Article
Chemistry, Multidisciplinary
Luca Pagano, Marta Marmiroli, Marco Villani, Jacopo Magnani, Riccardo Rossi, Andrea Zappettini, Jason C. White, Nelson Marmiroli
Summary: This study found that nanoparticles can affect the functionality and genome of chloroplasts and mitochondria in A. thaliana, and different nanoparticles have different effects, which are related to the toxicity and dissolution rate of the metal salts. These findings suggest that changes in stoichiometry are an adaptive response to nanoparticle exposure.
Review
Engineering, Environmental
Magdalena Kusiak, Patryk Oleszczuk, Izabela Josko
Summary: The review explores the development and implementation of nanotechnology in crop production, specifically focusing on nano-sensors, nanopesticides, and nano-fertilizers. Engineered nanomaterials are expected to be more efficient agrochemicals than conventional agents, but their growing production and usage also lead to environmental spread and both positive and negative effects on plants.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Raisibe Florence Lehutso, Yolanda Tancu, Arjun Maity, Melusi Thwala
Summary: Analytical limitations have hindered the determination of nanopollution characteristics from nano-enabled products (NEPs), which are actual sources of nanopollution. This study examined the properties of engineered nanomaterials (ENMs) in 18 commercial products, revealing their diverse morphologies and negative charges. Despite identifying key ENM characteristics for environmental risk assessment, challenges persist in accurately determining concentrations in NEPs.
Review
Public, Environmental & Occupational Health
Eleonora Scarcello, Adriana Sofranko, Tina Wahle, Roel P. F. Schins
Summary: Testing of engineered nanomaterials in neurotoxicology faces challenges due to their complex physicochemical properties and lack of toxicokinetic data, which may induce indirect neurotoxic effects.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Seth McCormick, Mamadou Niang, Matthew M. Dahm
Summary: This review consolidates exposure assessment methods for occupational research on engineered nanomaterials (ENMs) within the past 5 years, highlighting the most commonly used materials and methods, emphasizing the importance of combining online and offline instruments and analyses, and pointing out the lack of consensus methods for offline analyses of most ENMs.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Yung-Chang Lu, Ting-Kuo Chang, Shu-Ting Yeh, Tzu-Chiao Lin, Hung-Shih Lin, Chun-Hung Chen, Chun-Hsiung Huang, Chang-Hung Huang
Summary: Graphene, a novel material, has gained significant interest in the biomedical field for its potential in promoting bone formation. In this study, a blended graphene-contained polycaprolactone (PCL/G) filament was developed for 3D-printed bone scaffolds, showing good cell viability and improved mechanical strength. However, further evaluation is needed to ensure the comprehensive biosafety of graphene-derived biomaterials.
Article
Environmental Sciences
Mehnaz Shams, Linda M. Guiney, Mani Ramesh, Mark C. Hersam, Indranil Chowdhury
Summary: Graphene nanomaterials have been commercialized and disseminated into surface waters, but their photodegradation in natural aquatic environments is minimal and slow. This study evaluated the photodegradation of graphene oxide and partially reduced graphene oxide in Columbia River Water, finding that both direct and indirect photolysis occur simultaneously. However, the concentrations of photosensitizers in surface water are not sufficient to initiate degradation of graphene oxide. Overall, graphene nanomaterials show minimal phototransformation in natural surface water.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Chemistry, Multidisciplinary
Olga Wojciechowska, Adele Costabile, Malgorzata Kujawska
Summary: This review explores the interactions between graphene-based nanoparticles and the gut microbiome. The studies show that exposure to graphene is dose and time-dependent and different derivatives have varying effects on host bacteria cells. The route of exposure to graphene may also influence the composition of the gut microbiota.
NANOSCALE ADVANCES
(2023)
Review
Energy & Fuels
Ahmed Hussain Jawhari
Summary: This article reviews the application of nanomaterials in various aspects of hydrogen energy and elaborates on the milestones achieved with graphene and its nanocomposites. It emphasizes the need to broaden the applicability of graphene and its allied forms for hydrogen energy applications in the future.
Article
Chemistry, Physical
Clarissa Braccia, Valentina Castagnola, Ester Vazquez, Viviana Jehova Gonzalez, Fabrizio Loiacono, Fabio Benfenati, Andrea Armirotti
Summary: This paper reports the first investigation of lipid content in the biomolecular corona formed around few layers graphene (FLG) and graphene oxide (GO) nanomaterials, revealing significantly different lipid signatures associated with each material. The study also examines the role of specific lipids, such as sphingomyelins and triacylglycerols, in the uptake of FLG and GO in a blood-brain barrier cellular model.
Review
Agricultural Engineering
Santosh Kumar, Akash Tripathi, Indrajit Chakraborty, Makarand. M. Ghangrekar
Summary: The mounting threat of global warming is undeniable, and current carbon capture and storage technologies face challenges. The use of engineered nanomaterials in microbial electrochemical technologies has gained momentum as a promising solution, enhancing carbon capture efficiency while enabling bioenergy production and wastewater treatment.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Samantha V. Llewellyn, Gillian E. Conway, Ilaria Zanoni, Amalie Kofoed Jorgensen, Ume-Kulsoom Shah, Didem Ag Seleci, Johannes G. Keller, Jeong Won Kim, Wendel Wohlleben, Keld Alstrup Jensen, Anna Costa, Gareth J. S. Jenkins, Martin J. D. Clift, Shareen H. Doak
Summary: This study found that acute exposure to five ENMs caused significant genotoxicity in liver spheroids, while prolonged exposure only resulted in genotoxicity at low concentrations of ZnO ENMs. There was no significant difference in toxicity outcomes between fractionated, repeated exposure and single, bolus exposure regimes in liver spheroids.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
William K. Boyes, Bradley Beach, Gayle Chan, B. Lila M. Thornton, Paul Harten, Holly M. Mortensen
Summary: The US EPA Office of Research and Development has conducted a research program to assess potential risks of emerging materials and technologies, including engineered nanomaterials. As part of this program, a nanomaterial knowledge base called NaKnowBase has been developed to collect relevant research results.
Article
Environmental Sciences
Beatrice Bocca, Beatrice Battistini, Veruscka Leso, Luca Fontana, Stefano Caimi, Mauro Fedele, Ivo Iavicoli
Summary: This study developed a methodology for human biomonitoring, based on SP-ICP-MS, to assess the exposure of workers involved in nanomaterial activities. The results showed the presence of ENPs in both workers and controls, suggesting that extra-professional exposure is a potential source of ENPs.
Article
Biochemistry & Molecular Biology
Roberta Socoowski Britto, Jefferson Patricio Nascimento, Tiago Serodre, Adelina Pinheiro Santos, Amadeu M. V. M. Soares, Clascidia Furtado, Juliane Ventura-Lima, Jose M. Monserrat, Rosa Freitas
Summary: The study investigated the effects of graphene oxide on clams in aquatic ecosystems, finding that different concentrations of graphene oxide altered the biochemical parameters of clams, and in the presence of sediment, clams mostly invested in non-enzymatic defenses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Chiara Mando, Silvio Abati, Gaia Maria Anelli, Chiara Favero, Anais Serati, Laura Dioni, Marta Zambon, Benedetta Albetti, Valentina Bollati, Irene Cetin
Summary: This study found that the epigenetic profile in the saliva of obese pregnant women is markedly different from that of normal-weight pregnant women, suggesting the presence of impaired mechanisms and damaged pathways. The characterization of this profile can serve as a promising tool for the identification of obesity-related altered mechanisms and the development of biomarkers for early diagnosis and treatment of pregnancy-adverse conditions.
Article
Environmental Sciences
Alessandra Pulliero, Simona Iodice, Angela Cecilia Pesatori, Luisella Vigna, Zumama Khalid, Valentina Bollati, Alberto Izzotti
Summary: The study found an inverse association between long-term PM10 exposure and DNA adduct levels in adults with an unhealthy BMI, possibly due to an atypical reaction to airborne pollutants in this population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Antonello E. Rigamonti, Valentina Bollati, Chiara Favero, Benedetta Albetti, Diana Caroli, Laura Abbruzzese, Silvano G. Cella, Alessandro Sartorio
Summary: Obesity and aging share common molecular and cellular mechanisms underlying cardiovascular diseases. A 3-week in-hospital body weight reduction program (BWRP) can reduce the epigenetic age acceleration in obese adults, improving cardiometabolic outcomes and reducing markers of systemic inflammation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Clara Cambria, Francesca Ingegnoli, Eleonora Borzi, Laura Cantone, Lavinia Agra Coletto, Alessandra Stefania Rizzuto, Orazio De Lucia, Sabrina Briguglio, Massimiliano Ruscica, Roberto Caporali, Valentina Bollati, Massimiliano Buoli, Flavia Antonucci
Summary: Arthritides is a group of diverse disorders that affect joints, including localized joint disorders and systemic autoimmune-driven diseases. Poor mental health is common among arthritides patients. Research has shown that extracellular vesicles derived from synovial fluid can affect neuronal function, and the concentration of synovial vesicles is associated with psychiatric symptoms in arthritides patients.
Article
Biochemistry & Molecular Biology
Armelle Munnia, Valentina Bollati, Valentina Russo, Luca Ferrari, Marcello Ceppi, Marco Bruzzone, Stefano Dugheri, Giulio Arcangeli, Franco Merlo, Marco Peluso
Summary: Studies have shown that air pollution, including surface-level ozone (O-3), has a significant impact on the risk of chronic diseases. This study examined the association between traffic-related pollutants and DNA methylation alterations and bulky DNA adducts, two biomarkers of carcinogen exposure and cancer risk. The results revealed that air pollution exposure led to a reduction in global DNA methylation and an increase in DNA adducts. Regression models also indicated a correlation between higher levels of certain pollutants and changes in DNA methylation. Overall, these findings emphasize the importance of developing strategies to reduce traffic-related air pollution and its impact on molecular alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Marta Keller, Andrea Cattaneo, Andrea Spinazze, Letizia Carrozzo, Davide Campagnolo, Sabrina Rovelli, Francesca Borghi, Giacomo Fanti, Silvia Fustinoni, Mariella Carrieri, Angelo Moretto, Domenico Maria Cavallo
Summary: This study systematically reviewed 101 studies on the exposure levels of sevoflurane, desflurane, and isoflurane in hospitals. It was found that occupational exposure to these waste anaesthetic gases (WAGs) is still relatively high. However, there is a lack of consistent monitoring methods and instruments, and real-time monitoring techniques are underutilized, which hinders accurate assessment of short-term and long-term occupational exposure risks.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Urs Schlueter, Andrea Spinazze
Summary: Exposure modeling is crucial for regulatory organizations, companies, and professionals in managing occupational health risks. This commentary focuses on occupational inhalation exposure assessment models within the REACH framework, discussing their theoretical background, applications, limitations, and the need for improvement. Despite its unquestionable relevance in the context of REACH, occupational exposure modeling requires consensus on key issues, monitoring of model performance, and alignment of practices and policies.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2023)
Review
Medicine, General & Internal
Teresa Surace, Cecilia Quitadamo, Alice Caldiroli, Enrico Capuzzi, Fabrizia Colmegna, Guido Nosari, Elisa Borroni, Luca Fedrizzi, Valentina Bollati, Angela Cecilia Pesatori, Michele Carugno, Massimo Clerici, Massimiliano Buoli
Summary: The aim of this study was to summarize available data on the link between air pollution exposure and the onset and severity of psychiatric disorders in pregnant women during the perinatal period. Nine studies were included in the analysis, with most focusing on the association between air pollutant exposure and postpartum depression (PPD) onset. The results showed a significant association between PM2.5 and NO2 exposure and PPD onset, as well as an association between PBDE blood levels and more severe depressive symptoms. One study also observed a link between exposure to PM2.5, PM10 during pregnancy and stressful symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Patrizia Urso, Andrea Cattaneo, Salvatore Pulvirenti, Franco Vercelli, Domenico Maria Cavallo, Paolo Carrer
Summary: This statistical study aims to identify the key factors that have affected the spread of the Covid-19 virus during the early phase of the pandemic in Italy, including demographic, environmental pollution, and climate factors. The study found that population size confirmed the importance of social distancing, pollution had a significant impact on the increase in infection, and various weather factors were also related to virus transmission. The results suggest that caution should be taken in crowded, highly polluted, and weakly exposed areas.
Article
Biochemistry & Molecular Biology
Paola Monti, Giulia Solazzo, Veronica Accurti, Bianca Gambitta, Simona Iodice, Simona Boito, Laura Cantone, Alessandro Manenti, Laura Dioni, Emanuele Montomoli, Nicola Persico, Valentina Bollati
Summary: During pregnancy, infectious diseases can increase the risk of adverse pregnancy outcomes. This study suggests that SARS-CoV-2 infection may trigger pyroptosis through the activation of NLRP3 inflammasome, leading to inflammation and adverse pregnancy outcomes. The levels of NLRP3 were positively associated with certain circulating miRNAs, and specific miRNAs were found to be related to gestational diabetes, pre-eclampsia, and small for gestational age babies. These findings provide insight into the potential link between COVID-19, NLRP3-mediated pyroptosis, inflammation, and adverse pregnancy outcomes, highlighting the role of circulating miRNAs in this complex interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Pulliero, Luca Mastracci, Letizia Tarantini, Zumama Khalid, Valentina Bollati, Alberto Izzotti
Summary: This study reveals the relationship between KRAS mutation and let-7a downregulation in cigarette smoke-induced lung carcinogenesis. Long-term exposure to cigarette smoke leads to a significant decrease in let-7a expression and an increase in KRAS mutation, resulting in a higher incidence of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Valentina Bollati, Paola Monti, Davide Biganzoli, Giuseppe Marano, Chiara Favero, Simona Iodice, Luca Ferrari, Laura Dioni, Francesca Bianchi, Angela Cecilia Pesatori, Elia Mario Biganzoli
Summary: This study aims to explore the role of extracellular vesicles (EVs) and their cargo of microRNAs (EV-miRNAs) in intercellular communication and how they respond to environmental and lifestyle factors. By analyzing the associations between specific miRNAs related to common cancers (oncomiRs) and these factors, the study aims to provide insights into the complex regulatory networks of miRNAs in response to exogenous influences. The findings have the potential to revolutionize our understanding of cancer development and have important implications for exposome studies in the future.
Review
Public, Environmental & Occupational Health
F. Turati, M. Rossi, A. Spinazze, E. Pira, D. M. Cavallo, L. Patel, C. Mensi, C. La Vecchia, E. Negri
Summary: The association between asbestos exposure and ovarian cancer has been updated and explored in this study. While some misclassification between ovarian and peritoneal cancers cannot be excluded, the risk of ovarian cancer should be considered as an important factor in the overall disease burden of asbestos.
OCCUPATIONAL MEDICINE-OXFORD
(2023)