Article
Gastroenterology & Hepatology
Gabriele Bislenghi, Julie Van Den Bossch, Steffen Fieuws, Albert Wolthuis, Marc Ferrante, Gert de Hertogh, Severine Vermeire, Andre D'Hoore
Summary: The macroscopic appearance of the bowel and associated mesentery during surgery does not appear to be predictive of postoperative recurrence after ileocecal resection for Crohn's disease. Prospective studies investigating risk factors for Crohn's disease recurrence after surgery are scarce.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Salam P. Bachour, Ravi Shah, Florian Rieder, Taha Qazi, Jean Paul Achkar, Jessica Philpott, Bret Lashner, Stefan D. Holubar, Amy L. Lightner, Edward L. Barnes, Jordan Axelrad, Miguel Regueiro, Benjamin Click, Benjamin L. Cohen
Summary: Immediate postoperative intra-abdominal septic complications (IASC) increase the risk of endoscopic and surgical recurrence in patients with Crohn's disease. Preoperative optimization to prevent IASC, along with postoperative biological prophylaxis, may help reduce the risk of endoscopic and surgical recurrence.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Matthias Kelm, Friedrich Anger, Robin Eichlinger, Markus Brand, Mia Kim, Joachim Reibetanz, Katica Krajinovic, Christoph-Thomas Germer, Nicolas Schlegel, Sven Flemming
Summary: For patients with limited Crohn's Disease, early surgery is safe and effective, resulting in a lower need for immunosuppressive medication during the postoperative follow-up compared to patients who initially receive medical treatment before surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Terry Li, Salam P. Bachour, Takahiro Nakamura, Ravi Shah, Michael C. Sachs, Shannon Chang, David P. Hudesman, Stefan D. Holubar, Amy L. Lightner, Edward L. Barnes, Benjamin L. Cohen, Florian Rieder, Eren Esen, Feza Remzi, Miguel Regueiro, Benjamin Click
Summary: Postoperative recurrence of Crohn's disease is common after ileocecal resection. This dual-center study found that early initiation of an anti-TNF agent within 4 weeks following the surgery can reduce the risk of postoperative recurrence.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jeanine H. C. Arkenbosch, Joyce W. Y. Mak, Jacky C. L. Ho, Evelien M. J. Beelen, Nicole S. Erler, Frank Hoentjen, Alexander G. L. Bodelier, Gerard Dijkstra, Marielle Romberg-Camps, Nanne K. H. de Boer, Laurents P. S. Stassen, Andrea E. van der Meulen, Rachel West, Oddeke van Ruler, Christien Janneke van der Woude, Siew C. Ng, Annemarie C. de Vries
Summary: This study compares the indications, postoperative management, and long-term prognosis of patients with ileocecal resection (ICR) for Crohn's disease (CD) in Hong Kong and the Netherlands. The study finds that there are differences in the main indications and postoperative management between the two regions, but the long-term prognosis after ICR is similar.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Caroline Valibouze, Silvia Speca, Caroline Dubuquoy, Florian Mourey, Lena M'Ba, Lucil Schneider, Marie Titecat, Benoit Foligne, Michael Genin, Christel Neut, Philippe Zerbib, Pierre Desreumaux
Summary: In an HLA-B27 transgenic rat model, CNCM I-3856 was found to effectively prevent postoperative recurrence (POR) induced by LF82, reducing infection and gut inflammation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Henit Yanai, Anna Kagramanova, Oleg Knyazev, Joao Sabino, Shana Haenen, Gerassimos J. Mantzaris, Katerina Mountaki, Alessandro Armuzzi, Daniela Pugliese, Federica Furfaro, Gionata Fiorino, David Drobne, Tina Kurent, Sharif Yassin, Nitsan Maharshak, Fabiana Castiglione, Roberto de Sire, Olga Maria Nardone, Klaudia Farkas, Tamas Molnar, Zeljko Krznaric, Marko Brinar, Elena Chashkova, Moran Livne Margolin, Uri Kopylov, Cristina Bezzio, Ariella Bar-Gil Shitrit, Milan Lukas, Maria Chaparro, Marie Truyens, Stephane Nancey, Triana Lobaton, Javier P. Gisbert, Simone Saibeni, Peter Bacsur, Peter Bossuyt, Julien Schulberg, Frank Hoentjen, Chiara Vigano, Andrea Palermo, Joana Torres, Joana Reves, Konstantinos Karmiris, Magdalini Velegraki, Edoardo Savarino, Panagiotis Markopoulos, Eftychia Tsironi, Pierre Ellul, Cristina Calvino Suarez, Roni Weisshof, Dana Ben-Hur, Timna Naftali, Carl Eriksson, Ioannis E. Koutroubakis, Kalliopi Foteinogiannopoulou, Jimmy K. Limdi, Eleanor Liu, Gerard Suris, Emma Calabrese, Francesca Zorzi, Rafal Filip, Davide Giuseppe Ribaldone, Yifat Snir, Idan Goren, Hagar Banai-Eran, Yelena Broytman, Hadar Amir Barak, Irit Avni-Biron, Jacob E. Ollech, Iris Dotan, Maya Aharoni Golan
Summary: This study aimed to evaluate the effectiveness of early prophylaxis with biologics in preventing endoscopic-post-operative-recurrence (ePOR) in Crohn's disease (CD) after ileocecal resection (ICR). The study compared the effectiveness of anti-tumour necrosis factor (anti-TNF) therapy with vedolizumab (VDZ) and ustekinumab (UST). The results showed that 60% of patients successfully prevented ePOR within 1 year after surgery. Patients treated with VDZ or UST were more difficult to treat. After controlling for confounders, there were no differences in ePOR risk between anti-TNF prophylaxis and other treatment groups.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Lieven Pouillon, Thomas Remen, Caroline Amicone, Edouard Louis, Sielte Maes, Catherine Reenaers, Adeline Germain, Cedric Baumann, Peter Bossuyt, Laurent Peyrin-Biroulet
Summary: This study retrospectively examined late recurrence in CD patients after ileocecal resection, finding that 40.7% of patients experienced late post-operative recurrence after a median follow-up of 3.5 years. There was no significant correlation between prophylactic therapy, Rutgeerts scores, and late recurrence.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Jurij Hanzel, David Drobne
Summary: Surgery remains an important treatment modality in the management of Crohn's disease. Recent advances in postoperative CD management include refined endoscopic scoring indices and noninvasive monitoring methods.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Christian Schineis, Andrea Ullrich, Kai S. Lehmann, Christoph Holmer, Johannes C. Lauscher, Benjamin Weixler, Martin E. Kreis, Claudia Seifarth
Summary: Crohn's disease patients undergoing ileocecal resection commonly have microscopic inflammation at the resection margins, but histologically inflamed margins do not seem to affect the rate of anastomotic leakages. No extensive resections or frozen sections appear to be necessary to achieve inflammation-free resection margins.
Review
Gastroenterology & Hepatology
Linnea Samso Udholm, Simon Ladefoged Rasmussen, Thyge K. Madsboll, Mohammed Omairi, Alaa El-Hussuna
Summary: Urgent bowel resection in patients with Crohn's disease is associated with a higher risk of overall postoperative complications and intraabdominal septic complications. Most studies included in the review had a high risk of bias.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Medicine, General & Internal
Nicolas Avellaneda, Tora Haug, Mai-Britt Worm Orntoft, Sanne Harslof, Lars Peter Skovgaard Larsen, Anders Tottrup
Summary: Early surgical treatment could be an alternative to biological therapy for patients with ileocecal Crohn's disease. The study compares outcomes of ileocecal resection for luminal and complicated CD, finding that surgical procedures were longer and had lower laparoscopic approach rates for the complicated CD group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
N. Horesh, M. R. Freund, Z. Garoufalia, R. Gefen, D. Zhang, T. Smith, S. H. Emile, S. D. Wexner
Summary: The study aimed to assess the effect of preoperative biologic therapy on the surgical outcome of Crohn's disease patients undergoing repeat ileocolic resection. The results showed that patients treated with biologic therapy had fewer postoperative complications compared to the control group.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Review
Surgery
Ian S. Reynolds, Katie L. Doogan, Eanna J. Ryan, Daniel Hechtl, Frederik P. Lecot, Shobhit Arya, Sean T. Martin
Summary: Postoperative recurrence after ileocaecal resection for fibrostenotic terminal ileal Crohn's disease is a significant concern, with novel surgical techniques showing promise in reducing recurrence rates. Some techniques have demonstrated significant benefits for patients and have the potential to become standard practice, while others are still under investigation. Surgeons are likely to play a major role in reducing recurrence rates for Crohn's disease patients undergoing ileocaecal resection.
FRONTIERS IN SURGERY
(2021)
Article
Gastroenterology & Hepatology
Yi-Bo Wang, Guang-Hao Jiang, Zhen Zhang, Li-Ying Cui, Su-Ting Liu, Wen-Hao Zhang, Jian-Feng Gong, Ming Duan, Yi-Li, Qing Ji
Summary: This study aimed to identify the risk factors and develop a nomogram for predicting postoperative ileus (PPOI) in patients with Crohn's disease (CD) who underwent partial intestinal resection. The results showed that disease duration, operation time, lowest mean arterial pressure, fluid balance, postoperative infusion, lowest potassium concentration, and procalcitonin level were independent risk factors for PPOI in CD patients. The nomogram based on these risk factors had good discriminative ability and clinical effectiveness.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Jean-Francois Rahier, Julien Kirchgesner, Vered Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Karmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamas Molnar, Mark Lowenberg, Jonas Halfvarson, Edyta Zagorowicz, Helene Rousseau, Cedric Baumann, Filip Baert, Laurent Beaugerie
Summary: The I-CARE study aims to evaluate the benefit-risk ratio of current therapies in IBD patients. It collected data from 10,206 patients and observed the treatment risks of anti-tumor necrosis factor and other biologic therapies, particularly the risks of cancer/lymphoma and serious infections. The results showed that different treatment regimens had varying effects on patients, and further research is needed to assess specific risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Camille Danne, Chloe Michaudel, Jurate Skerniskyte, Julien Planchais, Aurelie Magniez, Allison Agus, Marie-Laure Michel, Bruno Lamas, Gregory Da Costa, Madeleine Spatz, Cyriane Oeuvray, Chloe Galbert, Maxime Poirier, Yazhou Wang, Alexia Lapiere, Nathalie Rolhion, Tatiana Ledent, Cedric Pionneau, Solenne Chardonnet, Floriant Bellvert, Edern Cahoreau, Amandine Rocher, Rafael Rose Arguello, Carole Peyssonnaux, Sabine Louis, Mathias L. Richard, Philippe Langella, Jamel El-Benna, Benoit Marteyn, Harry Sokol
Summary: Inflammatory bowel disease (IBD) is caused by a combination of genetic predisposition, gut microbiota dysbiosis, and environmental factors. Caspase recruitment domain 9 (Card9) is an IBD susceptibility gene that has been shown to protect against intestinal inflammation and fungal infection. However, the specific cell types and mechanisms involved in the CARD9 protective role against inflammation are still unknown.
Article
Gastroenterology & Hepatology
Chloe Michaudel, Camille Danne, Allison Agus, Aurelie Magniez, Anne Aucouturier, Madeleine Spatz, Antoine Lefevre, Julien Kirchgesner, Nathalie Rolhion, Yazhou Wang, Aonghus Lavelle, Chloe Galbert, Gregory Da Costa, Maxime Poirier, Alexia Lapiere, Julien Planchais, Petr Nadvornik, Peter Illes, Cyriane Oeuvray, Laura Creusot, Marie-Laure Michel, Nicolas Benech, Anne Bourrier, Isabelle Nion-Larmurier, Cecilia Landman, Mathias L. Richard, Patrick Emond, Philippe Seksik, Laurent Beaugerie, Rafael Rose Arguello, David Moulin, Sridhar Mani, Zdenek Dvorak, Luis G. Bermudez-Humaran, Philippe Langella, Harry Sokol
Summary: This study identified a new mechanism linking tryptophan metabolism to intestinal inflammation and inflammatory bowel diseases (IBDs). Bringing back xanthurenic acid (XANA) and kynurenic acid (KYNA) has protective effects involving Aryl hydrocarbon Receptor (AhR) activation and the rewiring of cellular energy metabolism in intestinal epithelial cells and CD4(+) T cells. Manipulating the endogenous metabolic pathway with aminoadipate aminotransferase (AADAT) may provide new therapeutic strategies for correcting tryptophan metabolism alterations in IBD.
Article
Gastroenterology & Hepatology
Anthony Buisson, Maria Nachury, Thomas Guilmoteau, Romain Altwegg, Xavier Treton, Mathurin Fumery, Melanie Serrero, Eloise Leclerc, Ludovic Caillo, Bruno Pereira, Aurelien Amiot, Guillaume Bouguen
Summary: This multicenter study compared the effectiveness of tofacitinib and vedolizumab in patients with ulcerative colitis. The results showed that tofacitinib had better clinical remission and endoscopic improvement, especially in severe disease and primary failure to biologics.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Anthony Buisson, Maria Nachury, Mathurin Fumery
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Catherine Robbe Masselot, Camille Cordier, Benjamin Marsac, Maria Nachury, Renaud Leonard, Boualem Sendid
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Multidisciplinary Sciences
Katherine M. Kennedy, Marcus C. de Goffau, Maria Elisa Perez-Munoz, Marie-Claire Arrieta, Fredrik Backhed, Peer Bork, Thorsten Braun, Frederic D. Bushman, Joel Dore, Willem M. de Vos, Ashlee M. Earl, Jonathan A. Eisen, Michal A. Elovitz, Stephanie C. Ganal-Vonarburg, Michael G. Ganzle, Wendy S. Garrett, Lindsay J. Hall, Mathias W. Hornef, Curtis Huttenhower, Liza Konnikova, Sarah Lebeer, Andrew J. Macpherson, Ruth C. Massey, Alice Carolyn McHardy, Omry Koren, Trevor D. Lawley, Ruth E. Ley, Liam O'Mahony, Paul W. O'Toole, Eric G. Pamer, Julian Parkhill, Jeroen Raes, Thomas Rattei, Anne Salonen, Eran Segal, Nicola Segata, Fergus Shanahan, Deborah M. Sloboda, Gordon C. S. Smith, Harry Sokol, Tim D. Spector, Michael G. Surette, Gerald W. Tannock, Alan W. Walker, Moran Yassour, Jens Walter
Summary: The colonization of microbial communities in the human fetus and the prenatal intrauterine environment is still controversial. Recent studies analyzing microbial populations in human fetuses indicate that the detected signals might be due to contamination during sample collection or DNA sequencing processes. The presence of live and replicating microbial populations in healthy fetal tissues contradicts fundamental concepts in immunology and clinical microbiology. This has significant implications for our understanding of human immune development and highlights the challenges in studying microbial communities in low-biomass environments.
Article
Substance Abuse
Tetsuya Kouno, Suling Zeng, Yanhan Wang, Yi Duan, Sonja Lang, Bei Gao, Phillipp Hartmann, Noemi Cabre, Cristina Llorente, Chloe Galbert, Patrick Emond, Harry Sokol, Michael James, Chun Cheih Chao, Jian-Rong Gao, Mylene Perreault, David L. Hava, Bernd Schnabl
Summary: This study demonstrates that engineering gut bacteria to produce tryptophan metabolites can alleviate liver disease caused by alcohol through Ahr activation in intestinal immune cells.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Article
Geriatrics & Gerontology
Adeline Dolly, Sarah A. Potgens, Morgane M. Thibaut, Audrey M. Neyrinck, Gabriela S. de Castro, Chloe Galbert, Camille Lefevre, Elisabeth Wyart, Silvio P. Gomes, Daniela C. Goncalves, Nicolas Lanthier, Pamela Baldin, Joshua R. Huot, Andrea Bonetto, Marilia Seelaender, Nathalie M. Delzenne, Harry Sokol, Laure B. Bindels
Summary: This study explores the potential role of the aryl hydrocarbon receptor (AHR) in cancer cachexia and finds that impaired AHR signaling contributes to hepatic inflammatory and metabolic disorders, exacerbating cachectic features. These findings provide innovative therapeutic strategies for cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Immunology
Leslie Landemaine, Gregory Da Costa, Elsa Fissier, Carine Francis, Stanislas Morand, Jonathan Verbeke, Marie-Laure Michel, Romain Briandet, Harry Sokol, Audrey Gueniche, Dominique Bernard, Jean-Marc Chatel, Luc Aguilar, Philippe Langella, Cecile Clavaud, Mathias L. Richard
Summary: This study demonstrates that Staphylococcus epidermidis strains originating from healthy skin and atopic skin have different effects. Strains from atopic skin alter the structure of a 3D reconstructed skin model, while strains from healthy skin do not. The metabolites produced by strains from healthy skin can activate the aryl hydrocarbon receptor pathway, while strains from atopic skin cannot.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Madeleine Spatz, Gregory Da Costa, Rebecka Ventin-Holmberg, Julien Planchais, Chloe Michaudel, Yazhou Wang, Camille Danne, Alexia Lapiere, Marie-Laure Michel, Kaija-Leena Kolho, Philippe Langella, Harry Sokol, Mathias L. Richard
Summary: This study investigated the effects of antibiotic treatment on the fungal microbiota in the gut. It was found that amoxicillin-clavulanic acid treatment led to a decrease in the overall fungal population in mouse feces and a remodeling of the fungal community. Certain bacterial strains were shown to inhibit fungal growth. This study provides new insights into the interactions between fungi and bacteria in the gut and may offer new strategies for modulating gut microbiota equilibrium.
Article
Medicine, General & Internal
Xavier Roblin, Gerard Duru, Konstantinos Papamichael, Adam S. Cheifetz, Sandy Kwiatek, Anne-Emmanuelle Berger, Mathilde Barrau, Louis Waeckel, Stephane Nancey, Stephane Paul
Summary: Monitoring of anti-drug antibodies in patients on ustekinumab is not recommended due to low immunogenicity. This study aimed to investigate the relationship between anti-drug antibodies and loss of response to ustekinumab in patients with IBD. The results showed that ATU was an independent predictor of LOR to ustekinumab in IBD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Nicolas Benech, Harry Sokol
CURRENT OPINION IN MICROBIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Stephane Nancey, Mathurin Fumery, Mathias Faure, Gilles Boschetti, Claire Gay, Laurent Milot, Xavier Roblin
Summary: Cross-sectional magnetic resonance enterography (MRE) and intestinal ultrasonography (IUS) are valuable and noninvasive imaging modalities for the assessment, monitoring, and prediction of disease activity and outcomes in inflammatory bowel disease (IBD) patients. However, the underutilization of IUS in clinical practice is due to the lack of validated indices and trained gastroenterologists and radiologists. Nevertheless, the increasing evidence highlights the importance of both IUS and MRE in aiding clinical decision-making.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)