Article
Mathematical & Computational Biology
Daewoo Pak, Jun Liu, Jing Ning, Guadalupe Gomez Melis, Yu Shen
Summary: This article discusses the estimation of the distribution of the incubation period in infectious disease cohort studies, focusing on handling uncertainty in infection onset and sampling bias. Using a generalized odds-rate class of regression models to model the incubation period and its correlation with covariates, the study evaluates the finite sample performance through simulation studies. The proposed method is demonstrated on data from an HIV/AIDS study in Spain.
STATISTICS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Luis A. A. Souto Arias, Pasquale Cirillo, Cornelis W. W. Oosterlee
Summary: We propose a non-parametric estimator that combines the expectation-maximization algorithm and the reinforced urn process for bivariate left-truncated and right-censored observations. The resulting expectation-reinforcement algorithm allows for the inclusion of prior distribution, making it a Bayesian model. This new approach recovers the distribution of the truncation variables, providing further insights into biases in the sampling process, especially in prevalent cohort studies. Numerical tests using artificial and empirical datasets compare the estimators with copula models and the Kaplan-Meier estimator.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Statistics & Probability
K. K. Sudheesh, S. Anjana, M. Xie
Summary: This paper analyzes left truncated and right censored data commonly found in survival and reliability analysis. The authors propose novel U-statistics and derive their asymptotic distribution using the counting process technique. A non-parametric test is developed to test the independence between time to failure and cause of failure in competing risks with observations subject to left truncation and right censoring. The proposed test is evaluated through a Monte Carlo simulation study and illustrated using transformer lifetime data.
Article
Biology
Peijie Wang, Danning Li, Jianguo Sun
Summary: The paper discusses regression analysis of left-truncated failure time data, proposing a pairwise pseudo-likelihood approach and demonstrating its efficiency and feasibility through a simulation study.
Article
Health Care Sciences & Services
Li Shao, Hongxi Li, Shuwei Li, Jianguo Sun
Summary: This paper proposes a pairwise pseudo-likelihood estimation method for regression analysis of left-truncated failure time data with various types of censoring mechanisms. It utilizes the conditional likelihood and the pairwise likelihood to eliminate the nuisance truncation distribution function and develops a flexible EM algorithm for implementation. The proposed method performs well in practical situations and is more efficient than the conditional likelihood approach.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Mathematics, Interdisciplinary Applications
Tianyi Lu, Shuwei Li, Liuquan Sun
Summary: In this paper, the regression analysis of left-truncated and interval-censored data is investigated using the additive hazards model. A conditional estimating equation approach is proposed for estimation, and its efficiency is further improved by combining it with the pairwise pseudo-score-based estimating equation. The proposed methods are evaluated through extensive simulation studies and applied to real data for illustration.
LIFETIME DATA ANALYSIS
(2023)
Article
Mathematics, Applied
Kambiz Ahmadi, Masoumeh Akbari, Liang Wang
Summary: This article discusses the reliability estimation of the generalized half-normal distribution (GHN) when data are subject to both left truncation and right censoring (LTRC). The maximum likelihood estimates and confidence intervals for the unknown parameters of GHN are briefly discussed. A hierarchical Bayesian approach is used with two sampling techniques, the Metropolis-Hastings algorithm and the slice sampler technique, to carry out the Bayesian estimation procedure. Furthermore, the article investigates the Bayesian prediction problem for the lifetime of a censored unit and the Bayesian estimation of the expected number of failures in a prefixed interval. Simulation studies are conducted to compare the proposed procedure with its competitor, and data analysis of electric power-transformers data is carried out to illustrate the purposes.
Article
Mathematical & Computational Biology
Sarah F. McGough, Devin Incerti, Svetlana Lyalina, Ryan Copping, Balasubramanian Narasimhan, Robert Tibshirani
Summary: The prevalence of high-dimensional data in the medical field has led to challenges in statistical modeling, particularly when dealing with left-truncated survival data. Feature selection or penalized methods are often used to address overfitting issues, highlighting the importance of adjusting for left truncation in survival modeling.
STATISTICS IN MEDICINE
(2021)
Article
Mathematics
Mengyue Zhang, Shishun Zhao, Tao Hu, Da Xu, Jianguo Sun
Summary: This paper examines the regression analysis of current status data with informative censoring times and left truncation. An inference approach based on sieve maximum likelihood estimation (SMLE) is proposed. A copula-based approach is used to describe the relationship between the failure time of interest and the censoring time. Simulation studies suggest that the developed procedure works well in practice, and the method is applied to a real dataset derived from an AIDS cohort research.
Article
Mathematical & Computational Biology
Shuwei Li, Tian Tian, Tao Hu, Jianguo Sun
Summary: This article discusses regression analysis of misclassified current status data from the additive hazards model, and proposes a SIMEX approach for estimation. The asymptotic properties of the estimators are established and a simulation study shows the method performs well, correcting estimation bias.
STATISTICS IN MEDICINE
(2021)
Article
Health Care Sciences & Services
Pao-sheng Shen
Summary: This study discusses statistical methods for commonly encountered doubly truncated and interval censored data in epidemiological research, proposing methods to overcome information bias through defining target populations and implementing specific sampling schemes, with simulation studies validating the effectiveness of the methods.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Statistics & Probability
Li-Pang Chen, Grace Y. Yi
Summary: This paper explores valid inference methods for handling left-truncated and right-censored survival data with measurement error under the widely used Cox model. The proposed methods enjoy appealing features that the distributions of the covariates and of the truncation times are left unspecified. Numerical studies are reported to assess the finite sample performance of the proposed methods.
ANNALS OF THE INSTITUTE OF STATISTICAL MATHEMATICS
(2021)
Article
Statistics & Probability
Tianyi Lu, Hongxi Li, Shuwei Li, Liuquan Sun
Summary: This paper proposes an efficient maximum likelihood estimation approach for proportional hazards model with left-truncated and interval-censored data, and establishes the asymptotic properties of the proposed estimators using empirical process theory.
Article
Computer Science, Interdisciplinary Applications
Xiaoyu Liu, Liming Xiang
Summary: This study proposes a more flexible class of generalized accelerated hazards mixture cure models for analyzing interval-censored failure times. A sieve maximum likelihood estimation method is used to approximate the unknown cumulative baseline hazard function with B-splines. Simulation results demonstrate satisfactory performance of the proposed method in finite samples.
COMPUTATIONAL STATISTICS & DATA ANALYSIS
(2021)
Article
Health Care Sciences & Services
Tao Sun, Yunlong Li, Zhengyan Xiao, Ying Ding, Xiaojun Wang
Summary: We develop a flexible two-parameter copula-based semiparametric transformation model for semi-competing risks data subject to interval censoring and left truncation. The proposed method corrects biases in the marginal method and provides new insights into preventing disability in the elderly. It can be applied to general semi-competing risks data with intermittently assessed disease status.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hui-Ju Chang, Ueng-Cheng Yang, Mei-Yu Lai, Chen-Hsin Chen, Yang-Cheng Fann
Summary: This study found that high BRCA1 gene expression is associated with increased tumour aggressiveness and risk of distant metastasis in breast cancers. High expression of proliferation marker genes was also found to be associated with high BRCA1 expression. The association between high BRCA1 expression and risk of distant metastasis was observed regardless of tamoxifen treatment.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Edith J. M. Feskens, Regan Bailey, Zulfiqar Bhutta, Hans-Konrad Biesalski, Heather Eicher-Miller, Klaus Kraemer, Wen-Harn Pan, James C. Griffiths
Summary: Sex differences are important to consider when it comes to nutrition and health policies. Women have unique physiological, neurological, and hormonal distinctions that affect their nutritional needs throughout different stages of life. However, current nutrition policies for women's health may be lacking, with some programs focused more on providing calories rather than achieving optimal nutrition. It is essential to offer targeted nutrition proposals that take into account different cultural, socio-economic, and geographic communities to properly support women's health at all stages of growth and development.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Chemistry, Applied
Kai-Wei Liao, Fang-Chi Chang, Chia-Huang Chang, Yu-Fang Huang, Wen-Harn Pan, Mei-Lien Chen
Summary: The study determined the levels of acrylamide metabolites in urine samples from the general Taiwanese population, investigated the association between internal exposure to acrylamide and dietary intake, and assessed health risks. Results showed a correlation between consumption of sweetened beverages and oily snacks with increased urinary metabolite concentrations. Monte Carlo simulation indicated that a percentage of the population may exceed the reference dose, posing potential health risks.
Article
Multidisciplinary Sciences
Sheng-Feng Lin, Yen-Chun Fan, Tzu-Tung Kuo, Wen-Harn Pan, Chyi-Huey Bai
Summary: Elderly Han Chinese adults with moderately impaired renal filtration may exhibit cognitive deficits in orientation to time, calculation, and impaired quality of life in physical role functioning.
Article
Medicine, General & Internal
Sheng-Feng Lin, Tzu-Tung Kuo, Wh Pan, Chyi Huey Bai
Summary: The implementation of National Health Insurance in Taiwan in 1995 improved the control of hypertension, but the role of individual socioeconomic status (iSES) in awareness, treatment, and control of blood pressure has not been well studied. This nationwide survey found that health education should focus on younger people with higher iSES in order to improve awareness and treatment of hypertension.
Article
Biochemistry & Molecular Biology
Kuang-Mao Chiang, Jia-Fu Chen, Chin-An Yang, Lili Xiu, Hsin-Chou Yang, Lie-Fen Shyur, Wen-Harn Pan
Summary: This study investigated the association between blood oxylipin profile and risk of developing coronary artery disease (CAD), and identified four oxylipins that are associated with CAD risk. Adding these oxylipins to the traditional risk prediction model significantly improved the prediction of CAD.
Article
Medicine, General & Internal
Chi Yan Leung, Hsi-Lan Huang, Sarah Krull Abe, Eiko Saito, Md Rashedul Islam, Md Shafiur Rahman, Ai Ikeda, Norie Sawada, Akiko Tamakoshi, Yu-Tang Gao, Woon-Puay Koh, Xiao-Ou Shu, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Sue K. Park, Chisato Nagata, San-Lin You, Jian-Min Yuan, Myung-Hee Shin, Wen-Harn Pan, Shoichiro Tsugane, Takashi Kimura, Wanqing Wen, Hui Cai, Kotaro Ozasa, Sanae Matsuyama, Seiki Kanemura, Yumi Sugawara, Aesun Shin, Keiko Wada, Chien-Jen Chen, Renwei Wang, Yoon-Ok Ahn, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Daehee Kang, Manami Inoue
Summary: This study analyzed data from 16 prospective studies in Asia and found that marital status is associated with total and cause-specific mortality, with unmarried individuals having a higher risk of death.
Correction
Nutrition & Dietetics
Sheng-Feng Lin, Yen-Chun Fan, Wen-Harn Pan, Chyi-Huey Bai
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Ya-Hui Shih, Hsin-Chuan Wu, Wen-Harn Pan, Hsing-Yi Chang
Summary: This study investigated the relationship between children's consumption of sugar-sweetened beverages and their sleep duration in Taiwan. The results showed that children who consumed these beverages frequently had shorter sleep durations on school days and exhibited greater sleep debt. However, the causal relationship was not clear.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Chien-Jen Wang, Huei-Ju Liu, Tzu-Chieh Chou, Ching-Chun Lin, Wen-Harn Pan, Pau-Chung Chen, Jing-Fang Hsu
Summary: An analytical method for simultaneously measuring eight beta-adrenergic agonist compounds in human urine was established. The method demonstrated high precision, accuracy, and capability for investigating the presence of these compounds in human populations, particularly in Taiwan.
Article
Biochemistry & Molecular Biology
Vanessa Joy Timoteo, Kuang-Mao Chiang, Hsin-Chou Yang, Wen-Harn Pan
Summary: Human iron nutrition is influenced by both genetic and environmental factors. This study compared the genetic determinants of hemoglobin (Hb) concentration between Taiwanese Han Chinese and European Whites. The results showed consistent associations of specific SNPs in TMPRSS6, ABO, and PRKCE with Hb levels in both ethnic groups. Ethnic-specific associations were also observed, such as the association of AXIN1 with Hb levels in Taiwanese Han Chinese. The findings highlight the importance of both common and ethnic-specific genetic factors in Hb regulation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Szu-Yun Wu, Shu-Chen Lee, Nai-Hua Yeh, Chi-Fen Wang, Shu-Yi Hung, Shin-Jiuan Wu, Wen-Harn Pan
Summary: It is unclear whether low dietary intake accompanied with multiple nutrient deficiencies or specific nutrient inadequacy is associated with geriatric syndrome. This study aimed to examine the nutrition inadequacy profiles associated with frailty and cognitive impairment (CI). Total energy intakes were significantly lower with the severity of both frailty and CI. Intake levels of multiple nutrients also decreased with the severity of frailty and CI. Most of the associations between micronutrients and the two geriatric syndromes disappeared after energy adjustment.
Article
Geriatrics & Gerontology
Shao-Yuan Chuang, Wen-Ling Liu, Hsing-Yi Chang, Chih-Cheng Hsu, Wen-Harn Pan
Summary: This study found that metabolic disorders in midlife are associated with physical and cognitive function decline in later life. Waist circumference and blood pressure are associated with physical function decline, while high blood pressure is associated with cognitive function decline. Managing waist circumference and blood pressure in midlife may slow the decline of physical and cognitive function in later life.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Nutrition & Dietetics
Szu-Yun Wu, Yu-Yao Cheng, Hsing-Yi Chang, Pei-Hsuan Wang, I-Ching Hsieh, Nai-Hua Yeh, Kuo-Chin Huang, Wen-Harn Pan
Summary: To make learning more interesting and practical, geriatric community centers offer group activity sessions for older adults. A study conducted in Taiwan found that a 3-month nutrition intervention combined with exercise significantly improved dietary intake, frailty status, working memory, and reduced depression symptoms among older adults.
Meeting Abstract
Peripheral Vascular Disease
Shao-Yuan Chuang, Jiun-Jr Wang Wang, Chen-Hua Lin, Wen-Harn Pan, Liang-Kung Chen, Pei-Ning Wang, Chen-Huan Chen, Hao-Min Cheng
JOURNAL OF HYPERTENSION
(2022)