4.7 Article

Enantioselective Copper-Catalyzed Intramolecular N-H Bond Insertion: Synthesis of Chiral 2-Carboxytetrahydroquinolines

期刊

ADVANCED SYNTHESIS & CATALYSIS
卷 358, 期 15, 页码 2366-2370

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600390

关键词

asymmetric catalysis; carbene insertion; 2-carboxytetrahydroquinolines; chiral spiro ligands; copper

资金

  1. National Natural Science Foundation of China
  2. National Basic Research Program of China [2012CB821600]
  3. 111 project of the Ministry of Education of China [B06005]
  4. National Program for Support of Top-notch Young Professionals

向作者/读者索取更多资源

The first highly enantioselective intramolecular N-H bond insertion was realized by using copper catalysts modified with chiral spirobisoxazoline ligands, which provides a novel strategy for the synthesis of chiral 2-carboxytetrahydroquinolines. This reaction features fast reaction rate, high yield, high enantioselectivity, and mild reaction conditions.

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