期刊
ALLERGY
卷 71, 期 10, 页码 1461-1471出版社
WILEY
DOI: 10.1111/all.12915
关键词
allergic rhinitis; birth cohorts; greenness; normalized difference vegetation index; sensitization
资金
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Stiftelsen Frimurare Barnhuset i Stockholm
- Matsumura's donation
- Stockholm County Council
- Swedish Environmental Protection Agency
- Swedish Society for Medical Research
- Swedish Foundation for Strategic Research
- Swedish Research Council for Health Working Life and Welfare
- Netherlands Organization for Health Research and Development
- Netherlands Organization for Scientific Research
- Netherlands Asthma Fund
- Netherlands Ministry of Spatial Planning, Housing, and the Environment
- Netherlands Ministry of Health, Welfare and Sport
- Federal Ministry for Education, Science, Research and Technology
- Helmholtz Zentrum Munich
- Federal Ministry for Environment (IUF) [FKZ 20462296]
- Helmholtz Centre for Environmental Research-UFZ, Leipzig
- Marien-Hospital Wesel
- Pediatric Practice, Bad Honnef
- Canadian Institutes of Health Research
- British Columbia Lung Association
- Manitoba Medical Service Foundation
- Nestec Ltd
- Asthma Foundation of Victoria
- NHMRC
- AllerGen Networks of Centres of Excellence
- European Community [211250]
Background: The prevalence of allergic rhinitis is high, but the role of environmental factors remains unclear. We examined cohort-specific and combined associations of residential greenness with allergic rhinitis and aeroallergen sensitization based on individual data from Swedish (BAMSE), Australian (MACS), Dutch (PIAMA), Canadian (CAPPS and SAGE), and German (GINI-plus and LISAplus) birth cohorts (n = 13 016). Methods: Allergic rhinitis (doctor diagnosis/symptoms) and aeroallergen sensitization were assessed in children aged 6-8 years in six cohorts and 10-12 years in five cohorts. Residential greenness was defined as the mean Normalized Difference Vegetation Index (NDVI) in a 500-m buffer around the home address at the time of health assessment. Cohort-specific associations per 0.2 unit increase in NDVI were assessed using logistic regression models and combined in a random-effects meta-analysis. Results: Greenness in a 500-m buffer was positively associated with allergic rhinitis at 6-8 years in BAMSE (odds ratio = 1.42, 95% confidence interval [1.13, 1.79]) and GINI/LISA South (1.69 [1.19, 2.41]) but inversely associated in GINI/LISA North (0.61 [0.36, 1.01]) and PIAMA (0.67 [0.47, 0.95]). Effect estimates in CAPPS and SAGE were also conflicting but not significant (0.63 [0.32, 1.24] and 1.31 [0.81, 2.12], respectively). All meta-analyses were nonsignificant. Results were similar for aeroallergen sensitization at 6-8 years and both outcomes at 10-12 years. Stratification by NO2 concentrations, population density, an urban vs rural marker, and moving did not reveal consistent trends within subgroups. Conclusion: Although residential greenness appears to be associated with childhood allergic rhinitis and aeroallergen sensitization, the effect direction varies by location.
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