Article
Nutrition & Dietetics
Janne Martikainen, Kari Jalkanen, Jari Heiskanen, Piia Lavikainen, Markku Peltonen, Tiina Laatikainen, Jaana Lindstrom
Summary: The prevalence of type 2 diabetes is increasing globally, and a healthy diet plays a crucial role in its prevention. Increased consumption of whole grain foods could lead to significant health and economic benefits in the Finnish adult population, reducing T2D-related costs and improving quality-adjusted life years.
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: The study found a negative association between the use of alendronate and the risk of developing type 2 diabetes, with a dose-response relationship observed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Peiwen Li, Yali Xu, Zhaoyang Li, Xu Cheng, Chengyong Jia, Shiyang Zhang, Jun An, Xin Zhang, Yan Yan, Meian He
Summary: This study investigated the association between polychlorinated biphenyls (PCBs) exposure and incident type 2 diabetes mellitus (T2DM), as well as the relationship between PCBs and 5-year fasting blood glucose (FBG) changes. The results showed significant associations between non-dioxin-like PCBs (NDL-PCBs) and higher T2DM incidence, as well as positive associations between NDL-PCBs and changes in FBG. It was concluded that PCBs increased T2DM incidence through lipid metabolic pathways.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biophysics
Yangyang Wen, Jie Li, Shichao Zhao, Haoran Fan, Hongyan Li, Jing Wang, Baoguo Sun
Summary: A highly efficient fluorescence sensing platform (CDs@MIP) was developed for rapid and sensitive analysis of alkylresorcinols (ARs), which can differentiate whole wheat foods from refined wheat foods. The platform utilized carbon dots as fluorophores and a molecularly imprinted polymer coating containing C21:0 AR as template molecules. The sensor showed a wide linear range and an ultralow detection limit for C21:0 AR, and successfully detected ARs in commercial whole-wheat foods.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Environmental Sciences
Fei Wang, Ying Zhang, Shiyang Zhang, Xu Han, Yue Wei, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Summary: This study found a U-shaped association between serum BPA levels and the risk of type 2 diabetes. Additionally, individuals with higher serum BPA levels and a genetic risk for diabetes had higher fasting plasma glucose levels and a higher risk of type 2 diabetes.
ENVIRONMENTAL POLLUTION
(2022)
Article
Endocrinology & Metabolism
Sarah Charlier, Janina Vavanikunnel, Claudia Becker, Susan S. Jick, Christian Meier, Christoph R. Meier
Summary: The study found that patients with good glycemic control who were treated with metformin monotherapy had a lower risk of fractures, while glycemic control in patients receiving other antidiabetic medications was not associated with fracture risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Food Science & Technology
Faezeh Ghanbari-Gohari, Seyed Mohammad Mousavi, Ahmad Esmaillzadeh
Summary: This study quantitatively summarized earlier findings on the association between whole grain intake and the risk of type 2 diabetes (T2D). The results showed that a high intake of whole grain was associated with a lower risk of T2D. Each additional 50 grams of whole grain consumption per day was associated with a 23% reduced risk of T2D.
FOOD SCIENCE & NUTRITION
(2022)
Article
Endocrinology & Metabolism
Jia Liu, Lu Wang, Yun Qian, Qian Shen, Man Yang, Yunqiu Dong, Hai Chen, Zhijie Yang, Yaqi Liu, Xuan Cui, Hongxia Ma, Guangfu Jin
Summary: This study aimed to identify novel metabolic markers for future type 2 diabetes (T2D) risk in Han Chinese individuals and determine if the combined effect of metabolic and genetic markers improves prediction accuracy. The researchers found that abnormal levels of 5 metabolites were associated with increased future T2D risk. The genetic risk score (GRS) based on 20 single nucleotide polymorphisms (SNPs) was also significantly associated with T2D risk and improved prediction models when combined with metabolites and clinical factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Maryam Moazzam-Jazi, Leila Najd-Hassan-Bonab, Sajedeh Masjoudi, Maryam Tohidi, Mehdi Hedayati, Fereidoun Azizi, Maryam S. Daneshpour
Summary: This study investigates the association of common KCNJ11 variants with type 2 diabetes (T2D) in Iranian adults and conducts a meta-analysis. The results show that KCNJ11 variants are not associated with T2D incidence in Iranian adults, but certain variants are significantly associated with increased T2D susceptibility in diverse populations. The meta-analysis also highlights the impact of sample size on the magnitude of pooled genetic effect size.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Tessa Schillemans, Lin Shi, Carolina Donat-Vargas, Kati Hanhineva, Andreas Tornevi, Ingegerd Johansson, Jani Koponen, Hannu Kiviranta, Olov Rolandsson, Ingvar A. Bergdahl, Rikard Landberg, Agneta Akesson, Carl Brunius
Summary: Researchers found that PFAS are associated with two groups of lipid species with opposite relations to T2D risk. Specifically, glycerophospholipids and diacylglycerols metabolite features correlated positively with PFAS but had opposite associations with T2D risk; glycerophospholipids were inversely associated with T2D risk, while diacylglycerols were positively associated with T2D risk.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Genetics & Heredity
Shengbing Huang, Pei Qin, Qing Chen, Dongdong Zhang, Cheng Cheng, Chunmei Guo, Quanman Li, Qionggui Zhou, Gang Tian, Ranran Qie, Minghui Han, Xiaoyan Wu, Xingjin Yang, Yifei Feng, Yang Li, Yanyan Zhang, Yuying Wu, Dechen Liu, Jie Lu, Ming Zhang, Yang Zhao, Dongsheng Hu
Summary: The methylation level on a CpG locus of FTO was positively associated with T2DM, while SNPs were not. Additionally, FTO methylation was associated with some risk factors for T2DM. Further studies with a larger sample size and metabolomic data are needed to confirm the findings.
Article
Endocrinology & Metabolism
Jia Wang, Yuanyuan Wang, Wei Zheng, Xianxian Yuan, Cheng Liu, Ya Zhang, Wei Song, Xiaoxin Wang, Shengnan Liang, Xu Ma, Guanghui Li
Summary: This study aimed to observe the dynamic changes of serum taurine during pregnancy and investigate its relationship with gestational diabetes mellitus (GDM) in early pregnancy. The results showed that low serum taurine concentration in the first trimester was significantly associated with the development of GDM, but the association disappeared as the pregnancy progressed. This may be related to the inhibition of taurine transporter (TauT) activity by high glucose.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Shiyang Zhang, Xu Cheng, Chengyong Jia, Jun An, Xin Zhang, Peiwen Li, Youbing Guan, Yan Yan, Zhuoya Zhao, Yuenan Liu, Tao Jing, Meian He
Summary: There were no significant associations found between serum PAEs levels and T2DM in the overall population, but current alcohol drinkers exposed to higher levels of DnBP, EDBP, and ELMW had a higher risk of T2DM. Furthermore, significant potential interactions were observed among certain PAEs and drinking status on T2DM risk.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Julie A. D. Van, Yihan Luo, Jayne S. Danska, Feihan Dai, Stacey E. Alexeeff, Erica P. Gunderson, Hannes Rost, Michael B. Wheeler
Summary: This study comprehensively characterized the postpartum profiles of women shortly after a GDM pregnancy and identified key mechanisms responsible for the progression to overt type 2 diabetes. The study revealed an inflammatory response and disturbances in amino acids and triglycerides that are associated with the development of diabetes.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Health Care Sciences & Services
Chao Cheng, Abigail Sloan, Molin Wang
Summary: This paper introduces two calibration methods to address measurement error and bias in pooling biomarker data from different studies. Simulation studies and application to a specific case were conducted to evaluate the performance of these methods.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Guillaume Marquis-Gravel, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyro, Gunnar Gislason, Augustin Scalbert, Anne Tjonneland, Kim Overvad, Jonathan M. Hodgson, Nicola P. Bondonno
Summary: This study found no overall association between habitual dietary flavonoid intake and the risk of ischemic heart disease (IHD). However, stratified analysis by sex and smoking status showed that higher intakes of specific subclasses of flavonoids were associated with a lower risk of IHD among ever-smokers, but not among never-smokers or either sex specifically.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Oncology
Wendy Yi-Ying Wu, Zahra Haider, Xiaoshuang Feng, Alicia K. Heath, Anne Tjonneland, Antonio Agudo, Giovanna Masala, Hilary A. Robbins, Maria-Jose Huerta, Marcela Guevara, Matthias B. Schulze, Miguel Rodriguez-Barranco, Paolo Vineis, Rosario Tumino, Rudolf Kaaks, Renee T. Fortner, Sabina Sieri, Salvatore Panico, Therese Haugdahl Nost, Torkjel M. Sandanger, Tonje Braaten, Mattias Johansson, Beatrice Melin, Mikael Johansson
Summary: The study evaluated the risk-discriminatory performance of the EarlyCDT-Lung test in ever-smokers and found that it is not effective in identifying high-risk individuals for lung cancer screening.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Alessandra Allione, Clara Viberti, Ilaria Cotellessa, Chiara Catalano, Elisabetta Casalone, Giovanni Cugliari, Alessia Russo, Simonetta Guarrera, Dario Mirabelli, Carlotta Sacerdote, Marco Gentile, Fabian Eichelmann, Matthias B. Schulze, Sophia Harlid, Anne Kirstine Eriksen, Anne Tjonneland, Martin Andersson, Martijn E. T. Dolle, Heleen Van Puyvelde, Elisabete Weiderpass, Miguel Rodriguez-Barranco, Antonio Agudo, Alicia K. Heath, Maria-Dolores Chirlaque, Therese Truong, Dzevka Dragic, Gianluca Severi, Sabina Sieri, Torkjel M. Sandanger, Eva Ardanaz, Paolo Vineis, Giuseppe Matullo
Summary: This study identified nine differentially methylated CpGs associated with malignant pleural mesothelioma (MPM) through DNA methylation analysis, and these CpGs can serve as noninvasive biomarkers for the early detection of cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Nena Karavasiloglou, David J. Hughes, Neil Murphy, Lutz Schomburg, Qian Sun, Vartiter Seher, Sabine Rohrmann, Elisabete Weiderpass, Anne Tjonneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kuhn, Matthias B. Schulze, Rosario Tumino, Salvatore Panico, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Jeroen W. G. Derksen, Guri Skeie, Anette Hjartaker, Cristina Lasheras, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Bethany Van Guelpen, Bjorn Gylling, Kathryn E. Bradbury, Keren Papier, Heinz Freisling, Elom K. Aglago, Amanda J. Cross, Elio Riboli, Dagfinn Aune, Marc J. Gunter, Mazda Jenab
Summary: Two large European cohort studies found that circulating calcium concentrations were associated with colorectal cancer risk. In the EPIC cohort, total serum calcium was not associated with colorectal cancer, while in the UK-BB cohort, serum ionized calcium was inversely associated with colorectal cancer risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Peripheral Vascular Disease
Kathy Trieu, Daisy H. Coyle, Emalie Rosewarne, Maria Shahid, Rain Yamamoto, Chizuru Nishida, Bruce Neal, Feng J. He, Matti Marklund, Jason H. Y. Wu
Summary: This study modeled the impact of complying with the World Health Organization's sodium benchmarks in Australia and found that adopting more stringent WHO benchmarks could more effectively prevent cardiovascular disease, chronic kidney disease, and stomach cancer, reducing deaths and new cases.
Article
Endocrinology & Metabolism
Jazmin Castaneda, Mercedes Gil-Lespinard, Enrique Almanza-Aguilera, Fjorida Llaha, Jesus-Humberto Gomez, Nicola Bondonno, Anne Tjonneland, Kim Overvad, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Magritt Brustad, Cristina Lasheras, Esther Molina-Montes, Maria-Dolores Chirlaque, Aurelio Barricarte, Emily Sonestedt, Marisa da Silva, Ingegerd Johansson, Johan Hultdin, Anne M. May, Nita G. Forouhi, Alicia K. Heath, Heinz Freisling, Elisabete Weiderpass, Augustin Scalbert, Raul Zamora-Ros
Summary: This study aimed to evaluate the associations between the intake of total polyphenols, polyphenol classes, and subclasses and body weight change over 5 years. The results showed an inverse association between total flavonoid intake and body weight change, and positive associations between total polyphenol and hydroxycinnamic acid intake and body weight gain. However, the positive association between hydroxycinnamic acid intake and body weight gain was only found in coffee consumers, not in coffee nonconsumers.
Article
Cardiac & Cardiovascular Systems
Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Emelia J. Benjamin, Kim Overvad, Anja Olsen, Christina Catherine Dahm, Henrik Kjaerulf Jensen
Summary: Increasing alcohol intake over a 5-year period is associated with a higher risk of atrial fibrillation (AF), while reducing alcohol intake does not significantly affect AF risk.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Environmental Sciences
Nina Roswall, Jesse D. Thacher, Mikael Ogren, Andrei Pyko, Agneta akesson, Anna Oudin, Anne Tjonneland, Annika Rosengren, Aslak H. Poulsen, Charlotta Eriksson, David Segersson, Debora Rizzuto, Emilie Helte, Eva M. Andersson, Gunn Marit Aasvang, Hrafnhildur Gudjonsdottir, Jibran Khan, Jenny Selander, Jesper H. Christensen, Jorgen Brandt, Karin Leander, Kristoffer Mattisson, Kristina Eneroth, Lara Stucki, Lars Barregard, Leo Stockfelt, Maria Albin, Mette K. Simonsen, Marten Spanne, Pekka Jousilahti, Pekka Tiittanen, Peter Molnar, Petter L. S. Ljungman, Tarja Yli-Tuomi, Thomas Cole-Hunter, Timo Lanki, Ulla A. Hvidtfeldt, Youn-Hee Lim, Zorana J. Andersen, Goran Pershagen, Mette Sorensen
Summary: This study investigated the association between traffic noise and colon cancer in a pooled population of 155,203 individuals from 11 Nordic cohorts. The results showed that road traffic noise was associated with an increased risk of colon cancer, particularly distal colon cancer.
ENVIRONMENTAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Gunnar Gislason, Anne Tjonneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno
Summary: Observational studies have shown a lower risk of type 2 diabetes with higher vitamin K-1 intake. This study found that higher intake of foods rich in vitamin K-1 was associated with a lower risk of diabetes. This association was present in all subgroups at higher risk, indicating that more cases of diabetes could be prevented.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Julie Louise Munk Andersen, Kirsten Frederiksen, Cecilie Kyro, Johnni Hansen, Ole Raaschou-Nielsen, Kim Overvad, Anne Tjonneland, Anja Olsen
Summary: This study aimed to investigate the association between organic food consumption and the incidence of type 2 diabetes mellitus. The results showed that organic food consumption was linearly associated with a lower incidence of the disease, but the association was not statistically significant. Similar patterns were observed for women with the consumption of specific organic food groups, but not for men. This suggests a possible association between organic food consumption and the incidence of type 2 diabetes mellitus.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
David J. Hughes, Lutz Schomburg, Mazda Jenab, Carine Biessy, Catherine Meplan, Aurelie Moskal, Qian Sun, Kamil Demircan, Veronika Fedirko, Elisabete Weiderpass, Maryam Mukhtar, Anja Olsen, Anne Tjonneland, Kim Overvad, Matthias Schulze, Therese Haugdahl Nost, Guri Skeie, Karina Standahl Olsen, Fulvio Ricceri, Sara Grioni, Domenico Palli, Giovanna Masala, Rosario Tumino, Fabrizio Pasanisi, Pilar Amiano, Sandra M. Colorado Yohar, Antonio Agudo, Maria-Jose Sanchez, Eva Ardanaz, Malin Sund, Anne Andersson, Aurora Perez-Cornago, Ruth Travis, Alicia K. Heath, Laure Dossus
Summary: The study found no significant association between selenium status and breast cancer risk. However, higher activity of the selenoenzyme GPX3 was associated with a lower risk of premenopausal breast cancer. Several genetic variants were also found to be associated with breast cancer risk.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Nutrition & Dietetics
Benjamin H. Parmenter, Pratik Pokharel, Frederik Dalgaard, Kevin Murray, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Cecilie Kyro, Anne Tjonneland, Kim Overvad, Jonathan M. Hodgson, Nicola P. Bondonno
Summary: This study found that habitual intakes of flavanols and anthocyanins are associated with a lower risk of ischemic stroke from large-artery atherosclerosis and/or cardioembolism, but not with other subtypes.
JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Tschiderer, Sanne A. E. Peters, Yvonne T. van der Schouw, Anniek C. van Westing, Tammy Y. N. Tong, Peter Willeit, Lisa Seekircher, Conchi Moreno-Iribas, Jose Maria Huerta, Marta Crous-Bou, Martin Soderholm, Matthias B. Schulze, Cecilia Johansson, Sara Sjalander, Alicia K. Heath, Alessandra Macciotta, Christina C. Dahm, Daniel B. Ibsen, Valeria Pala, Lene Mellemkjaer, Stephen Burgess, Angela Wood, Rudolf Kaaks, Verena Katzke, Pilar Amiano, Miguel Rodriguez-Barranco, Gunnar Engstrom, Elisabete Weiderpass, Anne Tjonneland, Jytte Halkjaer, Salvatore Panico, John Danesh, Adam Butterworth, N. Charlotte Onland-Moret
Summary: Early menopause is associated with a higher risk of stroke, but the relationships with stroke subtypes are inconsistent. However, genetically proxied age at menopause is not significantly associated with stroke risk, suggesting no causal relationship.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Christine Johnson Curtis, Matti Marklund, Akshar Saxena, Eva Goyena, Josie Desnacido, Adam D. Koon, Bethany Warren, Laura K. Cobb, Megan Henry, Lawrence J. Appel, Imelda Angeles-Agdeppa
Summary: Fiscal policies to improve diet are a promising strategy for addressing non-communicable diseases. Cost-effectiveness analyses can provide evidence for designing these policies. Modelling considerations for food taxes include data availability, nutrient content, tax structure, and rate. By taking these factors into account, policymakers can design food tax policies to improve the health and well-being of future generations.
Article
Public, Environmental & Occupational Health
Matti Marklund, Leopold N. Aminde, Mary Njeri Wanjau, Liping Huang, Celine Awuor, Lindsay Steele, Laura K. Cobb, J. Lennert Veerman, Jason H. Y. Wu
Summary: This study utilizes a multiple cohort proportional multistate life table model to demonstrate the potential health gains and cost-effectiveness of implementing a mandatory limit on industrial trans fatty acids (iTFA) in Kenya. The findings suggest that such intervention could prevent ischemic heart disease (IHD) events and deaths, save healthcare costs, and be a cost-saving strategy in the long term.
