期刊
ALZHEIMERS & DEMENTIA
卷 12, 期 12, 页码 1207-1215出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2016.05.004
关键词
Alzheimer's disease; Community-dwelling; Aerobic exercise; Cardiorespiratory fitness; Single-task physical performance; Dual-task performance; Self-efficacy
资金
- Innovation Fund Denmark [10-092814]
- Lundbeck Foundation [FP 73/2012]
- Danish Ministry of Health [2007-12143-112, 59506/J, 0901110, 34501]
- Danish Health Foundation [2007B004]
Introduction: Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease. Methods: The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour X 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy. Results: Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of >= 66.6% resulted in significant positive effects on single-task physical performance and dual-task performance. Discussion: Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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