Article
Pharmacology & Pharmacy
Yumei Zhou, Linhan Hu, Honglei Zhang, Haiyun Zhang, Juntong Liu, Xiaoshan Zhao, Ji Wang, Qi Wang
Summary: The study found that GMK achieves a similar effect as dexamethasone in controlling symptoms of allergic asthma and inhibiting inflammation, reconstructs the immune balance of Th1/Th2 and Treg/Th17 cells, and impacts asthma treatment by altering gut microbiota. Metabolome results reveal specific substances associated with Th1/Th2 and Treg/Th17 cell balance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Philipp Burt, Michael Peine, Caroline Peine, Zuzanna Borek, Sebastian Serve, Michael Flossdorf, Ahmed N. Hegazy, Thomas Hoefer, Max Loehning, Kevin Thurley
Summary: Selective differentiation of CD4+ T helper (Th) cells into specialized subsets is crucial for appropriate immune responses. While canonical Th-cell lineages are well understood, the transcriptional architecture of hybrid phenotypes remains unclear. This study explored the transcriptome of Th-cell differentiation, revealing an early bifurcation point in gene expression programs. Hybrid Th1/2 cells showed mixed effects from Th1 and Th2 cells for a minority of genes, while others followed a Th1 and Th2 cell-independent transcriptional program. These findings emphasize the importance of longitudinal data for characterizing cellular phenotypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Shukkur M. Farooq, Hossam M. Ashour
Summary: The study demonstrates that CII-specific ACAID B cells can induce peripheral tolerance, and the adoptively transferred B cells have the ability to suppress immune responses after challenges with CII. This effect was replicated in multiple strains of mice, indicating potential therapeutic implications for the treatment of CII-mediated autoimmune diseases.
Article
Immunology
Xiao-Di Chen, Jing Xie, Yong Wei, Ji-Feng Yu, Ye Cao, Lu Xiao, Xue-Jing Wu, Cong-Jian Mao, Run-Min Kang, Yong-Gang Ye
Summary: Despite long-term control efforts, hepatic coccidiosis caused by Eimeria stiedai infection remains persistent in rabbits in China. This study provides the first evidence of changes in Th1/Th2/Treg/Th17/Th9/Th21 cells in rabbits infected with E. stiedai, offering insights into immune regulation mechanisms and potential vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Immunology
Lei Zhang, Yuanlin Ying, Shuqiu Chen, Preston R. Arnold, Fafa Tian, Laurie J. Minze, Xiang Xiao, Xian C. Li
Summary: This study found that RelB plays a critical role in restraining ILC2s in vivo by primarily suppressing Bcl11b activity, consequently inhibiting the development of type 2 lung pathology.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Roy W. Beck
Summary: Automated insulin delivery systems, used in type 1 diabetes, hold promise for patients with type 2 diabetes and are expected to have a significant impact on public health.
Review
Endocrinology & Metabolism
Sara SantaCruz-Calvo, Leena Bharath, Gabriella Pugh, Lucia SantaCruz-Calvo, Raji Rajesh Lenin, Jenny Lutshumba, Rui Liu, Adam D. Bachstetter, Beibei Zhu, Barbara S. Nikolajczyk
Summary: The increasing prevalence of obesity and type 2 diabetes mellitus is mainly due to changes in lifestyle and the obesogenic environment, leading to alterations in metabolism, immunity, and endocrine regulation. Chronic low-grade inflammation in obesity can progress to systemic inflammation, contributing to insulin resistance, T2DM, and other comorbidities. Understanding adaptive immune cell dysregulation is crucial for developing immunomodulatory therapies to treat inflammation associated with obesity and/or T2DM.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Cell Biology
Matilde Masini, Mara Suleiman, Michela Novelli, Lorella Marselli, Piero Marchetti, Vincenzo De Tata
Summary: Mast cells are key regulators of the immune system, involved in both health mechanisms and disease pathogenesis. In diabetes, increased mast cell presence in the pancreas due to autoimmune destruction of insulin-secreting beta cells could offer new therapeutic targets.
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: In this 26-week trial, researchers found that once-weekly treatment with dulaglutide has significant efficacy in improving glycemic control among youths with type 2 diabetes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: The incidence of type 2 diabetes mellitus is increasing among youths. Treatment with dulaglutide at a once-weekly dose of 0.75 mg or 1.5 mg was superior to placebo in improving glycemic control through 26 weeks among youths with type 2 diabetes, without an effect on BMI.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Immunology
Jacob D. Painter, Omid Akbari
Summary: ILC2s, the innate counterparts of Th2 cells, play a critical role in maintaining tissue homeostasis by responding to external stimuli and controlling the inflammation balance in adipose tissue. Their effector function is associated with increased browning of adipose tissue and an anti-inflammatory immune profile, crucial for tissue homeostasis. The reaction of ILC2s to changes in the metabolic environment is a clear determinant of disease severity, providing a potential avenue for modulation of systemic homeostasis and treatment of T2DM.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jisu Oh, Amy E. Riek, Kevin T. Bauerle, Adriana Dusso, Kyle P. McNerney, Ruteja A. Barve, Isra Darwech, Jennifer E. Sprague, Clare Moynihan, Rong M. Zhang, Greta Kutz, Ting Wang, Xiaoyun Xing, Daofeng Li, Marguerite Mrad, Nicholas M. Wigge, Esmeralda Castelblanco, Alejandro Collin, Monika Bambouskova, Richard D. Head, Mark S. Sands, Carlos Bernal-Mizrachi
Summary: Environmental factors may modify the fetal genome, leading to metabolic diseases. This study investigates the impact of embryonic immune cell programming on the risk of later-life type 2 diabetes. The findings show that vitamin D deficiency during fetal development epigenetically suppresses Jarid2 expression in hematopoietic stem cells (HSCs) and activates the Mef2/PGC1a pathway, resulting in adipose macrophage infiltration. These macrophages secrete miR106-5p, which promotes adipose insulin resistance. Vitamin D-deficient monocytes from human cord blood also exhibit similar effects.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Magloire Pandoua Nekoua, Antoine Bertin, Famara Sane, Enagnon Kazali Alidjinou, Delphine Lobert, Jacques Trauet, Christine Hober, Ilka Engelmann, Kabirou Moutairou, Akadiri Yessoufou, Didier Hober
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Article
Immunology
Adnette Fagninou, Magloire Pandoua Nekoua, Darius Sossou, Kabirou Moutairou, Nadine Fievet, Akadiri Yessoufou
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Review
Microbiology
Abdulaziz Alhazmi, Famara Sane, Mouna Lazrek, Magloire Pandoua Nekoua, Francis Badia-Boungou, Ilka Engelmann, Enagnon Kazali Alidjinou, Didier Hober
Article
Microbiology
Arthur Dechaumes, Magloire Pandoua Nekoua, Sandrine Belouzard, Famara Sane, Ilka Engelmann, Jean Dubuisson, Enagnon Kazali Alidjinou, Didier Hober
Summary: Fluoxetine (FLX) has shown potential to inhibit SARS-CoV-2 in vitro, suggesting its value in further research as a potential anti-viral treatment option against SARS-CoV-2 infections.
Review
Microbiology
Abdulaziz Alhazmi, Magloire Pandoua Nekoua, Helene Michaux, Famara Sane, Aymen Halouani, Ilka Engelmann, Enagnon Kazali Alidjinou, Henri Martens, Hela Jaidane, Vincent Geenen, Didier Hober
Summary: Viral infections, especially CVB4 infection, can disrupt thymic functions and may play a role in the pathogenesis of type 1 diabetes (T1D) by affecting thymic cells and functions.
Article
Microbiology
Magloire Pandoua Nekoua, Antoine Bertin, Famara Sane, Jean-Pascal Gimeno, Isabelle Fournier, Michel Salzet, Ilka Engelmann, Enagnon Kazali Alidjinou, Didier Hober
Summary: Research shows that CV-B4 persistence in insulin-producing pancreatic beta cells leads to inhibition of pro-hormone convertase 2 expression, significant modification of cell protein patterns, and hypermethylation of cell DNA. These cellular changes caused by persistent CV-B4 infection can potentially contribute to the pathogenesis of type 1 diabetes.
Article
Medicine, General & Internal
Enagnon Kazali Alidjinou, Mickael Hirabidian, Anthony Rabat, Mahdi Ouafi, Magloire Pandoua Nekoua, Famara Sane, Julien Poissy, Didier Hober
Summary: This study found a significant association between levels of IFN alpha and age in COVID-19 patients, which may explain the higher susceptibility of the elderly to severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Magloire Pandoua Nekoua, Enagnon Kazali Alidjinou, Didier Hober
Summary: This review highlights the role of persistent enterovirus infections in triggering islet autoimmunity and type 1 diabetes mellitus (T1DM), and discusses the potential of vaccination or antiviral therapies in preventing T1DM onset.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Microbiology
Magloire Pandoua Nekoua, Ambroise Mercier, Abdulaziz Alhazmi, Famara Sane, Enagnon Kazali Alidjinou, Didier Hober
Summary: Enteroviruses, especially coxsackieviruses B, are believed to play a role in triggering or accelerating type 1 diabetes. Various antiviral drugs and vaccines have shown potential in preventing or reducing the risk of the disease.
Editorial Material
Microbiology
Magloire Pandoua Nekoua, Didier Hober
Review
Virology
Abdulaziz Alhazmi, Magloire Pandoua Nekoua, Ambroise Mercier, Ines Vergez, Famara Sane, Enagnon Kazali Alidjinou, Didier Hober
Summary: Coxsackieviruses B (CVB) is a common virus that can cause a wide range of diseases. Current approaches to control CVB infections include the development of drugs and vaccines, as well as alternative strategies. These methods have shown potential in preventing and treating CVB infections in vitro and in animal models.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Microbiology
Magloire Pandoua Nekoua, Cyril Debuysschere, Ines Vergez, Corentin Morvan, Chaldam Jespere Mbani, Famara Sane, Enagnon Kazali Alidjinou, Didier Hober
Summary: Viral infections have long been associated with physiological and pathological changes in the endocrine system. The current pandemic of COVID-19 has revealed numerous endocrine complications, highlighting the need to better understand the impact of viral infections on the endocrine system. Several viruses can directly damage endocrine cells or indirectly disrupt the system through the activation of the host antiviral immune response, leading to inflammation or organ-specific autoimmunity. Furthermore, endocrine disorders can also impact susceptibility to viral infections due to the immunoregulatory functions of endocrine hormones.
Review
Microbiology
Chaldam Jespere Mbani, Magloire Pandoua Nekoua, Donatien Moukassa, Didier Hober
Summary: Poliovirus (PV), classified within Enterovirus C species, causes both acute poliomyelitis and post-polio syndrome. Global Polio Eradication Initiative (GPEI) successfully eliminated two WPV serotypes, but WPV1 transmission remains in Afghanistan and Pakistan. Vaccine-derived poliovirus (VDPV) cases have been reported worldwide, leading to increased use of inactivated poliovirus vaccine (IPV) and development of new OPV formulations and alternative vaccines.
Review
Microbiology
Cyril Debuysschere, Magloire Pandoua Nekoua, Didier Hober
Summary: Viral infections, particularly Epstein-Barr virus (EBV), have long been suspected to play a role in the development and progression of autoimmune diseases such as multiple sclerosis (MS), lupus, rheumatoid arthritis, Sjogren's syndrome, and type 1 diabetes. EBV has a complex lifecycle in infected B-cells, producing viral proteins and miRNAs. This review highlights the detection of EBV infection in MS patients, focusing on markers of latency and lytic phases. The presence of latency proteins, antibodies, and miRNAs in the central nervous system of MS patients suggests a link between EBV and MS.
Review
Virology
Magloire Pandoua Nekoua, Ambroise Mercier, Ines Vergez, Corentin Morvan, Chaldam Jespere Mbani, Famara Sane, Delphine Lobert, Ilka Engelmann, Marie-Benedicte Romond, Enagnon Kazali Alidjinou, Didier Hober
Summary: Epidemiological and experimental studies suggest that enteroviruses, particularly coxsackieviruses B, may trigger or accelerate the onset of islet autoimmunity and the development of type 1 diabetes in genetically susceptible individuals. Several potential mechanisms have been proposed to explain the involvement of coxsackieviruses B in the pathogenesis of type 1 diabetes, including persistent infection in various cells and the resulting chronic inflammatory response and disruption of tolerance towards ss-cells. Vaccine or therapeutic strategies to control enterovirus infections show potential for the prevention or treatment of type 1 diabetes.
