Article
Chemistry, Multidisciplinary
Ming Chen, Ying Xie, Qian Luo, Jiarui Xu, Yuxin Ren, Rui Liu, Huihui Zhao, Yuling Chen, Hexuan Feng, Yafei Du, Jianwei Li, Guiling Wang, Wanliang Lu
Summary: A novel smart disulfide switchable nanoparticles complexing cisplatin (switch NPs-cisplatin) was designed and synthesized, which demonstrated pH and GSH responsiveness, as well as targeting effect in resistant breast cancer cells. The switch NPs-cisplatin effectively blocked cisplatin depletion by GSH, circumventing chemoresistance and displaying a remarkable killing effect in vitro and in vivo. This study provides a smart formulation of cisplatin to overcome chemoresistance in breast cancer and offers a universal drug delivery carrier platform for highly efficient but low toxic chemotherapy.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Physical
Yuuka Fukui, Kaori Fujino, Keiji Fujimoto
Summary: One-pot synthesis of gold nanoparticles (AuNPs) and AuNPs-polymer hybrid nanoparticles was investigated in a water-in-oil (W/O) miniemulsion. AuNPs were generated in water nanodroplets containing HAuCl4 with a mixture of 1-vinylpyrrolidone (VP) and N,N'-methylenebisacrylamide (MBAAm), while polymerization in water nanodroplets encapsulated AuNPs into polymer nanoparticles. The size and color of AuNPs and the number and location of AuNPs in polymer nanoparticles could be tuned by various factors, such as HAuCl4 concentration and additives.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Biochemistry & Molecular Biology
Beinuo Wang, Ruijie Zhang, Yao Wang, Hang Qian, Di Wu, Binfeng He, Hu Liao
Summary: Overcoming cisplatin-based drug resistance in lung cancer remains a challenge globally. Recent studies have shown that Rab GTPases play a role in multiple aspects of tumor progression, including drug resistance. In this study, a nanosystem was developed using Rab26 siRNA-loaded nanoparticles, which effectively transfected cisplatin-resistant lung cancer cells and induced apoptosis while inhibiting autophagy disruption. The combination therapy of siRab26 knockdown with cisplatin improved antitumor therapy in vitro and in vivo. These findings suggest that siRNP is an effective platform for lung cancer therapy in cases of drug resistance.
Article
Biochemistry & Molecular Biology
Parastoo Karami, Goran Othman, Zjwan Housein, Abbas Salihi, Mohammad Ali Hosseinpour Feizi, Hewa Jalal Azeez, Esmaeil Babaei
Summary: This study aimed to investigate the impact of polyphenolic curcumin on cisplatin-induced toxicity in MDA-MB-231 breast cancer cells. The results demonstrated that polyphenolic curcumin effectively sensitized cancer cells to cisplatin and suppressed cell growth through induction of apoptosis. This provides an attractive strategy for treating triple negative breast cancer by utilizing polyphenolic curcumin.
Review
Chemistry, Multidisciplinary
Sania Ghobadi Alamdari, Mohammad Amini, Nazila Jalilzadeh, Behzad Baradaran, Reza Mohammadzadeh, Ahad Mokhtarzadeh, Fatemeh Oroojalian
Summary: Nanotechnology plays an important role in photothermal therapy of breast cancer, enhancing the effectiveness by utilizing the characteristics of nanoparticles and combining with other treatment methods. Targeted therapy can be achieved by incorporating specific ligands on nanoparticles.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, Research & Experimental
Jing Li, Xiaoqin Xu, Xiting Peng
Summary: This study investigated the mechanism of cisplatin resistance in triple-negative breast cancer (TNBC). The results revealed that NDC80 was a cisplatin-resistant gene and its expression differed between cisplatin-sensitive and resistant cells. NDC80 was found to be overexpressed in TNBC tissues and increased after cisplatin treatment. Moreover, NDC80 overexpression promoted the viability and proliferation of TNBC cells and enhanced their resistance to cisplatin. The study also identified potential pathways associated with cisplatin resistance.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Kaiping Mao, Weina Zhang, Lan Yu, Yi Yu, Haixia Liu, Xiaotao Zhang
Summary: A transferrin-functionalized protein-lipid hybrid nanoparticle loaded with cisplatin and docetaxel showed significantly better antitumor ability in vitro and in vivo, potentially inhibiting lung tumor growth and aiding in lung cancer treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Shaimaa Maher, Haitham Kalil, Guiming Liu, Khalid Sossey-Alaoui, Mekki Bayachou
Summary: Breast cancer is a leading cause of death in women worldwide, and current treatment methods face challenges due to side effects and drug resistance. This study developed a composite platform called (Alg-AgNPs-CisPt) which combines silver nanoparticles and cisplatin in an alginate hydrogel. The results showed that this nanocomplex demonstrated greater efficacy against breast cancer cells compared to standalone treatments with AgNPs or cisplatin. The study highlights the potential of the (Alg-AgNPs-CisPt) nanocomplex as a promising platform for targeting breast cancer cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Chemistry, Medicinal
Dominick Salerno, Stavroula Sofou
Summary: The study shows that combinations of tumor-responsive nanoparticles (NP) with therapeutic drugs can improve treatment efficacy, especially for chemotherapy-resistant cells. This combination therapy is more effective than single agents or conventional liposomal forms of the drugs.
Article
Pharmacology & Pharmacy
Bianca de Melo Santana, Joana Claudio Pieretti, Rafael Nunes Gomes, Giselle Cerchiaro, Amedea Barozzi Seabra
Summary: Combining nitric oxide (NO) donor and silica nanoparticles loaded with cisplatin into a polymeric matrix can create a drug-delivery system that provides sustained and localized drug release against tumor cells.
Review
Engineering, Biomedical
Pallabita Chowdhury, Upasana Ghosh, Kamalika Samanta, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Summary: Management of aggressive breast cancer, particularly TNBC, remains challenging despite advances in treatment. New therapies like atezolizumab, olaparib, and sacituzumab show limited survival benefits. Current research aims to improve treatment strategies by enhancing bioavailability, targetability, and reducing toxicity for better therapeutic outcomes.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Gaili Chen, Dazhen Jiang, Shuaijie Ding, Chunyu Huang, Daoming Zhu, Huangang Jiang
Summary: A multifunctional nanozyme that mimics tumor cell exosomes (CuPy-Au@EM) was fabricated in this work for achieving a highly effective and secure cancer radiotherapy regimen.
Article
Acoustics
Aniket Pradip Udepurkar, Wim Dermaut, Christian Clasen, Simon Kuhn
Summary: In this article, a new system combining an ultrasonic microreactor with a tubular reactor is introduced for the continuous production of polymer nanoparticles. The system demonstrates the continuous generation of cross-linked polymer nanoparticles using the monomer butyl methacrylate and the cross-linker ethylene glycol dimethacrylate. The article investigates the miniemulsion polymerization of a monomer-in-water miniemulsion in a batch system and then utilizes a coiled tubular reactor for the continuous polymerization. The study also examines the impact of monomer volume fraction and surfactant concentration on the synthesized nanoparticles. The system showcased in this research successfully synthesizes polymer particles ranging from 50 to 250 nm in size and achieves a high polymerization conversion.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Oncology
Sina M. Matalqah, Khalid Aiedeh, Nizar M. Mhaidat, Karem H. Alzoubi, Belal A. Al-Husein
Summary: A novel pH-responsive modified chitosan-based nanoparticles system was developed for active loading and triggered intracellular release of the anti-cancer drug doxorubicin (DOX). The nanoparticles exhibited pH-dependent drug release and higher cytotoxicity against MCF-7 breast cancer cells compared to free DOX.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Materials Science, Multidisciplinary
Weslany Silverio Neto, Gabriel Victor Simoes Dutra, Maria de Sousa Brito Neta, Sacha Braun Chaves, Leonardo Fonseca Valadares, Fernando Gomes de Souza Junior, Fabricio Machado
Summary: The study developed a new magnetopolymeric fluid with potential for tumor treatment through embolization and hyperthermia. Characterization and cytotoxicity evaluation showed promising results, suggesting its potential as an embolic agent for selective and complete obstruction of blood vessels and for treatment by hyperthermia.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Maedeh Koohi Moftakhari Esfahani, Seyed Ebrahim Alavi, Peter J. Cabot, Nazrul Islam, Emad L. Izake
Summary: This study developed a new drug nanoformulation by loading fenbendazole (FBZ) into MCM-BLG nanoparticles, which improved the solubility and bioavailability of FBZ and exhibited higher anticancer effects against human prostate cancer cells.
Article
Chemistry, Medicinal
Seyed Ebrahim Alavi, Aun Raza, Maedeh Koohi Moftakhari Esfahani, Azim Akbarzadeh, Seyed Hossein Abdollahi, Hasan Ebrahimi Shahmabadi
Summary: This study aimed to develop a stable nano-niosome formulation of carboplatin (CB) and evaluate its therapeutic efficacy in breast cancer treatment. The results showed that the PEG-NS-CB formulation had controlled drug release, higher cytotoxicity, and greater stability compared to other formulations. In vivo experiments demonstrated that PEG-NS-CB had improved therapeutic effects and reduced toxicity in breast cancer-bearing mice. Overall, PEG-NS-CB showed promising potential for breast cancer treatment.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Maedeh Koohi Moftakhari Esfahani, Seyed Ebrahim Alavi, Peter J. Cabot, Nazrul Islam, Emad L. Izake
Summary: This review discusses the biomedical application of mesoporous silica nanoparticles (MSNs) as drug carriers for cancer therapy. MSNs, with their unique properties, show great potential for improving drug solubility and delivery. The development of multimodal anticancer therapeutics and chemical modifications can further enhance the applications of MSNs. Safety issues related to these nanoparticles are also discussed.
Article
Pharmacology & Pharmacy
Seyed Ebrahim Alavi, Urooj Bakht, Maedeh Koohi Moftakhari Esfahani, Hossein Adelnia, Seyed Hossein Abdollahi, Hasan Ebrahimi Shahmabadi, Aun Raza
Summary: This study demonstrates the use of PEGylated nanostructured lipid carrier nanoparticles as a promising approach for improving the oral delivery and efficacy of trimethoprim/sulfamethoxazole (TMP/SMZ) for the treatment of MRSA skin infection. The nanoformulation was found to have a controlled release of drugs at intestinal pH, decreased drug toxicity, enhanced drug permeability, and improved antibacterial effects. The stability of the nanoparticles was also shown. Overall, this study highlights the potential of PEGylated NLC nanoparticles in improving the treatment of MRSA skin infection.
Article
Pharmacology & Pharmacy
Mohsen Ghaferi, Aun Raza, Maedeh Koohi, Warda Zahra, Azim Akbarzadeh, Hasan Ebrahimi Shahmabadi, Seyed Ebrahim Alavi
Summary: This study evaluated the therapeutic efficacy of doxorubicin and carboplatin loaded into PEG-modified liposome nanoparticles for glioblastoma treatment. The results showed that PEG-Lip-DOX/CB exhibited controlled release of the drugs and significantly increased their cytotoxicity against cancer cells. In vivo experiments also demonstrated that PEGylated liposomes improved therapeutic effects and reduced side effects compared to non-PEGylated liposomes.
Review
Pharmacology & Pharmacy
Seyed Ebrahim Alavi, Aun Raza, Max Gholami, Michael Giles, Rayan Al-Sammak, Ali Ibrahim, Hasan Ebrahimi Shahmabadi, Lavanya A. Sharma
Summary: The oral cavity is a complex ecosystem that can be affected by various factors, leading to dysbiosis and the emergence of oral infectious diseases. Oral drug delivery systems (DDS), including nanoscopic DDS, have been developed to overcome challenges associated with systemic drug administration. This literature review highlights current therapeutic challenges and the applications of DDS for the treatment of oral infectious diseases. It also discusses the structures and therapeutic agents delivered by DDS, as well as strategies to improve treatment outcomes.
Article
Materials Science, Ceramics
Reza Boshrouyeh, Samar Amari, Mohammad Boshrouyeh Ghandashtani, Seyed Ebrahim Alavi, Hasan Ebrahimi Shahmabadi
Summary: This study aimed to improve the solubility and permeability of Amphotericin B (AmB) for the topical treatment of cutaneous leishmaniasis (CL) caused by Leishmania major. Two formulations of AmB, Lip-AmB and PEG-Lip-AmB, were developed using liposomes and polyethylene glycol (PEG)ylated liposomes. The results showed that PEG-Lip-AmB was more effective in reducing drug toxicity and increasing therapeutic effects compared to Lip-AmB. In vivo studies also demonstrated that PEG-Lip-AmB-Gel could significantly reduce lesion size and parasite burden compared to Lip-AmB-Gel. These findings suggest that PEG-Lip-AmB-Gel is a promising carrier for improving the properties of AmB for topical treatment of CL.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Pronalis Tapfumaneyi, Mohammad Imran, Seyed Ebrahim Alavi, Yousuf Mohammed
Summary: Studies have shown that the thermodynamic activity of drugs plays a significant role in skin drug delivery by increasing drug absorption. This activity can be altered based on the physicochemical parameters of the drug in the vehicle. Thermodynamic principles have been utilized to develop novel delivery systems and enhance drug permeation through the skin. This review provides insights into the importance of thermodynamic principles in optimizing topical and transdermal drug delivery systems.
DRUG DISCOVERY TODAY
(2023)
Review
Chemistry, Multidisciplinary
Shiromani Wijesundara, Lavanya A. A. Sharma, Seyed Ebrahim Alavi, Ajay Sharma
Summary: This study conducted a systematic review on the effect of surgical treatments on peri-implantitis by evaluating published literature. Five research studies with a minimum of 20 participants and two-year follow-up after surgery were selected based on PRISMA guidelines. The results showed a significant reduction in probing pocket depth and bleeding on probing in all five studies, but no significant variation in patients treated with different surgical methods. The study utilizing regenerative surgical therapy, deproteinized bovine bone mineral, enamel matrix derivative, and doxycycline showed the highest reduction in bleeding on probing. Overall, surgical treatment, including bone substitute material, demonstrated clinical improvement in the reviewed studies compared to pre-intervention, although statistical significance was not observed.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Xuping Jin, Seyed Ebrahim Alavi, Abbas Shafiee, Vania Rodrigues Leite-Silva, Kiarash Khosrotehrani, Yousuf Mohammed
Summary: The study found that the decrease in drug permeation during volatile solvent evaporation is due to increased viscosity and drug crystallization, rather than depletion of the applied dose. This study provides the necessary background for building complex models that incorporate evaporation, viscosity, and drug permeation.
Review
Medicine, General & Internal
Seyed Ebrahim Alavi, Max Gholami, Hasan Ebrahimi Shahmabadi, Peter Reher
Summary: This literature review comprehensively discusses various aspects of resorbable scaffolds in bone tissue engineering, including scaffold design, materials, fabrication techniques, and advanced manufacturing methods. The review also explores surface modifications to improve cellular responses and describes the mechanisms of bone regeneration. Furthermore, the review delves into emerging areas of metamaterials and artificial intelligence applications in tissue engineering and regenerative medicine.
JOURNAL OF CLINICAL MEDICINE
(2023)
