Article
Oncology
Kejia Hu, Maria Feychting, Donghao Lu, Arvid Sjolander, Kamila Czene, Per Hall, Fang Fang
Summary: The association between the use of NSAIDs and the risk of breast cancer is inconclusive, with inconsistent results between studies and lack of data on cancer subtype, stage, breast density, and previous breast disorders. This study investigated the association using data from women in Sweden and found no strong evidence to support a link between NSAID use and breast cancer risk.
Article
Allergy
Lily Li, Jillian Bensko, Kathleen Buchheit, Rebecca R. Saff, Tanya M. Laidlaw
Summary: This study investigated the safety and outcomes of two-step outpatient NSAID challenges for patients with non-aspirin-exacerbated respiratory disease (AERD)-related NSAID hypersensitivity. The results showed that more than 85% of the challenges were negative, allowing patients to use clinically indicated NSAIDs. The challenge reactions were generally mild.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Tamara Quint, Valerie Dahm, Dariga Ramazanova, Michael A. Arnoldner, Harald Kurz, Stefan Janik, Patrick M. Brunner, Birgit Knerer-Schally, Wolfgang Weninger, Johannes Griss, Robin Ristl, Sven Schneider, Christine Bangert
Summary: This study investigated the effect of omalizumab treatment on aspirin tolerance in atopic and nonatopic N-ERD patients. The results showed that omalizumab can improve aspirin tolerance in the majority of patients, regardless of atopic sensitization, and has a positive impact on chronic rhinosinusitis with nasal polyps, asthma, and biomarkers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
William C. Scott, Katherine N. Cahill, Ginger L. Milne, Ping Li, Quanhu Sheng, Li Ching Huang, Spencer Dennis, Jacob Snyder, Ashley M. Bauer, Rakesh K. Chandra, Naweed I. Chowdhury, Justin H. Turner
Summary: The study revealed differences in inflammatory cytokines levels between AERD and CRSwNP patients, with significant heterogeneity observed among AERD patients. Hierarchical cluster analysis identified 3 inflammatory subendotypes of AERD, each with distinct patterns of inflammation. Several lipid mediators were also associated with disease severity, but showed less variability compared to cytokines.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Transplantation
Hyung Ah Jo, Dong Ki Kim, Seokwoo Park, Yaerim Kim, Seung Seok Han, Bo Ram Yang, So-Hyun Choi, Mi-Sook Kim, Joongyub Lee, Hajeong Lee, Jung Pyo Lee, Chun Soo Lim, Yon Su Kim, Kwon Wook Joo
Summary: The study found that the use of NSAIDs significantly increased the risk of major adverse cardiac and cerebrovascular events (MACCEs) and mortality in dialysis patients, particularly nonselective NSAIDs. However, in the analysis based on the cumulative defined daily dosage of NSAIDs, there was no dose-dependent increase in the risk of MACCEs and mortality.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Environmental Sciences
Xiangju Li, Xue Xue, Jia Jia, Xiaocui Zou, Yongjing Guan, Long Zhu, Zaizhao Wang
Summary: The overuse of antimicrobial agents is a key factor in the emergence of antibiotic resistance bacteria (ARB), but it is unclear whether non-antibiotic chemicals like nonsteroidal anti-inflammatory drug (NSAID) can induce ARB. This study investigated whether NSAID diclofenac (DCF) promotes the emergence of antibiotic resistance in Escherichia coli K12 MG1655. The results showed that DCF induced hereditary stable ARB and caused gene variation on the chromosome. DCF also triggered bacterial oxidative stress and SOS response, leading to enhanced expression of antioxidant and SOS system-related genes. However, high-dosage DCF reduced mutation frequency but enhanced mutant resistance.
ENVIRONMENTAL POLLUTION
(2023)
Article
Allergy
Sen Hee Tay, Amelia Santosa, Eugene Chen Howe Goh, Chun Xiang Xu, Lik Hang Wu, Mei Bigliardi-Qi, Leroy Sivappiragasam S. O. Pakkiri, Bernett Teck Kwong Lee, Chester Lee Drum, Paul Lorenz Bigliardi
Summary: This study is the first to combine both transcriptomic and metabolomic approaches in patients with NIUA, contributing to a deeper understanding of the pathogenesis of NIUA and potentially paving the way for a molecular diagnosis of NSAID hypersensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Nafisseh S. Warner, Andrew C. Hanson, Phillip J. Schulte, Elizabeth B. Habermann, David O. Warner, Michelle M. Mielke
Summary: The study found that the use of prescription opioids in older adults is associated with small but statistically significant declines in long-term cognitive function. This may represent the effects of opioids themselves or other related factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Oncology
Jiaojiao Zheng, Giola Santoni, Shao-Hua Xie, Jesper Lagergren
Summary: The study suggests that the use of metformin in diabetes patients diagnosed with gastric adenocarcinoma may reduce the risk of disease-specific and all-cause mortality, particularly in female patients, patients with tumor stage III or IV, and those with the least comorbidity.
BRITISH JOURNAL OF CANCER
(2021)
Review
Medicine, Research & Experimental
Jianhan Ren, Melissa Rachel Fok, Yunfan Zhang, Bing Han, Yifan Lin
Summary: Periodontitis is a prevalent chronic disease that burdens societies and economies worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) have been proposed as adjunctive strategies for managing periodontitis due to their anti-inflammatory and pain-relieving properties. However, their effects on periodontal health and the risk-benefit ratio are still poorly understood. Recent evidence suggests a potential role for NSAIDs, especially aspirin, in periodontal regeneration.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Allergy
Lily Li, Yuchiao Chang, Elena Losina, Karen H. Costenbader, Antonia F. Chen, Tanya M. Laidlaw
Summary: This study examined the association between adverse drug reactions (ADRs) of nonsteroidal anti-inflammatory drugs (NSAIDs) and the use of opioids after total joint arthroplasty (TJA). The results showed that reported NSAID ADRs were associated with an increased risk of prolonged opioid use after surgery.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Els Mehuys, Tine De Backer, Filip De Keyser, Thierry Christiaens, Thierry Van Hees, Sophie Demarche, Inge Van Tongelen, Koen Boussery
Summary: The concomitant use of NSAIDs and antithrombotic agents increases the risk of bleeding and thromboembolism. In this intervention study, community pharmacists screened for and managed interactions between these drugs. The results showed that most interactions did not result in a change of pharmacotherapy, but in some cases, changes in medication were made.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Barbara Hutka, Anett Varallyay, Szilvia B. Laszlo, Andras S. Toth, Balint Scheich, Sandor Paku, Imre Voros, Zoltan Pos, Zoltan V. Varga, Derek D. Norman, Andrea Balogh, Zoltan Benyo, Gabor Tigyi, Klara Gyires, Zoltan S. Zadori
Summary: Lysophosphatidic acid (LPA) plays an important role in both NSAID-induced gastric injury and small intestinal injury. The signaling pathway of LPAR2 receptor is involved in the development of small intestinal injury, as well as the inflammatory responses associated with ulceration.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Sonia N. Pedro, Maria S. M. Mendes, Bruno M. Neves, Isabel Filipa Almeida, Paulo Costa, Ines Correia-Sa, Carla Vilela, Mara G. Freire, Armando J. D. Silvestre, Carmen S. R. Freire
Summary: This study found that aqueous solutions of bio-based deep eutectic solvents (DES) can significantly improve the solubility of nonsteroidal anti-inflammatory drug ibuprofen. These solutions showed no toxicity to cells and preserved the anti-inflammatory action of the drug. Incorporation into alginate-based hydrogels resulted in materials with a regular structure and high flexibility, and demonstrated sustained release of the drug.