Review
Gastroenterology & Hepatology
Luc Biedermann, Alex Straumann
Summary: This review provides an updated overview of the pathogenesis and clinical management of EoE, discussing treatment options and pointing out unresolved issues.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Edoardo Savarino, Aurelio Mauro, Roberto Penagini, Francesca Racca, Matteo Ghisa, Giorgio Laserra, Stefania Merli, Elena Arsie, Valeria Longoni, Nicola de Bortoli, Andrea Sostilio, Elisa Marabotto, Sebastiano Ziola, Alessandro Vanoli, Fabiana Zingone, Brigida Barberio, Salvatore Tolone, Ludovico Docimo, Gaia Pellegatta, Giovanni Paoletti, Mentore Ribolsi, Alessandro Repici, Catherine Klersy, Antonio Di Sabatino
Summary: The study on 261 EoE patients revealed a significant diagnostic delay issue, influenced by both patient-related and physician-related factors. Factors like previous misdiagnosis, symptoms, and medical history could contribute to diagnostic delays.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Immunology
Melanie A. Ruffner, Zhe Zhang, Kelly Maurer, Amanda B. Muir, Antonella Cianferoni, Kathleen E. Sullivan, Jonathan M. Spergel
Summary: This study focused on milk-induced eosinophilic oesophagitis (EoE) patients undergoing epicutaneous immunotherapy (EPIT) and identified transcriptional changes in peripheral CD4(+) T cells, suggesting potential therapeutic effects of EPIT on EoE.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Brigida Barberio, Giulio Del Corso, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford, Edoardo Savarino
Summary: A network meta-analysis was conducted to compare the efficacy of different drugs for active eosinophilic esophagitis (EoE). The results showed that most available drugs were more effective than placebo in treating EoE. However, significant heterogeneity among the trials hindered the establishment of a solid therapeutic hierarchy.
Article
Multidisciplinary Sciences
Joan Domenech Witek, Rosario Gonzalez Mendiola, Vicente Jover Cerda, Javier Pereira Gonzalez, Clara Carballas Vazquez, Felicitas Villas Martinez, Ramon Rodriguez Pacheco
Summary: This study aims to report the sensitivities to environmental, food allergens, and panallergens in patients with eosinophilic oesophagitis with atopic background, as well as characterizing other markers or analytical parameters. We suspect that the prevalence of sensitization to panallergens will be high and this will probably be relevant in terms of the onset and clinical course of the disease.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Jesus Gonzalez-Cervera, Angel Arias, Pilar Navarro, Rocio Juarez-Tosina, Maria Cobo-Palacios, Jose M. Olalla, Teresa Angueira-Lapena, Alfredo J. Lucendo
Summary: The study evaluated the tolerance of sterilised milk in EoE patients and its impact on quality of life. The results showed that the majority of patients could tolerate sterilised milk in both the short-term and long-term, but it may cause EoE recurrence in some patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Sonia Facchin, Matteo Calgaro, Mattia Pandolfo, Federico Caldart, Matteo Ghisa, Eliana Greco, Eleonora Sattin, Giorgio Valle, Evan Dellon, Nicola Vitulo, Edoardo Vincenzo Savarino
Summary: This study aimed to collect and characterize the microbiome of adult patients with eosinophilic oesophagitis (EoE) and correlate the findings with disease activity. Preliminary data suggest that salivary metabarcoding analysis in combination with machine learning approaches could become a valid, cheap, non-invasive test to distinguish between EoE and non-EoE patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Lillian Wang, Kristin C. Mara, Karthik Ravi, Tsung-Teh Wu, Thomas C. Smyrk, David A. Katzka, Jeffrey A. Alexander
Summary: This retrospective study aimed to determine the response rates and predictors of histologic response to elimination diets in adults with EoE. The results showed that a higher pre-SFED EREF score was associated with dietary non-response to SFED. Additionally, poor correlation between symptoms and histologic flares was observed, and ExSFED identified additional dietary responders. Therefore, histologic confirmation should be sought before committing patients to lifelong dietary changes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pediatrics
Mansoor Ahmed, Nyaish Mansoor, Tihami Mansoor
Summary: Eosinophilic oesophagitis is a chronic inflammatory disorder involving the esophagus, diagnosed by upper gastrointestinal endoscopy and esophageal biopsies. There is significant variation in treatment practices, including medications and dietary changes. Long-term treatment may be necessary to control symptoms and prevent complications.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Ashley L. Pyne, Mark W. Hazel, Amiko M. Uchida, Fares Qeadan, Kristine C. Jordan, Amy Holman, Brinnlie Harward, Gerald J. Gleich, Kathryn A. Peterson
Summary: This study found that there are immunoglobulins other than IgG4 and food-specific antibodies present in the oesophageal secretions of eosinophilic oesophagitis (EoE) patients. Patients with active EoE had elevated concentrations of IgG2, IgG4, and IgM in their oesophageal secretions, as well as increased levels of food-specific IgG1, IgG2, IgG4, and IgM. This suggests a potential role for multiple immunoglobulins and food-specific antibodies in the pathophysiology of EoE.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Stephan Miehlke, Christoph Schlag, Alfredo J. Lucendo, Luc Biedermann, Cecilio Santander Vaquero, Christoph Schmoecker, Jamal Hayat, Petr Hruz, Constanza Ciriza de los Rios, Albert Jan Bredenoord, Michael Vieth, Alain Schoepfer, Stephen Attwood, Ralph Mueller, Sarah Burrack, Roland Greinwald, Alex Straumann
Summary: This study confirms the effectiveness and safety of a novel budesonide orodispersible tablet in the treatment of active eosinophilic oesophagitis patients for 6 weeks in an open-label induction treatment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Anupama Ravi, Eric Marietta, Jeffrey A. Alexander, Kathryn Peterson, Crystal Lavey, Debra M. Geno, Joseph A. Murray, David A. Katzka
Summary: The study found that food antigens show prolonged presence in the esophageal epithelium of EoE patients, potentially triggering the Th2 allergic pathway. Active EoE patients had higher antigen staining density compared to inactive patients, especially for whey.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pediatrics
Irit Rosen, Aos Mahamed, Jamal Garah, Ramit Magen-Rimon, Ron Shaoul
Summary: This study reviewed the medical records of 102 pediatric EoE patients and found that treatment with topical steroids had the highest improvement rates clinically, endoscopically, and histologically, at 87.5%, 65.4%, and 88.5% respectively.
Article
Gastroenterology & Hepatology
Tanay Kaymak, Berna Kaya, Philipp Wuggenig, Sandro Nuciforo, Andreas Goldi, Franz Oswald, Julien Roux, Mario Noti, Hassan Melhem, Petr Hruz, Jan Hendrik Niess
Summary: This study illustrates the importance of the IL-20 subfamily in maintaining the barrier function of the esophagus in the context of EoE. The dysregulation of IL-20 subfamily signaling disrupts the integrity of the esophageal epithelial barrier and promotes the development of EoE. Targeting the IL-20 subfamily signaling pathway may provide a novel strategy for the treatment of EoE.
Editorial Material
Gastroenterology & Hepatology
Benjamin D. Rogers, C. Prakash Gyawali
Summary: This article is linked to papers by Frazzoni et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)