期刊
BIOFOULING
卷 31, 期 9-10, 页码 689-697出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2015.1094690
关键词
detergency; hydrogel; block copolymer; critical micelle concentration (CMC); contact lens; multipurpose solution (MPS)
资金
- FDA Medical Countermeasures Initiative (MCMi)
- Center for Devices and Radiological Health (CDRH)
Block co-polymer surfactants have been used for cleaning hydrogel medical devices that contact the body (eg contact lenses) because of their biocompatibility. This work examined the relationship between concentration and detergency of two non-ionic polymeric surfactants (Pluronic F127 and Triton X-100) for cleaning protein soil, with anionic surfactants (sodium dodecyl sulfate and sodium laureth sulfate) as positive controls. Surface plasmon resonance was used to quantify removal of simulated tear soil from self-assembled monolayer surfaces, and a microplate format was used to study the removal of fluorescently labeled soil proteins from contact lenses. While detergency increased as a function of concentration for anionic surfactants, it decreased with concentration for the two polymeric surfactants. The fact that the protein detergency of some non-ionic polymeric surfactants did not increase with concentration above the critical micelle concentration could have implications for optimizing the tradeoff between detergency and biocompatibility.
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