Article
Nutrition & Dietetics
Karolina Sledzinska, Piotr Landowski, Michal A. Zmijewski, Barbara Kaminska, Konrad Kowalski, Anna Liberek
Summary: The study showed that IBD children have higher levels of vitamin D compared to controls, but a significant portion still lack optimal vitamin D levels. Despite the higher level of vitamin D, IBD children had lower calcium levels compared to healthy controls, with no correlation to disease activity or location of lesions in the gastrointestinal tract.
Review
Pediatrics
Yan-hong Sun, Dan-dan Tian, Jian-ming Zhou, Qing Ye
Summary: This study aims to calculate the relationship between pediatric inflammatory bowel disease (IBD) and vitamin D. Results from comprehensive literature search and data extraction indicate that there is no obvious relationship between pediatric IBD and vitamin D, while vitamin D supplementation can improve disease activity. Therefore, further prospective studies are needed to confirm the relationship between pediatric IBD and vitamin D.
FRONTIERS IN PEDIATRICS
(2023)
Review
Nutrition & Dietetics
Somaye Fatahi, Naseem Alyahyawi, Naryman Albadawi, Farzaneh Mardali, Naghi Dara, Mohammad Hassan Sohouli, Kousalya Prabahar, Pejman Rohani, Nazanin Koushki, Aliakbar Sayyari, Amir Hossein Hosseini, Ahmed Abu-Zaid
Summary: This systematic review confirmed the association between vitamin D deficiency and IBD. Although there are conflicting results, the study found that vitamin D deficiency is very common among children with IBD.
FRONTIERS IN NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Cristiano Pagnini, Maria Carla Di Paolo, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: Inflammatory bowel diseases (IBD) are chronic conditions with unknown etiology and immunomediated pathogenesis. Research on the intestinal microbiome and the vitamin D/VDR pathway have shown promising potential for novel approaches to diagnosis and treatment of IBD. Probiotic bacteria have shown more exciting results in experimental models than in clinical practice, and understanding their properties and mechanisms of action may lead to new therapeutic applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Aleksandra Szymczak-Tomczak, Alicja Ewa Ratajczak, Marta Kaczmarek-Rys, Szymon Hryhorowicz, Anna Maria Rychter, Agnieszka Zawada, Ryszard Slomski, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Vitamin D plays various roles in patients with inflammatory bowel disease (IBD), including regulating bone mineral metabolism, modulating the immune system, and contributing to the pathogenesis of IBD. Vitamin D affects Th1 and Th2 lymphocytes, cytokine release, and the wnt/beta-catenin pathway. IBD is associated with dysbiosis of microbiota, abnormal inflammatory response, and vitamin D deficiency. Therefore, understanding the metabolic pathways, genetic determinants, and environmental factors of vitamin D is crucial for studying vitamin D supplementation in IBD patients, not only for osteoporosis prevention and therapy, but also for modulating the course and pharmacotherapy of IBD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Filippo Vernia, Giorgia Burrelli Scotti, Noemi Sara Bertetti, Giuseppe Donato, Stefano Necozione, Piero Vernia, Nadia Pallotta
Summary: The inadequate intake of Vitamin D and Vitamin K in the diet is a reversible factor for IBD-associated bone loss, but there is a lack of data on Vitamin K. A study found that both IBD patients and control patients had inadequate intake of Vitamin D, while the intake of Vitamin K was inadequate in IBD patients and high in controls. The study suggests that proactive nutritional intervention is needed to address Vitamin K shortages in IBD patients.
Article
Clinical Neurology
May A. Beydoun, Amanda E. Ng, Marie T. Fanelli-Kuczmarski, Sharmin Hossain, Hind A. Beydoun, Michele K. Evans, Alan B. Zonderman
Summary: This study found that vitamin D status was associated with improvements in sleep duration and quality among White urban adults, possibly due to sunlight exposure rather than dietary or supplemental intake. The relationship remained consistent after adjusting for potential confounders and remained significant in the longitudinal analysis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Nutrition & Dietetics
Claudia Savard, Agnieszka Bielecki, Anne-Sophie Plante, Simone Lemieux, Claudia Gagnon, Hope A. Weiler, Anne-Sophie Morisset
Summary: This study showed an increase in serum total 25(OH)D concentrations across pregnancy trimesters, independent of prepregnancy body mass index, seasonal variation, and vitamin D intake. Most women had serum total 25(OH)D concentrations over 40nmol/L by the second trimester, with vitamin D intake from supplements being the strongest determinant of third-trimester concentrations.
JOURNAL OF NUTRITION
(2021)
Review
Nutrition & Dietetics
Claudia Infantino, Roberta Francavilla, Adriana Vella, Sabrina Cenni, Nicola Principi, Caterina Strisciuglio, Susanna Esposito
Summary: Vitamin D plays a crucial role in calcium homeostasis and bone health, and it may also modulate the immune system to affect the development of autoimmune diseases such as celiac disease and inflammatory bowel diseases. Research suggests that vitamin D could be involved in the pathogenesis and treatment of these conditions.
Article
Gastroenterology & Hepatology
Anusha Shirwaikar Thomas, Zachary K. Criss, Noah F. Shroyer, Bincy P. Abraham
Summary: This study explored the associations between vitamin D receptor gene SNPs, vitamin D levels, and endoscopic disease activity in IBD patients. The results revealed that patients in endoscopic remission had higher vitamin D levels compared to those with active inflammation, while patients with lower vitamin D levels were homozygous for ancestral FokI alleles.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Carolina Battistini, Rafael Ballan, Marcos Edgar Herkenhoff, Susana Marta Isay Saad, Jun Sun
Summary: Inflammatory bowel disease is a chronic inflammation of the GI tract, including Crohn's disease and ulcerative colitis, associated with microbiota dysbiosis and vitamin D deficiency. Further studies are needed to explore the mechanisms and therapeutic potential related to vitamin D/VDR in gut microbiota modulation for IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Martyna Jasielska, Urszula Grzybowska-Chlebowczyk
Summary: The study found that the incidence of hypocalcemia and vitamin D deficiency is higher in children with inflammatory bowel diseases and lactose intolerance. However, the use of a low-lactose diet did not have a significant impact on these conditions.
Article
Otorhinolaryngology
Mehdi Bakhshaee, Susan Moradi, Masoud Mohebi, Majid Ghayour-Mobarhan, Payam Sharifan, Razieh Yousefi, Alireza Rezaei, Mohsen Rajati
Summary: The study aimed to evaluate the relation between vitamin D deficiency and Meniere's disease (MD) through a matched case-control study, which found that serum vitamin D level in MD patients was significantly lower than that of the control group. Further research is needed to understand the role of vitamin D supplementation in managing MD.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Immunology
Christos Triantos, Ioanna Aggeletopoulou, Gerassimos J. Mantzaris, Athanasia Mouzaki
Summary: There is growing evidence of the involvement of vitamin D in immune regulation and gut barrier function, suggesting its critical role in the development of inflammatory bowel disease (IBD). Vitamin D acts as an immunomodulator, alleviating inflammation, and contributing to intestinal homeostasis in IBD, highlighting its potential therapeutic value.
AUTOIMMUNITY REVIEWS
(2022)
Article
Medicine, General & Internal
Antonia Topalova-Dimitrova, Ivan Valentinov Dimitrov, Rosen Nikolov
Summary: Patients with IBD have lower levels of vitamin D, which are associated with inflammation.
Article
Gastroenterology & Hepatology
Rajat Garg, Abdul Mohammed, Amandeep Singh, Miguel Regueiro, Benjamin Click
Summary: Patients with inflammatory bowel disease (IBD) have increased risk and worse outcomes of acute diverticulitis (AD) compared with non-IBD patients, as shown by higher rates of percutaneous drainage, venous thromboembolism (VTE), longer length of stay (LOS), and higher total cost. Within IBD patients, those with ulcerative colitis (UC) have even higher rates of surgical intervention, mortality, VTE, total cost, and LOS compared to those with Crohn's disease (CD) in the context of AD.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Eirini Theodoraki, Eleni Orfanoudaki, Kalliopi Foteinogiannopoulou, Nikolaos-Panagiotis Andreou, Maria Gazouli, Ioannis E. Koutroubakis
Summary: This study investigated the association of serum antinuclear antibodies (ANA) with infliximab (IFX) and adalimumab (ADA) trough levels (TLs) and anti-drug antibodies in patients with inflammatory bowel disease (IBD) receiving IFX or ADA therapy. The results showed that ANA positivity was associated with lower TLs in IBD patients receiving anti-TNF therapy, but no significant association was found with the development of cutaneous or rheumatological manifestations.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Salam P. Bachour, Ravi S. Shah, Ruishen Lyu, Florian Rieder, Taha Qazi, Bret Lashner, Jean Paul Achkar, Jessica Philpott, Edward L. Barnes, Jordan Axelrad, Stefan D. Holubar, Amy L. Lightner, Miguel Regueiro, Benjamin L. Cohen, Benjamin H. Click
Summary: There is conflicting data on the impact of isolated post-operative anastomotic inflammation on future disease progression in Crohn's disease patients. This study found that post-operative ileal disease recurrence, rather than isolated anastomotic inflammation, is associated with an increased risk of severe endoscopic disease progression.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Marla C. Dubinsky, Fernando Magro, Flavio Steinwurz, David P. Hudesman, Jami A. Kinnucan, Ryan C. Ungaro, Markus F. Neurath, Nicole Kulisek, Jerome Paulissen, Chinyu Su, Dario Ponce de Leon, Miguel Regueiro
Summary: This study found associations between C-reactive protein (CRP) and partial Mayo score (PMS) with efficacy outcomes during tofacitinib induction in patients with ulcerative colitis (UC). It also demonstrated that measurements of CRP and PMS at specific time points have predictive value for efficacy outcomes.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Terry Li, Salam P. Bachour, Takahiro Nakamura, Ravi Shah, Michael C. Sachs, Shannon Chang, David P. Hudesman, Stefan D. Holubar, Amy L. Lightner, Edward L. Barnes, Benjamin L. Cohen, Florian Rieder, Eren Esen, Feza Remzi, Miguel Regueiro, Benjamin Click
Summary: Postoperative recurrence of Crohn's disease is common after ileocecal resection. This dual-center study found that early initiation of an anti-TNF agent within 4 weeks following the surgery can reduce the risk of postoperative recurrence.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Amanda M. Johnson, Maria Barsky, Waseem Ahmed, Samantha Zullow, Jonathan Galati, Vipul Jairath, Neeraj Narula, Farhad Peerani, Benjamin H. Click, Elliot S. Coburn, ThucNhi Tran Dang, Stephanie Gold, Manasi Agrawal, Rajat Garg, Manik Aggarwal, Danah Mohammad, Brendan Halloran, Gursimran S. Kochhar, Hannah Todorowski, Nabeeha Mohy Ud Din, James Izanec, Amanda Teeple, Chris Gasink, Erik Muser, Zhijie Ding, Arun Swaminath, Komal Lakhani, Dan Hogan, Samit Datta, Ryan C. Ungaro, Brigid S. Boland, Matthew Bohm, Monika Fischer, Sashidhar Sagi, Anita Afzali, Thomas Ullman, Garrett Lawlor, Daniel C. Baumgart, Shannon Chang, David Hudesman, Dana Lukin, Ellen J. Scherl, Jean-Frederic Colombel, Bruce E. Sands, Corey A. Siegel, Miguel Regueiro, William J. Sandborn, David Bruining, Sunanda Kane, Edward V. Loftus, Parambir S. Dulai
Summary: This study evaluated the real-world effectiveness and safety of ustekinumab in patients with Crohn's disease. The results demonstrated that ustekinumab is a safe and effective treatment option for Crohn's disease, especially for biologic-naive patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Samuel Tanner, Jeffry Katz, Fabio Cominelli, Miguel Regueiro, Gregory Cooper, Emad Mansoor
Summary: This article examines the prevalence of inflammatory bowel disease in patients with gastritis, duodenitis, and peptic ulcer disease, taking into consideration the presence of Helicobacter pylori infection. It is found that inflammatory bowel disease is less common in patients with H. pylori, and there is no increased risk of developing IBD after undergoing H. pylori eradication therapy.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, Research & Experimental
Miguel Regueiro, Theresa Hunter, Rina Lukanova, Mingyang Shan, Rosie Wild, Hannah Knight, Priyanka Bannikoppa, April N. Naegeli
Summary: This study assessed the prevalence of fatigue and its association with disease activity and patient-reported outcomes among patients with ulcerative colitis (UC) or Crohn's disease (CD). The results showed that fatigue is a common symptom among patients with UC or CD and is associated with higher disease activity levels and decreased work productivity. Managing fatigue may require a multidisciplinary approach.
ADVANCES IN THERAPY
(2023)
Article
Gastroenterology & Hepatology
Yaara Zisman-Ilani, Kimberly D. Thompson, Lori S. Siegel, Todd Mackenzie, Damara J. Crate, Joshua R. Korzenik, Gil Y. Melmed, Patricia Kozuch, Bruce E. Sands, David T. Rubin, Miguel D. Regueiro, Raymond Cross, Douglas C. Wolf, John S. Hanson, Ronald M. Schwartz, Raluca Vrabie, Michael D. Kreines, Timothy Scherer, Marla C. Dubinsky, Corey A. Siegel
Summary: This study aimed to test the impact of shared decision making (SDM) on choice of therapy, decision quality, and provider trust in patients with Crohn's disease. The results showed that patients who received the SDM intervention more frequently chose combination therapy, had lower decisional conflict, and had greater trust in their provider.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Medicine, General & Internal
Rafael Luis Luporini, Pamela Cristina Bellaz Do Amaral Campos Silva, Miguel Regueiro
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Jill K. J. Gaidos, Badr Al Bawardy, Francis A. Farraye, Miguel Regueiro
Summary: This study investigated the utilization rates of IBD endoscopic scoring systems in clinical practice and associated factors. The study found that the Mayo Endoscopic Subscore (MES) and the Rutgeerts Score were more commonly used, while endoscopic scores for Crohn's disease and pouchitis had lower rates of use. Regular attendance at IBD conferences, higher patient volumes, and incorporation of scoring systems into endoscopy software were associated with increased utilization of these scoring systems.
CROHNS & COLITIS 360
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Khaled Alsabbagh Alchirazi, Abdul Mohammed, Ahmed Eltelbany, Osama Hamid, Miguel Regueiro
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Miguel Regueiro, Theresa Hunter Gibble, Alison Potts Bleakman, Xingyuan Li, Nathan Morris, William J. Eastman
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Khaled Alsabbagh Alchirazi, Ahmed Eltelbany, Abdul Mohammed, Antoine Boustany, Eduard Krishtopaytis, Miguel Regueiro
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Remo Panaccione, Anita Afzali, David Hudesman, Garrett Lawlor, Mark T. Osterman, Devrim Eren, Arteid Memaj, Miguel D. Regueiro, Subrata Ghosh