Article
Geriatrics & Gerontology
M. H. Verwijs, O. van de Rest, G-J van der Putten, L. C. P. G. M. de Groot, S. Boesveldt
Summary: This study investigated the effects of food odor exposure on appetite, nutritional intake, and body weight of Dutch nursing home residents with dementia. The results showed that while there were some changes in appetite and nutritional intake after odor exposure, they were not clinically significant. Future studies should evaluate the impact of natural food odors and/or meal-tailored odors on nutritional intake in older adults with dementia.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Geriatrics & Gerontology
Nafisseh S. Warner, Andrew C. Hanson, Phillip J. Schulte, Elizabeth B. Habermann, David O. Warner, Michelle M. Mielke
Summary: The study found that the use of prescription opioids in older adults is associated with small but statistically significant declines in long-term cognitive function. This may represent the effects of opioids themselves or other related factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Gastroenterology & Hepatology
Raaj S. Mehta, Bharati Kochar, Zhen Zhou, Jonathan C. Broder, Paget Chung, Keming Yang, Jessica Lockery, Michelle Fravel, Joanne Ryan, Suzanne Mahady, Suzanne G. Orchard, John J. Mcneil, Anne Murray, Robyn L. Woods, Michael E. Ernst, Andrew T. Chan
Summary: This study investigated the associations of proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) use with dementia and cognitive decline. The study found that long-term use of PPI and H2RA was not associated with incident dementia, cognitive impairment without dementia (CIND), or decline in cognition over time.
Article
Geriatrics & Gerontology
Myoungsuk Kim, Kyung-Choon Lim, Hana Ko
Summary: The study identified that participating in religious activities, good sleep, fewer comorbidities, better perceived health status, lower depression, and higher self-esteem were associated with better subjective cognitive function in community-dwelling older adults. Approximately 25% of the variability in SCF was explained by perceived health status, religion, and depression.
Article
Multidisciplinary Sciences
Shahram Oveisgharan, Lei Yu, David A. Bennett, Aron S. Buchman
Summary: This study explored the transition from no motor impairment to mobility disability and parkinsonism in older adults and their associations with death. It found that mobility disability was more common than parkinsonism, and individuals with both impairments had a greater risk of death. The order in which impairments occurred did not affect the risk of death. Further research is needed to understand the underlying biology of these transitions and their impact on survival.
Article
Neuroimaging
Tugce Duran, James R. Bateman, Benjamin J. Williams, Mark A. Espeland, Timothy M. Hughes, Stephanie Okonmah-Obazee, Melissa M. Rundle, Suzanne Craft, Samuel N. Lockhart
Summary: This study investigated the impacts of neuroimaging and clinical biomarkers on cognitive migration, and identified several biomarkers that could predict cognitive migration status in early stages of disease. These findings may guide clinical diagnosis and treatments.
NEUROIMAGE-CLINICAL
(2022)
Review
Neurosciences
Karra D. Harrington, Shradha Vasan, Jee Eun Kang, Martin J. Sliwinski, Michelle H. Lim
Summary: This systematic review and meta-analysis examined the relationship between loneliness and cognitive function, showing that loneliness is associated with subtle impairment across multiple cognitive domains in older adults. These findings are important for understanding how loneliness affects cognitive function and providing valuable information for risk reduction and early detection strategies.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Marco Canevelli, Lindsay M. K. Wallace, Giuseppe Bruno, Matteo Cesari, Kenneth Rockwood, David D. Ward
Summary: Frailty is associated with cognitive expression of neuropsychological deficits in older adults, as found in the analysis of data from three large cohort studies. Among participants with higher frailty levels, there was a stronger negative association between neuropsychological deficits and cognitive performance.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Cell Biology
Teuntje A. D. Pelgrim, Magdalena Beran, Emma L. Twait, Mirjam Geerlings, Jet M. J. Vonk
Summary: Pathological tau is implicated in cognitive decline in the preclinical phase of Alzheimer's disease. A meta-analysis of 24 studies found associations between tau burden and episodic and semantic memory impairment in older adults without dementia, with episodic composite scores showing the strongest relationship.
AGEING RESEARCH REVIEWS
(2021)
Article
Geriatrics & Gerontology
Galit Weinstein, Shiraz Vered, Dana Ivancovsky-Wajcman, Ramit Ravona-Springer, Anthony Heymann, Shira Zelber-Sagi, Danit Rivka Shahar, Michal Schnaider Beeri
Summary: This study suggests that a high intake of ultra-processed meat and oils/spreads may be associated with accelerated cognitive decline in older individuals with T2D.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Nutrition & Dietetics
Jacob M. M. Eubank, Douglas J. J. Oberlin, Andrew Alto, Nadine R. R. Sahyoun, Elmira Asongwed, Lillie Monroe-Lord, Elgloria A. A. Harrison
Summary: The onset of dementia and Alzheimer's disease is expected to increase in the United States as the population ages, with Hispanics and African Americans being at higher risk. Lifestyle factors such as social engagement, physical activity, dietary intake, sleep, and stress are related to cognitive decline, but research in minority populations is limited.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Jennifer Weuve, Jennifer D'Souza, Todd Beck, Denis A. Evans, Joel D. Kaufman, Kumar B. Rajan, Carlos F. Mendes de Leon, Sara D. Adar
Summary: The study found that an increase in noise level was associated with higher odds of prevalent MCI and AD, as well as worse global cognitive performance, mainly in perceptual speed. However, the association with cognitive decline was not consistent.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Belinda M. Brown, Natalie Frost, Stephanie R. Rainey-Smith, James Doecke, Shaun Markovic, Nicole Gordon, Michael Weinborn, Hamid R. Sohrabi, Simon M. Laws, Ralph N. Martins, Kirk I. Erickson, Jeremiah J. Peiffer
Summary: The study investigated high-intensity and moderate-intensity exercise interventions on cognition, finding a dose-dependent effect on cardiorespiratory fitness but no direct effect on cognition. Future work in this field should focus on examining individual variability factors in response to intervention.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Maria Patricia A. Oliveira Monteiro, Danielle S. M. Salheb Oliveira, Patricia R. Manzine, Carla M. Crispim Nascimento, Ariene A. dos Santos Orlandi, Grace A. de Oliveira Gomes, Fabiana dos Santos Orlandi, Marisa S. Zazzetta, Henrique Pott-Junior, Marcia R. Cominetti
Summary: Blood-based biomarkers are urgently needed for Alzheimer's disease diagnosis in clinical practice. This study found that plasma ADAM10 levels were significantly associated with cognitive decline in older adults during a 3-year follow-up period. The results suggest that ADAM10 may serve as a potential predictor for cognitive worsening, contributing to the advancement of blood biomarkers for AD research.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Geriatrics & Gerontology
Lena M. Hofbauer, Francisca S. Rodriguez
Summary: The study found a significant association between social deprivation and cognitive status and decline in older adults. Preventing social deprivation can improve cognitive functioning and reduce the incidence of dementia in older populations. Policies that facilitate early intervention in social deprivation will be crucial.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Warona Mathuba, Rachel Deer, Brian Downer
Summary: This study found racial disparities in the improvement of activities of daily living during a skilled nursing facility stay, with black and Hispanic residents having lower odds of improvement compared to white residents, especially among hip fracture and stroke patients. Future research should investigate systemic factors contributing to these disparities.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Orthopedics
Amit Kumar, Indrakshi Roy, Meghan Warren, Stefany D. Shaibi, Maximilian Fabricant, Jason R. Falvey, Amit Vashist, Amol M. Karmarkar
Summary: The study examines the impact of hospital-based rehabilitation services on community discharge rates after hip and knee replacement surgery. The findings suggest that higher amounts of rehabilitation services are associated with a higher likelihood of discharge to the community.
Article
Multidisciplinary Sciences
Maricruz Rivera-Hernandez, Amit Kumar, Lin-Na Chou, Tamra Keeney, Nasim Ferdows, Amol Karmarkar, Kyriakos S. Markides, Kenneth Ottenbacher
Summary: This study examines Medicare health care spending and health services utilization among high-need population segments in older Mexican Americans, and explores the impact of frailty on health care spending and utilization. The findings highlight that participants with major complex chronic illnesses who are also pre-frail or frail have higher total costs and utilization compared to the healthy segment.
Review
Geriatrics & Gerontology
Ahmed M. Negm, Adrian Salopek, Mashal Zaide, Victoria J. Meng, Carlos Prada, Yaping Chang, Preeti Zanwar, Flavia H. Santos, Elena Philippou, Emily R. Rosario, Julie Faieta, Jason R. Falvey, Amit Kumar, Timothy A. Reistetter, Vanina Dal Bello-Haas, Jonathan F. Bean, Mohit Bhandari, Patricia C. Heyn
Summary: The COVID-19 pandemic has posed significant burdens on healthcare systems, economies, and social systems worldwide. Providing rehabilitation services for individuals with active COVID-19 infection presents challenges in maintaining a safe environment for patients and healthcare providers.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Amy Givan, Brian Downer, Lin-Na Chou, Soham Al Snih
Summary: This study aimed to examine the association between cognitive impairment and low physical function over a 20-year follow-up period among older Mexican Americans. The results showed that participants with cognitive impairment were more likely to experience a decline in physical function over time, despite having moderate to high physical function and being non-disabled at baseline.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Geriatrics & Gerontology
Sadaf Arefi Milani, David S. Lopez, Brian Downer, Rafael Samper-Ternent, Rebeca Wong
Summary: The study indicates that diabetes is significantly associated with the risk of cognitive impairment and mortality, while being overweight or obese is linked to a reduced risk. Diabetes, regardless of BMI, increases the risk of mortality.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Correction
Geriatrics & Gerontology
Sadaf Arefi Milani, David S. Lopez, Brian Downer, Rafael Samper-Ternent, Rebeca Wong
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Health Care Sciences & Services
Victoria Shepard, Soham Al Snih, Rebecca Burke, Brian Downer, Yong-Fang Kuo, Ioannis Malagaris, Mukaila Raji
Summary: Hospice use is lower among Mexican-Americans and their duration of hospice stay is shorter, highlighting the need for early intervention to reduce variation in use.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2023)
Article
Geriatrics & Gerontology
Sadaf Arefi Milani, Tyler R. Bell, Michael Crowe, Caitlin N. Pope, Brian Downer
Summary: This study aimed to evaluate the bidirectional association between pain interference and cognitive performance. The findings suggest that increased pain interference is associated with greater cognitive decline, while better baseline cognitive performance is related to lower pain interference at follow-up.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Brian Downer, Chih-Ying Li, Soham Al Snih
Summary: Research indicates that ER admissions and hospitalizations among Mexican American older adults are associated with caregiver stress and depressive symptoms, similar to non-Hispanic White populations. However, cultural differences may influence the caregiving experience and perception of care burden. Multiple ER admissions and hospitalizations are significantly associated with higher caregiver stress, particularly for circulatory diseases and injuries.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Orthopedics
Amit Kumar, Indrakshi Roy, Jason Falvey, James L. Rudolph, Maricruz Rivera-Hernandez, Stefany Shaibi, Pallavi Sood, Christine Childers, Amol Karmarkar
Summary: Provision of early rehabilitation services during acute hospitalization is crucial for improving outcomes in hip fracture patients. This study found that older patients who received less rehabilitation were at a higher risk of hospital readmission within 7 and 30 days.
Article
Multidisciplinary Sciences
Cheyanne Barba, Brian Downer, Olivio Clay, Richard Kennedy, Erin Ballard, Michael Crowe
Summary: Frailty is associated with adverse health outcomes and greater healthcare utilization. This study examined the relationship between pre-frailty and frailty with healthcare utilization in Puerto Rico. Pre-frailty was associated with a higher rate of doctor visits, while frailty was associated with a higher rate of ER visits, hospital stays, and doctor visits.
Article
Geriatrics & Gerontology
Juan Ventura, Brian Downer, Chih-Ying Li, Soham Al Snih
Summary: This study examines whether there are nativity differences in the relationship between handgrip strength (HGS) and cognitive impairment among Mexican Americans aged > 65 years with normal or high cognitive function at baseline. The study found that both US-born and foreign-born participants in the highest quartile of HGS at baseline had lower odds of cognitive impairment over time compared to those in the lowest quartile.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Geriatrics & Gerontology
Huey-Ming Tzeng, Brian Downer, Chih-Ying Li, Mukaila A. Raji, Allen Haas, Yong-Fang Kuo
Summary: This study examined the association between cognitive impairment and re-fractures in older adults with hip fractures. The results showed that beneficiaries with cognitive impairment, especially those with minor impairment, had a higher likelihood of experiencing re-fractures.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Orthopedics
Shweta Gore, Hargun Khanna, Amit Kumar
Summary: The purpose of this study was to systematically review and conduct a meta-analysis on the impact of comprehensive outpatient cardiac rehabilitation in patients with heart failure. The results showed that comprehensive outpatient cardiac rehabilitation significantly improved exercise capacity and oxygen consumption in heart failure patients, but did not have additional benefits for quality of life.
