Article
Oncology
Min Xu, Danxia Xu, Gang Dong, Zhigang Ren, Wu Zhang, Tuerganaili Aji, Qiyu Zhao, Xinhua Chen, Tian'an Jiang
Summary: This study aims to evaluate the feasibility, efficacy, and safety of nsPEF for the treatment of HCC in high-risk locations. The results may expand treatment options and offer an alternative therapy for HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Camera, Eleonora Colantoni, Tomas Garcia-Sanchez, Barbara Benassi, Claudia Consales, Adeline Muscat, Leslie Vallet, Luis M. Mir, Franck Andre, Caterina Merla
Summary: In recent years, the application of nanosecond pulsed electric fields has been investigated for novel medical purposes. This study focused on examining molecular calcium fluxes induced by different fractionated protocols of short electric pulses. The researchers found that fractionated doses of nanosecond pulsed electric fields did not increase cell electrosensitization, but targeted activation of calcium-dependent genes was observed based on the duration of calcium flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Isaac Aaron Rodriguez Osuna, Pablo Cobelli, Nahuel Olaiz
Summary: This study focuses on the local variations of the electric field and current density around bubbles formed by water electrolysis using PEF technology, and how these variations affect the electroporation protocol. It is found that the edge effect around the bubbles can significantly increase the electric field and current density, leading to unwanted limitations on PEF treatment.
Article
Biochemistry & Molecular Biology
Romanos Poulkouras, Gerwin Dijk, Marie Lefevre, Martin Baca, David Moreau, Rodney P. O'Connor
Summary: A study found that coating metal electrodes with an organic polymer PEDOT:PSS can prevent intracellular ROS generation and reduce cell electroporation and intracellular calcium response caused by PEF application. These coated electrodes can be used for PEF application in ROS-sensitive tissues and differentiate the effects of PEFs on cells from the metabolic impact of electrolytic events.
BIOELECTROCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Aleksander Kielbik, Wojciech Szlasa, Vitalij Novickij, Anna Szewczyk, Magdalena Maciejewska, Jolanta Saczko, Julita Kulbacka
Summary: High-frequency nsPEFs induce significant cytotoxicity in PCa cells, leading to increased cell permeabilization and cell death. The presence of MHz compression and extracellular Ca2+ enhances the cytotoxicity. This technology demonstrates therapeutic potential in the treatment of PCa.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Justina Jurgeleviciute, Nedas Bickovas, Andrius Sakalauskas, Vitalij Novickij, Vytautas Smirnovas, Egle Lastauskiene
Summary: Prions are misfolded proteins that can cause brain diseases, and applying a pulsed electric field can disintegrate their aggregates; Yeasts are ideal models for studying prions and it is found that prions can significantly increase cell survivability.
APPLIED SCIENCES-BASEL
(2021)
Review
Biotechnology & Applied Microbiology
Iris Haberkorn, Lya Siegenthaler, Leandro Buchmann, Lukas Neutsch, Alexander Mathys
Summary: Nanosecond pulsed electric field (nsPEF) processing is gaining traction as a method to enhance single-cell bioconversion efficiency, particularly for microbial production. However, the exact mechanisms behind its effectiveness remain unclear, necessitating further research to broaden its applications.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Biochemistry & Molecular Biology
Edwin A. Oshin, Siqi Guo, Chunqi Jiang
Summary: The nanosecond pulsed electric field (nsPEF) causes an increase in tissue conductivity, which is correlated with the number of pulses and voltage amplitude. Conductivity analysis of biological tissues under nsPEF treatment could be a fast and sensitive approach to evaluate its effectiveness in tissue ablation.
BIOELECTROCHEMISTRY
(2022)
Review
Chemistry, Applied
Cheng Zhang, Xiaomei Lyu, Rai Naveed Arshad, Rana Muhammad Aadil, Yanjun Tong, Wei Zhao, Ruijin Yang
Summary: This article reviews the application of PEF in solid food processing and its impact on food quality, discusses the evaluation techniques for PEF-treated tissues and characteristics of PEF treatment chambers, and explores the effects of other pre-treatments used in conjunction with PEF. The main obstacles and prospects of PEF in solid food processing are also examined.
Article
Food Science & Technology
Si-Yoen Kim, Ui-Chan Jeong, Hye-In Ju, Seho Jeong, Dong -Un Lee
Summary: In this study, the effects of various pulsed electric field (PEF) strengths on the drying kinetics, mass transfer rate, rehydration kinetics, and microstructure of sweet potato during hot air drying were investigated. The results showed that PEF pretreatment reduced drying and rehydration times, and improved the quality of sweet potatoes.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Microbiology
Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori, Brian Conlon
Summary: Treatment with short electric pulses can enhance the effects of multiple antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). This combination therapy reduces the necessary antibiotic dosage and improves the efficacy of treating S. aureus infections such as skin and soft-tissue infections (SSTIs). SSTIs are accessible to physical intervention, making electric pulse co-treatment a potential option for wound and abscess debridement.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Applied
Jie Zhang, Negareh Ghasemi, Firuz Zare, John A. Duley, David M. Cowley, Paul N. Shaw, Pieter Koorts, Nidhi Bansal
Summary: In this study, nanosecond pulsed electric fields (nsPEF) were used to optimize the processing conditions of donor human milk to reduce bacterial counts and evaluate its effect on bioactive proteins. Response surface methodology was used to optimize critical processing parameters, and two optimal nsPEF processing conditions were validated. The results showed that nsPEF processed milk had high retention rates of various important proteins and had lower protein loss compared to Holder pasteurization. This study suggests that nsPEF is a promising novel pasteurization method.
Article
Chemistry, Multidisciplinary
Yan Mi, Xin Ge, Jinyan Dai, Yong Chen, Yakui Zhu
Summary: This study used simulation to investigate the dielectrophoretic motion of boron nitride nanosheets in ultrapure water under a nanosecond pulsed electric field. The model explained the basic mechanism of particle motion and summarized the motion law under the pulsed electric field, providing insights for further research.
Article
Biochemistry & Molecular Biology
Asia Poudel, Adenrele Oludiran, Esin B. Sozer, Maura Casciola, Erin B. Purcell, Claudia Muratori
Summary: The study found that nanosecond pulsed electric fields (nsPEF) were not effective in inactivating planktonic cells of C. acnes, but showed higher killing efficiency against bacteria in biofilms. Pre-treatment with lysozyme increased the vulnerability of C. acnes to nsPEF, while growth in biofilms appeared to sensitize the bacteria to nsPEF-induced stress.
BIOELECTROCHEMISTRY
(2021)
Article
Food Science & Technology
Saban Thongkong, Artit Yawootti, Wannaporn Klangpetch, Olumide Oluwatoyosi Fashakin, Pipat Tangjaidee, Saroat Rawdkuen, Suphat Phongthai
Summary: The pulsed electric field technique (PEF) was used as the principal technique for the process development of quick-cooking rice products. The study evaluated the effect of pulse number, electric field strength, and frequency on cooking time and full grain portion. The optimal condition significantly reduced the cooking time of rice by 40-50% and improved the textural properties. PEF treatment also enhanced the in vitro digestibility of protein and starch.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Physics, Applied
Cheng Zhu, Chong Chen, Jinsong Guo, Qun Wang, Junfeng Rao, Hui Li, Xiaodong Wu, Jie Zhuang
Summary: Cold atmospheric plasma treatment has a significant impact on vesicle transport, causing disintegration of vesicle clusters and reducing transport velocity. Additionally, it inhibits vesicle transport between osteosarcoma cells and human bronchial epithelium.
PLASMA PROCESSES AND POLYMERS
(2022)
Article
Physics, Fluids & Plasmas
Dongjie Cui, Xiaoxia Hu, Yue Yin, Yupan Zhu, Jie Zhuang, Xiaojie Wang, Ruonan Ma, Zhen Mao
Summary: This study investigates the effects of non-thermal plasma on the quality and microbial reduction of mung bean sprouts. Short-time plasma treatment promotes seed germination and seedling growth, while long-time plasma treatment has inhibitory effects. Plasma also reduces microbial contamination and damages seed coat structure, increasing electrical conductivity of mung bean seeds.
PLASMA SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Yuqi Wang, Bing Li, Haihong Shang, Ruonan Ma, Yupan Zhu, Xudong Yang, Siyao Ju, Wenbo Zhao, Hao Sun, Jie Zhuang, Zhen Jiao
Summary: This study investigated the effects of cold atmospheric plasma (CAP) on the growth, deoxynivalenol (DON) biosynthesis, and pathogenicity of Fusarium spp. The results showed that CAP effectively inactivated major Fusarium strains by destructing cell membrane, accumulating intracellular ROS, and depolarizing mitochondrial membrane. CAP also inhibited DON biosynthesis and reduced the pathogenicity of F. graminearum on wheat. These findings provide insights into the antifungal and detoxification mechanism of CAP against F. graminearum, promoting its application in controlling fungal growth and mycotoxin production in grains and crops.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Environmental Sciences
Dongjie Cui, Yue Yin, Hao Sun, Xiaojie Wang, Jie Zhuang, Lin Wang, Ruonan Ma, Zhen Jiao
Summary: Atmospheric pressure cold plasma (APCP) has great potential in improving crop production. This study investigates the regulation mechanism of APCP-generated reactive oxygen and nitrogen species (RONS) on intracellular redox homeostasis and plant growth. The results demonstrate that APCP treatment has a dual effect on Arabidopsis seedling growth, depending on the treatment time. APCP treatment leads to an increase in RONS in the liquid, conductivity, and oxidation reduction potential, and a decrease in pH. APCP treatment also causes an enrichment of intracellular RONS and an increase in malondialdehyde generation. Low-dose APCP treatment enhances intracellular antioxidants while high doses decrease their levels. These results highlight the importance of improved antioxidant capacity induced by moderate APCP-generated RONS in promoting plant growth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Physics, Fluids & Plasmas
Shuai Yuan, Yonggang Wang, Zi Li, Song Jiang, Jie Zhuang, Junfeng Rao
Summary: This article proposes a passive synchronous isolated gate drive circuit based on decreasing the gate-source voltage to improve the reliability and lifetime of solid-state pulse generators. Experimental results demonstrate that the circuit provides overcurrent protection for short circuit situations and allows for flexible adjustment of response time, maximum transient voltage, and maximum current amplitude.
IEEE TRANSACTIONS ON PLASMA SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhuang, Cheng Zhu, Rui Han, Anna Steuer, Juergen F. Kolb, Fukun Shi
Summary: The influence of a Cole-Cole model's pertinent parameters on the assessment of cell-monolayers using electrical impedance spectroscopy (EIS) was investigated. Cold atmospheric plasma (CAP) was found to have an effect on intercellular junctions, potentially playing a key role in CAP-related biological effects. The analysis of Cole parameters revealed the frequency cut-off point between low and high frequency resistances, while the sensitivity analysis showed that certain parameters were more sensitive than others. The results indicated reversible changes in intercellular junctions and sustained changes in membrane permeability induced by CAP.
Article
Physics, Fluids & Plasmas
Raphael Rataj, Matthias Werneburg, Harald Below, Juergen F. Kolb
Summary: Submerged pulsed streamer discharges have shown potential in various applications, with short high-voltage pulses in the nanosecond range offering advantages in efficacies and efficiencies. The plasma chemistry relies on the production of short-lived species like hydroxyl radicals, and quantifying hydrogen peroxide provides insight into the underlying reactions. Parameters of high-voltage pulses, such as duration, amplitude, and steepness, impact the production rate and efficiency of hydrogen peroxide.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2022)
Review
Engineering, Environmental
Marcel Schneider, Raphael Rataj, Ludek Blaha, Juergen F. Kolb
Summary: The challenge of removing frequently occurring recalcitrant pollutants from drinking water has led to a rising interest in more advanced treatment methods. This study investigated six different treatment systems and found that a dielectric barrier discharge in a water mist was the most versatile approach for degradation of cylindrospermopsin.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Huidan Yu, Xueyan Song, Fan Yang, Jun Wang, Mingjian Sun, Guangxin Liu, Nafees Ahmad, Yuanshuai Zhou, Yina Zhang, Guohua Shi, Ruobing Zhang, Jianping Liu, Xiaobing Jiang, Peng Fu, Gang Chen, Jingmei Li, Jie Zhuang, Minxuan Sun
Summary: This study investigated the therapeutic combination of vitamin C and plasma-conditioned medium on glioblastoma cells in culture and in xenograft models. The combination treatment reduced cell viability and proliferation, while promoting apoptosis, with stronger effects than either treatment alone. Mechanistic insights were provided, suggesting the potential of this combination therapy against glioblastoma and other potential therapies.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Electrical & Electronic
Junfeng Rao, Rui Zhang, Fukun Shi, Longyu Zhuang, Zhenyu Ji, Jie Zhuang
Summary: A drive circuit for solid-state Marx generators with adjustable edges is proposed in this study. The circuit controls the Miller plateau by adjusting the gate voltage amplitude, allowing continuous and independent adjustment of the rise time and fall time of pulses. The feasibility of the method is verified through simulations and experimental results, demonstrating the generation of 4.8 kV pulses with adjustable edges in an 8-stage solid-state Marx generator prototype.
Article
Food Science & Technology
Hao Sun, Yaoke Duan, Huandong Li, Xiaoxia Hu, Bing Li, Jie Zhuang, Junxia Feng, Ruonan Ma, Zhen Jiao
Summary: This study investigated the effects of atmospheric cold plasma (ACP) on the microbiota community composition and diversity in blueberries, as well as its correlation with anthocyanin accumulation during storage. The results showed that ACP treatment did not selectively inactivate microbiota at the phylum level, but increased the proportion of Bacteroides and Faecalibacterium at the genus level. Certain bacterial species were identified as biomarkers of ACP-mediated sterilization. The surviving microbiota were less pathogenic and more sensitive to environmental stresses. The anthocyanin concentration in blueberries was slightly affected by a 10-min ACP treatment, but decreased after a 20-min treatment. Correlation analysis revealed specific bacteria that were positively or negatively correlated with anthocyanins. This study helps evaluate the performance and risk of ACP-mediated postharvest preservation of blueberries.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nadja Engel, Michael Dau, Vivien Engel, Denise Franz, Fabian Klemmstein, Christiane Thanisch, Juergen F. Kolb, Marcus Frank, Armin Springer, Ruediger Koehling, Rainer Bader, Bernhard Frerich, Nadine Wiesmann, Diana Heimes, Peer W. Kaemmerer
Summary: By combining electrical stimulation of a commercial titanium implant with real-time impedance sensing, osteogenesis progress can be monitored and electrical stimulation can be adjusted accordingly for individual fracture healing.
Article
Chemistry, Physical
Raphael Rataj, Matthias Werneburg, Harald Below, Juergen F. Kolb
Summary: The production of hydrogen peroxide (H2O2) is studied for pulsed discharges in water with different conductivities. An electrochemical flow injection analysis method based on the reaction of Prussian blue with H2O2 is developed to measure the H2O2 concentration. The results show that the H2O2 concentration increases quadratically with propagation time and is stable for different water conductivities. The production efficiency decreases with higher conductivity due to increased resistive losses within the bulk liquid.
Article
Physics, Multidisciplinary
Xiao-Dong Wu, Yan-Zhou Chen, Rui Han, Yu-Yi Guo, Jie Zhuang, Fu-Kun Shi
Summary: This study investigated the effects of pulse parameters on diffusion bubbles during pulsed electric field ablation. The experimental results showed that the area of diffusion bubbles generated in the liquid is positively correlated with pulse voltage and input energy. Higher conductivity and longer pulse width can enhance the thermal effect and increase the area of diffusion bubbles. The electrolytic reaction may be the main source of diffusion bubbles when the needle electrode is the cathode. This study is expected to optimize the parameters for pulsed electric field ablation.
ACTA PHYSICA SINICA
(2023)
Review
Chemistry, Multidisciplinary
Yue Yin, Hangbo Xu, Yupan Zhu, Jie Zhuang, Ruonan Ma, Dongjie Cui, Zhen Jiao
Summary: This paper discusses the application of atmospheric pressure plasma (APP) in wastewater purification and summarizes the effects of discharge parameters on degradation efficiency. The existing challenges and future prospects of plasma-based wastewater purification are also outlined.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Priyanga Kumar, Noel Nesakumar, Jayashree Gopal, Sakthivel Sivasubramanian, Srinivasan Vedantham, John Bosco Balaguru Rayappan
Summary: This study developed an electrochemical biosensor for measuring MG levels in the plasma of type-2 diabetes mellitus patients. The biosensor showed a wide linear concentration range, high sensitivity, and a 90% correlation with ELISA data. It also exhibited a significant correlation with HbA1c and fasting plasma glucose levels.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Cristina Tortolini, Valeria Gigli, Antonio Angeloni, Federico Tasca, Nguyen T. K. Thanh, Riccarda Antiochia
Summary: The development of a novel voltammetric immunosensor for the detection of salivary MMP-8 at the point-of-care is described. The sensor showed good performance and comparable results to the conventional ELISA method when tested in real saliva samples. This biosensor is single-use, cost-effective, and requires a small quantity of test medium and a short preparation time.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Rimsha B. Jamal, Ulrich Bay Gosewinkel, Elena E. Ferapontova
Summary: Pathogen-triggered infections are a severe global threat to human health. Researchers have developed a fast and inexpensive electrocatalytic aptamer assay for the specific and ultrasensitive detection of E. coli, allowing for timely treatment and prevention. The method is fast, sensitive, and can be used in field and point-of-care applications for analysis of bacteria in the human environment.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Miao Liu, Yuwei Wang, Shanshan Tang, Wei Wang, Axin Liang, Aiqin Luo
Summary: An unlabeled ratiometric molecular imprinted electrochemiluminescence sensor was developed for the determination of trace uric acid using MXene@NaAsc, CdSe@ZnS quantum dots, and molecularly imprinted polymer composites modified glass carbon electrode. This sensor, with easy preparation, great selectivity, and excellent sensitivity, successfully detected uric acid in human serum.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Charlotte Da Silva, Camille Lamarche, Carole Pichereaux, Emmanuelle Mouton-Barbosa, Gauthier Demol, Sebastien Boisne, Etienne Dague, Odile Burlet-Schiltz, Flavien Pillet, Marie-Pierre Rols
Summary: Low-energy electron beams (LEEB) are a safe and practical sterilization solution for industrial applications. To address the limitations of LEEB, we developed a low-energy pulsed electron beam generator (LEPEB) that can effectively and efficiently eradicate bacteria in a wide range of industrial applications.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Daniel Dobrovodsky, Ales Danhel, Daniel Renciuk, Jean-Louis Mergny, Miroslav Fojta
Summary: In this study, N-methyl mesoporphyrin IX (NMM) was utilized as a voltammetric probe for the electrochemical detection of G4s. The detection of NMM was achieved by cyclic voltammetry on a hanging mercury drop electrode (HMDE) with a limit of detection (LOD) of 40 nM. The reduction signal of NMM was found to be significantly higher when G4 oligodeoxynucleotides (G4 ODNs) were present compared to single- or double-stranded ODNs or unfolded ODNs capable of forming G4s. Gradual transition from unstructured single strand to G4, induced by increasing concentrations of the G4 stabilizing K+ ions, was detected for the first time using electrochemical methods. Circular dichroism spectroscopy provided support for the obtained results. This work expands on the utilization of electrochemical probes for DNA secondary structure recognition and offers a proof of principle for the development of novel electroanalytical methods for nucleic acid structure studies.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Mengjiao Zhu, Yu Liu, Meiyue Wang, Tao Liu, Zhenyu Chu, Wanqin Jin
Summary: Early rapid diagnosis of COVID-19 is crucial for reducing the risk of severe symptoms and loss of lung function. Researchers have proposed an ultrafast and ultrasensitive DNA sensor that can accurately detect the virus in a short period of time, with outstanding selectivity.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fatima-Zahra Ait-Itto, James A. Behan, Mathieu Martinez, Frederic Barriere
Summary: This study investigated the feasibility of using ancient marine sediments as inoculum for bioanode development in microbial fuel cells (MFC). The results showed the presence of two exoelectrogenic bacterial genera in these iron-rich sediments and confirmed that the development of the bioanode derived from the native microbiota. This study has important implications for understanding the role of these bacteria in broader paleoenvironmental phenomena.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Issa Fall, Bastien Doumeche, Sofiene Abdellaoui, Caroline Remond, Harivony Rakotoarivonina, Marjorie Ochs
Summary: This article presents a novel electrochemical tool based on lignin-coated paper electrodes for the detection and characterization of ligninolytic activity. The suitability of this method has been demonstrated using a catalaseperoxidase isolated from Thermobacillus xylanilyticus.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Chenyi Zhuo, Dehong Yu, Jiuying Cui, Zichun Song, Qianli Tang, Xianjiu Liao, Zhao Liu, Ning Xin, Lu Lou, Fenglei Gao
Summary: A label-free detection strategy for quantification of Apolipoprotein A4 (Apo-A4) has been developed based on rolling circle amplification (RCA) and proximity hybridization-induced DNAzyme-driven bipedal DNA walker. This method shows high sensitivity and selectivity for a wide range of protein targets.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Niloufar Fattahi, Jeffrey Reed, Evan Heronemus, Priyasha Fernando, Ryan Hansen, Prathap Parameswaran
Summary: In this study, polyethylene glycol hydrogels were developed as protective coatings for electroactive biofilms, improving their viability under low resource conditions and ammonia-N shocks.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiaopeng Hou, Qiongyi Cheng, Hui Wang
Summary: A self-cleaning paper-based microfluidic biosensor was developed using hydrophobic paper decorated with polymeric octadecyl trichlorosilane. The biosensor showed improved performance and could effectively measure the concentration of copper ions in livestock feed and manure.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yanling Zhang, Jie Wang, Min Liu, Yun Ni, Yao Yue, Dawei He, Ruijiang Liu
Summary: An innovative electrochemical biosensor has been developed for sensitive detection of HER2 protein, an important tumor marker for breast cancer diagnosis and treatment evaluation. The biosensor utilizes specific recognition probes and nanomaterials, along with a unique sensing strategy, to achieve ultra-low detection limit and demonstrate excellent selectivity, reproducibility, and stability.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Humayun Amir, Vasanth Subramanian, Sundaram Sornambikai, Nagamony Ponpandian, Chinnusamy Viswanathan
Summary: In this study, the electrochemical detection of breast cancer biomarker HER2 was successfully achieved using the N-CQDs/GS as the detector. The BSA-modified HER2 Antibody/N-CQDs/GS immunoelectrode preserved excellent activity for the biosensor, while the GS electrode provided high stability and conductivity. The method exhibited a low detection limit and optimal specificity, stability, and reproducibility for detecting HER-2 protein in untreated blood samples from breast cancer patients.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Anton Popov, Raminta Vaiciuleviciute, Gailute Kirdaite, Eiva Bernotiene, Almira Ramanaviciene
Summary: This review discusses the application of polypyrrole (Ppy), an electroconductive polymer, in cell culture experiments with electrical stimulation (ES) and its potential for tissue regeneration. Ppy can direct ES to cells and stimulate differentiation towards different cell lineages. Different types of Ppy materials and their combination with active molecules are explored.
BIOELECTROCHEMISTRY
(2024)
