4.8 Article

Quantitative Probing of Cu2+ Ions Naturally Present in Single Living Cells

期刊

ADVANCED MATERIALS
卷 28, 期 21, 页码 4071-4076

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201600161

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资金

  1. Ministry of Trade, Industry and Energy (MOTIE)
  2. Korea Institute for Advancement of Technology (KIAT) through International Cooperative RD Program
  3. Brain Korea 21 PLUS Project for Center for Creative Industrial Materials
  4. POSCO (AP-TP)
  5. POSCO (Green Science)
  6. Cooperative Research Program for Agriculture Science & Technology Development, Rural Development Administration, Republic of Korea [PJ01121602]
  7. Ministry of Trade, Industry & Energy (MOTIE), Republic of Korea [N0001706] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  8. National Research Foundation of Korea [161S-1-3-1503, 10Z20130012243] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Quantitative probing of Cu2+ ions naturally present in single living cells is realized by developing a quantum-dot-embedded nanowire-waveguide probe. The intracellular Cu2+ ion concentration is quantified by direct monitoring of photo luminescence quenching during the insertion of the nanowire in a living neuron. The measured intracellular Cu2+ ion concentration is 3.34 +/- 1.04 x 10(-6) M (mean +/- s.e.m.) in single hippocampal neurons.

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