Review
Pharmacology & Pharmacy
Esther Colomier, Joost Algera, Chloe Melchior
Summary: Irritable bowel syndrome is a common disorder affecting the gut-brain axis, with four subtypes and a focus on pharmacological treatment for patients with IBS-D. The treatment remains challenging due to the heterogeneous patient population, lack of effective drugs, and multifactorial pathophysiology. Healthcare professionals can use a proposed algorithm for treating individual patients with IBS-D.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Jonathan P. P. Jacobs, Venu Lagishetty, Megan C. C. Hauer, Jennifer S. S. Labus, Tien S. S. Dong, Ryan Toma, Momchilo Vuyisich, Bruce D. D. Naliboff, Jeffrey M. M. Lackner, Arpana Gupta, Kirsten Tillisch, Emeran A. A. Mayer
Summary: This study used multi-omics assessment methods to explore the changes in gut microbiome function in irritable bowel syndrome (IBS), and identified new microbial biomarkers. The findings support the application of integrated assessment of microbial function in IBS research, and contribute to the discovery of novel microbiome-related therapeutic targets.
Article
Biochemistry & Molecular Biology
Sholpan Omarova, Karem Awad, Verena Moos, Christoph Puening, Greta Goelz, Jorg-Dieter Schulzke, Roland Buecker
Summary: This study observed patients with persistent PI-IBS symptoms after C. jejuni infection and found that the epithelial resistance of the colon epithelium was unaltered, but the permeability of HRP increased and some inflammation-related markers were elevated. Therefore, targeting these mechanisms caused by the infection may help reduce sequelae such as PI-IBS.
Article
Nutrition & Dietetics
Glareh Koochakpoor, Asma Salari-Moghaddam, Ammar Hassanzadeh Keshteli, Ahmad Esmaillzadeh, Peyman Adibi
Summary: The study found a positive association between coffee and caffeine intake and the odds of IBS in the adult population, especially among women and overweight or obese individuals with a BMI >= 25 kg/m(2). Additionally, there was a significant relationship between caffeine intake and the severity of IBS symptoms among overweight or obese subjects (BMI >= 25 kg/m(2)).
FRONTIERS IN NUTRITION
(2021)
Article
Health Care Sciences & Services
Zahra A. Barandouzi, Joochul Lee, Kendra Maas, Angela R. Starkweather, Xiaomei S. Cong
Summary: The study compared food components and gut microbiota patterns between IBS patients and healthy controls, finding higher alpha diversity indices and altered gut microbiota in IBS patients. High microbial diversity and alterations in gut microbiota composition were observed in IBS individuals with high caffeine consumption, suggesting a potential link between caffeine intake and gut microbiome patterns.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Karolina S. Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Asa Johansson, Hans Tornblom, Magnus Simren, Gunnar C. Hansson
Summary: The study found potentially pathogenic Brachyspira species in a subset of patients with IBS, with a significantly higher prevalence of Brachyspira colonization in IBS patients compared to healthy volunteers, especially in IBS-D patients. Brachyspira colonization was associated with accelerated oro-anal transit, mild mucosal inflammation, mast cell activation, and alterations of molecular pathways linked to bacterial uptake and ion-fluid homeostasis.
Article
Gastroenterology & Hepatology
Wenjuan Fan, Xiucai Fang, Guijun Fei, Xiaoqing Li, Hongzhi Guan
Summary: This study tested anti-neuronal antibodies in the sera of IBS patients and found that these antibodies mainly targeted enteric neurons and a small part of cerebral neurons. ACNA was closely associated with headache and sleeping disorder, but unrelated to intestinal symptoms, depression, or anxiety of IBS patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Medicine, General & Internal
Alexandra Aupetit, Sebastien Grigioni, Horace Roman, Moise Coeffier, Amelie Breant, Clotilde Hennetier, Najate Achamrah
Summary: This study found a significant association between irritable bowel syndrome (IBS), eating disorders (ED), and endometriosis. The prevalence of IBS and ED in patients with endometriosis was higher than in the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yu-Tung Lai, Chung-Yu Chen, Ming-Jong Bair
Summary: The study revealed a decreasing trend in the incidence and prevalence of IBS in Taiwan from 2012 to 2018, with over 70% of patients receiving treatment and antispasmodics being the most commonly prescribed medication. However, only 48.58% of patients returned for a follow-up visit within 1 year of IBS diagnosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Chiara Ricci, Fernando Rizzello, Maria Chiara Valerii, Enzo Spisni, Paolo Gionchetti, Silvia Turroni, Marco Candela, Federica D'Amico, Renato Spigarelli, Irene Bellocchio, Giovanni Marasco, Giovanni Barbara
Summary: Geraniol, an acyclic monoterpene alcohol, has demonstrated anti-inflammatory and antimicrobial properties and positive effects on gut microbiota in IBS patients. In this study, IBS patients treated with a low-absorbable geraniol food supplement (LAGS) showed a significant reduction in IBS symptoms severity score compared to placebo. Geraniol administration also resulted in changes in gut microbiota composition, with a decrease in Oscillospira and an increase in Faecalibacterium. The findings suggest that LAGS is effective in treating overall IBS symptoms and improving gut microbiota profile, particularly in the IBS mixed subtype.
Review
Gastroenterology & Hepatology
Schin Bek, Yao Neng Teo, Xin-Hui Tan, Kristie H. R. Fan, Kewin Tien Ho Siah
Summary: Patients with irritable bowel syndrome (IBS) are at risk of developing micronutrient deficiencies, especially in vitamin B1, B2, calcium, iron, and zinc, due to exclusion diets. Dietary management of IBS patients should include a dietitian review to ensure nutritional adequacy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Tai Zhang, Xiangxue Ma, Wende Tian, Jiaqi Zhang, Yuchen Wei, Beihua Zhang, Fengyun Wang, Xudong Tang
Summary: Through bibliometric analysis, a study of literature on irritable bowel syndrome (IBS) between 2007 and 2022 was conducted. The United States and Mayo Clinic were found to have the most publications in this field, and researcher MAGNUS SIMREN emerged as the most active and impactful scholar. Key research topics include chromogranin A, rat model, peptide YY, gut microbiota, and low-FODMAP diet.
FRONTIERS IN MEDICINE
(2022)
Article
Medical Laboratory Technology
Erika Fabiola Lopez-Villalobos, Jose Francisco Munoz-Valle, Claudia Azucena Palafox-Sanchez, Samuel Garcia-Arellano, Diana Emilia Martinez-Fernandez, Gerardo Orozco-Barocio, Jose Antonio Garcia-Espinoza, Edith Oregon-Romero
Summary: Primary Sjogren's syndrome (pSS) patients exhibit heterogenic clinical and serological characteristics possibly influenced by the cytokine microenvironment. By analyzing a cluster of cytokines, researchers identified three distinct groups with varying severity levels, indicating the potential for subclassifying pSS patients based on cytokine levels and clinical parameters for personalized treatment strategies.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Multidisciplinary Sciences
A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: Alterations in the gut mycobiome were found to be significantly different between patients with Irritable Bowel Syndrome (IBS) and control subjects, but not among clinical subtypes of IBS. The mycobiome changes were significantly associated with alterations in the bacteriome and metabolome, but did not show a link with dietary habits. Despite co-variation with bacterial components, the mycobiome presents limited therapeutic and diagnostic potential for IBS.
SCIENTIFIC REPORTS
(2021)