Review
Biochemistry & Molecular Biology
Wei-Yu Chen, Shao-Chuan Chen, Shou-Yi Hsu, Yu-An Lin, Chun-Ming Shih, Chun-Yao Huang, Kuo-Hsien Wang, Ai-Wei Lee
Summary: Skin diseases have a significant impact on individuals and society, and there is a need for high attention and effective treatment methods in the medical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ya-Chu Tsai, Tsen-Fang Tsai
Summary: Psoriasis and atopic dermatitis are now considered to be a spectrum of disease, with overlapping genetic loci and immunopathogenesis. The clinical presentations also have similarities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Dengmei Xia, Yiyi Wang, Yue Xiao, Wei Li
Summary: Single-cell RNA sequencing (scRNA-seq) is a new technology that characterizes molecular heterogeneity at the single-cell level. It provides a deeper understanding of cell diversity in inflammatory skin diseases and sheds new light on cell-cell communication in disease responses. It holds promise as a tool in precision medicine for defining cell subsets with potential treatment targets and characterizing cell-specific responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Roudin Sarama, Priya K. Matharu, Yousef Abduldaiem, Mab P. Correa, Cristiane D. Gil, Karin V. Greco
Summary: Psoriasis and Atopic Dermatitis are common inflammatory skin diseases with immune response dysregulation playing a crucial role in their pathogenesis. In vitro disease models have been widely used to study these conditions, but further development is needed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Youming Guo, Lingling Luo, Jing Zhu, Chengrang Li
Summary: Psoriasis and atopic dermatitis are inflammatory skin diseases with multiple causes and heterogeneity. Despite years of research, there is no cure, and the costs of caring for patients with these diseases are a significant burden on society. Integrating multiple omics datasets allows simultaneous analysis of genes, RNAs, chromatins, proteins, and metabolites, revealing networks between different molecular levels. This review discusses the latest developments in genomics, transcriptomics, proteomics, and metabolomics, and explores how they are used to identify biomarkers and understand the pathogenic mechanisms of these diseases. Finally, strategies for achieving multi-omics integration and the potential of integrative omics and systems biology in advancing our knowledge and treatment of psoriasis and atopic dermatitis are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Article
Psychiatry
C. Jameson, K. A. Boulton, N. Silove, A. J. Guastella
Summary: Growing evidence suggests that genetic, neurological, and environmental factors contribute to the development of autism spectrum disorder (ASD). Interestingly, children with ASD often have skin disorders, possibly due to the shared embryonic origin of skin and neural tissue. This study found that atopic disorders, especially comorbid eczema, are associated with increased ASD symptom severity in children.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Allergy
Jacob P. Thyssen, Anne-Sofie Halling, Peter Schmid-Grendelmeier, Emma Guttman-Yassky, Jonathan I. Silverberg
Summary: Atopic dermatitis is a common disease associated with both atopic and nonatopic comorbidities. The presence or risk of comorbidities can significantly affect the management of AD patients. This review article provides an update on various comorbidities of AD based on recent systematic reviews and meta-analyses, highlighting the importance of studies presenting both relative risk and absolute risk. It discusses the association of AD with atopic comorbidities (such as asthma, rhinitis, and food allergy) and nonatopic comorbidities (including ocular, psychiatric, infectious, endocrine, autoimmune, and cardiovascular diseases, as well as certain cancers). Clinicians need to be aware of these associations and consider the positive and negative effects of different treatments for AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liis Ilves, Aigar Ottas, Bret Kaldvee, Kristi Abram, Ursel Soomets, Mihkel Zilmer, Viljar Jaks, Kulli Kingo
Summary: This study analyzed the metabolomic profiles of patients with atopic dermatitis (AD) and psoriasis (PS), and found clear differences between the two diseases. AD was associated with a deficient barrier function, while PS was associated with elevated cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Ju Hee Kim, Eun Lee, Eun Kyo Ha, Jeewon Shin, Gi Chun Lee, Yeong Ho Rha, Man Yong Han
Summary: This study used national health insurance data to track individuals born in Korea between 2002 and 2003 and found that atopic dermatitis in children can lead to other diseases. The study identified 20 diseases that are associated with a higher risk of atopic dermatitis, and revealed a temporal sequence of interconnected comorbidities, starting with febrile seizures, constipation, and asthma in childhood and progressing to food allergy, allergic rhinitis, psychiatric disorders, and autoimmune diseases.
Review
Biochemistry & Molecular Biology
Tatsuya Ogawa, Yosuke Ishitsuka
Summary: The KEAP1-NRF2 system plays an important role in the pathophysiology of atopic dermatitis and psoriasis, and can be utilized for the treatment of these skin diseases.
Review
Biochemistry & Molecular Biology
Monika Marko, Rafal Pawliczak
Summary: Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases with increasing prevalence worldwide, causing decreased quality of life and socioeconomic burden. Resveratrol and its derivatives, based on natural compounds, show potential therapeutic effects through anti-inflammatory and antioxidant pathways.
Review
Biochemistry & Molecular Biology
Stefan Blunder, Petra Pavel, Deborah Minzaghi, Sandrine Dubrac
Summary: PPARs are nuclear hormone receptors expressed in the skin that play a crucial role in regulating cellular functions and metabolism. While PPAR beta/delta remains the least studied member in the skin, its importance in regulating inflammation, cell proliferation and differentiation, metabolism, and oxidative stress response cannot be overlooked.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Michela Iannone, Agata Janowska, Salvatore Panduri, Riccardo Morganti, Giulia Davini, Marco Romanelli, Valentina Dini
Summary: The interaction between the immunological and nervous system in the skin has a significant impact on patients with psoriasis, atopic dermatitis, and hidradenitis suppurativa. Psychodermatological interventions can improve quality of life, disease flare-ups, and long-term management for these patients.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Natsuko Saito-Sasaki, Yu Sawada
Summary: This review provides detailed information on the interactions among various S100 proteins in inflammatory diseases, highlighting the significant role of S100 proteins as important substances in the inflammatory process of skin tissues.
Letter
Dermatology
Mette Gyldenlove, Howraman Meteran, Claus Zachariae, Alexander Egeberg
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jacob Christensen, Filip Soeskov Davidovski, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Alia Lassen, Alia Alhakak, Morten Sengelov, Anne Bjerg Nielsen, Niklas Dyrby Johansen, Henning Bundgaard, Christian Hassager, Reza Jabbari, Jorn Carlsen, Ole Kirk, Ole Peter Kristiansen, Olav Wendelboe Nielsen, Charlotte Suppli Ulrik, Pradeesh Sivapalan, Gunnar Gislason, Kasper Iversen, Jens Ulrik Staehr Jensen, Morten Schou, Anders Hviid, Tyra Grove Krause, Tor Biering-Sorensen
Summary: This study investigated whether the prognostic values of echocardiographic parameters changed with updates in treatment guidelines and the emergence of novel SARS-CoV-2 variants. The results showed that patients hospitalized during the second wave had worse left ventricular function, and reduced global longitudinal strain was associated with COVID-19-related mortality independently of wave, treatment, and SARS-CoV-2 variant.
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Deewa Zahir, Mona Fiuzat, Ersilia M. DeFilippis, James L. Januzzi, Javed Butler, Christopher M. O'Connor, William T. Abraham, Mitchell A. Psotka, John J. V. McMurray, Pooja Dewan, Brian L. Claggett, Scott D. Solomon, Daniel Modin, Jawad H. Butt, Jens Ulrik Staehr Jensen, Morten Schou, Christian Torp-Pedersen, Lars Kober, Gunnar H. Gislason, Tor Biering-Sorensen
Summary: This study validated the use of a composite medical therapy score in Danish heart failure patients and found that higher scores were associated with lower mortality.
CIRCULATION-HEART FAILURE
(2023)
Letter
Dermatology
Amy X. Du, Zarqa Ali, Kawa K. Ajgeiy, Maiken G. Dalager, Tomas N. Dam, Alexander Egeberg, Christoffer V. S. Nissen, Lone Skov, Simon Francis Thomsen, Sepideh Emam, Robert Gniadecki
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Letter
Dermatology
Mia-Louise Nielsen, David Thein, Mads Kirchheiner Rasmussen, Trine Bertelsen, Tomas Norman Dam, Lone Skov, Lars Erik Bryld, Jashin J. Wu, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Dermatology
Diva Amiri, Christopher Willy Schwarz, Lise Gether, Lone Skov
Summary: Facial and genital psoriasis can significantly impact the quality of life and are difficult to treat. Topical calcineurin inhibitors have been recognized as an effective off-label treatment for these sensitive areas, but limited data on safety and efficacy are available. A systematic review of the literature found positive efficacy in all 24 included studies, with statistically significant reductions in psoriasis severity observed in 11 studies. The most common short-term adverse effects reported were local stinging, burning, and itching. Topical calcineurin inhibitors play an important role in the treatment of facial and genital psoriasis, demonstrating effectiveness and generally good tolerability with minimal adverse effects.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Allergy
Lise Gether, Heidi Storgaard, Sanja Kezic, Ivone Jakasa, Bolette Hartmann, Kirsa Skov-Jeppesen, Jens J. Holst, Anders J. Pedersen, Julie Forman, Gerrit van Hall, Ole E. Sorensen, Lone Skov, Mads A. Ropke, Filip K. Knop, Jacob Pontoppidan Thyssen
Summary: This study investigated whether whole-body treatment with topical corticosteroids for atopic dermatitis could lead to insulin resistance and increased bone resorption. The results showed that short-term use of these corticosteroids did not affect glucose metabolism but had a negative impact on bone formation.
Article
Cardiac & Cardiovascular Systems
Dea Haagensen Kofod, Nicholas Carlson, Ellen Freese Ballegaard, Thomas Peter Almdal, Christian Torp-Pedersen, Gunnar Gislason, Jesper Hastrup Svendsen, Bo Feldt-Rasmussen, Mads Hornum
Summary: This study investigated the risk of cardiovascular mortality in patients with advanced chronic kidney disease (CKD). The results showed that diabetes, albuminuria, and anemia were significant risk factors for cardiovascular mortality, while the predictive value of LDL-cholesterol for cardiovascular mortality in advanced CKD may be limited.
CARDIOVASCULAR DIABETOLOGY
(2023)
Letter
Dermatology
Christopher W. Schwarz, Nikolai Loft, Diljit Kaur-Knudsen, Claus Zachariae, Lone Skov
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
David Thein, Nana A. L. Roseno, Julia-Tatjana Maul, Jashin J. Wu, Lone Skov, Lars Erik Bryld, Mads K. Rasmussen, Kawa Khaled Ajgeiy, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg
Summary: The real-world effectiveness of biologics in treating psoriasis was examined using a nationwide registry. The results showed that the risk of discontinuation or off-label dose escalation was lower for secukinumab compared to ustekinumab, but higher for adalimumab. However, the risk of discontinuation was higher for both secukinumab and adalimumab. For patients who were bio-naive, the risk of discontinuation was comparable between secukinumab and ustekinumab.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
J. P. Thyssen, D. Thaci, T. Bieber, M. Gooderham, M. de Bruin-Weller, W. Soong, K. Kabashima, S. Barbarot, P. C. Luna, J. Xu, X. Hu, Y. Liu, E. M. Raymundo, B. M. Calimlim, C. Nduaka, A. Gamelli, E. L. Simpson
Summary: This study evaluated the efficacy of oral Janus kinase inhibitor upadacitinib in subgroups of patients with moderate-to-severe atopic dermatitis (AD). The results showed that upadacitinib consistently improved skin condition and itch in these subgroups, regardless of age, sex, race, disease severity, body surface area involvement, past treatment history, etc. These findings support upadacitinib as a suitable treatment option for a variety of AD patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Brandon Smith, Priya Engel, Michael R. R. Collier, Shivali Devjani, Jacob P. P. Thyssen, Jashin J. J. Wu
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nina Fons Johnsen, Sidsel Normann Jensen, Karl Bang Christensen, Susanne S. Pedersen, Charlotte Helmark, Ann-Dorthe Zwisler, Gunnar H. Gislason
Summary: This study demonstrates that the combination of WHO-5, ASS-2, and MDI-2 can be used as an alternative to the HADS questionnaire in screening anxiety and depression in cardiac patients. Crosswalks (translation tables) were generated to facilitate clinical practice.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jarl Emanuel Strange, Daniel Molager Christensen, Caroline Sindet-Pedersen, Morten Schou, Alexander Christian Falkentoft, Lauge Ostergaard, Jawad Haider Butt, Peter Laursen Graversen, Lars Kober, Gunnar Gislason, Jonas Bjerring Olesen, Emil Loldrup Fosbol
Summary: Frailty is strongly associated with time in hospital and mortality among patients undergoing transcatheter aortic valve replacement. Higher frailty levels are linked to longer hospital stays and increased risk of death within one year. Strategies aimed at preventing hospitalization among frail patients could be beneficial in reducing the burden of care.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Darryl P. Leong, Philip Joseph, John J. Mcmurray, Jean Rouleau, Aldo P. Maggioni, Fernando Lanas, Sanjib K. Sharma, Julio Nunez, Bishav Mohan, Ahmet Celik, Jabir Abdullakutty, Okechukwu S. Ogah, Lisa M. Mielniczuk, Kumar Balasubramanian, Tara Mccready, Alex Grinvalds, Salim Yusuf, G CHF Investigators
Summary: Frailty has incremental prognostic importance in predicting death and HF hospitalization in HF populations, beyond conventional prognostic variables. This relationship is consistent across countries at all income levels.
EUROPEAN HEART JOURNAL
(2023)