期刊
BIOFOULING
卷 31, 期 8, 页码 665-675出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2015.1083985
关键词
Pseudomonas aeruginosa; biofilm; infection; heat shock; implanted medical device
资金
- American Heart Association [11SDG7600044]
- National Science Foundation [CBET-1133297]
- National Institute for General Medical Sciences of the National Institutes of Health [5T32GM008365]
- Iowa Center for Biocatalysis and Bioprocessing
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1133297] Funding Source: National Science Foundation
Bacterial biofilms infect 2-4% of medical devices upon implantation, resulting in multiple surgeries and increased recovery time due to the very great increase in antibiotic resistance in the biofilm phenotype. This work investigates the feasibility of thermal mitigation of biofilms at physiologically accessible temperatures. Pseudomonas aeruginosa biofilms were cultured to high bacterial density (1.7 x 10(9) CFU cm(-2)) and subjected to thermal shocks ranging from 50 degrees C to 80 degrees C for durations of 1-30 min. The decrease in viable bacteria was closely correlated with an Arrhenius temperature dependence and Weibull-style time dependence, demonstrating up to six orders of magnitude reduction in bacterial load. The bacterial load for films with more conventional initial bacterial densities dropped below quantifiable levels, indicating thermal mitigation as a viable approach to biofilm control.
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