & Pharmacy
Mojgan Allahyari, Reyhaneh Mohabati, Alireza Vatanara, Majid Golkar
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Oncology
Zahra Nasiri, Hamed Montazeri, Neda Akbari, Seyedeh Sara Mirfazli, Parastoo Tarighi
Summary: The study suggests that supernatant of Local Probiotic Lactobacillus Brevis can induce apoptosis in breast cancer cells and enhance the inhibitory effect of Tamoxifen, potentially serving as an adjuvant therapy in cancer treatment and prevention.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Samane Eftekhari, Hamed Montazeri, Parastoo Tarighi
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Oncology
Seyed Sadegh Eslami, Davod Jafari, Hamed Montazeri, Majid Sadeghizadeh, Parastoo Tarighi
Summary: The combined effect of curcumin and metformin on LNCaP prostate cancer cells significantly reduced cell viability within 48 hours and exhibited a synergistic effect. This combination induced apoptosis and maximum cytotoxicity, suggesting its potential as a therapeutic candidate for further investigation in prostate cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Chemistry, Medicinal
Mahdiyeh H. S. Javadi, Aida Iraji, Maliheh Safavi, Hamed Montazeri, Parastoo Tarighi, Samane Eftekhari, Latifeh Navidpour, Seyedeh Sara Mirfazli
Summary: Research focused on designing novel steroid sulfatase inhibitors through structure-based optimization, which showed significant cytotoxicity against breast cancer cell line MCF-7 via apoptosis. Molecular docking studies clarified the inhibition mode of the most promising compound, highlighting hydrogen bond interaction and hydrophobic interactions as significant descriptors for rationalizing the potential inhibition activity.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Review
Chemistry, Medicinal
Leila Janani, Hadi Bamehr, Kiarash Tanha, Parastoo Mirzabeigi, Hamed Montazeri, Parastoo Tarighi
Summary: Sitagliptin, either alone or in combination with metformin, can reduce body weight and body mass index in overweight or obese patients with type 2 diabetes, especially when taken for more than 6 months.
Review
Pharmacology & Pharmacy
Maryam Eini, Nahid Zainodini, Hamed Montazeri, Parastoo Mirzabeigi, Parastoo Tarighi
Summary: Monoclonal antibodies have been found to be useful in treating various diseases, with researchers achieving remarkable success by developing different types of monoclonal antibodies, especially in the field of breast cancer. Focus has been placed on recent PD-L1 or PD-1 inhibitor antibodies for breast cancer and beyond.
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Amir Shadboorestan, Parastoo Tarighi, Mahsa Koosha, Homa Faghihi, Mohammad Hossein Ghahremani, Hamed Montazeri
Summary: Liraglutide may stimulate the growth of MDA-MB-231 breast cancer cells and potentially lead to drug resistance and epithelial-mesenchymal transition. Caution should be exercised when using liraglutide in patients with a history of triple negative breast cancer.
Article
Pharmacology & Pharmacy
Vahideh Montazeri, Mohammad Hossein Ghahremani, Hamed Montazeri, Mandana Hasanzad, Majid Safavi, Mohsen Ayati, Mohammad Chehrazi, Baharak Arefi Moghaddam, Seyed Nasser Ostad
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Mohammad Reza Sepand, Mahdi Ghavami, Steven Zanganeh, Sabrina Stacks, Forough Ghasemi, Hamed Montazeri, Claudia Corbo, Hossein Derakhshankhah, Seyed Nasser Ostad, Mohammad Hossein Ghahremani, Morteza Mahmoudi
