Giant tortoise genomes provide insights into longevity and age-related disease

Tropical ancient DNA reveals relationships of the extinct Bahamian giant tortoiseChelonoidis alburyorum

(2017) Christian Kehlmaier et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites

(2016) Farokh Dotiwala et al.   NATURE MEDICINE

OrthoDB v9.1: cataloging evolutionary and functional annotations for animal, fungal, plant, archaeal, bacterial and viral orthologs

(2016) Evgeny M. Zdobnov et al.   NUCLEIC ACIDS RESEARCH

UniProt: the universal protein knowledgebase

(2016)   NUCLEIC ACIDS RESEARCH

Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells

(2016) Paola Corti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

(2016) Jorge Iván Castillo-Quan et al.   Cell Reports

A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging

(2015) Fabian Sanchis-Gomar et al.   AGE

DNA repair in species with extreme lifespan differences

(2015) Sheila L MacRae et al.   Aging-US

BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs

(2015) Felipe A. Simão et al.   BIOINFORMATICS

The Full Globin Repertoire of Turtles Provides Insights into Vertebrate Globin Evolution and Functions

(2015) Kim Schwarze et al.   Genome Biology and Evolution

A phylogenomic analysis of turtles

(2015) Nicholas G. Crawford et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

(2015) Adrian S. Tong et al.   Cell Reports

Insights into the Evolution of Longevity from the Bowhead Whale Genome

(2015) Michael Keane et al.   Cell Reports

The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat

(2015) Malene Brohus et al.   PLoS One

Neurolysin Knockout Mice Generation and Initial Phenotype Characterization

(2014) Diogo M. L. P. Cavalcanti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative genetics of longevity and cancer: insights from long-lived rodents

(2014) Vera Gorbunova et al.   NATURE REVIEWS GENETICS

Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection

(2014) James M. Daley et al.   NUCLEIC ACIDS RESEARCH

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Rapid Evolution of Beta-Keratin Genes Contribute to Phenotypic Differences That Distinguish Turtles and Birds from Other Reptiles

(2013) Yang I. Li et al.   Genome Biology and Evolution

The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan

(2013) Zhuo Wang et al.   NATURE GENETICS

Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau

(2013) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

(2013) C. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres

(2013) Albert Ribes-Zamora et al.   Cell Reports

Phylogenomic analyses support the position of turtles as the sister group of birds and crocodiles (Archosauria)

(2012) Ylenia Chiari et al.   BMC BIOLOGY

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies

(2012) Mette Soerensen et al.   EXPERIMENTAL GERONTOLOGY

Extensive DNA Damage-Induced Sumoylation Contributes to Replication and Repair and Acts in Addition to the Mec1 Checkpoint

(2012) Catherine A. Cremona et al.   MOLECULAR CELL

The legacy of Lonesome George

(2012) Henry Nicholls   NATURE

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Mind the Gap: Upgrading Genomes with Pacific Biosciences RS Long-Read Sequencing Technology

(2012) Adam C. English et al.   PLoS One

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

(2012) A. T. van der Goot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolution of island gigantism and body size variation in tortoises and turtles

(2011) A. L. Jaffe et al.   Biology Letters

Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

(2011) Alesia Ivashkevich et al.   CANCER LETTERS

Inference of human population history from individual whole-genome sequences

(2011) Heng Li et al.   NATURE

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

(2011) Eun Bae Kim et al.   NATURE

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Peto's Paradox: evolution's prescription for cancer prevention

(2011) Aleah F. Caulin et al.   TRENDS IN ECOLOGY & EVOLUTION

Scaffolding pre-assembled contigs using SSPACE

(2010) Marten Boetzer et al.   BIOINFORMATICS

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

Gene duplication and fragmentation in the zebra finch major histocompatibility complex

(2010) Christopher N Balakrishnan et al.   BMC BIOLOGY

Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals

(2010) Víctor Quesada et al.   BMC GENOMICS

The diverse functions of GAPDH: Views from different subcellular compartments

(2010) Carlos Tristan et al.   CELLULAR SIGNALLING

Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction

(2010) James M. Harper et al.   FASEB JOURNAL

Understanding the vertebrate immune system: insights from the reptilian perspective

(2010) L. M. Zimmerman et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

High-quality draft assemblies of mammalian genomes from massively parallel sequence data

(2010) S. Gnerre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

MIF Deficiency Reduces Chronic Inflammation in White Adipose Tissue and Impairs the Development of Insulin Resistance, Glucose Intolerance, and Associated Atherosclerotic Disease

(2009) Lars Verschuren et al.   CIRCULATION RESEARCH

From evolutionary genetics to human immunology: how selection shapes host defence genes

(2009) Luis B. Barreiro et al.   NATURE REVIEWS GENETICS

Ku86 represses lethal telomere deletion events in human somatic cells

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA