Article
Geriatrics & Gerontology
Tiina Fohr, Timo Tormakangas, Hannamari Lankila, Anne Viljanen, Taina Rantanen, Miina Ollikainen, Jaakko Kaprio, Elina Sillanpaa
Summary: The study found that DNAm GrimAge is associated with decline in physical functioning in older women, while other epigenetic clocks such as DNAmAge and PhenoAge have weaker associations with physical function decline.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Oncology
Fohr Tiina, Waller Katja, Viljanen Anne, Sanchez Riikka, Ollikainen Miina, Rantanen Taina, Kaprio Jaakko, Elina Sillanpaa
Summary: The study found that DNAm GrimAge is a strong predictor of mortality independent of genetic influences. Smoking attenuated the association between epigenetic aging and mortality risk.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Yun-Hsiang Lo, Wan-Yu Lin
Summary: This study comprehensively investigates the associations between cardiovascular health and four epigenetic clocks. The findings suggest that ideal cardiovascular health is associated with lower levels of biological aging, reducing the risk of aging-related disorders.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Xue-Yong Chang, Wan-Yu Lin
Summary: This study comprehensively investigates the role of five measures of epigenetic age acceleration (EAA) in mediating the associations of smoking with health outcomes in an Asian population. The results show that the second-generation epigenetic clocks (GrimEAA, DunedinPACE, and PhenoEAA) significantly mediate smoking associations with diabetes-related outcomes. In contrast, the first-generation epigenetic clocks (HannumEAA and IEAA) do not significantly mediate any associations of smoking variables with the four health outcomes. Cigarette smoking can directly and indirectly deteriorate human health through DNA methylation changes in aging-related CpG sites.
CLINICAL EPIGENETICS
(2023)
Article
Cell Biology
Natalia A. Prado, Janine L. Brown, Joseph A. Zoller, Amin Haghani, Mingjia Yao, Lora R. Bagryanova, Michael G. Campana, Jesus E. Maldonado, Ken Raj, Dennis Schmitt, Todd R. Robeck, Steve Horvath
Summary: Age-associated DNA-methylation profiles have been used to develop highly accurate biomarkers of age (epigenetic clocks) for African and Asian elephants. These clocks were developed using novel DNA methylation profiles of known age samples, and can be used for conservation efforts where accurate estimates of age are needed. Epigenome-wide association studies identified age-related CpGs and their proximal genes, revealing their importance in cellular differentiation, organismal development, metabolism, and circadian rhythms.
Article
Biochemistry & Molecular Biology
Zulfiya G. Guvatova, Anastasiya A. Kobelyatskaya, Elena A. Pudova, Irina V. Tarasova, Anna V. Kudryavtseva, Olga N. Tkacheva, Irina D. Strazhesko, Alexey A. Moskalev
Summary: This study estimated the epigenetic age of long-lived individuals and found that their epigenetic age was significantly lower than their chronological age, indicating a slowing of aging. However, there were no significant differences in epigenetic age between healthy long-lived individuals and those with frailty, and no differences in epigenetic age were observed based on sex. The study emphasizes the need for further research on the epigenetic status of centenarians.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Khyobeni Mozhui, Ake T. Lu, Caesar Z. Li, Amin Haghani, Jose Vladimir Sandoval-Sierra, Yibo Wu, Robert W. Williams, Steve Horvath
Summary: Changes in DNA methylation are related to aging. In this study, highly conserved CpGs in 339 mostly female mice from the BXD family were profiled to examine the relationship between epigenetic changes and longevity. The study found that a high-fat diet increases age-related changes in methylation, and that entropy increases with age. The research also identified genetic loci associated with epigenetic age acceleration and revealed a connection between metabolic state and epigenetic aging.
Article
Cell Biology
Noemie Gensous, Claudia Sala, Chiara Pirazzini, Francesco Ravaioli, Maddalena Milazzo, Katarzyna Malgorzata Kwiatkowska, Elena Marasco, Sara De Fanti, Cristina Giuliani, Camilla Pellegrini, Aurelia Santoro, Miriam Capri, Stefano Salvioli, Daniela Monti, Gastone Castellani, Claudio Franceschi, Maria Giulia Bacalini, Paolo Garagnani
Summary: In this study, a targeted epigenetic clock was developed to measure biological age based on DNA methylation. The results showed that the targeted epigenetic clock can serve as a new marker for biological age and should be further evaluated in large cohorts.
Article
Oncology
Mary E. Sehl, Jill E. Henry, Anna M. Storniolo, Steve Horvath, Patricia A. Ganz
Summary: The study found associations between earlier age at menarche and higher BMI with elevated DNA methylation-based age estimates in healthy breast tissues, indicating that cumulative estrogen exposure drives breast epigenetic aging. This suggests that epigenetic clock measures may help advance understanding of the relationship between accelerated breast tissue aging and increased breast cancer incidence in younger women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Biology
Isabel R. Sullivan, Danielle M. Adams, Lucas J. S. Greville, Paul A. Faure, Gerald S. Wilkinson
Summary: Comparative analyses of bats show that hibernation is associated with increased longevity. This study uses DNA methylation as an epigenetic biomarker of aging to investigate the effect of hibernation on the big brown bat. The results indicate that hibernation influences epigenetic age, and specific genomic sites show changes in DNA methylation during hibernation independent of age. These findings suggest that hibernation may have an impact on the aging and longevity of bats.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Antoine Daunay, Lise M. Hardy, Yosra Bouyacoub, Mourad Sahbatou, Mathilde Touvier, Helene Blanche, Jean-Francois Deleuze, Alexandre How-Kit
Summary: Aging is a progressive biological process that affects individuals in different ways. Epigenetic alterations, specifically the epigenetic drift and clock at the DNA methylation level, are one of the hallmarks of aging. This study examined the DNA methylation-based age (DNAmage) in French centenarians and semi-supercentenarians as well as nonagenarians' and centenarians' offspring. The findings showed that exceptionally long-lived individuals have a younger DNAmage compared to their chronological age, indicating a potential slowing of epigenetic and biological aging. Additionally, it was found that epigenetic clocks based on a small number of CpGs are sufficient to detect alterations in the overall epigenetic clock.
Article
Oncology
Chris P. Verschoor, David T. S. Lin, Michael S. Kobor, Oxana Mian, Jinhui Ma, Guillaume Pare, Gustavo Ybazeta
Summary: The study found that epigenetic clocks trained on phenotypic markers of health or mortality outperformed age-trained clocks in their association with frailty. GrimAge showed the strongest association with frailty. Some epigenetic clocks were significantly associated with short-term changes in frailty, supporting their utility in initiatives and interventions to promote healthy aging.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Shiori Minabe, Akira Takashima, Kozo Tanno, Makoto Sasaki, Atsushi Shimizu
Summary: This study analyzed the fluctuations of epigenetic age in samples from two Japanese men and found that there were considerable fluctuations in epigenetic age over a 3-month period, and these fluctuations were not suppressed by correcting for cell-type composition.
CLINICAL EPIGENETICS
(2022)
Review
Cell Biology
Ran Duan, Qiaoyu Fu, Yu Sun, Qingfeng Li
Summary: This review provides a comprehensive overview of the epigenetic clock as a biomarker of aging and its application in promoting healthy aging. Different types of epigenetic clocks continue to emerge and their correlation with morbidity, mortality, and other factors suggests their potential for risk prediction and evaluation of age-reversing interventions.
AGEING RESEARCH REVIEWS
(2022)
Article
Genetics & Heredity
Mary E. E. Sehl, Elizabeth Crabb Breen, Roger Shih, Larry Chen, Ruibin Wang, Steve Horvath, Jay H. H. Bream, Priya Duggal, Jeremy Martinson, Steven M. M. Wolinsky, Otoniel Martinez-Maza, Christina M. M. Ramirez, Beth D. D. Jamieson
Summary: This study found that the rate of epigenetic aging is significantly accelerated in untreated individuals living with HIV. HIV infection not only elevates epigenetic age, but also increases the rate of aging in the years following infection.
FRONTIERS IN GENETICS
(2022)
Article
Geriatrics & Gerontology
Laura Kananen, Mikko Hurme, Alexander Buerkle, Maria Moreno-Villanueva, Jurgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dolle, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Harkanen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimaki, Olli T. Raitakari, Olavi Ukkola, Mika Kahonen, Marja Jylha, Juulia Jylhava
Summary: Circulating cell-free DNA (cf-DNA) levels are associated with age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes, and various biomarkers. Higher cf-DNA levels were found in men, especially middle-aged men and women who smoke, and older frail individuals. Inflammatory markers, metabolites, and antioxidant levels were correlated with cf-DNA levels. These findings have implications for future studies on the epidemiology and biological mechanisms of cf-DNA and its potential as a clinical marker.
Letter
Dermatology
Ilari Maki-Opas, Mari Hamalainen, Lauri J. Moilanen, Heini Sood, Tiina Leppanen, Laura Kummola, Ilkka S. Junitila, Lauri Letimaki, Eeva Moilanen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Psychology, Clinical
Amanda Nurmi, Laura Pulkki-Raback, Pia Salo, Katja Pahkala, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Terho Lehtimaki, Eero Jokinen, Liisa Keltikangas-Jarvinen, Tomi P. Laitinen, Paivi Tossavainen, Leena Taittonen, Jorma S. A. Viikari, Olli T. Raitakari, Suvi P. Rovio
Summary: The study found that adverse childhood psychosocial factors are associated with midlife learning ability and memory. Specifically, poor self-regulatory behavior and social adjustment in childhood are related to poorer learning ability and memory 30 years later.
Article
Pediatrics
Anna P. Tikkakoski, Antti Tikkakoski, Kalle Sipila, Juho E. Kivisto, Heini Huhtala, Mika Kahonen, Jussi Karjalainen, Lauri Lehtimaki
Summary: Long-term exposure to air pollution is associated with asthma morbidity in children. It has been found that even low concentrations of particulate matter (PM2.5) may have an effect on exercise-induced bronchoconstriction (EIB) in children.
PEDIATRIC PULMONOLOGY
(2023)
Article
Genetics & Heredity
Tiit Ord, Tapio Lonnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen, Miika Kiema, Kadri Ounap, Maleeha Maria, Pierre R. Moreau, Pashupati P. Mishra, Senthil Palani, Jenni Virta, Heidi Liljenback, Einari Aavik, Anne Roivainen, Seppo Yla-Herttuala, Johanna P. Laakkonen, Terho Lehtimaki, Minna U. Kaikkonen
Summary: Coronary artery disease (CAD) is a global disease with significant genetic factors. By using single-cell and bulk RNA sequencing, this study explores the biological diversity of atherosclerosis-associated cell states and their contribution to CAD risk. The researchers identified disease-associated cell states, with Vcam1 thorn smooth muscle cells showing the highest contribution to CAD heritability. The findings provide insights into CAD risk mechanisms and have implications for precision medicine and tailored therapeutic interventions.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Endocrinology & Metabolism
Ville-Petteri Makinen, Johannes Kettunen, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Marjo-Riitta Jarvelin, Olli T. Raitakari, Mika Ala-Korpela
Summary: This observational study examines the complex temporal associations between body-mass index (BMI), waist-hip ratio (WHR), and circulating metabolomics. It uses longitudinal and cross-sectional population-based datasets and new systems epidemiology tools. The results show that age-associated weight variation in adults between 24 and 49 manifests as temporal divergence in BMI and uniform progression of WHR.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Correction
Multidisciplinary Sciences
Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni, Greg J. M. Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Mi Yeong Hwang, Sohee Han, Akira Narita, Ananyo Choudhury, Amy R. Bentley, Kenneth Ekoru, Anurag Verma, Bhavi Trivedi, Hilary C. Martin, Karen A. Hunt, Qin Hui, Derek Klarin, Xiang Zhu, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M. Brumpton, Humaira Rasheed, Sanni E. Ruotsalainen, Aki S. Havulinna, Yogasudha Veturi, QiPing Feng, Elisabeth A. Rosenthal, Todd Lingren, Jennifer Allen Pacheco, Sarah A. Pendergrass, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E. Miller, Archie Campbell, Kuang Lin, Iona Y. Millwood, George Hindy, Asif Rasheed, Jessica D. Faul, Wei Zhao, David R. Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Anubha Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian'an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez, Achilleas Pitsillides, Jouke Jan Hottenga, Gonneke Willemsen, Andrew R. Wood, Yingji Ji, Zishan Gao, Simon Haworth, Ruth E. Mitchell, Jin Fang Chai, Mette Aadahl, Jie Yao, Ani Manichaikul, Helen R. Warren, Julia Ramirez, Jette Bork-Jensen, Line L. Karhus, Anuj Goel, Maria Sabater-Lleal, Raymond Noordam, Carlo Sidore, Edoardo Fiorillo, Aaron F. McDaid, Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet, Naveed Sattar, Line T. Mollehave, Betina H. Thuesen, Matthias Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Claudia Lamina, Lukas Forer, Markus Scholz, Tessel E. Galesloot, Jonathan P. Bradfield, E. Warwick Daw, Joseph M. Zmuda, Jonathan S. Mitchell, Christian Fuchsberger, Henry Christensen, Jennifer A. Brody, Mary F. Feitosa, Mary K. Wojczynski, Michael Preuss, Massimo Mangino, Paraskevi Christofidou, Niek Verweij, Jan W. Benjamins, Jorgen Engmann, Rachel L. Kember, Roderick C. Slieker, Ken Sin Lo, Nuno R. Zilhao, Phuong Le, Marcus E. Kleber, Graciela E. Delgado, Shaofeng Huo, Daisuke D. Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, Hampton L. Leonard, Jonathan Marten, Boerge Schmidt, Marina Arendt, Laura J. Smyth, Marisa Canadas-Garre, Chaolong Wang, Masahiro Nakatochi, Andrew Wong, Nina Hutri-Kahonen, Xueling Sim, Rui Xia, Alicia Huerta-Chagoya, Juan Carlos Fernandez-Lopez, Valeriya Lyssenko, Meraj Ahmed, Anne U. Jackson, Noha A. Yousri, Marguerite R. Irvin, Christopher Oldmeadow, Han-Na Kim, Seungho Ryu, Paul R. H. J. Timmers, Liubov Arbeeva, Rajkumar Dorajoo, Leslie A. Lange, Xiaoran Chai, Gauri Prasad, Laura Lores-Motta, Marc Pauper, Jirong Long, Xiaohui Li, Elizabeth Theusch, Fumihiko Takeuchi, Cassandra N. Spracklen, Anu Loukola, Sailalitha Bollepalli, Sophie C. Warner, Ya Xing Wang, Wen B. Wei, Teresa Nutile, Daniela Ruggiero, Yun Ju Sung, Yi-Jen Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, Katherine A. Kentistou, Mathias Gorski, Marco Brumat, Karina Meidtner, Lawrence F. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, Edith Hofer, Maoxuan Lin, Chao Xue, Jifeng Zhang, Maria Pina Concas, Simona Vaccargiu, Peter J. van der Most, Niina Pitkanen, Brian E. Cade, Jiwon Lee, Sander W. van der Laan, Kumaraswamy Naidu Chitrala, Stefan Weiss, Martina E. Zimmermann, Jong Young Lee, Hyeok Sun Choi, Maria Nethander, Sandra Freitag-Wolf, Lorraine Southam, Nigel W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, Christian Couture, Leo-Pekka Lyytikainen, Kjell Nikus, Gabriel Cuellar-Partida, Henrik Vestergaard, Bertha Hildalgo, Olga Giannakopoulou, Qiuyin Cai, Morgan O. Obura, Jessica van Setten, Xiaoyin Li, Karen Schwander, Natalie Terzikhan, Jae Hun Shin, Rebecca D. Jackson, Alexander P. Reiner, Lisa Warsinger Martin, Zhengming Chen, Liming Li, Heather M. Highland, Kristin L. Young, Takahisa Kawaguchi, Joachim Thiery, Joshua C. Bis, Girish N. Nadkarni, Lenore J. Launer, Huaixing Li, Mike A. Nalls, Olli T. Raitakari, Sahoko Ichihara, Sarah H. Wild, Christopher P. Nelson, Harry Campbell, Susanne Jaeger, Toru Nabika, Fahd Al-Mulla, Harri Niinikoski, Peter S. Braund, Ivana Kolcic, Peter Kovacs, Tota Giardoglou, Tomohiro Katsuya, Konain Fatima Bhatti, Dominique de Kleijn, Gert J. de Borst, Eung Kweon Kim, Hieab H. H. Adams, M. Arfan Ikram, Xiaofeng Zhu, Folkert W. Asselbergs, Adriaan O. Kraaijeveld, Joline W. J. Beulens, Xiao-Ou Shu, Loukianos S. Rallidis, Oluf Pedersen, Torben Hansen, Paul Mitchell, Alex W. Hewitt, Mika Kahonen, Louis Perusse, Claude Bouchard, Anke Toenjes, Yii-Der Ida Chen, Craig E. Pennell, Trevor A. Mori, Wolfgang Lieb, Andre Franke, Claes Ohlsson, Dan Mellstrom, Yoon Shin Cho, Hyejin Lee, Jian-Min Yuan, Woon-Puay Koh, Sang Youl Rhee, Jeong-Taek Woo, Iris M. Heid, Klaus J. Stark, Henry Voelzke, Georg Homuth, Michele K. Evans, Alan B. Zonderman, Ozren Polasek, Gerard Pasterkamp, Imo E. Hoefer, Susan Redline, Katja Pahkala, Albertine J. Oldehinkel, Harold Snieder, Ginevra Biino, Reinhold Schmidt, Helena Schmidt, Y. Eugene Chen, Stefania Bandinelli, George Dedoussis, Thangavel Alphonse Thanaraj, Sharon L. R. Kardia, Norihiro Kato, Matthias B. Schulze, Giorgia Girotto, Bettina Jung, Carsten A. Boeger, Peter K. Joshi, David A. Bennett, Philip L. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris Brown, Mark J. Caulfield, Patricia B. Munroe, Xiuqing Guo, Marina Ciullo, Jost B. Jonas, Nilesh J. Samani, Jaakko Kaprio, Paeivi Pajukanta, Linda S. Adair, Sonny Augustin Bechayda, H. Janaka de Silva, Ananda R. Wickremasinghe, Ronald M. Krauss, Jer-Yuarn Wu, Wei Zheng, Anneke I. den Hollander, Dwaipayan Bharadwaj, Adolfo Correa, James G. Wilson, Lars Lind, Chew-Kiat Heng, Amanda E. Nelson, Yvonne M. Golightly, James F. Wilson, Brenda Penninx, Hyung-Lae Kim, John Attia, Rodney J. Scott, D. C. Rao, Donna K. Arnett, Steven C. Hunt, Mark Walker, Heikki A. Koistinen, Giriraj R. Chandak, Chittaranjan S. Yajnik, Josep M. Mercader, Teresa Tusie-Luna, Carlos A. Aguilar-Salinas, Clicerio Gonzalez Villalpando, Lorena Orozco, Myriam Fornage, E. Shyong Tai, Rob M. van Dam, Terho Lehtimaki, Nish Chaturvedi, Mitsuhiro Yokota, Jianjun Liu, Dermot F. Reilly, Amy Jayne McKnight, Frank Kee, Karl-Heinz Joeckel, Mark I. McCarthy, Colin N. A. Palmer, Veronique Vitart, Caroline Hayward, Eleanor Simonsick, Cornelia M. van Duijn, Fan Lu, Jia Qu, Haretsugu Hishigaki, Xu Lin, Winfried Maerz, Esteban J. Parra, Miguel Cruz, Vilmundur Gudnason, Jean-Claude Tardif, Guillaume Lettre, Leen M. 't Hart, Petra J. M. Elders, Scott M. Damrauer, Meena Kumari, Mika Kivimaki, Pim van der Harst, Tim D. Spector, Ruth J. F. Loos, Michael A. Province, Bruce M. Psaty, Ivan Brandslund, Peter P. Pramstaller, Kaare Christensen, Samuli Ripatti, Elisabeth Widen, Hakon Hakonarson, Struan F. A. Grant, Lambertus A. L. M. Kiemeney, Jacqueline de Graaf, Markus Loeffler, Florian Kronenberg, Dongfeng Gu, Jeanette Erdmann, Heribert Schunkert, Paul W. Franks, Allan Linneberg, J. Wouter Jukema, Amit V. Khera, Minna Mannikko, Marjo-Riitta Jarvelin, Zoltan Kutalik, Francesco Cucca, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Hugh Watkins, David P. Strachan, Niels Grarup, Peter Sever, Neil Poulter, Jerome I. Rotter, Thomas M. Dantoft, Fredrik Karpe, Matt J. Neville, Nicholas J. Timpson, Ching-Yu Cheng, Tien-Yin Wong, Chiea Chuen Khor, Charumathi Sabanayagam, Annette Peters, Christian Gieger, Andrew T. Hattersley, Nancy L. Pedersen, Patrik K. E. Magnusson, Dorret I. Boomsma, Eco J. C. de Geus, L. Adrienne Cupples, Joyce B. J. van Meurs, Mohsen Ghanbari, Penny Gordon-Larsen, Wei Huang, Young Jin Kim, Yasuharu Tabara, Nicholas J. Wareham, Claudia Langenberg, Eleftheria Zeggini, Johanna Kuusisto, Markku Laakso, Erik Ingelsson, Goncalo Abecasis, John C. Chambers, Jaspal S. Kooner, Paul S. de Vries, Alanna C. Morrison, Kari E. North, Martha Daviglus, Peter Kraft, Nicholas G. Martin, John B. Whitfield, Shahid Abbas, Danish Saleheen, Robin G. Walters, Michael V. Holmes, Corri Black, Blair H. Smith, Anne E. Justice, Aris Baras, Julie E. Buring, Paul M. Ridker, Daniel I. Chasman, Charles Kooperberg, Wei-Qi Wei, Gail P. Jarvik, Bahram Namjou, M. Geoffrey Hayes, Marylyn D. Ritchie, Pekka Jousilahti, Veikko Salomaa, Kristian Hveem, Bjorn Olav Asvold, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada, Yoshinori Murakami, Unnur Thorsteinsdottir, Kari Stefansson, Yuk-Lam Ho, Julie A. Lynch, Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Kelly Cho, Christopher J. O'Donnell, John M. Gaziano, Peter Wilson, Charles N. Rotimi, Scott Hazelhurst, Michele Ramsay, Richard C. Trembath, David A. van Heel, Gen Tamiya, Masayuki Yamamoto, Bong-Jo Kim, Karen L. Mohlke, Timothy M. Frayling, Joel N. Hirschhorn, Sekar Kathiresan, Michael Boehnke, Pradeep Natarajan, Gina M. Peloso, Christopher D. Brown, Andrew P. Morris, Themistocles L. Assimes, Panos Deloukas, Yan V. Sun, Cristen J. Willer
Correction
Multidisciplinary Sciences
Mitja I. Kurki, Juha Karjalainen, Priit Palta, Timo P. P. Sipila, Kati Kristiansson, Kati M. Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Paivi Laiho, Pietro Della Briotta Parolo, Arto A. Lehisto, Masahiro Kanai, Nina Mars, Joel Ramo, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rueger, Susanna Lemmela, Wei Zhou, Sanni Ruotsalainen, Kalle Parn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Benjamin Sun, Christopher N. Foley, Katriina Aalto-Setala, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Farkkila, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric M. Green, Antti Hakanen, Marco Hautalahti, Asa K. Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kahonen, Risto Kajanne, Lila Kallio, Reetta Kalviainen, Jaakko Kaprio, Nurlan Kerimov, Johannes Kettunen, Elina Kilpelainen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Magi, Johanna Makela, Antti Makitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar V. Mozaffari, Mari E. K. Niemi, Marianna Niemi, Teemu Niiranen, Christopher J. J. O'Donnell, Ma'en Obeidat, George Okafo, Hanna M. Ollila, Antti Palomaki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slave Petrovski, Anne Pitkaranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae Hoon Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tonu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi P. P. Makela, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly, Aarno Palotie
Article
Cardiac & Cardiovascular Systems
Juhani S. Koskinen, Ville Kyto, Markus Juonala, Jorma S. A. Viikari, Jaakko Nevalainen, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Tomi P. Laitinen, Paivi Tossavainen, Eero Jokinen, Costan G. Magnussen, Olli T. Raitakari
Summary: This study examines the association between childhood and adult dyslipidemia and adult carotid atherosclerotic plaques, and found that childhood dyslipidemia, even if resolved by adulthood, is still a risk factor for adult carotid plaques.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychiatry
Henrik Dobewall, Liisa Keltikangas-Jarvinen, Saara Marttila, Pashupati P. Mishra, Aino Saarinen, C. Robert Cloninger, Igor Zwir, Mika Kahonen, Mikko Hurme, Olli Raitakari, Terho Lehtimaki, Mirka Hintsanen
Summary: This study aims to examine the relationship between compassion and longevity, finding that individuals with higher levels of compassion exhibit a biological age that is closer to their chronological age, suggesting that compassion may have an impact on biological aging.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Jonathan K. L. Mak, Ralf Kuja-Halkola, Yunzhang Wang, Sara Haegg, Juulia Jylhaevae
Summary: The study found that frailty index (FI) and frailty phenotype (FP) scores are associated with the incidence of any cancer and certain common cancers. However, the predictive utility of frailty scores for most cancers is limited.
Article
Neurosciences
Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikainen, Vesa Paavonen, Nina Mononen, Terho Lehtimaki, Esa Leinonen, Olli Kampman
Summary: This study examined the clustering of Cloninger's temperament dimensions and their association with single nucleotide polymorphisms (SNPs). The results showed that multiple SNPs from different genes were associated with different temperament clusters. Genetic risk scores (GRSs) were also found to be associated with individuals' temperament profiles. However, further research is needed to explore the clinical applicability of these clusters.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Behavioral Sciences
Iina Tolonen, Aino Saarinen, Sampsa Puttonen, Mika Kahonen, Mirka Hintsanen
Summary: This study investigated the associations between self-reported compassion and sleep quality. The results showed that high compassion was associated with lesser sleep deficiency and predicted fewer sleep difficulties over an 11-year follow-up. The discussion suggests that compassion may buffer against sleep difficulties by reducing depressive symptoms.
BRAIN AND BEHAVIOR
(2023)
Article
Genetics & Heredity
Xia Li, Alexander Ploner, Yunzhang Wang, Jonathan K. L. Mak, Yi Lu, Patrik K. E. Magnusson, Juulia Jylhava, Sara Hagg
Summary: This study found that PA mutation burdens in the CRP and G6PC genes were strongly associated with decreased serum CRP concentrations in participants from the UK Biobank. Additionally, the effects of obesity and central obesity on CRP concentration were smaller among PA mutation carriers. These findings suggest that considering rare genetic factors may improve the delivery of precision medicine in clinical settings.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)