期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 184, 期 12, 页码 922-932出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kww102
关键词
aging; Health and Retirement Study; sex; smoking; smoking cessation; telomere length
资金
- National Institute on Aging [T32AG000243, P30AG012857]
- National Institute of Environmental Health [R01 ES020506]
- National Human Genome Research Institute at the National Institutes of Health [U01 HG007601]
Inconsistent associations between smoking and telomere length (TL) have been reported in epidemiologic studies, perhaps because of the time-varying nature of smoking behaviors. We estimated the associations of TL, which was measured by quantitative polymerase chain reaction using saliva DNA, with concurrent and past smoking status reported biennially for up to 16 years before TL measurement in 5,624 participants in the Health and Retirement Study (1992-2008). Smoking was associated with reduced TL when we used prospective data on smoking statuses among men and women, but the association was strongly attenuated among men in cross-sectional analyses. This attenuation was largely due to a higher rate of smoking cessation during the study period among men with shorter TL than among men with longer TL. Short TL was also associated with poorer overall health in men, which suggests that male smokers with short TL were more likely to quit smoking because of poor health. Analyses of years since cessation, smoking duration, and pack-years of smoking all support the hypothesis that increased cigarette use shortens TL. Our results provide a potential explanation for the inconsistent associations between smoking and TL reported in previous cross-sectional studies. Time-varying associations should be considered in future studies of smoking behavior, TL, aging, and disease risk.
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